Environmental Stresses Disrupt Telomere Length Homeostasis
Publication Date
September 05, 2013
Journal
PLOS Genetics
Authors
Gal Hagit Romano, Yaniv Harari, Tal Yehuda, Ariel Podhorzer, et al
Volume
9
Issue
9
Pages
e1003721
DOI
https://dx.plos.org/10.1371/journal.pgen.1003721
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1003721
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/24039592
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764183
Europe PMC
http://europepmc.org/abstract/MED/24039592
Web of Science
000325076600009
Scopus
84884691428
Mendeley
http://www.mendeley.com/research/environmental-stresses-disrupt-telomere-length-homeostasis
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Mendeley | Further Information

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CrossRef

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1192314"], "description"=>"<p>Wild-type yeast strain BY4741 was grown in the presence of various stresses and then released. <b>A</b>. YEPD containing 5% ethanol (released to YEPD after 300 generations). <b>B</b>. YEPD+8 mM caffeine (released to YEPD after 90 generations). <b>C</b>. YEPD at 37°C (released back to 30°C after 100 generations).</p>", "links"=>[], "tags"=>["telomere"], "article_id"=>789784, "categories"=>["Biological Sciences"], "users"=>["Gal Hagit Romano", "Yaniv Harari", "Tal Yehuda", "Ariel Podhorzer", "Linda Rubinstein", "Ron Shamir", "Assaf Gottlieb", "Yael Silberberg", "Dana Pe'er", "Eytan Ruppin", "Roded Sharan", "Martin Kupiec"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003721.g002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kinetics_of_telomere_length_change_after_exposure_to_environmental_stresses_/789784", "title"=>"Kinetics of telomere length change after exposure to environmental stresses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-05 02:31:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1192312"], "description"=>"<p>Strain BY4741 was grown for 100 generations on YEPD at optimal conditions and under mild stress conditions. DNA was extracted after 50 and 100 generations, digested with <i>Xho</i>I, and analyzed by Southern blot. The membrane was probed with a telomere sequence and with unique genomic sequences used as markers (779 bp and 2044 bp) to enable telomere length measurements. Telomere length was measured for at least three independent colonies. <b>A</b>. The difference (in bp) between telomere length grown under stress and that of cells grown on YEPD is represented by dark green bars (after 50 generations) and by light green bars (after 100 generations). <b>B</b>. Southern blots analyses after 100 generations showing the effect of various stresses on telomere length.</p>", "links"=>[], "tags"=>["telomere"], "article_id"=>789782, "categories"=>["Biological Sciences"], "users"=>["Gal Hagit Romano", "Yaniv Harari", "Tal Yehuda", "Ariel Podhorzer", "Linda Rubinstein", "Ron Shamir", "Assaf Gottlieb", "Yael Silberberg", "Dana Pe'er", "Eytan Ruppin", "Roded Sharan", "Martin Kupiec"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003721.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effect_of_environmental_stress_on_telomere_length_/789782", "title"=>"The effect of environmental stress on telomere length.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-05 02:31:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1192338", "https://ndownloader.figshare.com/files/1192339", "https://ndownloader.figshare.com/files/1192340", "https://ndownloader.figshare.com/files/1192341", "https://ndownloader.figshare.com/files/1192342", "https://ndownloader.figshare.com/files/1192343", "https://ndownloader.figshare.com/files/1192344", "https://ndownloader.figshare.com/files/1192345"], "description"=>"<div><p>Telomeres protect the chromosome ends from degradation and play crucial roles in cellular aging and disease. Recent studies have additionally found a correlation between psychological stress, telomere length, and health outcome in humans. However, studies have not yet explored the causal relationship between stress and telomere length, or the molecular mechanisms underlying that relationship. Using yeast as a model organism, we show that stresses may have very different outcomes: alcohol and acetic acid elongate telomeres, whereas caffeine and high temperatures shorten telomeres. Additional treatments, such as oxidative stress, show no effect. By combining genome-wide expression measurements with a systematic genetic screen, we identify the Rap1/Rif1 pathway as the central mediator of the telomeric response to environmental signals. These results demonstrate that telomere length can be manipulated, and that a carefully regulated homeostasis may become markedly deregulated in opposing directions in response to different environmental cues.</p></div>", "links"=>[], "tags"=>["stresses", "disrupt", "telomere"], "article_id"=>789803, "categories"=>["Biological Sciences"], "users"=>["Gal Hagit Romano", "Yaniv Harari", "Tal Yehuda", "Ariel Podhorzer", "Linda Rubinstein", "Ron Shamir", "Assaf Gottlieb", "Yael Silberberg", "Dana Pe'er", "Eytan Ruppin", "Roded Sharan", "Martin Kupiec"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1003721.s001", "https://dx.doi.org/10.1371/journal.pgen.1003721.s002", "https://dx.doi.org/10.1371/journal.pgen.1003721.s003", "https://dx.doi.org/10.1371/journal.pgen.1003721.s004", "https://dx.doi.org/10.1371/journal.pgen.1003721.s005", "https://dx.doi.org/10.1371/journal.pgen.1003721.s006", "https://dx.doi.org/10.1371/journal.pgen.1003721.s007", "https://dx.doi.org/10.1371/journal.pgen.1003721.s008"], "stats"=>{"downloads"=>61, "page_views"=>39, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Environmental_Stresses_Disrupt_Telomere_Length_Homeostasis_/789803", "title"=>"Environmental Stresses Disrupt Telomere Length Homeostasis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-09-05 02:31:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1192316"], "description"=>"<p>The effect of ethanol, caffeine and high temperature on telomere length was tested on strains carrying individual gene deletions/hypomorphic mutations. Each mutant was grown under the relevant stress for 100 generations and its telomere length was measured using Southern blot analysis. <b>A–C</b>. The X-axis shows the initial length of each mutant and the Y-axis shows the elongation or shortening after 100 generations. Each strain analyzed is represented by a circle (wt in green). A strong correlation (demarked by a red line; ±5% SD) was seen between the initial length and the effect of the stress. <b>A</b>. Ethanol. <b>B</b>. Caffeine. <b>C</b>. 37°C. <b>D</b>. Each bar represents the ratio between the initial telomere length and the elongation after 100 generations in ethanol. Very short <i>tlm</i> mutants (below 200 nt long) could be clearly separated into two groups: mutants of the Tel1 pathway (<i>tel1Δ</i>, <i>mre11Δ</i>, <i>rad50Δ</i>, <i>xrs2Δ</i>) were highly responsive to ethanol stress, while mutants of the NMD (<i>nam7Δ</i>, <i>upf3Δ</i>, <i>nmd2Δ</i>) and Ku (<i>yku70Δ</i>, <i>yku80Δ</i>) pathways show little telomeric elongation under ethanol stress.</p>", "links"=>[], "tags"=>["stresses", "telomere"], "article_id"=>789786, "categories"=>["Biological Sciences"], "users"=>["Gal Hagit Romano", "Yaniv Harari", "Tal Yehuda", "Ariel Podhorzer", "Linda Rubinstein", "Ron Shamir", "Assaf Gottlieb", "Yael Silberberg", "Dana Pe'er", "Eytan Ruppin", "Roded Sharan", "Martin Kupiec"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003721.g003", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Different_stresses_affect_telomere_length_via_different_genes_/789786", "title"=>"Different stresses affect telomere length via different genes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-05 02:31:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1192321"], "description"=>"<p><b>A</b>. The level of Rap1 protein is reduced upon exposure to ethanol in wt, <i>rif1Δ</i> and <i>rif2Δ</i> mutants, but not in a strain in which the <i>RAP1</i> gene is under the Tet promoter. <b>B</b>. The initial telomere length and the elongation after 100 generations in ethanol were measured by Southern blot. A deletion of <i>RIF1</i> (two independent cultures) inhibits the response to ethanol while deletion of <i>RIF2</i> (two independent cultures) increases it. A <i>rap1-17</i> strain, unable to bind Rif1 or Rif2, behaves similarly to the double mutant <i>rif1Δ rif2Δ</i>. Expressing Rap1 under the tetracycline promoter (which is not affected by ethanol) prevents the telomeric elongation under ethanol stress. <b>C</b>. Chromatin Immunoprecipitation (ChIP) analysis for the recruitment levels of Rif1 and Rif2 proteins to telomeres, in the absence and in the presence of ethanol. The non-telomeric <i>ARO1</i> locus was used to normalize the relative levels.</p>", "links"=>[], "tags"=>["elongation", "mutants", "grown"], "article_id"=>789791, "categories"=>["Biological Sciences"], "users"=>["Gal Hagit Romano", "Yaniv Harari", "Tal Yehuda", "Ariel Podhorzer", "Linda Rubinstein", "Ron Shamir", "Assaf Gottlieb", "Yael Silberberg", "Dana Pe'er", "Eytan Ruppin", "Roded Sharan", "Martin Kupiec"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003721.g004", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Telomere_elongation_of_different_mutants_grown_in_the_presence_of_ethanol_/789791", "title"=>"Telomere elongation of different mutants grown in the presence of ethanol.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-05 02:31:17"}

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Relative Metric

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