A Histone Deacetylase Adjusts Transcription Kinetics at Coding Sequences during Candida albicans Morphogenesis
- Publication Date
- December 06, 2012
- Journal
- PLOS Genetics
- Authors
- Denes Hnisz, Anaïs F. Bardet, Clarissa J. Nobile, Andriy Petryshyn, et al
- Volume
- 8
- Issue
- 12
- Pages
- e1003118
- DOI
- https://dx.plos.org/10.1371/journal.pgen.1003118
- Publisher URL
- http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1003118
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/23236295
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516536
- Europe PMC
- http://europepmc.org/abstract/MED/23236295
- Web of Science
- 000312905600025
- Scopus
- 84872007065
- Mendeley
- http://www.mendeley.com/research/histone-deacetylase-adjusts-transcription-kinetics-coding-sequences-during-candida-albicans-morphoge-1
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Mendeley | Further Information
{"title"=>"A Histone Deacetylase Adjusts Transcription Kinetics at Coding Sequences during Candida albicans Morphogenesis", "type"=>"journal", "authors"=>[{"first_name"=>"Denes", "last_name"=>"Hnisz", "scopus_author_id"=>"35098501100"}, {"first_name"=>"Anaïs F.", "last_name"=>"Bardet", "scopus_author_id"=>"55220518800"}, {"first_name"=>"Clarissa J.", "last_name"=>"Nobile", "scopus_author_id"=>"8664518700"}, {"first_name"=>"Andriy", "last_name"=>"Petryshyn", "scopus_author_id"=>"34877294600"}, {"first_name"=>"Walter", "last_name"=>"Glaser", "scopus_author_id"=>"7006335033"}, {"first_name"=>"Ulrike", "last_name"=>"Schöck", "scopus_author_id"=>"35068511400"}, {"first_name"=>"Alexander", "last_name"=>"Stark", "scopus_author_id"=>"9940234400"}, {"first_name"=>"Karl", "last_name"=>"Kuchler", "scopus_author_id"=>"7006436989"}], "year"=>2012, "source"=>"PLoS Genetics", "identifiers"=>{"sgr"=>"84872007065", "pmid"=>"23236295", "pui"=>"368067380", "isbn"=>"1553-7404 (Electronic)\\r1553-7390 (Linking)", "scopus"=>"2-s2.0-84872007065", "doi"=>"10.1371/journal.pgen.1003118", "issn"=>"15537390"}, "id"=>"bd7ea97c-a152-378c-a40f-40e209ffdc4e", "abstract"=>"Despite their classical role as transcriptional repressors, several histone deacetylases, including the baker's yeast Set3/Hos2 complex (Set3C), facilitate gene expression. In the dimorphic human pathogen Candida albicans, the homologue of the Set3C inhibits the yeast-to-filament transition, but the precise molecular details of this function have remained elusive. Here, we use a combination of ChIP-Seq and RNA-Seq to show that the Set3C acts as a transcriptional co-factor of metabolic and morphogenesis-related genes in C. albicans. Binding of the Set3C correlates with gene expression during fungal morphogenesis; yet, surprisingly, deletion of SET3 leaves the steady-state expression level of most genes unchanged, both during exponential yeast-phase growth and during the yeast-filament transition. Fine temporal resolution of transcription in cells undergoing this transition revealed that the Set3C modulates transient expression changes of key morphogenesis-related genes. These include a transcription factor cluster comprising of NRG1, EFG1, BRG1, and TEC1, which form a regulatory circuit controlling hyphal differentiation. Set3C appears to restrict the factors by modulating their transcription kinetics, and the hyperfilamentous phenotype of SET3-deficient cells can be reverted by mutating the circuit factors. These results indicate that the chromatin status at coding regions represents a dynamic platform influencing transcription kinetics. Moreover, we suggest that transcription at the coding sequence can be transiently decoupled from potentially conflicting promoter information in dynamic environments.", "link"=>"http://www.mendeley.com/research/histone-deacetylase-adjusts-transcription-kinetics-coding-sequences-during-candida-albicans-morphoge-1", "reader_count"=>50, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>19, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>19, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>42, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>42}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Belgium"=>1, "United States"=>1, "United Kingdom"=>1, "France"=>1}, "group_count"=>2}CrossRef
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Europe PMC Database Citations | Further Information
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