Rare Copy Number Variants Contribute to Congenital Left-Sided Heart Disease
- Publication Date
- September 06, 2012
- Journal
- PLOS Genetics
- Authors
- Marc Phillip Hitz, Louis Philippe Lemieux Perreault, Christian Marshall, Yassamin Feroz Zada, et al
- Volume
- 8
- Issue
- 9
- Pages
- e1002903
- DOI
- https://dx.plos.org/10.1371/journal.pgen.1002903
- Publisher URL
- http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1002903
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/22969434
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435243
- Europe PMC
- http://europepmc.org/abstract/MED/22969434
- Web of Science
- 000309817900005
- Scopus
- 84866915849
- Mendeley
- http://www.mendeley.com/research/rare-copy-number-variants-contribute-congenital-leftsided-heart-disease
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CiteULike | Further Information
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Mendeley | Further Information
{"title"=>"Rare Copy Number Variants Contribute to Congenital Left-Sided Heart Disease", "type"=>"journal", "authors"=>[{"first_name"=>"Marc Phillip", "last_name"=>"Hitz", "scopus_author_id"=>"56185773800"}, {"first_name"=>"Louis Philippe", "last_name"=>"Lemieux-Perreault", "scopus_author_id"=>"55371462600"}, {"first_name"=>"Christian", "last_name"=>"Marshall", "scopus_author_id"=>"7201903397"}, {"first_name"=>"Yassamin", "last_name"=>"Feroz-Zada", "scopus_author_id"=>"35331967000"}, {"first_name"=>"Robbie", "last_name"=>"Davies", "scopus_author_id"=>"55370994500"}, {"first_name"=>"Shi Wei", "last_name"=>"Yang", "scopus_author_id"=>"56698933900"}, {"first_name"=>"Anath Christopher", "last_name"=>"Lionel", "scopus_author_id"=>"23393441400"}, {"first_name"=>"Guylaine", "last_name"=>"D'Amours", "scopus_author_id"=>"37261078800"}, {"first_name"=>"Emmanuelle", "last_name"=>"Lemyre", "scopus_author_id"=>"55913639800"}, {"first_name"=>"Rebecca", "last_name"=>"Cullum", "scopus_author_id"=>"10340701900"}, {"first_name"=>"Jean Luc", "last_name"=>"Bigras", "scopus_author_id"=>"6603947021"}, {"first_name"=>"Maryse", "last_name"=>"Thibeault", "scopus_author_id"=>"54411355400"}, {"first_name"=>"Philippe", "last_name"=>"Chetaille", "scopus_author_id"=>"6602257248"}, {"first_name"=>"Alexandre", "last_name"=>"Montpetit", "scopus_author_id"=>"6603250038"}, {"first_name"=>"Paul", "last_name"=>"Khairy", "scopus_author_id"=>"6603925410"}, {"first_name"=>"Bert", "last_name"=>"Overduin", "scopus_author_id"=>"57189011455"}, {"first_name"=>"Sabine", "last_name"=>"Klaassen", "scopus_author_id"=>"24338568000"}, {"first_name"=>"Pamela", "last_name"=>"Hoodless", "scopus_author_id"=>"6602719972"}, {"first_name"=>"Mona", "last_name"=>"Nemer", "scopus_author_id"=>"7006091355"}, {"first_name"=>"Alexandre F.R.", "last_name"=>"Stewart", "scopus_author_id"=>"56962727600"}, {"first_name"=>"Cornelius", "last_name"=>"Boerkoel", "scopus_author_id"=>"6701809729"}, {"first_name"=>"Stephen W.", "last_name"=>"Scherer", "scopus_author_id"=>"35374654500"}, {"first_name"=>"Andrea", "last_name"=>"Richter", "scopus_author_id"=>"7401645844"}, {"first_name"=>"Marie Pierre", "last_name"=>"Dubé", "scopus_author_id"=>"7103243627"}, {"first_name"=>"Gregor", "last_name"=>"Andelfinger", "scopus_author_id"=>"6603437102"}], "year"=>2012, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537390", "scopus"=>"2-s2.0-84866915849", "sgr"=>"84866915849", "pui"=>"365755968", "isbn"=>"10.1371/journal.pgen.1002903", "pmid"=>"22969434", "doi"=>"10.1371/journal.pgen.1002903"}, "id"=>"f03b78b1-ac49-3448-a400-40a02e61ff04", "abstract"=>"Left-sided congenital heart disease (CHD) encompasses a spectrum of malformations that range from bicuspid aortic valve to hypoplastic left heart syndrome. It contributes significantly to infant mortality and has serious implications in adult cardiology. Although left-sided CHD is known to be highly heritable, the underlying genetic determinants are largely unidentified. In this study, we sought to determine the impact of structural genomic variation on left-sided CHD and compared multiplex families (464 individuals with 174 affecteds (37.5%) in 59 multiplex families and 8 trios) to 1,582 well-phenotyped controls. 73 unique inherited or de novo CNVs in 54 individuals were identified in the left-sided CHD cohort. After stringent filtering, our gene inventory reveals 25 new candidates for LS-CHD pathogenesis, such as SMC1A, MFAP4, and CTHRC1, and overlaps with several known syndromic loci. Conservative estimation examining the overlap of the prioritized gene content with CNVs present only in affected individuals in our cohort implies a strong effect for unique CNVs in at least 10% of left-sided CHD cases. Enrichment testing of gene content in all identified CNVs showed a significant association with angiogenesis. In this first family-based CNV study of left-sided CHD, we found that both co-segregating and de novo events associate with disease in a complex fashion at structural genomic level. Often viewed as an anatomically circumscript disease, a subset of left-sided CHD may in fact reflect more general genetic perturbations of angiogenesis and/or vascular biology.", "link"=>"http://www.mendeley.com/research/rare-copy-number-variants-contribute-congenital-leftsided-heart-disease", "reader_count"=>78, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>8, "Researcher"=>26, "Student > Ph. D. Student"=>13, "Student > Postgraduate"=>3, "Other"=>4, "Student > Master"=>5, "Student > Bachelor"=>3, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>8, "Researcher"=>26, "Student > Ph. D. Student"=>13, "Student > Postgraduate"=>3, "Other"=>4, "Student > Master"=>5, "Student > Bachelor"=>3, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>18, "Medicine and Dentistry"=>22, "Agricultural and Biological Sciences"=>28, "Neuroscience"=>2, "Physics and Astronomy"=>1, "Computer Science"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>22}, "Neuroscience"=>{"Neuroscience"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>28}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>18}, "Unspecified"=>{"Unspecified"=>4}}, "reader_count_by_country"=>{"Canada"=>1, "Hong Kong"=>1, "Germany"=>1}, "group_count"=>5}CrossRef
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Scopus | Further Information
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- {"month"=>"3", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"42"}
- {"month"=>"4", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"35"}
- {"month"=>"5", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"59"}
- {"month"=>"6", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"36"}
- {"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"35"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"34"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"35"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"45"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"42"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"28"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"22"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"11"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"8", "html_views"=>"20"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"8"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"10"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"4", "html_views"=>"17"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"8"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"6"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"6"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"17"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"9"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"12"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"3"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"14"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"17"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"10"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"4", "html_views"=>"17"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"10"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"5"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"15"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"6"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"10"}
- {"month"=>"1", "year"=>"2020", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"17"}
- {"month"=>"2", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"11"}
- {"month"=>"3", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"13"}
- {"month"=>"4", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"3"}
- {"month"=>"5", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"3"}
- {"month"=>"6", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"8"}
- {"month"=>"7", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"8", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
- {"month"=>"9", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"11"}
- {"month"=>"10", "year"=>"2020", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"7"}
- {"month"=>"11", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"7"}
- {"month"=>"12", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"5"}
- {"month"=>"1", "year"=>"2021", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"10"}
- {"month"=>"2", "year"=>"2021", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"3", "year"=>"2021", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"1"}
PMC Usage Stats | Further Information
- {"unique-ip"=>"89", "full-text"=>"96", "pdf"=>"45", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
- {"unique-ip"=>"107", "full-text"=>"105", "pdf"=>"72", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"19", "supp-data"=>"43", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
- {"unique-ip"=>"42", "full-text"=>"40", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
- {"unique-ip"=>"59", "full-text"=>"68", "pdf"=>"26", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
- {"unique-ip"=>"53", "full-text"=>"53", "pdf"=>"21", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"24", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
- {"unique-ip"=>"31", "full-text"=>"33", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
- {"unique-ip"=>"32", "full-text"=>"38", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
- {"unique-ip"=>"55", "full-text"=>"53", "pdf"=>"28", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
- {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
- {"unique-ip"=>"29", "full-text"=>"26", "pdf"=>"22", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
- {"unique-ip"=>"46", "full-text"=>"46", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"24", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
- {"unique-ip"=>"29", "full-text"=>"37", "pdf"=>"25", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
- {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
- {"unique-ip"=>"19", "full-text"=>"15", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
- {"unique-ip"=>"29", "full-text"=>"37", "pdf"=>"19", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
- {"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
- {"unique-ip"=>"26", "full-text"=>"27", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
- {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
- {"unique-ip"=>"25", "full-text"=>"24", "pdf"=>"7", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"16", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
- {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
- {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
- {"unique-ip"=>"32", "full-text"=>"30", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
- {"unique-ip"=>"19", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2014", "month"=>"7"}
- {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
- {"unique-ip"=>"25", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
- {"unique-ip"=>"28", "full-text"=>"22", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
- {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
- {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
- {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
- {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
- {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
- {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
- {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
- {"unique-ip"=>"18", "full-text"=>"24", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
- {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
- {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
- {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
- {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
- {"unique-ip"=>"15", "full-text"=>"31", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
- {"unique-ip"=>"25", "full-text"=>"32", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
- {"unique-ip"=>"24", "full-text"=>"37", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
- {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
- {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
- {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
- {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
- {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
- {"unique-ip"=>"6", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
- {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
- {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
- {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
- {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
- {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
- {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
- {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
- {"unique-ip"=>"15", "full-text"=>"21", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
- {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
- {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
- {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
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Relative Metric
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