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• {"link"=>{"url"=>"http://www.citeulike.org/user/meru/article/12443771"}, "post_time"=>"2013-06-24 06:50:43", "tag"=>["human", "qtl"], "linkout"=>{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pgen.1003372"}, "username"=>"meru", "article_id"=>"12443771"}

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{"title"=>"Genetic Architecture of Skin and Eye Color in an African-European Admixed Population", "type"=>"journal", "authors"=>[{"first_name"=>"Sandra", "last_name"=>"Beleza", "scopus_author_id"=>"6603216912"}, {"first_name"=>"Nicholas A.", "last_name"=>"Johnson", "scopus_author_id"=>"37037641700"}, {"first_name"=>"Sophie I.", "last_name"=>"Candille", "scopus_author_id"=>"6506495126"}, {"first_name"=>"Devin M.", "last_name"=>"Absher", "scopus_author_id"=>"57198406019"}, {"first_name"=>"Marc A.", "last_name"=>"Coram", "scopus_author_id"=>"14065755100"}, {"first_name"=>"Jailson", "last_name"=>"Lopes", "scopus_author_id"=>"55511760500"}, {"first_name"=>"Joana", "last_name"=>"Campos", "scopus_author_id"=>"57197560623"}, {"first_name"=>"Isabel Inês", "last_name"=>"Araújo", "scopus_author_id"=>"55512229500"}, {"first_name"=>"Tovi M.", "last_name"=>"Anderson", "scopus_author_id"=>"26323136900"}, {"first_name"=>"Bjarni J.", "last_name"=>"Vilhjálmsson", "scopus_author_id"=>"35754070300"}, {"first_name"=>"Magnus", "last_name"=>"Nordborg", "scopus_author_id"=>"7003535749"}, {"first_name"=>"António", "last_name"=>"Correia e Silva", "scopus_author_id"=>"55512280100"}, {"first_name"=>"Mark D.", "last_name"=>"Shriver", "scopus_author_id"=>"24390641500"}, {"first_name"=>"Jorge", "last_name"=>"Rocha", "scopus_author_id"=>"7202074316"}, {"first_name"=>"Gregory S.", "last_name"=>"Barsh", "scopus_author_id"=>"35394756500"}, {"first_name"=>"Hua", "last_name"=>"Tang", "scopus_author_id"=>"56544900000"}], "year"=>2013, "source"=>"PLoS Genetics", "identifiers"=>{"pui"=>"368694391", "issn"=>"15537390", "isbn"=>"1553-7404 (Electronic)\\r1553-7390 (Linking)", "doi"=>"10.1371/journal.pgen.1003372", "scopus"=>"2-s2.0-84875987440", "pmid"=>"23555287", "sgr"=>"84875987440"}, "id"=>"49774df4-35a0-3be5-b4b8-407455817cc0", "abstract"=>"Variation in human skin and eye color is substantial and especially apparent in admixed populations, yet the underlying genetic architecture is poorly understood because most genome-wide studies are based on individuals of European ancestry. We study pigmentary variation in 699 individuals from Cape Verde, where extensive West African/European admixture has given rise to a broad range in trait values and genomic ancestry proportions. We develop and apply a new approach for measuring eye color, and identify two major loci (HERC2[OCA2] P = 2.3 x 10(-62), SLC24A5 P = 9.6 x 10(-9)) that account for both blue versus brown eye color and varying intensities of brown eye color. We identify four major loci (SLC24A5 P = 5.4 x 10(-27), TYR P = 1.1 x 10(-9), APBA2[OCA2] P = 1.5 x 10(-8), SLC45A2 P = 6 x 10(-9)) for skin color that together account for 35% of the total variance, but the genetic component with the largest effect (~44%) is average genomic ancestry. Our results suggest that adjacent cis-acting regulatory loci for OCA2 explain the relationship between skin and eye color, and point to an underlying genetic architecture in which several genes of moderate effect act together with many genes of small effect to explain ~70% of the estimated heritability.", "link"=>"http://www.mendeley.com/research/genetic-architecture-skin-eye-color-africaneuropean-admixed-population", "reader_count"=>193, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>12, "Researcher"=>40, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>61, "Student > Postgraduate"=>11, "Student > Master"=>18, "Other"=>7, "Student > Bachelor"=>18, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>13}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>12, "Researcher"=>40, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>61, "Student > Postgraduate"=>11, "Student > Master"=>18, "Other"=>7, "Student > Bachelor"=>18, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>13}, "reader_count_by_subject_area"=>{"Unspecified"=>10, "Agricultural and Biological Sciences"=>128, "Arts and Humanities"=>3, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>1, "Computer Science"=>2, "Engineering"=>1, "Environmental Science"=>4, "Biochemistry, Genetics and Molecular Biology"=>22, "Mathematics"=>2, "Medicine and Dentistry"=>12, "Physics and Astronomy"=>1, "Psychology"=>2, "Social Sciences"=>2, "Immunology and Microbiology"=>1, "Nursing and Health Professions"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Social Sciences"=>{"Social Sciences"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>2}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>10}, "Environmental Science"=>{"Environmental Science"=>4}, "Arts and Humanities"=>{"Arts and Humanities"=>3}, "Engineering"=>{"Engineering"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>128}, "Computer Science"=>{"Computer Science"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>22}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United States"=>8, "United Kingdom"=>1, "Thailand"=>1, "Switzerland"=>2, "Russia"=>1, "Spain"=>1, "Canada"=>2, "Netherlands"=>1, "Austria"=>1, "Korea (South)"=>1, "Iran"=>1, "Finland"=>1, "Brazil"=>4, "Uganda"=>1, "France"=>1, "Germany"=>1}, "group_count"=>4}

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• 4615358
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• 3820762
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• {"referral"=>"http://blogs.plos.org/?p=9992", "language"=>"English", "title"=>"Understanding Images: Human nose shape and climate adaptation | PLOS Blogs Network", "type"=>"Blog", "publication"=>"PLOS Blogs Network", "published_on"=>"", "link_state"=>"APPROVED", "id"=>75489, "created"=>"2017-12-30T06:48:59.000Z", "crowdsourced"=>false, "article"=>{"id"=>14400, "doi"=>"10.1371/journal.pgen.1003372", "title"=>"Genetic Architecture of Skin and Eye Color in an African-European Admixed Population", "published_on"=>"2013-03-21T00:00:00.000Z"}}

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• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosgenetics%2Farticle%3Fid%3D10.1371%252Fjournal.pgen.1003372", "share_count"=>37, "like_count"=>100, "comment_count"=>26, "click_count"=>0, "total_count"=>163}

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• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/6c88a7c9-c3a9-4feb-9113-444f7b21f4fc", "title"=>"Into Africa", "body"=>"A point on this statement --\n\n\"The derived APBA2 (OCA2) allele is present at low frequencies in most populations of African ancestry, and at high frequencies in most populations of Asian and European ancestry. [...] These results suggest that an APBA2 (OCA2) mutation conferring light skin arose before the spread of humans out of Africa [...]\"\n\nIf this gene, as found in Sub-Saharan Africa, does not have a specific molecular indication of being ancestral, there are numerous likely migrations into Sub-Saharan Africa to account for its presence there, as well as gene diffusion from 30,000 years of Caucasians in North Africa.\n\nUnfortunately the anti-colonialist doctrine of today's leftist-dominated anthropology establishment adds \"Never Into Africa\" to its Recent Out of Africa. Entry from ancient Europe is utterly banned, and from the Middle East only grudgingly and conditionally tolerated where unavoidable. \n\nAlso if the derived gene in Africa is indeed indigenous, the question is whether this was originally associated with the Bushmen. They are still today lighter-skinned than Central Africans, and prior to the Bantu domination of southern Africa may have been more tan than brown. (Their generally light skin incidentally also challenges the vitamin D theory of skin color, with perhaps camouflage in jungle shadows being a factor for darkest brown skin.)\n\nBut certainly Eurasian forms of the APBA2 (OCA2) gene will be found in Sub-Saharan Africa -- among the Lemba with the Cohanim Modal Haplotype, among the 10% of Ethiopians with R1b Y-chromosomes, among that mystery cluster of R1b centered on northern Cameroon, among the light-skinned, European-featured Fulani (traditionally regarded as ancestral to the entire Niger-Congo/Bantu expansion), and of course all along the Arab slave coast, and throughout areas of European colonial inhabitation.", "isRemoved"=>false, "created"=>"2013-04-24T10:19:40Z", "lastModified"=>"2013-04-24T10:19:40Z", "creator"=>{"userId"=>"312743"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pgen.1003372", "state"=>"published", "journals"=>{"PLoSGenetics"=>{"journalKey"=>"PLoSGenetics", "eIssn"=>"1553-7404", "title"=>"PLOS Genetics"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2013-04-24T10:19:40Z", "replies"=>[]}

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• {"id"=>"1270701368324521990", "text"=>"@FuerstJgr @Race__Realist Capo verde\n\nhttps://t.co/NwmAmQ5iPW\n\nKhoisan\n\nhttps://t.co/Fd92JEDLBD", "created_at"=>"2020-06-10T12:56:29Z", "user"=>"pp0196", "user_name"=>"Bioinfhotep", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1210329772766715914/GImRnboi_normal.jpg"}
• {"id"=>"1279516888289153029", "text"=>"@razibkhan @halvorz They see here that this variant does not act on skin colour, only on eye colour: https://t.co/vYs19u2d3b", "created_at"=>"2020-07-04T20:46:13Z", "user"=>"dr_appie", "user_name"=>"Abdel Abdellaoui", "user_profile_image"=>"http://pbs.twimg.com/profile_images/623828260548259841/W5D8ShzG_normal.jpg"}
• {"id"=>"314843826525188097", "text"=>"#PLOSGenetics: Genetic Architecture of Skin and Eye Color in an African-European Admixed Population http://t.co/Eh2uYxrP35", "created_at"=>"2013-03-21T20:59:52Z", "user"=>"razibkhan", "user_name"=>"Razib Khan", "user_profile_image"=>"http://a0.twimg.com/profile_images/1022247236/discprofile1_normal.jpg"}
• {"id"=>"314847990609219584", "text"=>"RT @razibkhan: #PLOSGenetics: Genetic Architecture of Skin and Eye Color in an African-European Admixed Population http://t.co/Eh2uYxrP35", "created_at"=>"2013-03-21T21:16:25Z", "user"=>"gwardis", "user_name"=>"Gerry Ward", "user_profile_image"=>"http://a0.twimg.com/profile_images/531605099/DSCF6856_normal.JPG"}
• {"id"=>"315103320714907648", "text"=>"Absolutely fantastic paper on genetics of human pigmentation variation http://t.co/HiCl1AaGa8", "created_at"=>"2013-03-22T14:11:00Z", "user"=>"joe_pickrell", "user_name"=>"Joe Pickrell", "user_profile_image"=>"http://a0.twimg.com/profile_images/1397871733/cuba_normal.jpg"}
• {"id"=>"315103598860189696", "text"=>"RT @joe_pickrell: Absolutely fantastic paper on genetics of human pigmentation variation http://t.co/HiCl1AaGa8", "created_at"=>"2013-03-22T14:12:06Z", "user"=>"ctitusbrown", "user_name"=>"Titus Brown", "user_profile_image"=>"http://a0.twimg.com/profile_images/2341608206/1v12iz3xg0w80911u76a_normal.png"}
• {"id"=>"315104869562327040", "text"=>"RT @joe_pickrell: Absolutely fantastic paper on genetics of human pigmentation variation http://t.co/HiCl1AaGa8", "created_at"=>"2013-03-22T14:17:09Z", "user"=>"APV2600", "user_name"=>"Adam Van Arsdale", "user_profile_image"=>"http://a0.twimg.com/profile_images/2503320881/6yi42vbz1nomu1sssxi2_normal.jpeg"}
• {"id"=>"315104970057842688", "text"=>"RT @joe_pickrell: Absolutely fantastic paper on genetics of human pigmentation variation http://t.co/HiCl1AaGa8", "created_at"=>"2013-03-22T14:17:33Z", "user"=>"AaronJSams", "user_name"=>"Aaron Sams", "user_profile_image"=>"http://a0.twimg.com/profile_images/1306223811/image_normal.jpg"}
• {"id"=>"315107996218834945", "text"=>"RT @joe_pickrell: Absolutely fantastic paper on genetics of human pigmentation variation http://t.co/HiCl1AaGa8", "created_at"=>"2013-03-22T14:29:35Z", "user"=>"aylwyn_scally", "user_name"=>"Aylwyn Scally", "user_profile_image"=>"http://a0.twimg.com/profile_images/2751534682/659b5aa4fe913d12f1b91cf426d99add_normal.jpeg"}
• {"id"=>"315117894897909760", "text"=>"RT @joe_pickrell: Absolutely fantastic paper on genetics of human pigmentation variation http://t.co/HiCl1AaGa8", "created_at"=>"2013-03-22T15:08:55Z", "user"=>"Graham_Coop", "user_name"=>"Graham Coop", "user_profile_image"=>"http://a0.twimg.com/profile_images/2427468315/Portugal_graham_small_normal.jpg"}
• {"id"=>"315134735976366080", "text"=>"RT @joe_pickrell: Absolutely fantastic paper on genetics of human pigmentation variation http://t.co/HiCl1AaGa8", "created_at"=>"2013-03-22T16:15:50Z", "user"=>"WiringTheBrain", "user_name"=>"Kevin Mitchell", "user_profile_image"=>"http://a0.twimg.com/profile_images/1456578216/WB-square-small_normal.jpg"}
• {"id"=>"315139080537124864", "text"=>"RT @joe_pickrell: Absolutely fantastic paper on genetics of human pigmentation variation http://t.co/HiCl1AaGa8", "created_at"=>"2013-03-22T16:33:06Z", "user"=>"nextgenseek", "user_name"=>"nextgenseek", "user_profile_image"=>"http://a0.twimg.com/profile_images/2538708602/9a3cxp94du7z0jbbjqkq_normal.jpeg"}
• {"id"=>"315165292953231361", "text"=>"RT @joe_pickrell: Absolutely fantastic paper on genetics of human pigmentation variation http://t.co/HiCl1AaGa8", "created_at"=>"2013-03-22T18:17:15Z", "user"=>"bryan_howie", "user_name"=>"Bryan Howie", "user_profile_image"=>"http://a0.twimg.com/profile_images/2209520166/shades_normal.jpg"}
• {"id"=>"315175471295913984", "text"=>"RT @joe_pickrell: Absolutely fantastic paper on genetics of human pigmentation variation http://t.co/HiCl1AaGa8", "created_at"=>"2013-03-22T18:57:42Z", "user"=>"anshul", "user_name"=>"ANSHUL KUNDAJE", "user_profile_image"=>"http://a0.twimg.com/profile_images/3001862173/4dc86f565ba23454ec1c9760228b3d60_normal.jpeg"}
• {"id"=>"315197030727303169", "text"=>"RT @joe_pickrell: Absolutely fantastic paper on genetics of human pigmentation variation http://t.co/HiCl1AaGa8", "created_at"=>"2013-03-22T20:23:22Z", "user"=>"paleogenomics", "user_name"=>"paleogenomics", "user_profile_image"=>"http://a0.twimg.com/profile_images/3174893356/919bb8926b52c8ce721527f9f8d13392_normal.jpeg"}
• {"id"=>"315285565870321664", "text"=>"PLOS Genetics: Genetic Architecture of Skin and Eye Color in an African-European Admixed Population http://t.co/i02TwIfQ0q", "created_at"=>"2013-03-23T02:15:11Z", "user"=>"reiver", "user_name"=>"Charles", "user_profile_image"=>"http://a0.twimg.com/profile_images/1542967349/reiver-star_normal.png"}
• {"id"=>"316301686551494656", "text"=>"Color de la piel en humanos ¿pocos genes de gran efecto o muchos de pequeño efecto? ¿O todo a la vez? http://t.co/FIk9uXYpQT", "created_at"=>"2013-03-25T21:32:53Z", "user"=>"paleofreak", "user_name"=>"Sir Peter O'Saur", "user_profile_image"=>"http://a0.twimg.com/profile_images/3282042767/e57a9ee0fc334103f9b45b93be1b1ed5_normal.jpeg"}
• {"id"=>"319805920660045825", "text"=>"Check out March’s issue: http://t.co/cfccrKsmWq Image by Sandra Beleza & Sophie Candille http://t.co/6CGX4cVUKe http://t.co/n5KovKcZ56", "created_at"=>"2013-04-04T13:37:28Z", "user"=>"PLOSGenetics", "user_name"=>"PLOS Genetics", "user_profile_image"=>"http://a0.twimg.com/profile_images/2435441933/pk712n4blw8kyf7yzqwc_normal.jpeg"}
• {"id"=>"333757122280046592", "text"=>"Cape Verde #geneticeyeandskinvariation http://t.co/SSShzuoI8A", "created_at"=>"2013-05-13T01:34:33Z", "user"=>"ILIOJ", "user_name"=>"Cris Barros", "user_profile_image"=>"http://a0.twimg.com/profile_images/3645938004/9c773bfeb5bd771da7b1fbc9014bd55c_normal.jpeg"}
• {"id"=>"387979235362476033", "text"=>"#PLOSGenetics: Genetic Architecture of Skin and Eye Color in an African-European Admixed Population http://t.co/sxm7lM8frn", "created_at"=>"2013-10-09T16:33:52Z", "user"=>"Graham_Mallen", "user_name"=>"Graham Mallen", "user_profile_image"=>"http://a0.twimg.com/profile_images/378800000551663287/15e5f983001fdc6cabd2f57e5dcd8470_normal.jpeg"}
• {"id"=>"387980765566627840", "text"=>"http://t.co/cwPXIREamZ", "created_at"=>"2013-10-09T16:39:57Z", "user"=>"Graham_Mallen", "user_name"=>"Graham Mallen", "user_profile_image"=>"http://a0.twimg.com/profile_images/378800000551663287/15e5f983001fdc6cabd2f57e5dcd8470_normal.jpeg"}
• {"id"=>"387982185938309120", "text"=>"Fascinating stuff @DrAliceRoberts - http://t.co/cwPXIREamZ if only you'd of been my Science teacher! My PhD would of been so different :-)", "created_at"=>"2013-10-09T16:45:36Z", "user"=>"Graham_Mallen", "user_name"=>"Graham Mallen", "user_profile_image"=>"http://a0.twimg.com/profile_images/378800000551663287/15e5f983001fdc6cabd2f57e5dcd8470_normal.jpeg"}
• {"id"=>"419081357449392128", "text"=>"@ewencallaway after reading this http://t.co/JEvvNcAt34 blue eye description very defensible i think...though still uncertain", "created_at"=>"2014-01-03T12:22:36Z", "user"=>"razibkhan", "user_name"=>"Razib Khan", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1022247236/discprofile1_normal.jpg"}
• {"id"=>"542983915196411904", "text"=>"MN: Eye and skin color GWAS on Cap Verdeans did lead to informative results: http://t.co/kic6fXRAuM", "created_at"=>"2014-12-11T10:07:08Z", "user"=>"aivelo", "user_name"=>"Tuomas Aivelo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1743638788/kuvaNI_normal.jpg"}
• {"id"=>"542986384018264064", "text"=>"RT @aivelo: MN: Eye and skin color GWAS on Cap Verdeans did lead to informative results: http://t.co/kic6fXRAuM", "created_at"=>"2014-12-11T10:16:56Z", "user"=>"HannaIsotalus", "user_name"=>"Hanna Isotalus", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000468751436/469c3ddd160ad51ccb6705af867728bc_normal.png"}
• {"id"=>"807714841985241088", "text"=>"Genetic Architecture of Skin and Eye Color in an African-European Admixed Population https://t.co/x7yuefF4ja https://t.co/U2fEVcC9Lf", "created_at"=>"2016-12-10T22:33:19Z", "user"=>"KirkegaardEmil", "user_name"=>"Emil OW Kirkegaard", "user_profile_image"=>"http://pbs.twimg.com/profile_images/767418130293547008/I3RKD6xz_normal.jpg"}
• {"id"=>"807869665519120384", "text"=>"RT @KirkegaardEmil: Genetic Architecture of Skin and Eye Color in an African-European Admixed Population https://t.co/x7yuefF4ja https://t.…", "created_at"=>"2016-12-11T08:48:32Z", "user"=>"Biorealism", "user_name"=>"Holtz", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2888671964/d0202ad1ca3099f9b0e85f30d6c8c738_normal.png"}
• {"id"=>"980251573602476034", "text"=>"@Paul_Bergkamp @ent3c https://t.co/SMM3amFz9R", "created_at"=>"2018-04-01T01:12:41Z", "user"=>"magnusnordborg", "user_name"=>"Magnus Nordborg", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000618155128/69ce57329e7d7cab1017d2ebf672c115_normal.jpeg"}
• {"id"=>"981999215256768512", "text"=>"I should say I do not about Figure S3 in https://t.co/f7m6HYMc69", "created_at"=>"2018-04-05T20:57:12Z", "user"=>"IanDworkin", "user_name"=>"Ian Dworkin", "user_profile_image"=>"http://pbs.twimg.com/profile_images/721352894960791552/k5sUeVMD_normal.jpg"}
• {"id"=>"981999291882459136", "text"=>"I should say I know about figure S3 in \nhttps://t.co/f7m6HYMc69", "created_at"=>"2018-04-05T20:57:30Z", "user"=>"IanDworkin", "user_name"=>"Ian Dworkin", "user_profile_image"=>"http://pbs.twimg.com/profile_images/721352894960791552/k5sUeVMD_normal.jpg"}

Wikipedia | Further Information

• {"title"=>"Human skin color", "url"=>"http://en.wikipedia.org/wiki/Human_skin_color", "timestamp"=>"2019-02-23T23:24:00Z"}
• {"title"=>"Color de la piel humana", "url"=>"http://es.wikipedia.org/wiki/Color_de_la_piel_humana", "timestamp"=>"2019-02-20T21:36:06Z"}
• {"title"=>"Cor da pele humana", "url"=>"http://pt.wikipedia.org/wiki/Cor_da_pele_humana", "timestamp"=>"2019-02-28T09:33:47Z"}
• {"title"=>"File:Quantitative assessment of human eye color.png", "url"=>"http://commons.wikimedia.org/wiki/File:Quantitative_assessment_of_human_eye_color.png", "timestamp"=>"2016-06-25T08:56:32Z"}
• {"title"=>"File:Ancestry proportion and skin and eye color in Cape Verde.png", "url"=>"http://commons.wikimedia.org/wiki/File:Ancestry_proportion_and_skin_and_eye_color_in_Cape_Verde.png", "timestamp"=>"2016-08-13T15:59:41Z"}
• {"title"=>"File:Genetic architecture of human skin color variation.png", "url"=>"http://commons.wikimedia.org/wiki/File:Genetic_architecture_of_human_skin_color_variation.png", "timestamp"=>"2018-10-28T00:14:25Z"}
• {"title"=>"File:Allele frequency analysis for eye and skin color loci at 15q13.1.png", "url"=>"http://commons.wikimedia.org/wiki/File:Allele_frequency_analysis_for_eye_and_skin_color_loci_at_15q13.1.png", "timestamp"=>"2016-06-25T08:25:53Z"}
• {"title"=>"File:GWAS of human eye color in the Cape Verdean cohort.png", "url"=>"http://commons.wikimedia.org/wiki/File:GWAS_of_human_eye_color_in_the_Cape_Verdean_cohort.png", "timestamp"=>"2016-06-25T10:01:46Z"}
• {"title"=>"File:GWAS results for skin and eye color in the total Cape Verdean cohort.png", "url"=>"http://commons.wikimedia.org/wiki/File:GWAS_results_for_skin_and_eye_color_in_the_total_Cape_Verdean_cohort.png", "timestamp"=>"2018-10-28T00:14:25Z"}
• {"title"=>"File:African ancestry distribution in Cape Verdeans and in African Americans.png", "url"=>"http://commons.wikimedia.org/wiki/File:African_ancestry_distribution_in_Cape_Verdeans_and_in_African_Americans.png", "timestamp"=>"2016-08-13T16:03:29Z"}
• {"title"=>"File:GWAS of human skin color in the Cape Verdean cohort.png", "url"=>"http://commons.wikimedia.org/wiki/File:GWAS_of_human_skin_color_in_the_Cape_Verdean_cohort.png", "timestamp"=>"2018-10-28T00:14:25Z"}
• {"title"=>"File:Major loci for human skin and eye color r in the Cape Verdean cohort.png", "url"=>"http://commons.wikimedia.org/wiki/File:Major_loci_for_human_skin_and_eye_color_r_in_the_Cape_Verdean_cohort.png", "timestamp"=>"2018-10-28T00:14:25Z"}
• {"title"=>"File:Imputation, fine-mapping, and positive selection scores for human skin and eye color loci.png", "url"=>"http://commons.wikimedia.org/wiki/File:Imputation,_fine-mapping,_and_positive_selection_scores_for_human_skin_and_eye_color_loci.png", "timestamp"=>"2018-10-28T00:14:25Z"}

Wordpress.com | Further Information

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/993437"], "description"=>"<p>(a) Effect sizes of the loci associated with skin color. Effect values represent the beta values obtained from a regression model containing the four associated loci plus ancestry. (b) The pie chart represents the proportion of phenotypic variation accounted for by the different components, including non-heritable factors (∼20%), the four major loci (∼35%, color-coded as in [a]), and average genomic ancestry (44%). The heritable contributions were estimated by regression and variance decomposition as described in Material and Methods, and are also represented below the pie chart separately as grey (genomic ancestry) or open (four major loci) areas. However, because of admixture stratification, the heritable contributions overlap as described in the text.</p>", "links"=>[], "tags"=>["genetics and genomics", "Evolutionary biology"], "article_id"=>656905, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Sandra Beleza", "Nicholas A. Johnson", "Sophie I. Candille", "Devin M. Absher", "Marc A. Coram", "Jailson Lopes", "Joana Campos", "Isabel Inês Araújo", "Tovi M. Anderson", "Bjarni J. Vilhjálmsson", "Magnus Nordborg", "António Correia e Silva", "Mark D. Shriver", "Jorge Rocha", "Gregory S. Barsh", "Hua Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003372.g007", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genetic_architecture_of_skin_color_variation_/656905", "title"=>"Genetic architecture of skin color variation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-22 03:24:00"}
• {"files"=>["https://ndownloader.figshare.com/files/993433"], "description"=>"<p>(a) Power estimated at three different alpha levels, plotted as a function of effect size (number of MM units by which each copy of the derived allele lightens skin pigmentation). The results shown here are based on derived allele frequencies of 0.1 and 0.9 in the ancestral African and European populations, respectively. The effect sizes detected in Cape Verde for the four major skin color loci are shown in blue; effect sizes for <i>ASIP</i> and <i>KITLG</i> as estimated (see Material and Methods) from <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372-Bonilla1\" target=\"_blank\">[12]</a> and <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372-Miller1\" target=\"_blank\">[15]</a>, respectively are shown in red. (b) Distribution of <i>P</i> values for SNPs in 47 candidate genes, 16 regions with strong signatures of selection, and random SNPs, all shown as a q-q plot of the −log₁₀ (<i>P</i>) values. Observed −log₁₀ (<i>P</i>) values specifically for <i>ASIP</i> and <i>KITLG</i> SNPs are shown above the plot.</p>", "links"=>[], "tags"=>["genetics and genomics", "Evolutionary biology"], "article_id"=>656903, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Sandra Beleza", "Nicholas A. Johnson", "Sophie I. Candille", "Devin M. Absher", "Marc A. Coram", "Jailson Lopes", "Joana Campos", "Isabel Inês Araújo", "Tovi M. Anderson", "Bjarni J. Vilhjálmsson", "Magnus Nordborg", "António Correia e Silva", "Mark D. Shriver", "Jorge Rocha", "Gregory S. Barsh", "Hua Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003372.g005", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Power_and_candidate_gene_analyses_/656903", "title"=>"Power and candidate gene analyses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-22 03:23:00"}
• {"files"=>["https://ndownloader.figshare.com/files/993435"], "description"=>"<p>(a,b) Allele frequency distributions for the SNPs most significantly associated with eye [<i>HERC2</i> rs1291382; (a)] and skin [<i>APBA2</i> rs4424881; (b)] in the HapmapIII <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372-Consortium1\" target=\"_blank\">[19]</a> and HGDP <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372-Li1\" target=\"_blank\">[39]</a> panels for the old world. Blue/orange shading corresponds to the frequency of the ancestral/derived alleles, as determined by comparison with the chimp reference sequence (assembly CGSC2.1/pan Tro2). Frequency values are presented in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372.s006\" target=\"_blank\">Table S3</a>. c) Visual displays of the haplotypes extending from <i>HERC2</i> to the second intron of <i>APBA2</i> in Europeans from HapMap phase III (CEU) and HGDP (French, French Basque, North Italian, Tuscan, Sardinian, Orcadian, and Russian) panels. Haplotypes were inferred on the basis of 26 SNPs common to both datasets; blue and orange shades represent the ancestral and derived alleles, respectively. Haplotypes were ordered according to the ancestral/derived states at <i>HERC2</i> rs1291382 and <i>APBA2</i> rs4424881 (marked with red arrows), as follows: haplotypes bearing the ancestral alleles for both SNPs (Anc-Anc); haplotypes bearing the derived allele for <i>HERC2</i> rs1291382 and the ancestral allele for <i>APBA2</i> rs4424881 (Der-Anc); haplotypes bearing the ancestral allele for <i>HERC2</i> rs1291382 and the derived allele for <i>APBA2</i> rs4424881 (Anc-Der); and haplotypes bearing the derived allele for both SNPs (Der-Der).</p>", "links"=>[], "tags"=>["haplotype", "loci"], "article_id"=>656904, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Sandra Beleza", "Nicholas A. Johnson", "Sophie I. Candille", "Devin M. Absher", "Marc A. Coram", "Jailson Lopes", "Joana Campos", "Isabel Inês Araújo", "Tovi M. Anderson", "Bjarni J. Vilhjálmsson", "Magnus Nordborg", "António Correia e Silva", "Mark D. Shriver", "Jorge Rocha", "Gregory S. Barsh", "Hua Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003372.g006", "stats"=>{"downloads"=>3, "page_views"=>94, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Allele_frequency_and_haplotype_analysis_for_eye_and_skin_color_loci_at_15q13_1_/656904", "title"=>"Allele frequency and haplotype analysis for eye and skin color loci at 15q13.1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-22 03:23:25"}
• {"files"=>["https://ndownloader.figshare.com/files/993432"], "description"=>"<p>Each panel shows the genotype-association results and the distribution of Composite of Multiple Signals scores of positive selection (CMS scores) <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372-Grossman1\" target=\"_blank\">[38]</a> for genotyped and imputed SNPs (dark and light blue points in the association plots, respectively) surrounding the candidate loci; identities of individual SNPs are given in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen-1003372-t001\" target=\"_blank\">Table 1</a>. Dashed red lines correspond to the genome-wide significance thresholds. (a) 5p13.3 region containing the <i>SLC45A2</i> gene. (b) 11q14.3 region containing the <i>GRM5</i> and <i>TYR</i> genes. (c) 15q21.1 region containing the <i>SLC24A5</i> gene. (d) 15q13.1 region containing the <i>OCA2</i>, <i>HERC2</i> and <i>APBA2</i> genes. The interval between <i>HERC2</i> and <i>APBA2</i> contains a cluster of segmental duplications and a paucity of SNPs <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372-Makoff1\" target=\"_blank\">[45]</a>, and is also a source of a frequent deletion breakpoint as described in the <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#s3\" target=\"_blank\">Discussion</a>. Previously identified candidate causative non-synonymous variants <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372-Shriver1\" target=\"_blank\">[11]</a>, <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372-Lamason1\" target=\"_blank\">[13]</a>, <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372-Norton1\" target=\"_blank\">[14]</a> are denoted as red dots in the association plots of panels (a,b,c). The location and identity of candidate genes are colored to correspond with chromosomal location; individual SNPs are given in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen-1003372-t001\" target=\"_blank\">Table 1</a>.</p>", "links"=>[], "tags"=>["selective", "scores"], "article_id"=>656902, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Sandra Beleza", "Nicholas A. Johnson", "Sophie I. Candille", "Devin M. Absher", "Marc A. Coram", "Jailson Lopes", "Joana Campos", "Isabel Inês Araújo", "Tovi M. Anderson", "Bjarni J. Vilhjálmsson", "Magnus Nordborg", "António Correia e Silva", "Mark D. Shriver", "Jorge Rocha", "Gregory S. Barsh", "Hua Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003372.g004", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Imputation_fine_mapping_and_selective_signature_scores_for_skin_and_eye_color_loci_/656902", "title"=>"Imputation, fine-mapping, and selective signature scores for skin and eye color loci.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-22 03:22:43"}
• {"files"=>["https://ndownloader.figshare.com/files/993429"], "description"=>"<p>Plotted are the normalized median values of green (x-axis) and blue (y-axis) levels of each individual's irises. We fitted a principal curve that explains most of the variation in the data (red dashed curve). The T-index is defined by the arc-length from the projection of each point on the curve to the end of the curve that corresponds to the lightest eye color. In the figure are examples of eye photos at their respective position in the T-index curve.</p>", "links"=>[], "tags"=>["genetics and genomics", "Evolutionary biology"], "article_id"=>656899, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Sandra Beleza", "Nicholas A. Johnson", "Sophie I. Candille", "Devin M. Absher", "Marc A. Coram", "Jailson Lopes", "Joana Campos", "Isabel Inês Araújo", "Tovi M. Anderson", "Bjarni J. Vilhjálmsson", "Magnus Nordborg", "António Correia e Silva", "Mark D. Shriver", "Jorge Rocha", "Gregory S. Barsh", "Hua Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003372.g002", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantitative_assessment_of_eye_color_/656899", "title"=>"Quantitative assessment of eye color.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-22 03:22:00"}
• {"files"=>["https://ndownloader.figshare.com/files/993428"], "description"=>"<p>Individual ancestry proportions for Cape Verdeans displayed on all four panels were obtained from a supervised analysis in <i>frappe</i> with K = 2 and HapMap's CEU and YRI fixed as European and African parental populations. (a) Bar plots of individual ancestry proportions for Cape Verdeans across the islands. The width of the plots is proportional to sample size (Santiago, n = 172; Fogo, n = 129; NW cluster, n = 192; Boa Vista, n = 27). The proportion of African vs. European ancestry of the individuals is indicated by the proportion of blue vs. red color in each plot. (b) Individual African ancestry distribution in the total cohort of 685 Cape Verdeans (histogram) and in 802 African Americans (kernel density curve) from the Family Blood Pressure Program (FBPP) <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372-Tang2\" target=\"_blank\">[21]</a>. (c) Scatter-plot of skin color vs. Individual African ancestry proportions. Skin color is measured by the MM index described in Material and Methods. (d) Scatter-plot of eye color vs. Individual African ancestry proportions. Eye color is measured by the T-index, described in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen-1003372-g002\" target=\"_blank\">Figure 2</a> and Material and Methods. Points in scatter-plots are color coded according to the island of origin of the individuals.</p>", "links"=>[], "tags"=>["geography", "ancestry"], "article_id"=>656898, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Sandra Beleza", "Nicholas A. Johnson", "Sophie I. Candille", "Devin M. Absher", "Marc A. Coram", "Jailson Lopes", "Joana Campos", "Isabel Inês Araújo", "Tovi M. Anderson", "Bjarni J. Vilhjálmsson", "Magnus Nordborg", "António Correia e Silva", "Mark D. Shriver", "Jorge Rocha", "Gregory S. Barsh", "Hua Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003372.g001", "stats"=>{"downloads"=>1, "page_views"=>27, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relationship_of_geography_and_ancestry_to_skin_and_eye_color_/656898", "title"=>"Relationship of geography and ancestry to skin and eye color.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-22 03:21:28"}
• {"files"=>["https://ndownloader.figshare.com/files/993439", "https://ndownloader.figshare.com/files/993440", "https://ndownloader.figshare.com/files/993441", "https://ndownloader.figshare.com/files/993442", "https://ndownloader.figshare.com/files/993444", "https://ndownloader.figshare.com/files/993446", "https://ndownloader.figshare.com/files/993447", "https://ndownloader.figshare.com/files/993449"], "description"=>"<div><p>Variation in human skin and eye color is substantial and especially apparent in admixed populations, yet the underlying genetic architecture is poorly understood because most genome-wide studies are based on individuals of European ancestry. We study pigmentary variation in 699 individuals from Cape Verde, where extensive West African/European admixture has given rise to a broad range in trait values and genomic ancestry proportions. We develop and apply a new approach for measuring eye color, and identify two major loci (<i>HERC2</i>[<i>OCA2</i>] <i>P</i> = 2.3×10⁻⁶², <i>SLC24A5 P</i> = 9.6×10⁻⁹) that account for both blue versus brown eye color and varying intensities of brown eye color. We identify four major loci (<i>SLC24A5 P</i> = 5.4×10⁻²⁷, <i>TYR P</i> = 1.1×10⁻⁹, <i>APBA2</i>[OCA2] <i>P</i> = 1.5×10⁻⁸, <i>SLC45A2 P</i> = 6×10⁻⁹) for skin color that together account for 35% of the total variance, but the genetic component with the largest effect (∼44%) is average genomic ancestry. Our results suggest that adjacent cis-acting regulatory loci for <i>OCA2</i> explain the relationship between skin and eye color, and point to an underlying genetic architecture in which several genes of moderate effect act together with many genes of small effect to explain ∼70% of the estimated heritability.</p> </div>", "links"=>[], "tags"=>["african-european", "admixed", "population"], "article_id"=>656906, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Sandra Beleza", "Nicholas A. Johnson", "Sophie I. Candille", "Devin M. Absher", "Marc A. Coram", "Jailson Lopes", "Joana Campos", "Isabel Inês Araújo", "Tovi M. Anderson", "Bjarni J. Vilhjálmsson", "Magnus Nordborg", "António Correia e Silva", "Mark D. Shriver", "Jorge Rocha", "Gregory S. Barsh", "Hua Tang"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1003372.s001", "https://dx.doi.org/10.1371/journal.pgen.1003372.s002", "https://dx.doi.org/10.1371/journal.pgen.1003372.s003", "https://dx.doi.org/10.1371/journal.pgen.1003372.s004", "https://dx.doi.org/10.1371/journal.pgen.1003372.s005", "https://dx.doi.org/10.1371/journal.pgen.1003372.s006", "https://dx.doi.org/10.1371/journal.pgen.1003372.s007", "https://dx.doi.org/10.1371/journal.pgen.1003372.s008"], "stats"=>{"downloads"=>31, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Genetic_Architecture_of_Skin_and_Eye_Color_in_an_African_European_Admixed_Population__/656906", "title"=>"Genetic Architecture of Skin and Eye Color in an African-European Admixed Population", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-03-22 03:24:35"}
• {"files"=>["https://ndownloader.figshare.com/files/993430"], "description"=>"<p><a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#s2\" target=\"_blank\">Results</a> are shown as −log₁₀(<i>P</i> value) for the genotyped SNPs. Plots are ordered by chromosomal position. (a,c) Genotype and admixture association scan results for skin color. (b,d) Genotype and admixture association scan results for eye color. (a,b) show the <i>P</i> values obtained in the initial scans and (c,d) the <i>P</i> values of the following scans adjusting for the strongest associated SNP (in <i>SLC24A5</i> for skin color and in <i>HERC2</i> for eye color). Dashed red lines correspond to the genome-wide significance threshold (P<5×10⁻⁸ in the genotype scan; <i>P</i><7×10⁻⁶ in the ancestry scan [see Material and Methods]). The location and identity of candidate genes are colored to correspond with chromosomal location; individual SNPs are given in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen-1003372-t001\" target=\"_blank\">Table 1</a>.</p>", "links"=>[], "tags"=>["cape", "verdean"], "article_id"=>656900, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Sandra Beleza", "Nicholas A. Johnson", "Sophie I. Candille", "Devin M. Absher", "Marc A. Coram", "Jailson Lopes", "Joana Campos", "Isabel Inês Araújo", "Tovi M. Anderson", "Bjarni J. Vilhjálmsson", "Magnus Nordborg", "António Correia e Silva", "Mark D. Shriver", "Jorge Rocha", "Gregory S. Barsh", "Hua Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003372.g003", "stats"=>{"downloads"=>13, "page_views"=>115, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GWAS_results_for_skin_and_eye_color_in_the_total_Cape_Verdean_cohort_/656900", "title"=>"GWAS results for skin and eye color in the total Cape Verdean cohort.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-22 03:22:14"}
• {"files"=>["https://ndownloader.figshare.com/files/1007840"], "description"=>"a<p><i>P</i> value for association of skin (n = 685) or eye (n = 625) color with genotype or local ancestry, adjusted for sex and the first three principal components, as described in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#s4\" target=\"_blank\">Materials and Methods</a>.</p>b<p>Sign of the beta value in four groups (combined sample/Santiago/Fogo/Northern Islands). A “–” sign indicates that the derived allele causes lighter skin or a lower T index (<a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372.s004\" target=\"_blank\">Table S1</a>).</p>c<p>EUR—individuals with Northern and Western European ancestry, HapMap phase III CEU; AFR—individuals with West African ancestry, HapMap phase III YRI; CV—Cape Verdeans.</p>d<p><i>P</i> values obtained after controlling for <i>SLC24A5</i>, in addition to the other covariates. The corresponding values without controlling for <i>SLC24A5</i> are given in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372.s005\" target=\"_blank\">Table S2</a>.</p>e<p><i>P</i> values obtained after controlling for <i>HERC2</i>, in addition to the other covariates. The corresponding values without controlling for <i>HERC2</i> are given in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372.s005\" target=\"_blank\">Table S2</a>.</p>f<p>After imputation, the most strongly associated SNP at 5p13.3 is the non-synonymous variant <i>SLC45A2</i> L374F (rs16891982), previously associated with pigmentation <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003372#pgen.1003372-Graf1\" target=\"_blank\">[27]</a>. The frequencies of the derived, lightening, alleles are 0.98 and 0.00 in EUR and AFR, respectively.</p>", "links"=>[], "tags"=>["loci"], "article_id"=>668454, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Sandra Beleza", "Nicholas A. Johnson", "Sophie I. Candille", "Devin M. Absher", "Marc A. Coram", "Jailson Lopes", "Joana Campos", "Isabel Inês Araújo", "Tovi M. Anderson", "Bjarni J. Vilhjálmsson", "Magnus Nordborg", "António Correia e Silva", "Mark D. Shriver", "Jorge Rocha", "Gregory S. Barsh", "Hua Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003372.t001", "stats"=>{"downloads"=>14, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Major_loci_for_skin_and_eye_color_/668454", "title"=>"Major loci for skin and eye color.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-21 02:20:54"}

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Relative Metric

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F1000Prime