CiteULike | Further Information

• {"link"=>{"url"=>"http://www.citeulike.org/user/gdv/article/4208633"}, "post_time"=>"2010-05-04 11:04:17", "tag"=>"warfarin", "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pgen.1000433"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/19300499"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=19300499"}], "username"=>"gdv", "article_id"=>"4208633"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/Borelli/article/4208633"}, "post_time"=>"2011-02-09 16:34:02", "tag"=>["gwas", "partial_correlation"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pgen.1000433"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/19300499"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=19300499"}], "username"=>"Borelli", "article_id"=>"4208633"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/tkaczor/article/4208633"}, "post_time"=>"2009-07-06 21:04:45", "tag"=>["k", "predictive", "snp", "warfarin"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pgen.1000433"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/19300499"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=19300499"}], "username"=>"tkaczor", "article_id"=>"4208633"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/turnersd/article/4208633"}, "post_time"=>"2009-04-24 18:46:20", "tag"=>["gwas", "pharmacogenetics"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pgen.1000433"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/19300499"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=19300499"}], "username"=>"turnersd", "article_id"=>"4208633"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/rdiaz/article/4208633"}, "post_time"=>"2009-03-23 10:14:01", "tag"=>["gwas", "wgas"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pgen.1000433"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/19300499"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=19300499"}], "username"=>"rdiaz", "article_id"=>"4208633"}

Mendeley | Further Information

{"title"=>"A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose", "type"=>"journal", "authors"=>[{"first_name"=>"Fumihiko", "last_name"=>"Takeuchi", "scopus_author_id"=>"7103237031"}, {"first_name"=>"Ralph", "last_name"=>"McGinnis", "scopus_author_id"=>"7003755585"}, {"first_name"=>"Stephane", "last_name"=>"Bourgeois", "scopus_author_id"=>"8098017100"}, {"first_name"=>"Chris", "last_name"=>"Barnes", "scopus_author_id"=>"24764733700"}, {"first_name"=>"Niclas", "last_name"=>"Eriksson", "scopus_author_id"=>"15072587100"}, {"first_name"=>"Nicole", "last_name"=>"Soranzo", "scopus_author_id"=>"55800239500"}, {"first_name"=>"Pamela", "last_name"=>"Whittaker", "scopus_author_id"=>"56804575900"}, {"first_name"=>"Venkatesh", "last_name"=>"Ranganath", "scopus_author_id"=>"21741481400"}, {"first_name"=>"Vasudev", "last_name"=>"Kumanduri", "scopus_author_id"=>"12776775800"}, {"first_name"=>"William", "last_name"=>"McLaren", "scopus_author_id"=>"16686734100"}, {"first_name"=>"Lennart", "last_name"=>"Holm", "scopus_author_id"=>"24080378700"}, {"first_name"=>"Jonatan", "last_name"=>"Lindh", "scopus_author_id"=>"7003857375"}, {"first_name"=>"Anders", "last_name"=>"Rane", "scopus_author_id"=>"7102519032"}, {"first_name"=>"Mia", "last_name"=>"Wadelius", "scopus_author_id"=>"6603005522"}, {"first_name"=>"Panos", "last_name"=>"Deloukas", "scopus_author_id"=>"7003287098"}], "year"=>2009, "source"=>"PLoS Genetics", "identifiers"=>{"scopus"=>"2-s2.0-63449117825", "pui"=>"354404871", "pmid"=>"19300499", "issn"=>"15537390", "isbn"=>"1553-7404 (Electronic)", "doi"=>"10.1371/journal.pgen.1000433", "sgr"=>"63449117825"}, "id"=>"eb6ae9b8-f78e-3512-92af-86e327b8feb6", "abstract"=>"We report the first genome-wide association study (GWAS) whose sample size (1,053 Swedish subjects) is sufficiently powered to detect genome-wide significance (p<1.5 x 10(-7)) for polymorphisms that modestly alter therapeutic warfarin dose. The anticoagulant drug warfarin is widely prescribed for reducing the risk of stroke, thrombosis, pulmonary embolism, and coronary malfunction. However, Caucasians vary widely (20-fold) in the dose needed for therapeutic anticoagulation, and hence prescribed doses may be too low (risking serious illness) or too high (risking severe bleeding). Prior work established that approximately 30% of the dose variance is explained by single nucleotide polymorphisms (SNPs) in the warfarin drug target VKORC1 and another approximately 12% by two non-synonymous SNPs (*2, *3) in the cytochrome P450 warfarin-metabolizing gene CYP2C9. We initially tested each of 325,997 GWAS SNPs for association with warfarin dose by univariate regression and found the strongest statistical signals (p<10(-78)) at SNPs clustering near VKORC1 and the second lowest p-values (p<10(-31)) emanating from CYP2C9. No other SNPs approached genome-wide significance. To enhance detection of weaker effects, we conducted multiple regression adjusting for known influences on warfarin dose (VKORC1, CYP2C9, age, gender) and identified a single SNP (rs2108622) with genome-wide significance (p = 8.3 x 10(-10)) that alters protein coding of the CYP4F2 gene. We confirmed this result in 588 additional Swedish patients (p<0.0029) and, during our investigation, a second group provided independent confirmation from a scan of warfarin-metabolizing genes. We also thoroughly investigated copy number variations, haplotypes, and imputed SNPs, but found no additional highly significant warfarin associations. We present power analysis of our GWAS that is generalizable to other studies, and conclude we had 80% power to detect genome-wide significance for common causative variants or markers explaining at least 1.5% of dose variance. These GWAS results provide further impetus for conducting large-scale trials assessing patient benefit from genotype-based forecasting of warfarin dose.", "link"=>"http://www.mendeley.com/research/genomewide-association-study-confirms-vkorc1-cyp2c9-cyp4f2-principal-genetic-determinants-warfarin-d", "reader_count"=>231, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>17, "Librarian"=>1, "Researcher"=>49, "Student > Doctoral Student"=>12, "Student > Ph. D. Student"=>42, "Student > Postgraduate"=>18, "Student > Master"=>30, "Other"=>7, "Student > Bachelor"=>39, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>5, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>17, "Librarian"=>1, "Researcher"=>49, "Student > Doctoral Student"=>12, "Student > Ph. D. Student"=>42, "Student > Postgraduate"=>18, "Student > Master"=>30, "Other"=>7, "Student > Bachelor"=>39, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>5, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>11, "Agricultural and Biological Sciences"=>111, "Business, Management and Accounting"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Chemical Engineering"=>1, "Computer Science"=>4, "Decision Sciences"=>1, "Earth and Planetary Sciences"=>1, "Engineering"=>1, "Environmental Science"=>3, "Biochemistry, Genetics and Molecular Biology"=>20, "Mathematics"=>2, "Medicine and Dentistry"=>61, "Design"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>7, "Psychology"=>3, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>61}, "Social Sciences"=>{"Social Sciences"=>2}, "Decision Sciences"=>{"Decision Sciences"=>1}, "Psychology"=>{"Psychology"=>3}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>11}, "Environmental Science"=>{"Environmental Science"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>7}, "Chemical Engineering"=>{"Chemical Engineering"=>1}, "Design"=>{"Design"=>1}, "Engineering"=>{"Engineering"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>111}, "Computer Science"=>{"Computer Science"=>4}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>20}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Republic of Singapore"=>1, "Colombia"=>1, "United States"=>6, "Japan"=>3, "United Kingdom"=>1, "Portugal"=>2, "Switzerland"=>1, "Russia"=>1, "Spain"=>2, "Canada"=>1, "Netherlands"=>1, "Pakistan"=>1, "Brazil"=>1, "Mexico"=>3, "Italy"=>1, "France"=>1, "Chile"=>1, "Germany"=>2}, "group_count"=>14}

ORCID | Further Information

CrossRef

• http://doi.org/10.1586/ecp.11.15
• http://doi.org/10.7705/biomedica.v30i3.275
• http://doi.org/10.1007/s40291-016-0190-7
• http://doi.org/10.1007/s00204-013-1013-9
• http://doi.org/10.2217/pgs-2017-0186
• http://doi.org/10.1002/jcph.392
• http://doi.org/10.1007/s12185-012-1205-8
• http://doi.org/10.1016/j.cca.2011.07.013
• http://doi.org/10.5482/HAMO-13-09-0047
• http://doi.org/10.2217/pgs.13.152
• http://doi.org/10.1371/journal.pone.0099069
• http://doi.org/10.1111/j.1365-2796.2011.02509.x
• http://doi.org/10.2217/pme.09.55
• http://doi.org/10.1155/2011/739751
• http://doi.org/10.1038/clpt.2014.78
• http://doi.org/10.2217/pgs.11.184
• http://doi.org/10.1111/jth.12647
• http://doi.org/10.1109/JBHI.2014.2336974
• http://doi.org/10.1007/s11239-010-0467-3
• http://doi.org/10.1161/CIRCRESAHA.117.310782
• http://doi.org/10.1007/s12291-011-0133-3
• http://doi.org/10.1371/journal.pone.0071505
• http://doi.org/10.1007/s00228-011-0995-6
• http://doi.org/10.1097/FPC.0b013e3283317ab5
• http://doi.org/10.1371/journal.pone.0150456
• http://doi.org/10.7861/clinmedicine.9-5-493
• http://doi.org/10.1007/s10840-011-9561-5
• http://doi.org/10.1016/j.abb.2014.10.006
• http://doi.org/10.4338/ACI-2016-05-RA-0081
• http://doi.org/10.1007/s00439-013-1268-5
• http://doi.org/10.1093/hmg/dds341
• http://doi.org/10.2217/pgs.12.164
• http://doi.org/10.2217/pgs-2017-0148
• http://doi.org/10.1097/FPC.0b013e328358dd70
• http://doi.org/10.1517/17425255.2015.1004053
• http://doi.org/10.1016/j.jns.2014.04.039
• http://doi.org/10.1097/FPC.0000000000000108
• http://doi.org/10.1080/17425255.2017.1338274
• http://doi.org/10.2217/pme.11.68
• http://doi.org/10.1186/s13104-016-2306-x
• http://doi.org/10.1111/j.1365-2044.2011.06918.x
• http://doi.org/10.1371/journal.pone.0011210
• http://doi.org/10.1111/jphp.12084
• http://doi.org/10.1038/nrg.2016.12
• http://doi.org/10.1038/tpj.2011.7
• http://doi.org/10.3389/fphar.2018.00542
• http://doi.org/10.1016/j.ihj.2018.02.005
• http://doi.org/10.1038/s41397-019-0083-3
• http://doi.org/10.1016/j.ijcard.2015.02.025
• http://doi.org/10.1093/bioinformatics/btw125
• http://doi.org/10.1007/s00228-013-1617-2
• http://doi.org/10.1592/phco.31.12.1192
• http://doi.org/10.2217/pgs.12.2
• http://doi.org/10.1002/jcph.425
• http://doi.org/10.1002/gepi.21719
• http://doi.org/10.1007/s00228-011-1060-1
• http://doi.org/10.1517/17425255.2014.894020
• http://doi.org/10.1016/j.cjca.2012.08.020
• http://doi.org/10.1097/HCO.0b013e32835f0bbc
• http://doi.org/10.2217/pgs.14.88
• http://doi.org/10.1186/s13073-015-0255-y
• http://doi.org/10.1016/j.medcli.2010.05.001
• http://doi.org/10.2217/pgs.10.162
• http://doi.org/10.2217/pgs.13.29
• http://doi.org/10.1111/jcpt.12527
• http://doi.org/10.1016/j.pharmthera.2017.02.036
• http://doi.org/10.3109/03014460.2015.1068372
• http://doi.org/10.1515/dmpt-2015-0039
• http://doi.org/10.1097/MCP.0b013e32833b1c6c
• http://doi.org/10.4065/mcp.2009.0278
• http://doi.org/10.1097/GIM.0b013e318238b38c
• http://doi.org/10.2217/pgs.15.89
• http://doi.org/10.1016/j.rmclc.2015.04.008
• http://doi.org/10.2217/pgs.10.99
• http://doi.org/10.2217/pgs.11.36
• http://doi.org/10.3389/fphar.2017.00347
• http://doi.org/10.1038/tpj.2013.4
• http://doi.org/10.1007/s00228-010-0857-7
• http://doi.org/10.1111/bcp.12220
• http://doi.org/10.1186/1749-8090-7-97
• http://doi.org/10.2217/pgs-2017-0207
• http://doi.org/10.2217/pgs.09.127
• http://doi.org/10.1016/j.pharmthera.2011.11.002
• http://doi.org/10.1186/1878-5085-3-10
• http://doi.org/10.1038/tpj.2012.45
• http://doi.org/10.4061/2011/212485
• http://doi.org/10.2217/pgs.11.156
• http://doi.org/10.1016/j.clinthera.2016.10.014
• http://doi.org/10.3389/fphar.2017.00323
• http://doi.org/10.3390/genes5020430
• http://doi.org/10.1093/eurheartj/ehr239
• http://doi.org/10.1093/hmg/ddq389
• http://doi.org/10.1016/j.pain.2014.05.032
• http://doi.org/10.1146/annurev-pharmtox-011112-140237
• http://doi.org/10.2217/pgs-2018-0143
• http://doi.org/10.1007/s00228-010-0950-y
• http://doi.org/10.1146/annurev-pharmtox-010611-134743
• http://doi.org/10.1038/s41397-018-0048-y
• http://doi.org/10.1016/j.clinthera.2012.02.009
• http://doi.org/10.1002/pbc.24592
• http://doi.org/10.1016/j.cca.2013.05.008
• http://doi.org/10.3724/SP.J.1263.2012.04162
• http://doi.org/10.2217/pgs.09.149
• http://doi.org/10.1160/TH14-02-0189
• http://doi.org/10.1182/blood-2011-07-367763
• http://doi.org/10.1371/journal.pone.0183561
• http://doi.org/10.1007/s40262-015-0324-9
• http://doi.org/10.1002/ps.4797
• http://doi.org/10.1111/j.1365-2125.2011.03942.x
• http://doi.org/10.1038/jhg.2015.78
• http://doi.org/10.1097/FTD.0b013e318256a77c
• http://doi.org/10.2217/pgs.13.149
• http://doi.org/10.1038/nrcardio.2015.64
• http://doi.org/10.1186/s13073-018-0513-x
• http://doi.org/10.1007/s40142-012-0001-3
• http://doi.org/10.2217/pgs.09.71
• http://doi.org/10.1007/s00228-013-1581-x
• http://doi.org/10.1097/FPC.0b013e32835a3a6d
• http://doi.org/10.1016/S2211-9698(11)71437-6
• http://doi.org/10.1038/tpj.2014.36
• http://doi.org/10.1038/tpj.2017.8
• http://doi.org/10.1161/CIRCULATIONAHA.112.105908
• http://doi.org/10.1097/MBC.0000000000000213
• http://doi.org/10.1051/medsci/201430s203
• http://doi.org/10.1002/pbc.24932
• http://doi.org/10.1371/journal.pcbi.1002457
• http://doi.org/10.2217/pgs.12.62
• http://doi.org/10.1371/journal.pone.0156000
• http://doi.org/10.1016/j.tcm.2014.09.001
• http://doi.org/10.1007/s11910-010-0157-8
• http://doi.org/10.1517/17425255.2015.976201
• http://doi.org/10.1038/jhg.2013.40
• http://doi.org/10.1016/j.thromres.2010.05.016
• http://doi.org/10.1002/jcph.1444
• http://doi.org/10.1007/s00228-010-0809-2
• http://doi.org/10.1016/j.jvn.2016.05.002
• http://doi.org/10.2217/pgs-2015-0007
• http://doi.org/10.1016/j.jacc.2012.01.067
• http://doi.org/10.2217/fca.12.31
• http://doi.org/10.1038/clpt.2013.7
• http://doi.org/10.2217/pgs.14.18
• http://doi.org/10.1080/17425255.2017.1363887
• http://doi.org/10.1371/journal.pone.0105250
• http://doi.org/10.1177/1358863X13503193
• http://doi.org/10.1146/annurev-pharmtox-010818-021154
• http://doi.org/10.2217/pgs-2016-0152
• http://doi.org/10.1016/j.ajhg.2012.07.010
• http://doi.org/10.1016/j.thromres.2011.11.043
• http://doi.org/10.1007/s00103-013-1930-z
• http://doi.org/10.1007/s00228-017-2373-5
• http://doi.org/10.2217/fca.10.6
• http://doi.org/10.1177/1076029616683046
• http://doi.org/10.1371/journal.pone.0076328
• http://doi.org/10.1124/dmd.115.067900
• http://doi.org/10.1038/tpj.2014.83
• http://doi.org/10.1016/j.bcp.2016.03.025
• http://doi.org/10.1248/yakushi.14-00230-1
• http://doi.org/10.1517/17530059.2011.540567
• http://doi.org/10.1002/wsbm.1302
• http://doi.org/10.1007/s12288-018-0987-0
• http://doi.org/10.1007/s00228-011-1143-z
• http://doi.org/10.3923/pjbs.2009.1160.1163
• http://doi.org/10.1038/tpj.2010.71
• http://doi.org/10.1101/cshperspect.a033027
• http://doi.org/10.2217/pgs.09.171
• http://doi.org/10.1002/eji.201344270
• http://doi.org/10.1161/CIRCRESAHA.117.310965
• http://doi.org/10.1016/j.gpb.2016.03.008
• http://doi.org/10.1253/circj.CJ-09-0876
• http://doi.org/10.2217/pgs.11.164
• http://doi.org/10.1016/j.cjca.2012.07.845
• http://doi.org/10.1097/FPC.0000000000000244
• http://doi.org/10.1146/annurev-pharmtox-010510-100502
• http://doi.org/10.1007/s00228-009-0651-6
• http://doi.org/10.1371/journal.pone.0172880
• http://doi.org/10.1515/cclm.2011.748
• http://doi.org/10.2217/pgs.11.76
• http://doi.org/10.1016/j.cca.2013.07.010
• http://doi.org/10.1517/17425255.2011.570260
• http://doi.org/10.1016/j.canlet.2018.02.012
• http://doi.org/10.1038/nrg3352
• http://doi.org/10.2217/PGS.15.54
• http://doi.org/10.1038/jhg.2010.73
• http://doi.org/10.1371/journal.pcbi.1002817
• http://doi.org/10.1111/add.13818
• http://doi.org/10.1208/s12248-015-9726-8
• http://doi.org/10.1038/clpt.2009.223
• http://doi.org/10.1007/s00228-018-2528-z
• http://doi.org/10.4236/jbise.2012.510069
• http://doi.org/10.1016/S0140-6736(13)60681-9
• http://doi.org/10.1016/j.sder.2010.04.006
• http://doi.org/10.1038/clpt.2010.142
• http://doi.org/10.2217/pgs.11.147
• http://doi.org/10.1038/tpj.2014.39
• http://doi.org/10.1042/BJ20100522
• http://doi.org/10.1038/clpt.2012.184
• http://doi.org/10.1161/CIRCRESAHA.110.230995
• http://doi.org/10.1007/BF03257189
• http://doi.org/10.1371/journal.pgen.1005663
• http://doi.org/10.1002/wsbm.125
• http://doi.org/10.1038/tpj.2012.7
• http://doi.org/10.4065/mcp.2011.0337
• http://doi.org/10.1016/j.drudis.2011.09.001
• http://doi.org/10.1371/journal.pone.0027808
• http://doi.org/10.3378/027.084.0103
• http://doi.org/10.1111/bcp.13157
• http://doi.org/10.4061/2010/754919
• http://doi.org/10.1038/nrcardio.2013.35
• http://doi.org/10.1146/annurev.publhealth.012809.103723
• http://doi.org/10.1097/HCO.0b013e32835220e3
• http://doi.org/10.1038/clpt.2009.178
• http://doi.org/10.1073/pnas.1001827107
• http://doi.org/10.1097/FPC.0b013e32833d7b45
• http://doi.org/10.1586/erc.09.137
• http://doi.org/10.1111/j.1460-9592.2011.03533.x
• http://doi.org/10.1111/jcpt.12835
• http://doi.org/10.1182/blood-2013-05-505123
• http://doi.org/10.2217/pgs.09.106
• http://doi.org/10.1016/j.cell.2013.09.006
• http://doi.org/10.1051/medsci/2010266-7641
• http://doi.org/10.1038/clpt.2011.179
• http://doi.org/10.1208/s12248-017-0161-x
• http://doi.org/10.1007/s11886-013-0381-3
• http://doi.org/10.1111/j.1365-2125.2012.04354.x
• http://doi.org/10.2217/pgs.13.232
• http://doi.org/10.1111/j.1365-2125.2012.04328.x
• http://doi.org/10.2217/pgs-2016-0061
• http://doi.org/10.1155/2013/136524
• http://doi.org/10.1007/s11096-011-9486-1
• http://doi.org/10.2976/1.3292182
• http://doi.org/10.2217/pgs.10.49
• http://doi.org/10.1097/FPC.0000000000000100
• http://doi.org/10.1002/ddr.21050
• http://doi.org/10.1097/CCM.0b013e3181de09f8
• http://doi.org/10.1111/cts.12522
• http://doi.org/10.1007/s12288-016-0725-4
• http://doi.org/10.1038/jhg.2012.94
• http://doi.org/10.1016/j.thromres.2015.02.019
• http://doi.org/10.1146/annurev-med-101712-122545
• http://doi.org/10.1097/FPC.0b013e32834f45f9
• http://doi.org/10.1016/j.pmu.2015.04.002
• http://doi.org/10.1111/bcp.12308
• http://doi.org/10.2217/pgs-2018-0055
• http://doi.org/10.1016/j.thromres.2013.05.002
• http://doi.org/10.1073/pnas.1508425112
• http://doi.org/10.1002/art.37751
• http://doi.org/10.1038/nrg2751
• http://doi.org/10.1016/j.cll.2016.05.002
• http://doi.org/10.1186/1471-2350-12-80
• http://doi.org/10.1097/HJH.0b013e32834091a5
• http://doi.org/10.1038/clpt.2009.307
• http://doi.org/10.1038/clpt.2010.322
• http://doi.org/10.1038/clpt.2014.26
• http://doi.org/10.1161/CIRCRESAHA.115.306360
• http://doi.org/10.1007/s40256-013-0024-5
• http://doi.org/10.1002/phar.1982
• http://doi.org/10.1002/psp4.12054
• http://doi.org/10.1016/j.thromres.2012.02.003
• http://doi.org/10.2217/pgs.09.74
• http://doi.org/10.1155/2013/641089
• http://doi.org/10.2217/pgs.14.10
• http://doi.org/10.1182/blood-2011-07-365502
• http://doi.org/10.1371/journal.pone.0064469
• http://doi.org/10.1002/phar.1717
• http://doi.org/10.1111/bcpt.12024
• http://doi.org/10.1016/j.cll.2009.05.003
• http://doi.org/10.1097/FPC.0b013e32834f288f
• http://doi.org/10.1038/s41397-017-0007-z
• http://doi.org/10.2217/pgs.11.115
• http://doi.org/10.1371/journal.pone.0094573
• http://doi.org/10.1007/s11096-012-9678-3
• http://doi.org/10.2217/pgs.12.174
• http://doi.org/10.1038/nbt.2424
• http://doi.org/10.1097/MD.0000000000014365
• http://doi.org/10.1002/pbc.26653
• http://doi.org/10.1371/journal.pone.0037844
• http://doi.org/10.1016/j.tips.2015.01.003
• http://doi.org/10.1016/j.gene.2013.03.128
• http://doi.org/10.1586/erc.09.117
• http://doi.org/10.1515/dmpt-2017-0034
• http://doi.org/10.1371/journal.pone.0095366
• http://doi.org/10.1016/j.etap.2015.05.008
• http://doi.org/10.1038/ncomms12460
• http://doi.org/10.1097/FPC.0b013e328350ca5f
• http://doi.org/10.1160/TH13-02-0145
• http://doi.org/10.1016/S1734-1140(13)70977-0
• http://doi.org/10.1007/s00246-012-0592-1
• http://doi.org/10.1016/j.xphs.2016.11.017
• http://doi.org/10.1080/17425255.2019.1623878
• http://doi.org/10.1534/genetics.114.162107
• http://doi.org/10.1160/TH13-07-0555
• http://doi.org/10.1111/j.1748-720X.2012.00717.x
• http://doi.org/10.4236/ojgen.2012.24024
• http://doi.org/10.1111/j.1365-2710.2012.01340.x
• http://doi.org/10.1182/blood-2009-12-255992
• http://doi.org/10.1016/j.cca.2011.05.035
• http://doi.org/10.3109/07853890.2010.507601
• http://doi.org/10.2217/pgs.15.26
• http://doi.org/10.2217/pme.12.34
• http://doi.org/10.1007/BF03319099
• http://doi.org/10.1097/MBC.0000000000000272
• http://doi.org/10.1007/s13546-011-0336-x
• http://doi.org/10.2217/pgs.10.31
• http://doi.org/10.5582/ddt.2017.01031
• http://doi.org/10.2217/pgs-2016-0130
• http://doi.org/10.1007/s11096-010-9448-z
• http://doi.org/10.1586/ecp.09.32
• http://doi.org/10.1038/tpj.2012.32
• http://doi.org/10.1038/s41398-018-0150-6
• http://doi.org/10.1182/blood-2011-08-372722
• http://doi.org/10.1155/2018/1686297
• http://doi.org/10.1309/AJCPAO82OTNPUBLW
• http://doi.org/10.1056/NEJMra1010600
• http://doi.org/10.1371/journal.pone.0053049
• http://doi.org/10.1111/j.1365-2125.2011.04095.x
• http://doi.org/10.1038/clpt.2013.234
• http://doi.org/10.1007/s10340-010-0330-5
• http://doi.org/10.1097/MJT.0b013e3181cea0cd
• http://doi.org/10.2133/dmpk.DMPK-12-RG-078
• http://doi.org/10.1038/clpt.2009.291
• http://doi.org/10.1002/wsbm.1199
• http://doi.org/10.2217/pgs.10.8
• http://doi.org/10.1097/PAT.0b013e32834f4d69
• http://doi.org/10.1002/phar.1329
• http://doi.org/10.2217/pgs-2017-0046
• http://doi.org/10.1016/j.drudis.2011.03.006
• http://doi.org/10.2217/pgs.09.138
• http://doi.org/10.1007/s00228-012-1448-6
• http://doi.org/10.3390/jpm8010001
• http://doi.org/10.1160/TH12-05-0362
• http://doi.org/10.1097/FPC.0b013e3283311347
• http://doi.org/10.1371/journal.pgen.1002824
• http://doi.org/10.1371/journal.pgen.1002025
• http://doi.org/10.1160/TH11-12-0848
• http://doi.org/10.2217/pgs.09.125
• http://doi.org/10.1038/clpt.2011.76
• http://doi.org/10.1038/s41598-017-17731-1
• http://doi.org/10.2217/pgs.15.73
• http://doi.org/10.1371/journal.pgen.1004648
• http://doi.org/10.1161/CIRCULATIONAHA.109.914820
• http://doi.org/10.2217/pgs.14.153
• http://doi.org/10.1002/clc.22200
• http://doi.org/10.3390/jpm7040020
• http://doi.org/10.1111/cge.12881
• http://doi.org/10.1111/j.1365-2125.2010.03698.x
• http://doi.org/10.1016/j.mgene.2019.100564
• http://doi.org/10.3109/00498254.2014.952800
• http://doi.org/10.1586/eci.12.51
• http://doi.org/10.1007/s10646-012-1032-y
• http://doi.org/10.1038/clpt.2013.235
• http://doi.org/10.1371/journal.pone.0168732
• http://doi.org/10.1007/s40262-012-0009-6
• http://doi.org/10.1016/j.thromres.2014.06.022
• http://doi.org/10.1007/s11845-013-0978-y
• http://doi.org/10.2165/11318240-000000000-00000

DataCite

Europe PMC Citations | Further Information

Europe PMC Database Citations | Further Information

{"OMIM"=>1, "UNIPROT"=>50}

PubMed Central | Further Information

• 2889115
• 4568216
• 2967750
• 3133537
• 2992873
• 3129254
• 3511993
• 3251364
• 3692386
• 2911553
• 3175513
• 3370347
• 3477339
• 3579249
• 3971980
• 4168390
• 4174953
• 2737687
• 2826717
• 2835152
• 2903229
• 2904527
• 2928561
• 3038469
• 3048822
• 3091944
• 3110519
• 3123434
• 3160494
• 2949522
• 2991422
• 3003940
• 3261355
• 3269890
• 3290900
• 3092476
• 3093198
• 3098751
• 3361510
• 3463230
• 3482399
• 3184612
• 3190669
• 3201825
• 3625373
• 3655533
• 3655546
• 3292047
• 3295228
• 3306231
• 3731755
• 3731766
• 3759580
• 3527666
• 3529768
• 3586586
• 3819119
• 3874723
• 3941038
• 3668552
• 3670944
• 3716458
• 4013286
• 4029408
• 4067047
• 3766418
• 3786327
• 3809070
• 4110075
• 4134937
• 4157963
• 3969849
• 3985126
• 3997166
• 4273087
• 4278947
• 4280295
• 4074513
• 4081861
• 4086864
• 4441275
• 4221483
• 4258421
• 4261059
• 4827719
• 4294552
• 4304738
• 4407810
• 3320573
• 3531317
• 3077384
• 3390407
• 3475673
• 4183418
• 4664282
• 3160494
• 3330749
• 4277706
• 3291838
• 4791456
• 4696409
• 3428819
• 3487995
• 2887839
• 3218053
• 3358293
• 3430615
• 3532425
• 3656883
• 4134280
• 4792430
• 3753327
• 3799779
• 3984158
• 3997354
• 4045902
• 3759580
• 2865873
• 3384479
• 3901071
• 3326718
• 3128324
• 2914759
• 4406951
• 2880025
• 3141882
• 3698938
• 2787394
• 3127553
• 2768995
• 3506911
• 4702374
• 3562678
• 3656522
• 3841554
• 3216369
• 2958670
• 3162950
• 4078496
• 3852638
• 3257847
• 3490409
• 3603526
• 3418912
• 3492156
• 3513224
• 4157398
• 4397717
• 4807465
• 4807465
• 4094941
• 4711506

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/63449117825"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/63449117825?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=63449117825&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=63449117825&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/63449117825", "dc:identifier"=>"SCOPUS_ID:63449117825", "eid"=>"2-s2.0-63449117825", "dc:title"=>"A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose", "dc:creator"=>"Takeuchi F.", "prism:publicationName"=>"PLoS Genetics", "prism:issn"=>"15537390", "prism:eIssn"=>"15537404", "prism:volume"=>"5", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2009-03-01", "prism:coverDisplayDate"=>"March 2009", "prism:doi"=>"10.1371/journal.pgen.1000433", "citedby-count"=>"466", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Wellcome Trust Sanger Institute", "affiliation-city"=>"Cambridge", "affiliation-country"=>"United Kingdom"}], "pubmed-id"=>"19300499", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "source-id"=>"4000151808", "openaccess"=>"1", "openaccessFlag"=>true}

Web of Science® | Further Information

Article Coverage

Article Coverage Curated

Facebook

• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosgenetics%2Farticle%3Fid%3D10.1371%252Fjournal.pgen.1000433", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments

Nature

Reddit

Research Blogging

ScienceSeeker | Further Information

Twitter

Wikipedia

Wordpress.com | Further Information

Counter

• {"month"=>"3", "year"=>"2009", "pdf_views"=>"499", "xml_views"=>"7", "html_views"=>"1172"}
• {"month"=>"4", "year"=>"2009", "pdf_views"=>"94", "xml_views"=>"0", "html_views"=>"269"}
• {"month"=>"5", "year"=>"2009", "pdf_views"=>"47", "xml_views"=>"0", "html_views"=>"123"}
• {"month"=>"6", "year"=>"2009", "pdf_views"=>"88", "xml_views"=>"1", "html_views"=>"231"}
• {"month"=>"7", "year"=>"2009", "pdf_views"=>"62", "xml_views"=>"1", "html_views"=>"193"}
• {"month"=>"8", "year"=>"2009", "pdf_views"=>"51", "xml_views"=>"0", "html_views"=>"144"}
• {"month"=>"9", "year"=>"2009", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"146"}
• {"month"=>"10", "year"=>"2009", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"123"}
• {"month"=>"11", "year"=>"2009", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"156"}
• {"month"=>"12", "year"=>"2009", "pdf_views"=>"41", "xml_views"=>"1", "html_views"=>"131"}
• {"month"=>"1", "year"=>"2010", "pdf_views"=>"37", "xml_views"=>"2", "html_views"=>"129"}
• {"month"=>"2", "year"=>"2010", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"116"}
• {"month"=>"3", "year"=>"2010", "pdf_views"=>"63", "xml_views"=>"9", "html_views"=>"208"}
• {"month"=>"4", "year"=>"2010", "pdf_views"=>"45", "xml_views"=>"5", "html_views"=>"175"}
• {"month"=>"5", "year"=>"2010", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"138"}
• {"month"=>"6", "year"=>"2010", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"144"}
• {"month"=>"7", "year"=>"2010", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"122"}
• {"month"=>"8", "year"=>"2010", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"113"}
• {"month"=>"9", "year"=>"2010", "pdf_views"=>"47", "xml_views"=>"1", "html_views"=>"172"}
• {"month"=>"10", "year"=>"2010", "pdf_views"=>"39", "xml_views"=>"1", "html_views"=>"196"}
• {"month"=>"11", "year"=>"2010", "pdf_views"=>"46", "xml_views"=>"0", "html_views"=>"273"}
• {"month"=>"12", "year"=>"2010", "pdf_views"=>"47", "xml_views"=>"0", "html_views"=>"174"}
• {"month"=>"1", "year"=>"2011", "pdf_views"=>"35", "xml_views"=>"2", "html_views"=>"189"}
• {"month"=>"2", "year"=>"2011", "pdf_views"=>"47", "xml_views"=>"1", "html_views"=>"177"}
• {"month"=>"3", "year"=>"2011", "pdf_views"=>"54", "xml_views"=>"0", "html_views"=>"249"}
• {"month"=>"4", "year"=>"2011", "pdf_views"=>"55", "xml_views"=>"0", "html_views"=>"155"}
• {"month"=>"5", "year"=>"2011", "pdf_views"=>"30", "xml_views"=>"2", "html_views"=>"116"}
• {"month"=>"6", "year"=>"2011", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"117"}
• {"month"=>"7", "year"=>"2011", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"82"}
• {"month"=>"8", "year"=>"2011", "pdf_views"=>"27", "xml_views"=>"2", "html_views"=>"128"}
• {"month"=>"9", "year"=>"2011", "pdf_views"=>"43", "xml_views"=>"1", "html_views"=>"164"}
• {"month"=>"10", "year"=>"2011", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"152"}
• {"month"=>"11", "year"=>"2011", "pdf_views"=>"36", "xml_views"=>"1", "html_views"=>"183"}
• {"month"=>"12", "year"=>"2011", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"255"}
• {"month"=>"1", "year"=>"2012", "pdf_views"=>"53", "xml_views"=>"0", "html_views"=>"282"}
• {"month"=>"2", "year"=>"2012", "pdf_views"=>"47", "xml_views"=>"0", "html_views"=>"301"}
• {"month"=>"3", "year"=>"2012", "pdf_views"=>"43", "xml_views"=>"1", "html_views"=>"282"}
• {"month"=>"4", "year"=>"2012", "pdf_views"=>"39", "xml_views"=>"1", "html_views"=>"164"}
• {"month"=>"5", "year"=>"2012", "pdf_views"=>"53", "xml_views"=>"1", "html_views"=>"148"}
• {"month"=>"6", "year"=>"2012", "pdf_views"=>"37", "xml_views"=>"2", "html_views"=>"146"}
• {"month"=>"7", "year"=>"2012", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"132"}
• {"month"=>"8", "year"=>"2012", "pdf_views"=>"27", "xml_views"=>"5", "html_views"=>"114"}
• {"month"=>"9", "year"=>"2012", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"94"}
• {"month"=>"10", "year"=>"2012", "pdf_views"=>"43", "xml_views"=>"1", "html_views"=>"173"}
• {"month"=>"11", "year"=>"2012", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"200"}
• {"month"=>"12", "year"=>"2012", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"120"}
• {"month"=>"1", "year"=>"2013", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"153"}
• {"month"=>"2", "year"=>"2013", "pdf_views"=>"31", "xml_views"=>"2", "html_views"=>"280"}
• {"month"=>"3", "year"=>"2013", "pdf_views"=>"37", "xml_views"=>"1", "html_views"=>"215"}
• {"month"=>"4", "year"=>"2013", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"175"}
• {"month"=>"5", "year"=>"2013", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"182"}
• {"month"=>"6", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"174"}
• {"month"=>"7", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"194"}
• {"month"=>"8", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"155"}
• {"month"=>"9", "year"=>"2013", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"136"}
• {"month"=>"10", "year"=>"2013", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"173"}
• {"month"=>"11", "year"=>"2013", "pdf_views"=>"25", "xml_views"=>"3", "html_views"=>"177"}
• {"month"=>"12", "year"=>"2013", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"144"}
• {"month"=>"1", "year"=>"2014", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"169"}
• {"month"=>"2", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"143"}
• {"month"=>"3", "year"=>"2014", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"139"}
• {"month"=>"4", "year"=>"2014", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"147"}
• {"month"=>"5", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"132"}
• {"month"=>"6", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"132"}
• {"month"=>"7", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"104"}
• {"month"=>"8", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"93"}
• {"month"=>"9", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"106"}
• {"month"=>"10", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"176"}
• {"month"=>"11", "year"=>"2014", "pdf_views"=>"23", "xml_views"=>"2", "html_views"=>"141"}
• {"month"=>"12", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"96"}
• {"month"=>"1", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"94"}
• {"month"=>"2", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"72"}
• {"month"=>"3", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"118"}
• {"month"=>"4", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"115"}
• {"month"=>"5", "year"=>"2015", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"115"}
• {"month"=>"6", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"64"}
• {"month"=>"7", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"47"}
• {"month"=>"8", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"62"}
• {"month"=>"9", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"106"}
• {"month"=>"10", "year"=>"2015", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"109"}
• {"month"=>"11", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"99"}
• {"month"=>"12", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"102"}
• {"month"=>"1", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"87"}
• {"month"=>"2", "year"=>"2016", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"79"}
• {"month"=>"3", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"75"}
• {"month"=>"4", "year"=>"2016", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"148"}
• {"month"=>"5", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"67"}
• {"month"=>"6", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"50"}
• {"month"=>"7", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"53"}
• {"month"=>"8", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"78"}
• {"month"=>"9", "year"=>"2016", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"116"}
• {"month"=>"10", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"84"}
• {"month"=>"11", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"102"}
• {"month"=>"12", "year"=>"2016", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"83"}
• {"month"=>"1", "year"=>"2017", "pdf_views"=>"23", "xml_views"=>"3", "html_views"=>"69"}
• {"month"=>"2", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"84"}
• {"month"=>"3", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"3", "html_views"=>"81"}
• {"month"=>"4", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"87"}
• {"month"=>"5", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"84"}
• {"month"=>"6", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"53"}
• {"month"=>"7", "year"=>"2017", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"109"}
• {"month"=>"8", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"53"}
• {"month"=>"9", "year"=>"2017", "pdf_views"=>"21", "xml_views"=>"2", "html_views"=>"55"}
• {"month"=>"10", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"46"}
• {"month"=>"11", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"91"}
• {"month"=>"12", "year"=>"2017", "pdf_views"=>"27", "xml_views"=>"1", "html_views"=>"109"}
• {"month"=>"1", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"68"}
• {"month"=>"2", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"22"}
• {"month"=>"3", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"39"}
• {"month"=>"4", "year"=>"2018", "pdf_views"=>"45", "xml_views"=>"1", "html_views"=>"73"}
• {"month"=>"5", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"50"}
• {"month"=>"6", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"40"}
• {"month"=>"7", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"5", "html_views"=>"23"}
• {"month"=>"8", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"30"}
• {"month"=>"9", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"22"}
• {"month"=>"10", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"62"}
• {"month"=>"11", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"47"}
• {"month"=>"12", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"52"}
• {"month"=>"1", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"45"}
• {"month"=>"2", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"33"}
• {"month"=>"3", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"2", "html_views"=>"34"}
• {"month"=>"4", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"55"}
• {"month"=>"5", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"34"}
• {"month"=>"6", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"12"}
• {"month"=>"7", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"30"}
• {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"8"}

Figshare

• {"files"=>["https://ndownloader.figshare.com/files/904446"], "description"=>"<p>Horizontal axis shows SNP location and vertical axis is −log10(p-value) for each SNP tested by univariate regression (A) or multivariate regression (B). Red dots and red lettering show SNPs and implicated genes with p-values beyond the genome-wide significance threshold (1.5×10⁻⁷) which is denoted by a horizontal line. (A) Univariate regression shows genome-wide significant association to SNPs clustering near the warfarin drug target <i>VKORC1</i> (e.g., <i>P</i> = 5.4×10⁻⁷⁸, rs9923231) and near the warfarin-metabolizing gene <i>CYP2C9</i> (<i>P</i> = 4.5×10⁻¹⁷ for non-synonymous <i>*3 SNP</i> rs1057910, <i>P</i> = 8.8×10⁻¹³ for non-synonymous <i>*2 SNP</i> rs1799853, <i>P</i> = 3.1×10⁻³¹ for <i>*2*3</i> “composite” SNP rs4917639). (B) Multivariate regression adjusting for the contributions of <i>VKORC1</i> and <i>CYP2C9</i> had greater power than univariate regression and detected genome-wide significant association to the <i>CYP4F2</i> gene (<i>P</i> = 8.3×10⁻¹⁰, non-synonymous SNP rs2108622).</p>", "links"=>[], "tags"=>["GWAS", "snp", "tested", "warfarin"], "article_id"=>574881, "categories"=>["Mathematics", "Genetics", "Pharmacology"], "users"=>["Fumihiko Takeuchi", "Ralph McGinnis", "Stephane Bourgeois", "Chris Barnes", "Niclas Eriksson", "Nicole Soranzo", "Pamela Whittaker", "Venkatesh Ranganath", "Vasudev Kumanduri", "William McLaren", "Lennart Holm", "Jonatan Lindh", "Anders Rane", "Mia Wadelius", "Panos Deloukas"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000433.g001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_P_values_for_each_GWAS_SNP_tested_for_association_with_warfarin_dose_/574881", "title"=>"P-values for each GWAS SNP tested for association with warfarin dose.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-03-20 01:21:21"}
• {"files"=>["https://ndownloader.figshare.com/files/447056", "https://ndownloader.figshare.com/files/447118", "https://ndownloader.figshare.com/files/447173", "https://ndownloader.figshare.com/files/447188", "https://ndownloader.figshare.com/files/447202", "https://ndownloader.figshare.com/files/447219", "https://ndownloader.figshare.com/files/447227"], "description"=>"<div><p>We report the first genome-wide association study (GWAS) whose sample size (1,053 Swedish subjects) is sufficiently powered to detect genome-wide significance (<em>p</em><1.5×10⁻⁷) for polymorphisms that modestly alter therapeutic warfarin dose. The anticoagulant drug warfarin is widely prescribed for reducing the risk of stroke, thrombosis, pulmonary embolism, and coronary malfunction. However, Caucasians vary widely (20-fold) in the dose needed for therapeutic anticoagulation, and hence prescribed doses may be too low (risking serious illness) or too high (risking severe bleeding). Prior work established that ∼30% of the dose variance is explained by single nucleotide polymorphisms (SNPs) in the warfarin drug target <em>VKORC1</em> and another ∼12% by two non-synonymous SNPs (<em>*2</em>, <em>*3</em>) in the cytochrome P450 warfarin-metabolizing gene <em>CYP2C9</em>. We initially tested each of 325,997 GWAS SNPs for association with warfarin dose by univariate regression and found the strongest statistical signals (<em>p</em><10⁻⁷⁸) at SNPs clustering near <em>VKORC1</em> and the second lowest p-values (<em>p</em><10⁻³¹) emanating from <em>CYP2C9</em>. No other SNPs approached genome-wide significance. To enhance detection of weaker effects, we conducted multiple regression adjusting for known influences on warfarin dose (<em>VKORC1</em>, <em>CYP2C9</em>, age, gender) and identified a single SNP (rs2108622) with genome-wide significance (<em>p</em> = 8.3×10⁻¹⁰) that alters protein coding of the <em>CYP4F2</em> gene. We confirmed this result in 588 additional Swedish patients (<em>p</em><0.0029) and, during our investigation, a second group provided independent confirmation from a scan of warfarin-metabolizing genes. We also thoroughly investigated copy number variations, haplotypes, and imputed SNPs, but found no additional highly significant warfarin associations. We present power analysis of our GWAS that is generalizable to other studies, and conclude we had 80% power to detect genome-wide significance for common causative variants or markers explaining at least 1.5% of dose variance. These GWAS results provide further impetus for conducting large-scale trials assessing patient benefit from genotype-based forecasting of warfarin dose.</p></div>", "links"=>[], "tags"=>["genome-wide", "confirms", "determinants", "warfarin"], "article_id"=>148123, "categories"=>["Mathematics", "Genetics", "Pharmacology"], "users"=>["Fumihiko Takeuchi", "Ralph McGinnis", "Stephane Bourgeois", "Chris Barnes", "Niclas Eriksson", "Nicole Soranzo", "Pamela Whittaker", "Venkatesh Ranganath", "Vasudev Kumanduri", "William McLaren", "Lennart Holm", "Jonatan Lindh", "Anders Rane", "Mia Wadelius", "Panos Deloukas"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1000433.s001", "https://dx.doi.org/10.1371/journal.pgen.1000433.s002", "https://dx.doi.org/10.1371/journal.pgen.1000433.s003", "https://dx.doi.org/10.1371/journal.pgen.1000433.s004", "https://dx.doi.org/10.1371/journal.pgen.1000433.s005", "https://dx.doi.org/10.1371/journal.pgen.1000433.s006", "https://dx.doi.org/10.1371/journal.pgen.1000433.s007"], "stats"=>{"downloads"=>1, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_Genome_Wide_Association_Study_Confirms_VKORC1_CYP2C9_and_CYP4F2_as_Principal_Genetic_Determinants_of_Warfarin_Dose/148123", "title"=>"A Genome-Wide Association Study Confirms <em>VKORC1</em>, <em>CYP2C9</em>, and <em>CYP4F2</em> as Principal Genetic Determinants of Warfarin Dose", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2009-03-20 02:15:23"}
• {"files"=>["https://ndownloader.figshare.com/files/904680"], "description"=>"a<p>Linear regression on warfarin dose was calculated for the 1,053 GWAS subjects.</p>", "links"=>[], "tags"=>["snps", "tested", "univariate", "regression"], "article_id"=>575115, "categories"=>["Mathematics", "Genetics", "Pharmacology"], "users"=>["Fumihiko Takeuchi", "Ralph McGinnis", "Stephane Bourgeois", "Chris Barnes", "Niclas Eriksson", "Nicole Soranzo", "Pamela Whittaker", "Venkatesh Ranganath", "Vasudev Kumanduri", "William McLaren", "Lennart Holm", "Jonatan Lindh", "Anders Rane", "Mia Wadelius", "Panos Deloukas"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000433.t001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_p_value_of_SNPs_tested_by_univariate_regression_or_multiple_regression_with_progressive_addition_of_known_dose_predictors_a_/575115", "title"=>"Association (<i>p</i>-value) of SNPs tested by univariate regression or multiple regression with progressive addition of known dose predictors^a.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-03-20 01:25:15"}
• {"files"=>["https://ndownloader.figshare.com/files/904563"], "description"=>"a<p>Power calculations assumed a sample size of 1,053 subjects and significance level of 1.5E-7 as employed in our GWAS.</p>", "links"=>[], "tags"=>["dose-altering", "snp", "variance", "predictors", "regression"], "article_id"=>574997, "categories"=>["Mathematics", "Genetics", "Pharmacology"], "users"=>["Fumihiko Takeuchi", "Ralph McGinnis", "Stephane Bourgeois", "Chris Barnes", "Niclas Eriksson", "Nicole Soranzo", "Pamela Whittaker", "Venkatesh Ranganath", "Vasudev Kumanduri", "William McLaren", "Lennart Holm", "Jonatan Lindh", "Anders Rane", "Mia Wadelius", "Panos Deloukas"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000433.t003", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Power_to_detect_a_dose_altering_SNP_as_a_function_of_its_contribution_to_dose_variance_R_2_and_adjustment_by_other_predictors_in_the_multiple_regression_model_a_/574997", "title"=>"Power to detect a dose-altering SNP as a function of its contribution to dose variance (<i>R</i>²) and adjustment by other predictors in the multiple regression model^a.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-03-20 01:23:17"}
• {"files"=>["https://ndownloader.figshare.com/files/904615"], "description"=>"a<p>In parenthesis are major/minor allele, and minor allele frequency.</p>b<p>Effect of individual predictor on dose is indicated by regression coefficient and 95% confidence interval, proportion of explained variance (<i>R</i>²) and <i>P</i>-value.</p>c<p>Association in same direction as GWAS was assessed by a one-tailed test.</p>", "links"=>[], "tags"=>["regression", "warfarin", "replication"], "article_id"=>575057, "categories"=>["Mathematics", "Genetics", "Pharmacology"], "users"=>["Fumihiko Takeuchi", "Ralph McGinnis", "Stephane Bourgeois", "Chris Barnes", "Niclas Eriksson", "Nicole Soranzo", "Pamela Whittaker", "Venkatesh Ranganath", "Vasudev Kumanduri", "William McLaren", "Lennart Holm", "Jonatan Lindh", "Anders Rane", "Mia Wadelius", "Panos Deloukas"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000433.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multiple_regression_analysis_of_warfarin_dose_in_the_GWAS_replication_and_combined_panels_/575057", "title"=>"Multiple regression analysis of warfarin dose in the GWAS, replication and combined panels.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-03-20 01:24:17"}

PMC Usage Stats | Further Information

• {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"102", "year"=>"2010", "pdf"=>"68", "unique-ip"=>"96", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"4"}
• {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"74", "unique-ip"=>"70", "pdf"=>"58", "year"=>"2010", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"6", "full-text"=>"135", "year"=>"2010", "pdf"=>"84", "unique-ip"=>"117", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"3"}
• {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"90", "unique-ip"=>"78", "pdf"=>"51", "year"=>"2010", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"19"}
• {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"4", "full-text"=>"92", "year"=>"2010", "pdf"=>"50", "unique-ip"=>"77", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"14"}
• {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"80", "unique-ip"=>"75", "pdf"=>"54", "year"=>"2010", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"12"}
• {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"75", "year"=>"2010", "pdf"=>"52", "unique-ip"=>"74", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"11"}
• {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"50", "unique-ip"=>"48", "pdf"=>"32", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"3"}
• {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"57", "year"=>"2010", "pdf"=>"42", "unique-ip"=>"62", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"4"}
• {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"51", "unique-ip"=>"52", "pdf"=>"39", "year"=>"2010", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"13"}
• {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"62", "year"=>"2010", "pdf"=>"43", "unique-ip"=>"64", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"5"}
• {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"52", "unique-ip"=>"54", "pdf"=>"41", "year"=>"2010", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"10"}
• {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"58", "year"=>"2011", "pdf"=>"36", "unique-ip"=>"49", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"6"}
• {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"1", "abstract"=>"1", "full-text"=>"78", "unique-ip"=>"73", "pdf"=>"46", "year"=>"2011", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"73", "year"=>"2011", "pdf"=>"47", "unique-ip"=>"74", "figure"=>"20", "scanned-summary"=>"0", "supp-data"=>"6"}
• {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"93", "unique-ip"=>"78", "pdf"=>"55", "year"=>"2011", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"51", "year"=>"2011", "pdf"=>"35", "unique-ip"=>"53", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"65", "unique-ip"=>"58", "pdf"=>"36", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"4"}
• {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"40", "year"=>"2011", "pdf"=>"23", "unique-ip"=>"40", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"6"}
• {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"40", "unique-ip"=>"40", "pdf"=>"25", "year"=>"2011", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"2"}
• {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"49", "year"=>"2011", "pdf"=>"25", "unique-ip"=>"44", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"66", "unique-ip"=>"64", "pdf"=>"40", "year"=>"2011", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"53", "year"=>"2011", "pdf"=>"22", "unique-ip"=>"48", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"51", "unique-ip"=>"44", "pdf"=>"29", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"8"}
• {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"51", "unique-ip"=>"49", "pdf"=>"26", "year"=>"2012", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"48", "year"=>"2012", "pdf"=>"30", "unique-ip"=>"46", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"62", "unique-ip"=>"54", "pdf"=>"29", "year"=>"2012", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"12"}
• {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"44", "year"=>"2012", "pdf"=>"28", "unique-ip"=>"47", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"3"}
• {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"71", "unique-ip"=>"60", "pdf"=>"30", "year"=>"2012", "figure"=>"17", "scanned-summary"=>"0", "supp-data"=>"2"}
• {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"119", "year"=>"2009", "pdf"=>"95", "unique-ip"=>"110", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"32"}
• {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"253", "unique-ip"=>"209", "pdf"=>"184", "year"=>"2009", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"45"}
• {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"136", "year"=>"2009", "pdf"=>"108", "unique-ip"=>"119", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"10"}
• {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"156", "unique-ip"=>"148", "pdf"=>"114", "year"=>"2009", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"2"}
• {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"152", "year"=>"2009", "pdf"=>"122", "unique-ip"=>"137", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"17"}
• {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"106", "unique-ip"=>"99", "pdf"=>"98", "year"=>"2009", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"13"}
• {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"116", "year"=>"2009", "pdf"=>"87", "unique-ip"=>"98", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"21"}
• {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"56", "unique-ip"=>"49", "pdf"=>"33", "year"=>"2009", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"10"}
• {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"3", "full-text"=>"151", "year"=>"2009", "pdf"=>"110", "unique-ip"=>"139", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"5"}
• {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"96", "unique-ip"=>"83", "pdf"=>"74", "year"=>"2009", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"5"}
• {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"40", "year"=>"2012", "pdf"=>"16", "unique-ip"=>"34", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"4"}
• {"unique-ip"=>"40", "full-text"=>"44", "pdf"=>"20", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
• {"unique-ip"=>"33", "full-text"=>"43", "pdf"=>"20", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
• {"unique-ip"=>"49", "full-text"=>"49", "pdf"=>"32", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
• {"unique-ip"=>"46", "full-text"=>"53", "pdf"=>"18", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"6", "cited-by"=>"2", "year"=>"2012", "month"=>"10"}
• {"unique-ip"=>"28", "full-text"=>"25", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
• {"unique-ip"=>"42", "full-text"=>"45", "pdf"=>"20", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
• {"unique-ip"=>"38", "full-text"=>"48", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
• {"unique-ip"=>"40", "full-text"=>"40", "pdf"=>"15", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
• {"unique-ip"=>"37", "full-text"=>"45", "pdf"=>"16", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
• {"unique-ip"=>"34", "full-text"=>"32", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
• {"unique-ip"=>"28", "full-text"=>"39", "pdf"=>"16", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
• {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
• {"unique-ip"=>"26", "full-text"=>"27", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
• {"unique-ip"=>"23", "full-text"=>"28", "pdf"=>"10", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
• {"unique-ip"=>"30", "full-text"=>"45", "pdf"=>"31", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
• {"unique-ip"=>"24", "full-text"=>"29", "pdf"=>"16", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
• {"unique-ip"=>"29", "full-text"=>"32", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
• {"unique-ip"=>"27", "full-text"=>"39", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
• {"unique-ip"=>"25", "full-text"=>"28", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
• {"unique-ip"=>"35", "full-text"=>"35", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
• {"unique-ip"=>"40", "full-text"=>"43", "pdf"=>"19", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
• {"unique-ip"=>"29", "full-text"=>"34", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
• {"unique-ip"=>"40", "full-text"=>"47", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"6"}
• {"unique-ip"=>"30", "full-text"=>"29", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
• {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"15", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
• {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
• {"unique-ip"=>"49", "full-text"=>"44", "pdf"=>"19", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
• {"unique-ip"=>"58", "full-text"=>"50", "pdf"=>"19", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"19", "cited-by"=>"1", "year"=>"2014", "month"=>"10"}
• {"unique-ip"=>"25", "full-text"=>"24", "pdf"=>"13", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
• {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
• {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
• {"unique-ip"=>"22", "full-text"=>"19", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
• {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
• {"unique-ip"=>"31", "full-text"=>"32", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
• {"unique-ip"=>"25", "full-text"=>"33", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
• {"unique-ip"=>"24", "full-text"=>"31", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
• {"unique-ip"=>"27", "full-text"=>"29", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"8", "cited-by"=>"1", "year"=>"2015", "month"=>"7"}
• {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
• {"unique-ip"=>"33", "full-text"=>"30", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
• {"unique-ip"=>"33", "full-text"=>"35", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
• {"unique-ip"=>"34", "full-text"=>"41", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"5", "year"=>"2015", "month"=>"11"}
• {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
• {"unique-ip"=>"29", "full-text"=>"31", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
• {"unique-ip"=>"24", "full-text"=>"22", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
• {"unique-ip"=>"33", "full-text"=>"34", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
• {"unique-ip"=>"29", "full-text"=>"33", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
• {"unique-ip"=>"30", "full-text"=>"40", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
• {"unique-ip"=>"22", "full-text"=>"25", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
• {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
• {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
• {"unique-ip"=>"25", "full-text"=>"26", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
• {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
• {"unique-ip"=>"26", "full-text"=>"28", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
• {"unique-ip"=>"30", "full-text"=>"32", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
• {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
• {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
• {"unique-ip"=>"24", "full-text"=>"32", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
• {"unique-ip"=>"48", "full-text"=>"57", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
• {"unique-ip"=>"20", "full-text"=>"27", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
• {"unique-ip"=>"17", "full-text"=>"20", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
• {"unique-ip"=>"32", "full-text"=>"36", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
• {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
• {"unique-ip"=>"23", "full-text"=>"29", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
• {"unique-ip"=>"29", "full-text"=>"27", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
• {"unique-ip"=>"45", "full-text"=>"63", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
• {"unique-ip"=>"23", "full-text"=>"26", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
• {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
• {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
• {"unique-ip"=>"17", "full-text"=>"25", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
• {"unique-ip"=>"38", "full-text"=>"40", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
• {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
• {"unique-ip"=>"65", "full-text"=>"81", "pdf"=>"24", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
• {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
• {"unique-ip"=>"26", "full-text"=>"26", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
• {"unique-ip"=>"35", "full-text"=>"48", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"7", "cited-by"=>"1", "year"=>"2018", "month"=>"8"}
• {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
• {"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
• {"unique-ip"=>"43", "full-text"=>"49", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
• {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
• {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
• {"unique-ip"=>"26", "full-text"=>"34", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
• {"unique-ip"=>"75", "full-text"=>"94", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
• {"unique-ip"=>"50", "full-text"=>"61", "pdf"=>"18", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2009-01-01T00:00:00Z", "end_date"=>"2009-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Evolutionary biology", "average_usage"=>[422, 680, 795, 921, 1012, 1113, 1216, 1296, 1396, 1468, 1545, 1617, 1701, 1770, 1872, 1951, 2013, 2071, 2118, 2171, 2251, 2290, 2345, 2401, 2471, 2528, 2576, 2634, 2702, 2776, 2840, 2897, 2962, 3046, 3101, 3141, 3222, 3292, 3342, 3436, 3483, 3533, 3604, 3662, 3804, 3843, 3919, 3979, 4043, 4119, 4170, 4198, 4285, 4336, 4402, 4455, 4522, 4607, 4649, 4668, 4713]}, {"subject_area"=>"/Biology and life sciences/Molecular biology", "average_usage"=>[334, 613, 751, 863, 964, 1078, 1181, 1270, 1358, 1443, 1536, 1616, 1690, 1768, 1826, 1902, 1969, 2031, 2095, 2149, 2202, 2258, 2305, 2349, 2417, 2482, 2541, 2598, 2662, 2720, 2768, 2832, 2897, 2947, 2998, 3058, 3121, 3175, 3235, 3292, 3368, 3442, 3507, 3563, 3621, 3676, 3736, 3802, 3852, 3922, 3977, 4025, 4071, 4141, 4199, 4258, 4316, 4376, 4422, 4467, 4518]}, {"subject_area"=>"/Medicine and health sciences/Pharmaceutics", "average_usage"=>[383, 606, 753, 875, 970, 1073, 1195, 1283, 1367, 1455, 1557, 1631, 1730, 1807, 1861, 1926, 1991, 2036, 2133, 2190, 2227, 2273, 2326, 2386, 2456, 2523, 2583, 2637, 2755, 2806, 2877, 2938, 3022, 3101, 3141, 3201, 3254, 3306, 3358, 3396, 3467, 3517, 3568, 3675, 3716, 3757, 3799, 3847, 3896, 3937, 3989, 4042, 4089, 4167, 4226, 4265, 4351, 4425, 4497, 4573, 4648, 4730]}, {"subject_area"=>"/Physical sciences/Mathematics", "average_usage"=>[390, 657, 764, 869, 966, 1052, 1148, 1251, 1329, 1410, 1469, 1529, 1603, 1663, 1723, 1784, 1858, 1929, 1995, 2054, 2103, 2155, 2202, 2268, 2305, 2346, 2398, 2449, 2484, 2546, 2590, 2652, 2726, 2763, 2825, 2879, 2926, 2985, 3054, 3114, 3160, 3243, 3304, 3389, 3466, 3519, 3561, 3631, 3679, 3731, 3805, 3859, 3907, 3944, 3994, 4076, 4150, 4202, 4229, 4275, 4344, 4373]}]}

F1000Prime | Further Information

• {"year"=>2014, "month"=>5, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2014-05-26T08:31:50Z"}
• {"year"=>2014, "month"=>6, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2014-06-30T08:31:47Z"}
• {"year"=>2014, "month"=>7, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2014-07-28T08:31:54Z"}
• {"year"=>2014, "month"=>8, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2014-08-25T08:31:52Z"}
• {"year"=>2014, "month"=>9, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2014-09-29T08:31:53Z"}
• {"year"=>2014, "month"=>10, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2014-10-27T08:31:46Z"}
• {"year"=>2014, "month"=>11, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2014-11-24T09:31:11Z"}
• {"year"=>2014, "month"=>12, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2014-12-29T09:41:04Z"}
• {"year"=>2015, "month"=>1, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2015-01-26T09:40:28Z"}
• {"year"=>2015, "month"=>2, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2015-02-23T09:40:27Z"}
• {"year"=>2015, "month"=>3, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2015-03-23T08:40:31Z"}
• {"year"=>2015, "month"=>4, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2015-04-27T08:40:30Z"}
• {"year"=>2015, "month"=>5, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2015-05-25T08:40:25Z"}
• {"year"=>2015, "month"=>6, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2015-06-29T08:40:31Z"}
• {"year"=>2015, "month"=>7, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2015-07-27T08:40:23Z"}
• {"year"=>2015, "month"=>8, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2015-08-31T08:40:30Z"}
• {"year"=>2015, "month"=>9, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2015-09-28T08:40:27Z"}
• {"year"=>2015, "month"=>10, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2015-10-26T08:40:32Z"}
• {"year"=>2015, "month"=>11, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2015-11-30T09:40:32Z"}
• {"year"=>2015, "month"=>12, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2015-12-28T09:40:33Z"}
• {"year"=>2016, "month"=>1, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2016-01-25T09:40:34Z"}
• {"year"=>2016, "month"=>2, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2016-02-29T09:40:22Z"}
• {"year"=>2016, "month"=>3, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2016-03-28T08:40:23Z"}
• {"year"=>2016, "month"=>4, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2016-04-25T08:40:24Z"}
• {"year"=>2016, "month"=>5, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2016-05-16T08:40:24Z"}
• {"year"=>2016, "month"=>6, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2016-06-27T08:40:24Z"}
• {"year"=>2016, "month"=>7, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2016-07-25T08:40:26Z"}
• {"year"=>2016, "month"=>8, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2016-08-29T08:40:21Z"}
• {"year"=>2016, "month"=>9, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2016-09-26T08:40:27Z"}
• {"year"=>2016, "month"=>10, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2016-10-31T08:40:23Z"}
• {"year"=>2016, "month"=>11, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2016-11-28T09:40:25Z"}
• {"year"=>2016, "month"=>12, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2016-12-26T09:40:29Z"}
• {"year"=>2017, "month"=>1, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2017-01-30T09:40:24Z"}
• {"year"=>2017, "month"=>2, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2017-02-27T09:40:25Z"}
• {"year"=>2017, "month"=>3, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2017-03-27T08:40:20Z"}
• {"year"=>2017, "month"=>4, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2017-04-24T08:40:18Z"}
• {"year"=>2017, "month"=>5, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2017-05-29T08:40:36Z"}
• {"year"=>2017, "month"=>6, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"http://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2017-06-26T08:40:17Z"}
• {"year"=>2017, "month"=>7, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2017-07-31T08:40:33Z"}
• {"year"=>2017, "month"=>8, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2017-08-28T08:40:39Z"}
• {"year"=>2017, "month"=>9, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2017-09-25T08:40:20Z"}
• {"year"=>2017, "month"=>10, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2017-10-30T08:40:36Z"}
• {"year"=>2017, "month"=>11, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2017-11-27T09:40:44Z"}
• {"year"=>2017, "month"=>12, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2017-12-25T09:40:24Z"}
• {"year"=>2018, "month"=>1, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2018-01-29T09:40:18Z"}
• {"year"=>2018, "month"=>2, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2018-02-26T09:40:19Z"}
• {"year"=>2018, "month"=>3, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2018-03-26T08:40:21Z"}
• {"year"=>2018, "month"=>4, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2018-04-30T08:40:19Z"}
• {"year"=>2018, "month"=>5, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2018-05-28T08:40:21Z"}
• {"year"=>2018, "month"=>6, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2018-06-25T08:40:20Z"}
• {"year"=>2018, "month"=>7, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2018-07-30T08:40:23Z"}
• {"year"=>2018, "month"=>8, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2018-08-27T08:40:20Z"}
• {"year"=>2018, "month"=>9, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2018-09-24T08:40:21Z"}
• {"year"=>2018, "month"=>10, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2018-10-29T08:40:30Z"}
• {"year"=>2018, "month"=>11, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2018-11-26T09:40:22Z"}
• {"year"=>2018, "month"=>12, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2018-12-31T09:40:37Z"}
• {"year"=>2019, "month"=>1, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2019-01-28T09:40:22Z"}
• {"year"=>2019, "month"=>2, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2019-02-25T09:40:25Z"}
• {"year"=>2019, "month"=>3, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2019-03-25T08:40:20Z"}
• {"year"=>2019, "month"=>4, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2019-04-29T08:40:24Z"}
• {"year"=>2019, "month"=>5, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2019-05-27T08:40:32Z"}
• {"year"=>2019, "month"=>6, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2019-06-24T08:40:23Z"}
• {"year"=>2019, "month"=>7, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2019-07-29T08:40:28Z"}
• {"year"=>2019, "month"=>8, "doi"=>"10.1371/journal.pgen.1000433", "f1000_id"=>"1158915", "url"=>"https://f1000.com/prime/1158915", "score"=>2, "classifications"=>["confirmation"], "updated_at"=>"2019-08-12T08:40:21Z"}