Aberration in DNA Methylation in B-Cell Lymphomas Has a Complex Origin and Increases with Disease Severity
- Publication Date
- January 10, 2013
- Journal
- PLOS Genetics
- Authors
- Subhajyoti De, Rita Shaknovich, Markus Riester, Olivier Elemento, et al
- Volume
- 9
- Issue
- 1
- Pages
- e1003137
- DOI
- https://dx.plos.org/10.1371/journal.pgen.1003137
- Publisher URL
- http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1003137
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/23326238
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542081
- Europe PMC
- http://europepmc.org/abstract/MED/23326238
- Web of Science
- 000314651500008
- Scopus
- 84873519286
- Mendeley
- http://www.mendeley.com/research/aberration-dna-methylation-bcell-lymphomas-complex-origin-increases-disease-severity
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CiteULike | Further Information
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Mendeley | Further Information
{"title"=>"Aberration in DNA Methylation in B-Cell Lymphomas Has a Complex Origin and Increases with Disease Severity", "type"=>"journal", "authors"=>[{"first_name"=>"Subhajyoti", "last_name"=>"De", "scopus_author_id"=>"18433337200"}, {"first_name"=>"Rita", "last_name"=>"Shaknovich", "scopus_author_id"=>"6602407720"}, {"first_name"=>"Markus", "last_name"=>"Riester", "scopus_author_id"=>"22135891300"}, {"first_name"=>"Olivier", "last_name"=>"Elemento", "scopus_author_id"=>"12779628700"}, {"first_name"=>"Huimin", "last_name"=>"Geng", "scopus_author_id"=>"8529515600"}, {"first_name"=>"Matthias", "last_name"=>"Kormaksson", "scopus_author_id"=>"36521243600"}, {"first_name"=>"Yanwen", "last_name"=>"Jiang", "scopus_author_id"=>"55584434900"}, {"first_name"=>"Bruce", "last_name"=>"Woolcock", "scopus_author_id"=>"7801355393"}, {"first_name"=>"Nathalie", "last_name"=>"Johnson", "scopus_author_id"=>"25421867100"}, {"first_name"=>"Jose M.", "last_name"=>"Polo", "scopus_author_id"=>"7101663943"}, {"first_name"=>"Leandro", "last_name"=>"Cerchietti", "scopus_author_id"=>"14626116800"}, {"first_name"=>"Randy D.", "last_name"=>"Gascoyne", "scopus_author_id"=>"7006757172"}, {"first_name"=>"Ari", "last_name"=>"Melnick", "scopus_author_id"=>"7004323589"}, {"first_name"=>"Franziska", "last_name"=>"Michor", "scopus_author_id"=>"55927966900"}], "year"=>2013, "source"=>"PLoS Genetics", "identifiers"=>{"pui"=>"368295386", "issn"=>"15537390", "isbn"=>"1553-7404", "doi"=>"10.1371/journal.pgen.1003137", "scopus"=>"2-s2.0-84873519286", "pmid"=>"23326238", "sgr"=>"84873519286"}, "id"=>"c03aad60-9f4e-368f-8041-6939878cb397", "abstract"=>"Despite mounting evidence that epigenetic abnormalities play a key role in cancer biology, their contributions to the malignant phenotype remain poorly understood. Here we studied genome-wide DNA methylation in normal B-cell populations and subtypes of B-cell non-Hodgkin lymphoma: follicular lymphoma and diffuse large B-cell lymphomas. These lymphomas display striking and progressive intra-tumor heterogeneity and also inter-patient heterogeneity in their cytosine methylation patterns. Epigenetic heterogeneity is initiated in normal germinal center B-cells, increases markedly with disease aggressiveness, and is associated with unfavorable clinical outcome. Moreover, patterns of abnormal methylation vary depending upon chromosomal regions, gene density and the status of neighboring genes. DNA methylation abnormalities arise via two distinct processes: i) lymphomagenic transcriptional regulators perturb promoter DNA methylation in a target gene-specific manner, and ii) aberrant epigenetic states tend to spread to neighboring promoters in the absence of CTCF insulator binding sites.", "link"=>"http://www.mendeley.com/research/aberration-dna-methylation-bcell-lymphomas-complex-origin-increases-disease-severity", "reader_count"=>87, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>8, "Librarian"=>1, "Researcher"=>26, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>23, "Student > Postgraduate"=>5, "Student > Master"=>6, "Other"=>5, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>8, "Librarian"=>1, "Researcher"=>26, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>23, "Student > Postgraduate"=>5, "Student > Master"=>6, "Other"=>5, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>11, "Agricultural and Biological Sciences"=>52, "Medicine and Dentistry"=>16, "Veterinary Science and Veterinary Medicine"=>1, "Physics and Astronomy"=>1, "Computer Science"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>16}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>52}, "Computer Science"=>{"Computer Science"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>11}, "Unspecified"=>{"Unspecified"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "United States"=>3, "Denmark"=>1, "Mexico"=>1, "Malaysia"=>1, "Switzerland"=>1, "Spain"=>2}, "group_count"=>4}CrossRef
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- {"month"=>"7", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"38"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"30"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"25"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"35"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"32"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"16"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"26"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"19"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"26"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"12"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"15"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"3", "html_views"=>"12"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"16"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"9"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"13"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"9"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"16"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"6"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"12"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"14"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"7"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"108", "xml_views"=>"0", "html_views"=>"15"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"978", "xml_views"=>"0", "html_views"=>"4"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"18"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"15"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"86", "xml_views"=>"0", "html_views"=>"4"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"15"}
- {"month"=>"1", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"13"}
- {"month"=>"2", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"11"}
- {"month"=>"3", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"27"}
- {"month"=>"4", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"14"}
- {"month"=>"5", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"11"}
- {"month"=>"6", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"18"}
- {"month"=>"7", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"14"}
- {"month"=>"8", "year"=>"2020", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"16"}
- {"month"=>"9", "year"=>"2020", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"12"}
- {"month"=>"10", "year"=>"2020", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"18"}
- {"month"=>"11", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"14"}
- {"month"=>"12", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"18"}
- {"month"=>"1", "year"=>"2021", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"13"}
PMC Usage Stats | Further Information
- {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
- {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
- {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
- {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
- {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
- {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
- {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
- {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
- {"unique-ip"=>"14", "full-text"=>"19", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"4", "year"=>"2017", "month"=>"1"}
- {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
- {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
- {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
- {"unique-ip"=>"4", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
- {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
- {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
- {"unique-ip"=>"14", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
- {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
- {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
- {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
- {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
- {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
- {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
- {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
- {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
- {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
- {"unique-ip"=>"17", "full-text"=>"10", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
- {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
- {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
- {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
- {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
- {"unique-ip"=>"10", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
- {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
- {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
- {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
- {"unique-ip"=>"83", "full-text"=>"91", "pdf"=>"90", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
- {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
- {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
- {"unique-ip"=>"26", "full-text"=>"25", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
- {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
- {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"18", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
- {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
- {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
- {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
- {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
- {"unique-ip"=>"39", "full-text"=>"15", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"36", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
- {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
- {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
- {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
Relative Metric
{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[266, 466, 591, 701, 799, 887, 982, 1067, 1155, 1237, 1317, 1395, 1458]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[238, 424, 545, 650, 749, 839, 926, 1006, 1090, 1167, 1243, 1316, 1380]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[262, 463, 587, 693, 790, 882, 965, 1051, 1135, 1218, 1300, 1376, 1438]}]}Loading … 

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