Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression
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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1067283", "https://ndownloader.figshare.com/files/1067285", "https://ndownloader.figshare.com/files/1067286", "https://ndownloader.figshare.com/files/1067289", "https://ndownloader.figshare.com/files/1067290", "https://ndownloader.figshare.com/files/1067292", "https://ndownloader.figshare.com/files/1067294", "https://ndownloader.figshare.com/files/1067297"], "description"=>"<div><p>Mouse <i>Ikbkap</i> gene encodes IKAP—one of the core subunits of Elongator—and is thought to be involved in transcription. However, the biological function of IKAP, particularly within the context of an animal model, remains poorly characterized. We used a loss-of-function approach in mice to demonstrate that <i>Ikbkap</i> is essential for meiosis during spermatogenesis. Absence of <i>Ikbkap</i> results in defects in synapsis and meiotic recombination, both of which result in increased apoptosis and complete arrest of gametogenesis. In <i>Ikbkap-</i>mutant testes, a few meiotic genes are down-regulated, suggesting IKAP's role in transcriptional regulation. In addition, <i>Ikbkap</i>-mutant testes exhibit defects in wobble uridine tRNA modification, supporting a conserved tRNA modification function from yeast to mammals. Thus, our study not only reveals a novel function of IKAP in meiosis, but also suggests that IKAP contributes to this process partly by exerting its effect on transcription and tRNA modification.</p></div>", "links"=>[], "tags"=>["genetics", "epigenetics", "genomics", "Chromosome biology", "meiosis", "deficiency", "causes", "infertility", "disrupting", "meiotic"], "article_id"=>706658, "categories"=>["Biological Sciences"], "users"=>["Fu-Jung Lin", "Li Shen", "Chuan-Wei Jang", "Pål Ø. Falnes", "Yi Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1003516.s001", "https://dx.doi.org/10.1371/journal.pgen.1003516.s002", "https://dx.doi.org/10.1371/journal.pgen.1003516.s003", "https://dx.doi.org/10.1371/journal.pgen.1003516.s004", "https://dx.doi.org/10.1371/journal.pgen.1003516.s005", "https://dx.doi.org/10.1371/journal.pgen.1003516.s006", "https://dx.doi.org/10.1371/journal.pgen.1003516.s007", "https://dx.doi.org/10.1371/journal.pgen.1003516.s008"], "stats"=>{"downloads"=>8, "page_views"=>40, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ikbkap_Elp1_Deficiency_Causes_Male_Infertility_by_Disrupting_Meiotic_Progression_/706658", "title"=>"Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-05-23 01:50:58"}

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