CiteULike | Further Information

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Mendeley | Further Information

{"title"=>"Environmental Stresses Disrupt Telomere Length Homeostasis", "type"=>"journal", "authors"=>[{"first_name"=>"Gal Hagit", "last_name"=>"Romano", "scopus_author_id"=>"34877684400"}, {"first_name"=>"Yaniv", "last_name"=>"Harari", "scopus_author_id"=>"51664776900"}, {"first_name"=>"Tal", "last_name"=>"Yehuda", "scopus_author_id"=>"36012170700"}, {"first_name"=>"Ariel", "last_name"=>"Podhorzer", "scopus_author_id"=>"55866205000"}, {"first_name"=>"Linda", "last_name"=>"Rubinstein", "scopus_author_id"=>"54881295300"}, {"first_name"=>"Ron", "last_name"=>"Shamir", "scopus_author_id"=>"7005411902"}, {"first_name"=>"Assaf", "last_name"=>"Gottlieb", "scopus_author_id"=>"7101920843"}, {"first_name"=>"Yael", "last_name"=>"Silberberg", "scopus_author_id"=>"36349572100"}, {"first_name"=>"Dana", "last_name"=>"Pe'er", "scopus_author_id"=>"7801385757"}, {"first_name"=>"Eytan", "last_name"=>"Ruppin", "scopus_author_id"=>"7005381250"}, {"first_name"=>"Roded", "last_name"=>"Sharan", "scopus_author_id"=>"7005271135"}, {"first_name"=>"Martin", "last_name"=>"Kupiec", "scopus_author_id"=>"7006462515"}], "year"=>2013, "source"=>"PLoS Genetics", "identifiers"=>{"pmid"=>"24039592", "doi"=>"10.1371/journal.pgen.1003721", "isbn"=>"1553-7404 (Electronic)\\r1553-7390 (Linking)", "scopus"=>"2-s2.0-84884691428", "issn"=>"15537390", "pui"=>"369903992", "sgr"=>"84884691428"}, "id"=>"72e81414-dc58-3fda-9cc7-78e967d628c8", "abstract"=>"Telomeres protect the chromosome ends from degradation and play crucial roles in cellular aging and disease. Recent studies have additionally found a correlation between psychological stress, telomere length, and health outcome in humans. However, studies have not yet explored the causal relationship between stress and telomere length, or the molecular mechanisms underlying that relationship. Using yeast as a model organism, we show that stresses may have very different outcomes: alcohol and acetic acid elongate telomeres, whereas caffeine and high temperatures shorten telomeres. Additional treatments, such as oxidative stress, show no effect. By combining genome-wide expression measurements with a systematic genetic screen, we identify the Rap1/Rif1 pathway as the central mediator of the telomeric response to environmental signals. These results demonstrate that telomere length can be manipulated, and that a carefully regulated homeostasis may become markedly deregulated in opposing directions in response to different environmental cues", "link"=>"http://www.mendeley.com/research/environmental-stresses-disrupt-telomere-length-homeostasis", "reader_count"=>120, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>10, "Researcher"=>22, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>29, "Student > Postgraduate"=>6, "Other"=>8, "Student > Master"=>15, "Student > Bachelor"=>16, "Professor"=>6}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>10, "Researcher"=>22, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>29, "Student > Postgraduate"=>6, "Other"=>8, "Student > Master"=>15, "Student > Bachelor"=>16, "Professor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Engineering"=>1, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>20, "Mathematics"=>1, "Agricultural and Biological Sciences"=>73, "Medicine and Dentistry"=>6, "Neuroscience"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>5, "Chemistry"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>73}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>20}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>7}, "Environmental Science"=>{"Environmental Science"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Czech Republic"=>1, "United States"=>1, "United Kingdom"=>2, "France"=>2, "Germany"=>1}, "group_count"=>4}

ORCID | Further Information

CrossRef

• http://doi.org/10.1093/nar/gky618
• http://doi.org/10.1016/j.jtbi.2016.11.010
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DataCite

Europe PMC Citations | Further Information

Europe PMC Database Citations | Further Information

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PubMed Central

• 4135794
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• 4264833
• 4503340
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Scopus | Further Information

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• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosgenetics%2Farticle%3Fid%3D10.1371%252Fjournal.pgen.1003721", "share_count"=>16, "like_count"=>26, "comment_count"=>27, "click_count"=>0, "total_count"=>69}

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• {"domain"=>"self.zmarter", "banned_by"=>nil, "media_embed"=>{}, "subreddit"=>"zmarter", "selftext_html"=>"<!-- SC_OFF --><div class=\"md\"><blockquote>\n<p><a href=\"http://www.reddit.com/r/smarter/comments/17zl0v/healing_herbs_and_foods_reference/\"><strong><em>smarter link</em></strong></a></p>\n</blockquote>\n\n<p>healing herbs and foods reference.\n<a href=\"http://www.herbreference.com/\">http://www.herbreference.com/</a> </p>\n\n<p>Icariin is an important, active component in Herba Epimedii. This well-known Chinese herbal medicine has proven efficacy in treating cardiovascular diseases and osteoporosis, and.. ( aging )<br/>\n<a href=\"http://www.hindawi.com/journals/bmri/aip/895976/\">http://www.hindawi.com/journals/bmri/aip/895976/</a><br/>\nPDF <a href=\"http://downloads.hindawi.com/journals/bmri/aip/895976.pdf\">http://downloads.hindawi.com/journals/bmri/aip/895976.pdf</a></p>\n\n<p>Curcumin turmeric protects lungs.<br/>\n<a href=\"http://ajplung.physiology.org/content/early/2013/06/24/ajplung.00082.2013\">http://ajplung.physiology.org/content/early/2013/06/24/ajplung.00082.2013</a></p>\n\n<p>Cinnamon May Be Used to Halt the Progression of Parkinson’s disease<br/>\n<a href=\"http://www.rush.edu/webapps/MEDREL/servlet/NewsRelease?id=1768\">http://www.rush.edu/webapps/MEDREL/servlet/NewsRelease?id=1768</a></p>\n\n<p>Sauerkraut for belly.<br/>\n<a href=\"http://thehealthbank.co.uk/fancy-some-sauerkraut/\">http://thehealthbank.co.uk/fancy-some-sauerkraut/</a></p>\n\n<p>Japanese pickle influenza flu<br/>\n<a href=\"http://onlinelibrary.wiley.com/doi/10.1111/lam.12160/abstract\">http://onlinelibrary.wiley.com/doi/10.1111/lam.12160/abstract</a> </p>\n\n<p>Tomato extract relieves damaged arteries, finds Cambridge study\n Lycopene is found in tomatoes and its potency appears to be enhanced when it is consumed pureed, in ketchup or in the presence of olive oil ( fats ie almonds ). It is also found in other fruit and vegetables, such as grapefruit, pink watermelon...<br/>\n<a href=\"http://www.theguardian.com/science/2014/jun/09/tomato-extract-lycopene-relieves-damaged-arteries-cambridge-study\">http://www.theguardian.com/science/2014/jun/09/tomato-extract-lycopene-relieves-damaged-arteries-cambridge-study</a></p>\n\n<p>Share network Live Kefir Grains & Kombucha.<br/>\n<a href=\"http://www.torontoadvisors.com/kefir/suppliers?keywords=&order=%7Ekefir.userCountry&page=9\">http://www.torontoadvisors.com/kefir/suppliers?keywords=&order=%7Ekefir.userCountry&page=9</a></p>\n\n<p>You can freeze Kefir Milk.<br/>\n<a href=\"http://waterkefir.ca/can-kefir-frozen/\">http://waterkefir.ca/can-kefir-frozen/</a></p>\n\n<p>Current evidence on physiological activity and expected health effects of kombucha fermented beverage.<br/>\n<a href=\"http://www.ncbi.nlm.nih.gov/pubmed/24192111\">http://www.ncbi.nlm.nih.gov/pubmed/24192111</a></p>\n\n<p>Stevia info<br/>\n<a href=\"http://www.stevia.com/Stevia_Article/Frequently_asked_questions_FAQ/2269\">http://www.stevia.com/Stevia_Article/Frequently_asked_questions_FAQ/2269</a></p>\n\n<p>Two 2010 review studies found no health concerns with stevia or its sweetening extracts.In addition, a 2009 review study found that stevioside and related compounds have anti-hyperglycemic,anti-hypertensive, anti-inflammatory,anti-tumor, anti-diarrheal, diuretic, andimmunomodulatory actions in mice ...<br/>\n<a href=\"http://en.wikipedia.org/wiki/Stevia\">http://en.wikipedia.org/wiki/Stevia</a></p>\n\n<p>To get rid of stevia bitter taste I found that mixing it half and half with lemon juice and let it sit overnight works great, so, you need a lemony sweet something? </p>\n\n<p>Stevia bitter receptors..<br/>\n<a href=\"http://www.wzw.tum.de/index.php?id=185&no_cache=1&L=1&tx_ttnews%5Btt_news%5D=391\">http://www.wzw.tum.de/index.php?id=185&no_cache=1&L=1&tx_ttnews%5Btt_news%5D=391</a></p>\n\n<p>A new study at Sahlgrenska Academy confirms that moderate alcohol consumption can protect against coronary heart disease. But only for the 15% of the population that have a particular genotype.<br/>\n<a href=\"http://www.sahlgrenska.gu.se/english/news_and_events/news/News_Detail//moderate-drinking-is-healthy-only-for-some-people.cid1242619\">http://www.sahlgrenska.gu.se/english/news_and_events/news/News_Detail//moderate-drinking-is-healthy-only-for-some-people.cid1242619</a></p>\n\n<p>Safe alcohol level in a day.One standard drink a day for women e.g. a glass (175ml) of wine or a pint of beer or cider, two standard drinks a day for men e.g. 2 glasses (175ml) of wine or 2 pints of beer or cider.<br/>\n<a href=\"http://www.cancerresearchuk.org/cancer-info/healthyliving/alcohol/alcohol-and-cancer\">http://www.cancerresearchuk.org/cancer-info/healthyliving/alcohol/alcohol-and-cancer</a></p>\n\n<p>Heavy drinking is classified by the University College, London researchers, who began their work in 1997, as more than four units of alcohol a day – a third of a pint is defined as a single unit.<br/>\n<a href=\"http://www.irishtimes.com/news/world/uk/brains-age-faster-even-with-moderate-drinking-study-finds-1.1656717\">http://www.irishtimes.com/news/world/uk/brains-age-faster-even-with-moderate-drinking-study-finds-1.1656717</a></p>\n\n<p>As for the argument that there’s a certain risk with much of the food we consume—nonorganic fruits and vegetables marinated in pesticides, for example, or brown rice, once thought to be healthy, but now found to contain risky levels of arsenic–Naimi replies, “Alcohol is not a food. Alcohol is a drug.<br/>\n<a href=\"http://www.futurity.org/health-medicine/don%E2%80%99t-ignore-the-risks-of-moderate-drinking/\">http://www.futurity.org/health-medicine/don%E2%80%99t-ignore-the-risks-of-moderate-drinking/</a></p>\n\n<p>Diet drink mixers cause higher Blood Alcohol readings<br/>\n<a href=\"http://news.yahoo.com/diet-regular-choice-alcohol-mixer-affects-intoxication-210556806.html\">http://news.yahoo.com/diet-regular-choice-alcohol-mixer-affects-intoxication-210556806.html</a></p>\n\n<p>Coffee or beer can change your DNA<br/>\n<a href=\"http://www.aftau.org/site/News2?page=NewsArticle&id=19499\">http://www.aftau.org/site/News2?page=NewsArticle&id=19499</a>\n Environmental Stresses Disrupt Telomere Length Homeostasis</p>\n\n<h1><a href=\"http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003721\">http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003721</a></h1>\n\n<p>Some telomeres are too long, and some are too short. Perhaps striking the right balance of caffeine and alcohol is the key to keeping them just right.<br/>\n<a href=\"http://arstechnica.com/science/2013/12/caffeine-alcohol-keeps-your-chromosomes-just-right/\">http://arstechnica.com/science/2013/12/caffeine-alcohol-keeps-your-chromosomes-just-right/</a> </p>\n\n<p>The researchers found that, as expected based on human epidemiological data, those animals that drank the largest amounts of alcohol showed greatly diminished vaccine responses compared to the control group. In contrast, animals that drank moderate amounts of ethanol displayed enhanced vaccine responses.<br/>\n<a href=\"http://scienceer.com/2013/12/glass-of-wine-a-day-keeps-the-doctor-away-study-finds/\">http://scienceer.com/2013/12/glass-of-wine-a-day-keeps-the-doctor-away-study-finds/</a> </p>\n\n<p>Mounting evidence has demonstrated that resveratrol, a compound found in the skin of grapes as well as in peanuts and berries promotes health and longevity.<br/>\n<a href=\"http://hms.harvard.edu/news/new-study-validates-longevity-pathway-3-7-13\">http://hms.harvard.edu/news/new-study-validates-longevity-pathway-3-7-13</a></p>\n\n<p>Grapes, The whole fruit contains hundreds of individual components, which we suspect likely work together to provide a synergistic beneficial effect...<br/>\n<a href=\"http://www.newswise.com/articles/study-uncovers-mechanism-for-how-grapes-reduce-heart-failure-associated-with-hypertension\">http://www.newswise.com/articles/study-uncovers-mechanism-for-how-grapes-reduce-heart-failure-associated-with-hypertension</a></p>\n\n<p>Resveratrol in the diet is no help at all, study says<br/>\n<a href=\"http://www.latimes.com/science/sciencenow/la-sci-sn-resveratrol-diet-ineffective-20140512-story.html\">http://www.latimes.com/science/sciencenow/la-sci-sn-resveratrol-diet-ineffective-20140512-story.html</a></p>\n\n<p>Resveratrol Ramps Up Vitamin D Action In The Body<br/>\n<a href=\"http://preventionpractice.com/2014/12/30/resveratrol-ramps-up-vitamin-d-action-in-the-body/\">http://preventionpractice.com/2014/12/30/resveratrol-ramps-up-vitamin-d-action-in-the-body/</a> </p>\n\n<p>Hangover tips bottom of page. ( act. charcoal pill or burnt toast 1water per 1 glass.<br/>\n<a href=\"http://www.thelibertybeacon.com/tag/pesticides-in-wine/\">http://www.thelibertybeacon.com/tag/pesticides-in-wine/</a></p>\n\n<p>How to determine the bioavailability of iron in a diet<br/>\n<a href=\"http://www.researchgate.net/post/How_to_determine_the_bioavailability_of_iron_in_a_diet\">http://www.researchgate.net/post/How_to_determine_the_bioavailability_of_iron_in_a_diet</a></p>\n\n<p>Iron bioavailability and dietary reference values. 119 pages gtp.05<br/>\n<a href=\"http://www.ncbi.nlm.nih.gov/pubmed/11029010\">http://www.ncbi.nlm.nih.gov/pubmed/11029010</a></p>\n\n<p>Iron and calcium<br/>\n<a href=\"http://goaskalice.columbia.edu/iron-calcium-and-constipation-oh-my\">http://goaskalice.columbia.edu/iron-calcium-and-constipation-oh-my</a></p>\n\n<p>Bio enhancer<br/>\n<a href=\"https://en.wikipedia.org/w/index.php?title=Bioenhancer\">https://en.wikipedia.org/w/index.php?title=Bioenhancer</a> </p>\n\n<p>A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers<br/>\n<a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458266/#B24\">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458266/#B24</a></p>\n\n<p>Piperine Enhances the Bioavailability of the Tea Polyphenol (−)-Epigallocatechin-3-gallate in Mice<br/>\n<a href=\"http://jn.nutrition.org/content/134/8/1948/F1.expansion.html\">http://jn.nutrition.org/content/134/8/1948/F1.expansion.html</a><br/>\nC <a href=\"https://en.wikipedia.org/wiki/Epigallocatechin_gallate\">https://en.wikipedia.org/wiki/Epigallocatechin_gallate</a> </p>\n\n<p>Vitamin c<br/>\n<a href=\"http://jn.nutrition.org/content/133/5/1560S.full?sid=ad914404-6ee5-45e5-9b22-f0d8c9349b6c\">http://jn.nutrition.org/content/133/5/1560S.full?sid=ad914404-6ee5-45e5-9b22-f0d8c9349b6c</a></p>\n\n<p>Vitamin-c control gene<br/>\n<a href=\"http://www.newswise.com/articles/vitamin-c-helps-control-gene-activity-in-stem-cells\">http://www.newswise.com/articles/vitamin-c-helps-control-gene-activity-in-stem-cells</a></p>\n\n<p>Dietary Supplements. What it takes to overdose on vitamins and minerals.<br/>\n<a href=\"http://www.consumerreports.org//cro/magazine/2012/09/10-surprising-dangers-of-vitamins-and-supplements/index.htm\">http://www.consumerreports.org//cro/magazine/2012/09/10-surprising-dangers-of-vitamins-and-supplements/index.htm</a></p>\n\n<p>Vitamin on trial.<br/>\n“Nutrition is complex, and I don't think we're necessarily going to find one formula that works for everybody,” says Mayne. But new tools in development could “really change the way we look at this”. The big question is whether, once scientists have all the pieces they need, they can put them together to create a clear and cohesive picture.<br/>\n<a href=\"http://www.nature.com/news/nutrition-vitamins-on-trial-1.15459?WT.ec_id=NATURE-20140626\">http://www.nature.com/news/nutrition-vitamins-on-trial-1.15459?WT.ec_id=NATURE-20140626</a></p>\n\n<p>Multivitamin not so good ? Has a few plants-side effects/ stevia<br/>\n<a href=\"http://www.guardian.co.uk/lifeandstyle/2013/jun/07/vitamins-stop-taking-the-pills\">http://www.guardian.co.uk/lifeandstyle/2013/jun/07/vitamins-stop-taking-the-pills</a></p>\n\n<p>Multi vitamins good for some people.<br/>\n<a href=\"http://oregonstate.edu/ua/ncs/archives/2013/dec/review-most-clinical-studies-vitamins-flawed-poor-methodology\">http://oregonstate.edu/ua/ncs/archives/2013/dec/review-most-clinical-studies-vitamins-flawed-poor-methodology</a> </p>\n\n<p>Vitamin<br/>\n<a href=\"http://www.bbc.co.uk/news/magazine-24563590\">http://www.bbc.co.uk/news/magazine-24563590</a> </p>\n\n<p>Vitamins and Minerals: Understanding Their Role<br/>\n<a href=\"http://www.helpguide.org/harvard/vitamins_and_minerals.htm?no_redirect=true\">http://www.helpguide.org/harvard/vitamins_and_minerals.htm?no_redirect=true</a></p>\n\n<p>Vitamin WIKI<br/>\n<a href=\"http://en.wikipedia.org/wiki/Vitamin\">http://en.wikipedia.org/wiki/Vitamin</a></p>\n\n<p>Vitamin uses, side effects, interactions,, dosing.<br/>\n<a href=\"http://www.webmd.com/vitamins-supplements/ingredientmono-926-VITAMIN+B12.aspx?activeIngredientId=926&activeIngredientName=VITAMIN+B12&source=2\">http://www.webmd.com/vitamins-supplements/ingredientmono-926-VITAMIN+B12.aspx?activeIngredientId=926&activeIngredientName=VITAMIN+B12&source=2</a></p>\n\n<p>VITAMIN & MINERAL Nutritional Benefit and Function , Relationships & Interactions.<br/>\n<a href=\"http://www.carlsonlabs.com/t-vitamin-and-mineral-facts.aspx\">http://www.carlsonlabs.com/t-vitamin-and-mineral-facts.aspx</a></p>\n\n<p>Vitamin destroyers<br/>\n<a href=\"http://www.nutrition-info.com/nutrientdestroyers.php\">http://www.nutrition-info.com/nutrientdestroyers.php</a></p>\n\n<p>Vitamin, good for / sign of deficiency / good sources of / RDA / destroyer /...<br/>\n<a href=\"http://www.netdoctor.co.uk/health_advice/facts/vitamins_which.htm\">http://www.netdoctor.co.uk/health_advice/facts/vitamins_which.htm</a></p>\n\n<p>Chemistry ( minerals comb ratio )<br/>\n<a href=\"http://www.acu-cell.com/mr.html\">http://www.acu-cell.com/mr.html</a></p>\n\n<p>Olive oil sources<br/>\n<a href=\"http://www.oliveoilsource.com/page/freezing-olive-oil\">http://www.oliveoilsource.com/page/freezing-olive-oil</a></p>\n\n<p>Green tea news ,articles and information.<br/>\n<a href=\"http://www.naturalnews.com/green_tea.html\">http://www.naturalnews.com/green_tea.html</a></p>\n\n<p>Tea and coffee contain compounds called phenols that inhibit iron absorption - so they shouldn't be consumed alongside iron-rich foods.<br/>\n<a href=\"http://news.bbc.co.uk/2/hi/4777607.stm\">http://news.bbc.co.uk/2/hi/4777607.stm</a></p>\n\n<p>Green tea and alzheimer<br/>\n<a href=\"http://scicasts.com/bio/2050-biochemistry/5554-study-reveals-green-tea-extract-interferes-with-the-formation-of-amyloid-plaques-in-alzheimer-s-disease\">http://scicasts.com/bio/2050-biochemistry/5554-study-reveals-green-tea-extract-interferes-with-the-formation-of-amyloid-plaques-in-alzheimer-s-disease</a></p>\n\n<p>The positive health effects of tea disappear even if just a dash of milk is added.If you eat large amounts of protein during the day, they will neutralise all those good substances in green tea. Take your daily dosage in one go first thing in the morning, and wait about an hour before eating any proteins.<br/>\n<a href=\"http://www.ergo-log.com/egcgprotein.html\">http://www.ergo-log.com/egcgprotein.html</a></p>\n\n<p>Green tea contains insulin booster. If green tea also increases the uptake of glucose<br/>\n<a href=\"http://www.ergo-log.com/egcginsulin.html\">http://www.ergo-log.com/egcginsulin.html</a></p>\n\n<p>Green Tea Side Effects Warnings!Advice To New Drinkers<br/>\n<a href=\"http://www.amazing-green-tea.com/green-tea-side-effects.html\">http://www.amazing-green-tea.com/green-tea-side-effects.html</a></p>\n\n<p>The content of flavonoids may vary dramatically amongst different tea products** Green tea wiki<br/>\n<a href=\"http://en.wikipedia.org/wiki/Green_tea\">http://en.wikipedia.org/wiki/Green_tea</a></p>\n\n<p>Which Foods are highest in phytonutrient antioxidants ? Does cooking affect antioxidant content ?<br/>\n<a href=\"http://www.whfoods.com/genpage.php?tname=faq&dbid=42\">http://www.whfoods.com/genpage.php?tname=faq&dbid=42</a></p>\n\n<p>Ranked antioxidant food table (conflicting (a little) w-whfoods up there,)<br/>\n<a href=\"http://www.ajcn.org/cgi/pmidlookup?view=long&pmid=16825686\">http://www.ajcn.org/cgi/pmidlookup?view=long&pmid=16825686</a> </p>\n\n<p>15k<br/>\n__ </p>\n\n<p><a href=\"https://www.reddit.com/r/zmarter/comments/37594i/healing_herbs_and_foods_reference_3/\">hh3</a> <a href=\"http://www.reddit.com/r/zmarter/comments/1lsneo/healing_herbs_and_foods_reference_2/\">hh2</a></p>\n</div><!-- SC_ON -->", "selftext"=>">[***smarter link***](http://www.reddit.com/r/smarter/comments/17zl0v/healing_herbs_and_foods_reference/)\n\nhealing herbs and foods reference.\nhttp://www.herbreference.com/ \n\nIcariin is an important, active component in Herba Epimedii. This well-known Chinese herbal medicine has proven efficacy in treating cardiovascular diseases and osteoporosis, and.. ( aging ) \nhttp://www.hindawi.com/journals/bmri/aip/895976/ \nPDF http://downloads.hindawi.com/journals/bmri/aip/895976.pdf\n\nCurcumin turmeric protects lungs. \nhttp://ajplung.physiology.org/content/early/2013/06/24/ajplung.00082.2013\n\nCinnamon May Be Used to Halt the Progression of Parkinson’s disease \nhttp://www.rush.edu/webapps/MEDREL/servlet/NewsRelease?id=1768\n\nSauerkraut for belly. \nhttp://thehealthbank.co.uk/fancy-some-sauerkraut/\n\nJapanese pickle influenza flu \nhttp://onlinelibrary.wiley.com/doi/10.1111/lam.12160/abstract \n\nTomato extract relieves damaged arteries, finds Cambridge study\n Lycopene is found in tomatoes and its potency appears to be enhanced when it is consumed pureed, in ketchup or in the presence of olive oil ( fats ie almonds ). It is also found in other fruit and vegetables, such as grapefruit, pink watermelon... \nhttp://www.theguardian.com/science/2014/jun/09/tomato-extract-lycopene-relieves-damaged-arteries-cambridge-study\n\nShare network Live Kefir Grains & Kombucha. \nhttp://www.torontoadvisors.com/kefir/suppliers?keywords=&order=%7Ekefir.userCountry&page=9\n\nYou can freeze Kefir Milk. \nhttp://waterkefir.ca/can-kefir-frozen/\n\nCurrent evidence on physiological activity and expected health effects of kombucha fermented beverage. \nhttp://www.ncbi.nlm.nih.gov/pubmed/24192111\n\nStevia info \nhttp://www.stevia.com/Stevia_Article/Frequently_asked_questions_FAQ/2269\n\nTwo 2010 review studies found no health concerns with stevia or its sweetening extracts.In addition, a 2009 review study found that stevioside and related compounds have anti-hyperglycemic,anti-hypertensive, anti-inflammatory,anti-tumor, anti-diarrheal, diuretic, andimmunomodulatory actions in mice ... \nhttp://en.wikipedia.org/wiki/Stevia\n\nTo get rid of stevia bitter taste I found that mixing it half and half with lemon juice and let it sit overnight works great, so, you need a lemony sweet something? \n\nStevia bitter receptors.. \nhttp://www.wzw.tum.de/index.php?id=185&no_cache=1&L=1&tx_ttnews%5Btt_news%5D=391\n\nA new study at Sahlgrenska Academy confirms that moderate alcohol consumption can protect against coronary heart disease. But only for the 15% of the population that have a particular genotype. \nhttp://www.sahlgrenska.gu.se/english/news_and_events/news/News_Detail//moderate-drinking-is-healthy-only-for-some-people.cid1242619\n\nSafe alcohol level in a day.One standard drink a day for women e.g. a glass (175ml) of wine or a pint of beer or cider, two standard drinks a day for men e.g. 2 glasses (175ml) of wine or 2 pints of beer or cider. \nhttp://www.cancerresearchuk.org/cancer-info/healthyliving/alcohol/alcohol-and-cancer\n\nHeavy drinking is classified by the University College, London researchers, who began their work in 1997, as more than four units of alcohol a day – a third of a pint is defined as a single unit. \nhttp://www.irishtimes.com/news/world/uk/brains-age-faster-even-with-moderate-drinking-study-finds-1.1656717\n\nAs for the argument that there’s a certain risk with much of the food we consume—nonorganic fruits and vegetables marinated in pesticides, for example, or brown rice, once thought to be healthy, but now found to contain risky levels of arsenic–Naimi replies, “Alcohol is not a food. Alcohol is a drug. \nhttp://www.futurity.org/health-medicine/don%E2%80%99t-ignore-the-risks-of-moderate-drinking/\n\nDiet drink mixers cause higher Blood Alcohol readings \nhttp://news.yahoo.com/diet-regular-choice-alcohol-mixer-affects-intoxication-210556806.html\n\nCoffee or beer can change your DNA \nhttp://www.aftau.org/site/News2?page=NewsArticle&id=19499\n Environmental Stresses Disrupt Telomere Length Homeostasis\n#http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003721 \n\nSome telomeres are too long, and some are too short. Perhaps striking the right balance of caffeine and alcohol is the key to keeping them just right. \nhttp://arstechnica.com/science/2013/12/caffeine-alcohol-keeps-your-chromosomes-just-right/ \n\nThe researchers found that, as expected based on human epidemiological data, those animals that drank the largest amounts of alcohol showed greatly diminished vaccine responses compared to the control group. In contrast, animals that drank moderate amounts of ethanol displayed enhanced vaccine responses. \nhttp://scienceer.com/2013/12/glass-of-wine-a-day-keeps-the-doctor-away-study-finds/ \n \n\nMounting evidence has demonstrated that resveratrol, a compound found in the skin of grapes as well as in peanuts and berries promotes health and longevity. \nhttp://hms.harvard.edu/news/new-study-validates-longevity-pathway-3-7-13\n\nGrapes, The whole fruit contains hundreds of individual components, which we suspect likely work together to provide a synergistic beneficial effect... \nhttp://www.newswise.com/articles/study-uncovers-mechanism-for-how-grapes-reduce-heart-failure-associated-with-hypertension\n\nResveratrol in the diet is no help at all, study says \nhttp://www.latimes.com/science/sciencenow/la-sci-sn-resveratrol-diet-ineffective-20140512-story.html\n\nResveratrol Ramps Up Vitamin D Action In The Body \nhttp://preventionpractice.com/2014/12/30/resveratrol-ramps-up-vitamin-d-action-in-the-body/ \n\nHangover tips bottom of page. ( act. charcoal pill or burnt toast 1water per 1 glass. \nhttp://www.thelibertybeacon.com/tag/pesticides-in-wine/\n\nHow to determine the bioavailability of iron in a diet \nhttp://www.researchgate.net/post/How_to_determine_the_bioavailability_of_iron_in_a_diet\n\nIron bioavailability and dietary reference values. 119 pages gtp.05 \nhttp://www.ncbi.nlm.nih.gov/pubmed/11029010\n\nIron and calcium \nhttp://goaskalice.columbia.edu/iron-calcium-and-constipation-oh-my\n\nBio enhancer \nhttps://en.wikipedia.org/w/index.php?title=Bioenhancer \n\nA Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers \nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458266/#B24\n\nPiperine Enhances the Bioavailability of the Tea Polyphenol (−)-Epigallocatechin-3-gallate in Mice \nhttp://jn.nutrition.org/content/134/8/1948/F1.expansion.html \nC https://en.wikipedia.org/wiki/Epigallocatechin_gallate \n\nVitamin c \nhttp://jn.nutrition.org/content/133/5/1560S.full?sid=ad914404-6ee5-45e5-9b22-f0d8c9349b6c\n\nVitamin-c control gene \nhttp://www.newswise.com/articles/vitamin-c-helps-control-gene-activity-in-stem-cells\n\nDietary Supplements. What it takes to overdose on vitamins and minerals. \nhttp://www.consumerreports.org//cro/magazine/2012/09/10-surprising-dangers-of-vitamins-and-supplements/index.htm\n\nVitamin on trial. \n“Nutrition is complex, and I don't think we're necessarily going to find one formula that works for everybody,” says Mayne. But new tools in development could “really change the way we look at this”. The big question is whether, once scientists have all the pieces they need, they can put them together to create a clear and cohesive picture. \nhttp://www.nature.com/news/nutrition-vitamins-on-trial-1.15459?WT.ec_id=NATURE-20140626\n\nMultivitamin not so good ? Has a few plants-side effects/ stevia \nhttp://www.guardian.co.uk/lifeandstyle/2013/jun/07/vitamins-stop-taking-the-pills\n\nMulti vitamins good for some people. \nhttp://oregonstate.edu/ua/ncs/archives/2013/dec/review-most-clinical-studies-vitamins-flawed-poor-methodology \n\nVitamin \nhttp://www.bbc.co.uk/news/magazine-24563590 \n\nVitamins and Minerals: Understanding Their Role \nhttp://www.helpguide.org/harvard/vitamins_and_minerals.htm?no_redirect=true\n\nVitamin WIKI \nhttp://en.wikipedia.org/wiki/Vitamin\n\nVitamin uses, side effects, interactions,, dosing. \nhttp://www.webmd.com/vitamins-supplements/ingredientmono-926-VITAMIN+B12.aspx?activeIngredientId=926&activeIngredientName=VITAMIN+B12&source=2\n\nVITAMIN & MINERAL Nutritional Benefit and Function , Relationships & Interactions. \nhttp://www.carlsonlabs.com/t-vitamin-and-mineral-facts.aspx\n\nVitamin destroyers \nhttp://www.nutrition-info.com/nutrientdestroyers.php\n\nVitamin, good for / sign of deficiency / good sources of / RDA / destroyer /... \nhttp://www.netdoctor.co.uk/health_advice/facts/vitamins_which.htm\n\nChemistry ( minerals comb ratio ) \nhttp://www.acu-cell.com/mr.html\n\nOlive oil sources \nhttp://www.oliveoilsource.com/page/freezing-olive-oil\n\nGreen tea news ,articles and information. \nhttp://www.naturalnews.com/green_tea.html\n\nTea and coffee contain compounds called phenols that inhibit iron absorption - so they shouldn't be consumed alongside iron-rich foods. \nhttp://news.bbc.co.uk/2/hi/4777607.stm\n\nGreen tea and alzheimer \nhttp://scicasts.com/bio/2050-biochemistry/5554-study-reveals-green-tea-extract-interferes-with-the-formation-of-amyloid-plaques-in-alzheimer-s-disease\n\nThe positive health effects of tea disappear even if just a dash of milk is added.If you eat large amounts of protein during the day, they will neutralise all those good substances in green tea. Take your daily dosage in one go first thing in the morning, and wait about an hour before eating any proteins. \nhttp://www.ergo-log.com/egcgprotein.html\n\nGreen tea contains insulin booster. If green tea also increases the uptake of glucose \nhttp://www.ergo-log.com/egcginsulin.html\n\nGreen Tea Side Effects Warnings!Advice To New Drinkers \nhttp://www.amazing-green-tea.com/green-tea-side-effects.html\n\nThe content of flavonoids may vary dramatically amongst different tea products** Green tea wiki \nhttp://en.wikipedia.org/wiki/Green_tea\n\nWhich Foods are highest in phytonutrient antioxidants ? Does cooking affect antioxidant content ? \nhttp://www.whfoods.com/genpage.php?tname=faq&dbid=42\n\nRanked antioxidant food table (conflicting (a little) w-whfoods up there,) \nhttp://www.ajcn.org/cgi/pmidlookup?view=long&pmid=16825686 \n\n15k \n__ \n\n [hh3](https://www.reddit.com/r/zmarter/comments/37594i/healing_herbs_and_foods_reference_3/) [hh2](http://www.reddit.com/r/zmarter/comments/1lsneo/healing_herbs_and_foods_reference_2/)\n", "likes"=>nil, "suggested_sort"=>nil, "user_reports"=>[], "secure_media"=>nil, "link_flair_text"=>nil, "id"=>"1lsn09", "from_kind"=>nil, "gilded"=>0, "archived"=>true, "clicked"=>false, "report_reasons"=>nil, "author"=>"Gallionella", "media"=>nil, "score"=>0, "approved_by"=>nil, "over_18"=>false, "hidden"=>false, "preview"=>{"images"=>[{"source"=>{"url"=>"https://i.redditmedia.com/maNYtsErqVmFIQL4JuQkOLownclui7_Ywa3COiaw7cc.jpg?s=a4da934f2416e29aed9cd852167c0434", "width"=>70, "height"=>75}, "resolutions"=>[], "variants"=>{}, "id"=>"9kYAa_uAO5bKCzmHFru1bDGq7Z_vg5Kz0_YL-rfh_4o"}]}, "num_comments"=>0, "thumbnail"=>"self", "subreddit_id"=>"t5_2wp4y", "hide_score"=>false, "edited"=>1432694415.0, "link_flair_css_class"=>nil, "author_flair_css_class"=>nil, "downs"=>0, "secure_media_embed"=>{}, "saved"=>false, "removal_reason"=>nil, "post_hint"=>"self", "stickied"=>false, "from"=>nil, "is_self"=>true, "from_id"=>nil, "permalink"=>"/r/zmarter/comments/1lsn09/healing_herbs_and_foods_reference_1/?ref=search_posts", "locked"=>false, "name"=>"t3_1lsn09", "created"=>1378430339.0, "url"=>"https://www.reddit.com:80/r/zmarter/comments/1lsn09/healing_herbs_and_foods_reference_1/", "author_flair_text"=>nil, "quarantine"=>false, "title"=>"Healing herbs and foods reference 1", "created_utc"=>1378401539.0, "distinguished"=>nil, "mod_reports"=>[], "visited"=>false, "num_reports"=>nil, "ups"=>0}

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• {"id"=>"1023270865528651776", "text"=>"Environmental Stresses Disrupt Telomere Length Homeostasis https://t.co/fEiFYh5YX0", "created_at"=>"2018-07-28T18:16:00Z", "user"=>"suzanne_keogh", "user_name"=>"Suzanne Keogh", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1614486887/hols_maui_138_normal.jpg"}
• {"id"=>"1023492568607125506", "text"=>"RT @suzanne_keogh: Environmental Stresses Disrupt Telomere Length Homeostasis https://t.co/fEiFYh5YX0", "created_at"=>"2018-07-29T08:56:58Z", "user"=>"TelomereCoin", "user_name"=>"TelomereCoin_ICO", "user_profile_image"=>"http://pbs.twimg.com/profile_images/989927297066061824/DiMA_sge_normal.jpg"}
• {"id"=>"375726267015757824", "text"=>"#PLoS #Genetics: Environmental Stresses Disrupt Telomere Length Homeostasis http://t.co/fn9cRR4G1A", "created_at"=>"2013-09-05T21:04:57Z", "user"=>"whatDNAtest", "user_name"=>"Carlos Esteban PhD", "user_profile_image"=>"http://a0.twimg.com/profile_images/2209463838/c-azul-negro2_normal.jpg"}
• {"id"=>"375847761888825344", "text"=>"Environmental stresses shown to affect telomeric length in yeast. http://t.co/GMJaWJxYAv", "created_at"=>"2013-09-06T05:07:44Z", "user"=>"scilahn", "user_name"=>"Richard Ahn", "user_profile_image"=>"http://a0.twimg.com/profile_images/1816907812/me_vienna_normal.jpg"}
• {"id"=>"392289151334481920", "text"=>"Deney bira mayası üzerinde yapılmış, memelilerde doğrularlarsa daha inandırıcı olur :)\nhttp://t.co/psj6QEGwHG\n@KKAYABALI @s_hablemitoglu", "created_at"=>"2013-10-21T13:59:56Z", "user"=>"cagriyalgin", "user_name"=>"Çağrı Yalgın", "user_profile_image"=>"http://a0.twimg.com/profile_images/378800000314631787/5b7b9faa4e3b7b8a0ce7b5eef0a1f19b_normal.png"}
• {"id"=>"408611813484277761", "text"=>"Just 1 more cup may be just that:#coffee’s #caffeine& #ethanol(#alcohol)appear to effect the #genetic length of life.http://t.co/9YvjhpfZ2u", "created_at"=>"2013-12-05T15:00:22Z", "user"=>"Handm8stail", "user_name"=>"Handmate's tail", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000231577018/2c3ae14b8b4a170f0b0f28c35925dc7b_normal.png"}
• {"id"=>"408785437134946304", "text"=>"Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #Health", "created_at"=>"2013-12-06T02:30:17Z", "user"=>"HealthHabits", "user_name"=>"Health Habits", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000230908154/d7f5c96580ec2a55aa855e0d51c1f23c_normal.jpeg"}
• {"id"=>"408785593846759424", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T02:30:55Z", "user"=>"A_vivid_G", "user_name"=>"Anna G", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000321352459/cfe5363c4707c9b8d4b925f8bd2533e9_normal.jpeg"}
• {"id"=>"408785933946068992", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T02:32:16Z", "user"=>"ChiefBoomstick", "user_name"=>"Chief Boomstick", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3413197240/a4ad204f71b8e7d4c8c7cda995624430_normal.jpeg"}
• {"id"=>"408786590497243136", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T02:34:52Z", "user"=>"antiarthritis", "user_name"=>"AA Cookbook", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3784037988/07dfdccbc71f40221fac9962bc3957b7_normal.png"}
• {"id"=>"408786996958478337", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T02:36:29Z", "user"=>"WayneGilmore", "user_name"=>"Wayne Gilmore", "user_profile_image"=>"http://pbs.twimg.com/profile_images/675348189/Wayne.head_normal.jpg"}
• {"id"=>"408789019385143296", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T02:44:31Z", "user"=>"Christiankaze", "user_name"=>"Christian Gonzalez", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3692777330/18bc492cf57d88ebec4c7a6bf43d3352_normal.jpeg"}
• {"id"=>"408790971648720897", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T02:52:17Z", "user"=>"mrs_dewi", "user_name"=>"Sakuntala Dewi", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000703275793/70f5a8d10879116b2b50450105512449_normal.jpeg"}
• {"id"=>"408792749132242944", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T02:59:21Z", "user"=>"Miguel_Tiff", "user_name"=>"Mike", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3764402890/99b02b6e809801c681562327224f1d2b_normal.jpeg"}
• {"id"=>"408793730531856384", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T03:03:15Z", "user"=>"edmondelite", "user_name"=>"John Matteson", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000274536441/3e3f4c0e1952d2a3099ad60f3a38cce6_normal.jpeg"}
• {"id"=>"408797148248276992", "text"=>"👎👎👎 “@HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/ybU19sPBb1”", "created_at"=>"2013-12-06T03:16:49Z", "user"=>"courtney_cth", "user_name"=>"missy tee", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000441019434/f66d10d996584b22ae4501d2bd73a5ca_normal.jpeg"}
• {"id"=>"408797165431975936", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T03:16:53Z", "user"=>"GWeichers", "user_name"=>"bigwick", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000787168188/73798c5397a16691bcaadc87f869a1bb_normal.jpeg"}
• {"id"=>"408797883761037312", "text"=>"“@Awickdancer Bad news for all- Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/TNcvvlK7a5 #Health”", "created_at"=>"2013-12-06T03:19:45Z", "user"=>"GWeichers", "user_name"=>"bigwick", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000787168188/73798c5397a16691bcaadc87f869a1bb_normal.jpeg"}
• {"id"=>"408809925981507584", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T04:07:36Z", "user"=>"Ardiseven", "user_name"=>"Ardiseven", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1670367257/image_normal.jpg"}
• {"id"=>"408810410733600768", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T04:09:31Z", "user"=>"MarthaHogan", "user_name"=>"Martha", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3184168877/1c5ba2315fb97c296f9988c0df265713_normal.jpeg"}
• {"id"=>"408811033671634944", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T04:12:00Z", "user"=>"jomaxx", "user_name"=>"Jomaxx", "user_profile_image"=>"http://pbs.twimg.com/profile_images/76842577/Kenobi-EpIII_2_normal.jpg"}
• {"id"=>"408825750591004672", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T05:10:29Z", "user"=>"InspireHappy", "user_name"=>"Jeanne Floresca", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2798811715/273649665718ff1ba0ff0830d5a9529b_normal.png"}
• {"id"=>"408828989352837120", "text"=>"Better start swapping your coffee for wine or beer! Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/LynQgpyi7r", "created_at"=>"2013-12-06T05:23:21Z", "user"=>"reneefougere", "user_name"=>"Renée Fougere", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3623535921/8572ed2398aebf2b266ddf1a3bf564db_normal.jpeg"}
• {"id"=>"408839587549954048", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T06:05:28Z", "user"=>"RDBoliter", "user_name"=>"Richard Dean Boliter", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000821138436/452445f1032970e4005b2787b75d098d_normal.jpeg"}
• {"id"=>"408852189868617728", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T06:55:32Z", "user"=>"RubyLmurianJade", "user_name"=>"Cancerian Libra ", "user_profile_image"=>"http://abs.twimg.com/sticky/default_profile_images/default_profile_6_normal.png"}
• {"id"=>"408895412406198272", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens telomeres - http://t.co/a5QU7pdhfo ~ What! No! But I love tea! 😩", "created_at"=>"2013-12-06T09:47:17Z", "user"=>"BarbieKeleigh", "user_name"=>"Keleigh", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000712508032/19492930b9b74f7997279ef691b0c635_normal.jpeg"}
• {"id"=>"408908093213655040", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T10:37:41Z", "user"=>"Nadia_Mac", "user_name"=>"Nadia McGill", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1147780101/35130_433043682791_581002791_5754770_2638441_n_normal.jpg"}
• {"id"=>"408944642479390720", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-06T13:02:55Z", "user"=>"M1Barrow", "user_name"=>"MB 1", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3194967721/f8259a85386d5d23deb007c0b0ae6089_normal.jpeg"}
• {"id"=>"409000012283011072", "text"=>"PLOS Genetics: Environmental Stresses Disrupt Telomere Length Homeostasis - http://t.co/gJ5RJ7HPY9", "created_at"=>"2013-12-06T16:42:56Z", "user"=>"bio_utmn", "user_name"=>"bio", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000504733108/a4aef3842334f55af59f58a9fa5e8d92_normal.jpeg"}
• {"id"=>"409009973264273408", "text"=>"Alcohol elongates telomeres but caffeine and high temperatures shorten them in yeast @PLOSGenetics http://t.co/X83z5igCMu", "created_at"=>"2013-12-06T17:22:31Z", "user"=>"SBGenomics", "user_name"=>"SevenBridgesGenomics", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2622185281/u6vmtajjqxm9ulcep34k_normal.png"}
• {"id"=>"409067304995921922", "text"=>"Full Study Published @ http://t.co/jyFYhH3c8N", "created_at"=>"2013-12-06T21:10:20Z", "user"=>"N1XTW1X1", "user_name"=>"n1xtr1x", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000551784156/d9828d3eded6d42f8377628ae234ce29_normal.jpeg"}
• {"id"=>"409081461417857024", "text"=>"#PLOSGenetics: Environmental Stresses Disrupt Telomere Length Homeostasis http://t.co/9z7JNUOdFa", "created_at"=>"2013-12-06T22:06:35Z", "user"=>"apmweber", "user_name"=>"Andreas Weber", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3066018246/ace0a3ca7e0f9cb0773f7e62cdedc9d7_normal.jpeg"}
• {"id"=>"409086166558711809", "text"=>"Artículo del estudio: \"Environmental Stresses Disrupt Telomere Length Homeostasis\", Kupiec, et al.,Plos Genetics 2013 http://t.co/aGqzPDkPuA", "created_at"=>"2013-12-06T22:25:17Z", "user"=>"DRABQ_", "user_name"=>"Gloria", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000746006915/1d3fa8b7b9e413429f26cec57d525dd7_normal.jpeg"}
• {"id"=>"409125645726146560", "text"=>"At least my vices cancel out! http://t.co/Bfs1TgVweK", "created_at"=>"2013-12-07T01:02:09Z", "user"=>"becscotland", "user_name"=>"Rebecca L. Scotland", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1566649506/Headshot_RL_Scotland_compressed_normal.jpg"}
• {"id"=>"409130949746507776", "text"=>"Environment and DNA: alcohol and acetic acid elongate telomeres, caffeine and high temperatures shorten them http://t.co/D1PGwl610P", "created_at"=>"2013-12-07T01:23:14Z", "user"=>"Aurametrix", "user_name"=>"Aurametrix, Inc.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1317513257/Logo_retouched_normal.png"}
• {"id"=>"409153536086528000", "text"=>"RT @SBGenomics: Alcohol elongates telomeres but caffeine and high temperatures shorten them in yeast @PLOSGenetics http://t.co/X83z5igCMu", "created_at"=>"2013-12-07T02:52:59Z", "user"=>"quantumdot", "user_name"=>"Mladen Srdić", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2148262097/466415_10150795224046419_586381418_11530553_1959671126_o_normal.jpg"}
• {"id"=>"409255317558411265", "text"=>"#PLOSGenetics: Environmental Stresses Disrupt Telomere Length Homeostasis http://t.co/VLLyKTL7e7", "created_at"=>"2013-12-07T09:37:25Z", "user"=>"alb_bergareche", "user_name"=>"alberto bergareche", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000346349667/eca84ae616e49fa9f9286d2ffc110095_normal.jpeg"}
• {"id"=>"409382289726902272", "text"=>"#PLOSGenetics: Environmental Stresses Disrupt Telomere Length Homeostasis http://t.co/7MlMOZ43AB", "created_at"=>"2013-12-07T18:01:58Z", "user"=>"CenegenicsNYC", "user_name"=>"CenegenicsNYC", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000780823242/596b9e7e4ac8c8f3fa803e938ffc8e15_normal.jpeg"}
• {"id"=>"409432163994456064", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2013-12-07T21:20:09Z", "user"=>"Ajay_Bagga", "user_name"=>"Ajay Bagga", "user_profile_image"=>"http://pbs.twimg.com/profile_images/500044984/vcm_s_kf_m160_159x159_normal.jpg"}
• {"id"=>"409466912314101760", "text"=>"Bottoms up! // Environmental Stresses Disrupt Telomere Length Homeostasis http://t.co/FvNwKG0KWl", "created_at"=>"2013-12-07T23:38:14Z", "user"=>"aemonten", "user_name"=>"Alejandro Montenegro", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1113525592/twitter3_normal.jpg"}
• {"id"=>"410162038984278016", "text"=>"Environmental Stresses Disrupt Telomere Length Homeostasis : Better a Beer than a Coffee! http://t.co/PaN9exI2O5", "created_at"=>"2013-12-09T21:40:25Z", "user"=>"PacoMH00", "user_name"=>"Francisco Molina-Hol", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2728697125/a98c8f968ae9be7efb04cf6c6e308019_normal.png"}
• {"id"=>"410166356961533952", "text"=>"Beer lengthens & caffeine shortens telomere. Working on finding the right balance ;)\n#PLOSGenetics #science http://t.co/Tb68Z5kRbv", "created_at"=>"2013-12-09T21:57:34Z", "user"=>"kellydeannad", "user_name"=>"Kelly Daughtry", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000109566868/15ac0148f88f529798043ddc42f31d01_normal.jpeg"}
• {"id"=>"410212885554413568", "text"=>"@kitijouji こいつですね。in vitro 研究だけと…マウス細胞ですらないのに、人間の寿命を縮めるっぽい言い方は勘弁してください。\n\nhttp://t.co/3ypSNyueev", "created_at"=>"2013-12-10T01:02:27Z", "user"=>"cocoa_box", "user_name"=>"ｺｺｱ 101%", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2763595051/fbc1700f763e8906b88dca9418a1577e_normal.png"}
• {"id"=>"410865208379183104", "text"=>"#Alcohol and #Caffeine affect telomeres! #PLOSGenetics: Environmental Stresses Disrupt #Telomere Length Homeostasis http://t.co/lukPR8ojDG", "created_at"=>"2013-12-11T20:14:33Z", "user"=>"telomereDx", "user_name"=>"Telomere Diagnostics", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000670417819/c3f92ed7e5961cbe5fa5a94c891ff5c1_normal.png"}
• {"id"=>"411992300555104256", "text"=>"http://t.co/9OLmnTh02J impresionante estudio, ojo con el consumo de cafeína....", "created_at"=>"2013-12-14T22:53:13Z", "user"=>"albertohdez", "user_name"=>"Alberto Hernández", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2360049655/qecivyj81efd03tmszvs_normal.jpeg"}
• {"id"=>"413012860403343361", "text"=>"PLOS Genetics: Environmental Stresses Disrupt Telomere Length Homeostasis http://t.co/yWJ8sNSVaR", "created_at"=>"2013-12-17T18:28:33Z", "user"=>"3ops", "user_name"=>"tri-ops", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1675530116/41592_101071216601762_3459_n_normal.jpg"}
• {"id"=>"413057805374197761", "text"=>"Álcool aumenta os telômeros, a Estrutura da Imortalidade. YEAH!!!! http://t.co/7o8As2oVFD", "created_at"=>"2013-12-17T21:27:09Z", "user"=>"Cardoso", "user_name"=>"cardoso", "user_profile_image"=>"http://pbs.twimg.com/profile_images/411896805475885056/LNPtA_dm_normal.jpeg"}
• {"id"=>"413058040309760000", "text"=>"RT @Cardoso: Álcool aumenta os telômeros, a Estrutura da Imortalidade. YEAH!!!! http://t.co/7o8As2oVFD", "created_at"=>"2013-12-17T21:28:05Z", "user"=>"Gabriel_LoFs", "user_name"=>"Gabriel godfather", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000852806781/700315ca677786c9d4f19c4ff039d7f0_normal.jpeg"}
• {"id"=>"413058045036732417", "text"=>"RT @Cardoso: Álcool aumenta os telômeros, a Estrutura da Imortalidade. YEAH!!!! http://t.co/7o8As2oVFD", "created_at"=>"2013-12-17T21:28:06Z", "user"=>"EdmilsonMarinho", "user_name"=>"Edmilson Marinho", "user_profile_image"=>"http://pbs.twimg.com/profile_images/412335065884930048/iktanKsR_normal.jpeg"}
• {"id"=>"413058106684637184", "text"=>"RT @Cardoso: Álcool aumenta os telômeros, a Estrutura da Imortalidade. YEAH!!!! http://t.co/7o8As2oVFD", "created_at"=>"2013-12-17T21:28:21Z", "user"=>"FellipeC", "user_name"=>"Fellipe Carneiro", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2250369050/Avatar-Instagram-Urch_normal.jpg"}
• {"id"=>"413058470502752256", "text"=>"RT @Cardoso: Álcool aumenta os telômeros, a Estrutura da Imortalidade. YEAH!!!! http://t.co/7o8As2oVFD", "created_at"=>"2013-12-17T21:29:48Z", "user"=>"zenatureza357", "user_name"=>"Áртур ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000658097258/64ef68ec70d832d95fc4c7aa4a4dd4b4_normal.jpeg"}
• {"id"=>"413060513644695554", "text"=>"RT @Cardoso: Álcool aumenta os telômeros, a Estrutura da Imortalidade. YEAH!!!! http://t.co/7o8As2oVFD", "created_at"=>"2013-12-17T21:37:55Z", "user"=>"rodrigoalecio", "user_name"=>"Rodrigo Alécio", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000068741806/94ed20ba861d8446e6c04d458d370cf7_normal.jpeg"}
• {"id"=>"413061001756409857", "text"=>"Álcool aumenta os telômeros, aumentado a longevidade! Haha! http://t.co/GcK94iDcpT", "created_at"=>"2013-12-17T21:39:51Z", "user"=>"Th91v", "user_name"=>"Thiago Vieira", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000041098841/c866c9b37a53080baf65073513c93457_normal.png"}
• {"id"=>"413066623021756418", "text"=>"RT @Cardoso: Álcool aumenta os telômeros, a Estrutura da Imortalidade. YEAH!!!! http://t.co/7o8As2oVFD", "created_at"=>"2013-12-17T22:02:12Z", "user"=>"cesaredgar", "user_name"=>"Edgar /o\\", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2903008377/6999eb3293985f43fb2307f9e3345136_normal.jpeg"}
• {"id"=>"413076456139673600", "text"=>"RT @Cardoso: Álcool aumenta os telômeros, a Estrutura da Imortalidade. YEAH!!!! http://t.co/7o8As2oVFD", "created_at"=>"2013-12-17T22:41:16Z", "user"=>"vividasboas", "user_name"=>"Vividas Boas ✈", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000160588258/494966fda333990abfa63cc9bde80f2d_normal.png"}
• {"id"=>"413194136507125760", "text"=>"#Genetics: Environmental Stresses Disrupt Telomere Length Homeostasis - http://t.co/WbhDIUiYg9\n\n#Caffeine & #Alcohol might be good for you.", "created_at"=>"2013-12-18T06:28:53Z", "user"=>"cybernoelie", "user_name"=>"Noel Dolan", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1840521790/avatar_normal.JPEG"}
• {"id"=>"413216858175594496", "text"=>"Alcohol elongates your telomeres, but coffee shortens them http://t.co/P2LhfTz0mJ!", "created_at"=>"2013-12-18T07:59:10Z", "user"=>"marc_dema", "user_name"=>"Marco Demaria", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000842013060/a1bb466924a6d7d0c9e2022836710251_normal.jpeg"}
• {"id"=>"413345899965075456", "text"=>"Caffeine and alcohol keep your telomeres just right @arstechnica http://t.co/QUkY5Mm0B6 New @PLOSGenetics study http://t.co/lsFHM64jDx", "created_at"=>"2013-12-18T16:31:56Z", "user"=>"kmkubo", "user_name"=>"Ken Kubo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000016609630/d4a56796249d772576af65f234183752_normal.jpeg"}
• {"id"=>"413350652266307584", "text"=>"Julkaistu tutkimus täältä:\nhttp://t.co/u8jiVJPpoB http://t.co/pJeY7ov6SK", "created_at"=>"2013-12-18T16:50:49Z", "user"=>"FabledO2", "user_name"=>"Tony Kunnari", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000447723435/08a8851f2f019ec347c9527a50a52135_normal.png"}
• {"id"=>"413692941535051777", "text"=>"PLOS Genetics: Environmental Stresses Disrupt Telomere Length Homeostasis http://t.co/BsXLE1sP61", "created_at"=>"2013-12-19T15:30:57Z", "user"=>"zenchaos", "user_name"=>"Jerry", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2823243218/1ba9855a4fdc03375636a539faab3b06_normal.jpeg"}
• {"id"=>"413694182268481536", "text"=>"Environmental Stresses Disrupt Telomere Length Homeostasis http://t.co/lvlX7eIko9", "created_at"=>"2013-12-19T15:35:53Z", "user"=>"wahyuwei", "user_name"=>"wahyuwei", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000528260887/7d1b0c41fa7ab122b5c341ca0bd7edfa_normal.jpeg"}
• {"id"=>"413714900385792000", "text"=>"RT @zenchaos: PLOS Genetics: Environmental Stresses Disrupt Telomere Length Homeostasis http://t.co/BsXLE1sP61", "created_at"=>"2013-12-19T16:58:13Z", "user"=>"appliedynamics", "user_name"=>"Francisco A. Montiel", "user_profile_image"=>"http://pbs.twimg.com/profile_images/413431586764238848/PEgfE3AS_normal.jpeg"}
• {"id"=>"415188684510474240", "text"=>"TL; DR: Drinking beer fights aging! (Yes, I am taking wild liberties in my analysis.) http://t.co/1Lxh2Y0JGe", "created_at"=>"2013-12-23T18:34:30Z", "user"=>"NoxDineen", "user_name"=>"Nox Dineen", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2904896071/d54f8c3d1aebeff0bbc87a87070c6099_normal.jpeg"}
• {"id"=>"415997542006939649", "text"=>"lean esto!!!\ny con lo que me gusta el cafe\nhttp://t.co/hO2InChL3p", "created_at"=>"2013-12-26T00:08:37Z", "user"=>"willygonzalezi", "user_name"=>"willy ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2465688972/serms68y8vbg6kuczcxs_normal.jpeg"}
• {"id"=>"418013180162351104", "text"=>"#PLOSGenetics: Environmental Stresses Disrupt Telomere Length Homeostasis http://t.co/Jk9SfLM1pp", "created_at"=>"2013-12-31T13:38:03Z", "user"=>"melikedonertas", "user_name"=>"Melike Dönertaş", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2470428661/yropdtuquhfm8mx2zk4o_normal.png"}
• {"id"=>"419538065736990720", "text"=>"http://t.co/1QqmMIn8qr Love this study - coffee, beer and telomeres! http://t.co/HsfePVvBvI", "created_at"=>"2014-01-04T18:37:24Z", "user"=>"vickyyyf", "user_name"=>"Vicky ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/412233889801699328/DlnQpzNQ_normal.jpeg"}
• {"id"=>"420138590187048960", "text"=>"Puede ser mejor la cerveza que el café para preservar la salud? Seguro qué la dosis también influye http://t.co/gZnWQg0Ndw", "created_at"=>"2014-01-06T10:23:40Z", "user"=>"DrAlfonsoVidal", "user_name"=>"Dr. Alfonso Vidal", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000620195521/a7e0a385aa11d5dff4d070359aecb5ac_normal.jpeg"}
• {"id"=>"427440120430477312", "text"=>"RT @telomereDx: #Alcohol and #Caffeine affect telomeres! #PLOSGenetics: Environmental Stresses Disrupt #Telomere Length Homeostasis http://…", "created_at"=>"2014-01-26T13:57:20Z", "user"=>"AgePotential", "user_name"=>"Lori Campbell", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1277619438/12_normal.jpg"}
• {"id"=>"430575234664497152", "text"=>"RT @telomereDx: #Alcohol and #Caffeine affect telomeres! #PLOSGenetics: Environmental Stresses Disrupt #Telomere Length Homeostasis http://…", "created_at"=>"2014-02-04T05:35:10Z", "user"=>"Chiquetet33", "user_name"=>"Sydney Vand", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000848218186/f8076cf686171388ae98cad11a1acd36_normal.jpeg"}
• {"id"=>"521717391437598721", "text"=>"PLOS Genetics: Environmental Stresses Disrupt Telomere Length Homeostasis #neuroscience #stress #biology http://t.co/QPM9ajlut6", "created_at"=>"2014-10-13T17:41:33Z", "user"=>"ergaucho", "user_name"=>"Fabio Gualtieri", "user_profile_image"=>"http://pbs.twimg.com/profile_images/459226641445961728/xDtpwk_d_normal.jpeg"}
• {"id"=>"521734447742586880", "text"=>"RT @ergaucho: PLOS Genetics: Environmental Stresses Disrupt Telomere Length Homeostasis #neuroscience #stress #biology http://t.co/QPM9ajlu…", "created_at"=>"2014-10-13T18:49:20Z", "user"=>"DCOutreachInc", "user_name"=>"DC Outreach, Inc.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/482240678986928128/9DpU2Ll8_normal.jpeg"}
• {"id"=>"525882579984343040", "text"=>"RT @HealthHabits: Bad news for coffee drinkers - Caffeine shortens your telomeres - shortened telomers = aging :( http://t.co/i7h6iApkd0 #…", "created_at"=>"2014-10-25T05:32:32Z", "user"=>"markallan777", "user_name"=>"Mark Allan", "user_profile_image"=>"http://pbs.twimg.com/profile_images/504492113782784000/pcxj-3Fr_normal.jpeg"}
• {"id"=>"703339987492839424", "text"=>"\"Telomeres protect the chromosome ends from degradation and play crucial roles in cellular aging and disease.... https://t.co/LRTZ6208Tt", "created_at"=>"2016-02-26T22:04:55Z", "user"=>"emercer", "user_name"=>"Eduardo Mercer", "user_profile_image"=>"http://pbs.twimg.com/profile_images/470873083654328321/8uHJyRxG_normal.jpeg"}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/1192314"], "description"=>"<p>Wild-type yeast strain BY4741 was grown in the presence of various stresses and then released. <b>A</b>. YEPD containing 5% ethanol (released to YEPD after 300 generations). <b>B</b>. YEPD+8 mM caffeine (released to YEPD after 90 generations). <b>C</b>. YEPD at 37°C (released back to 30°C after 100 generations).</p>", "links"=>[], "tags"=>["telomere"], "article_id"=>789784, "categories"=>["Biological Sciences"], "users"=>["Gal Hagit Romano", "Yaniv Harari", "Tal Yehuda", "Ariel Podhorzer", "Linda Rubinstein", "Ron Shamir", "Assaf Gottlieb", "Yael Silberberg", "Dana Pe'er", "Eytan Ruppin", "Roded Sharan", "Martin Kupiec"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003721.g002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kinetics_of_telomere_length_change_after_exposure_to_environmental_stresses_/789784", "title"=>"Kinetics of telomere length change after exposure to environmental stresses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-05 02:31:17"}
• {"files"=>["https://ndownloader.figshare.com/files/1192312"], "description"=>"<p>Strain BY4741 was grown for 100 generations on YEPD at optimal conditions and under mild stress conditions. DNA was extracted after 50 and 100 generations, digested with <i>Xho</i>I, and analyzed by Southern blot. The membrane was probed with a telomere sequence and with unique genomic sequences used as markers (779 bp and 2044 bp) to enable telomere length measurements. Telomere length was measured for at least three independent colonies. <b>A</b>. The difference (in bp) between telomere length grown under stress and that of cells grown on YEPD is represented by dark green bars (after 50 generations) and by light green bars (after 100 generations). <b>B</b>. Southern blots analyses after 100 generations showing the effect of various stresses on telomere length.</p>", "links"=>[], "tags"=>["telomere"], "article_id"=>789782, "categories"=>["Biological Sciences"], "users"=>["Gal Hagit Romano", "Yaniv Harari", "Tal Yehuda", "Ariel Podhorzer", "Linda Rubinstein", "Ron Shamir", "Assaf Gottlieb", "Yael Silberberg", "Dana Pe'er", "Eytan Ruppin", "Roded Sharan", "Martin Kupiec"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003721.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effect_of_environmental_stress_on_telomere_length_/789782", "title"=>"The effect of environmental stress on telomere length.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-05 02:31:17"}
• {"files"=>["https://ndownloader.figshare.com/files/1192338", "https://ndownloader.figshare.com/files/1192339", "https://ndownloader.figshare.com/files/1192340", "https://ndownloader.figshare.com/files/1192341", "https://ndownloader.figshare.com/files/1192342", "https://ndownloader.figshare.com/files/1192343", "https://ndownloader.figshare.com/files/1192344", "https://ndownloader.figshare.com/files/1192345"], "description"=>"<div><p>Telomeres protect the chromosome ends from degradation and play crucial roles in cellular aging and disease. Recent studies have additionally found a correlation between psychological stress, telomere length, and health outcome in humans. However, studies have not yet explored the causal relationship between stress and telomere length, or the molecular mechanisms underlying that relationship. Using yeast as a model organism, we show that stresses may have very different outcomes: alcohol and acetic acid elongate telomeres, whereas caffeine and high temperatures shorten telomeres. Additional treatments, such as oxidative stress, show no effect. By combining genome-wide expression measurements with a systematic genetic screen, we identify the Rap1/Rif1 pathway as the central mediator of the telomeric response to environmental signals. These results demonstrate that telomere length can be manipulated, and that a carefully regulated homeostasis may become markedly deregulated in opposing directions in response to different environmental cues.</p></div>", "links"=>[], "tags"=>["stresses", "disrupt", "telomere"], "article_id"=>789803, "categories"=>["Biological Sciences"], "users"=>["Gal Hagit Romano", "Yaniv Harari", "Tal Yehuda", "Ariel Podhorzer", "Linda Rubinstein", "Ron Shamir", "Assaf Gottlieb", "Yael Silberberg", "Dana Pe'er", "Eytan Ruppin", "Roded Sharan", "Martin Kupiec"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1003721.s001", "https://dx.doi.org/10.1371/journal.pgen.1003721.s002", "https://dx.doi.org/10.1371/journal.pgen.1003721.s003", "https://dx.doi.org/10.1371/journal.pgen.1003721.s004", "https://dx.doi.org/10.1371/journal.pgen.1003721.s005", "https://dx.doi.org/10.1371/journal.pgen.1003721.s006", "https://dx.doi.org/10.1371/journal.pgen.1003721.s007", "https://dx.doi.org/10.1371/journal.pgen.1003721.s008"], "stats"=>{"downloads"=>61, "page_views"=>39, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Environmental_Stresses_Disrupt_Telomere_Length_Homeostasis_/789803", "title"=>"Environmental Stresses Disrupt Telomere Length Homeostasis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-09-05 02:31:17"}
• {"files"=>["https://ndownloader.figshare.com/files/1192316"], "description"=>"<p>The effect of ethanol, caffeine and high temperature on telomere length was tested on strains carrying individual gene deletions/hypomorphic mutations. Each mutant was grown under the relevant stress for 100 generations and its telomere length was measured using Southern blot analysis. <b>A–C</b>. The X-axis shows the initial length of each mutant and the Y-axis shows the elongation or shortening after 100 generations. Each strain analyzed is represented by a circle (wt in green). A strong correlation (demarked by a red line; ±5% SD) was seen between the initial length and the effect of the stress. <b>A</b>. Ethanol. <b>B</b>. Caffeine. <b>C</b>. 37°C. <b>D</b>. Each bar represents the ratio between the initial telomere length and the elongation after 100 generations in ethanol. Very short <i>tlm</i> mutants (below 200 nt long) could be clearly separated into two groups: mutants of the Tel1 pathway (<i>tel1Δ</i>, <i>mre11Δ</i>, <i>rad50Δ</i>, <i>xrs2Δ</i>) were highly responsive to ethanol stress, while mutants of the NMD (<i>nam7Δ</i>, <i>upf3Δ</i>, <i>nmd2Δ</i>) and Ku (<i>yku70Δ</i>, <i>yku80Δ</i>) pathways show little telomeric elongation under ethanol stress.</p>", "links"=>[], "tags"=>["stresses", "telomere"], "article_id"=>789786, "categories"=>["Biological Sciences"], "users"=>["Gal Hagit Romano", "Yaniv Harari", "Tal Yehuda", "Ariel Podhorzer", "Linda Rubinstein", "Ron Shamir", "Assaf Gottlieb", "Yael Silberberg", "Dana Pe'er", "Eytan Ruppin", "Roded Sharan", "Martin Kupiec"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003721.g003", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Different_stresses_affect_telomere_length_via_different_genes_/789786", "title"=>"Different stresses affect telomere length via different genes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-05 02:31:17"}
• {"files"=>["https://ndownloader.figshare.com/files/1192321"], "description"=>"<p><b>A</b>. The level of Rap1 protein is reduced upon exposure to ethanol in wt, <i>rif1Δ</i> and <i>rif2Δ</i> mutants, but not in a strain in which the <i>RAP1</i> gene is under the Tet promoter. <b>B</b>. The initial telomere length and the elongation after 100 generations in ethanol were measured by Southern blot. A deletion of <i>RIF1</i> (two independent cultures) inhibits the response to ethanol while deletion of <i>RIF2</i> (two independent cultures) increases it. A <i>rap1-17</i> strain, unable to bind Rif1 or Rif2, behaves similarly to the double mutant <i>rif1Δ rif2Δ</i>. Expressing Rap1 under the tetracycline promoter (which is not affected by ethanol) prevents the telomeric elongation under ethanol stress. <b>C</b>. Chromatin Immunoprecipitation (ChIP) analysis for the recruitment levels of Rif1 and Rif2 proteins to telomeres, in the absence and in the presence of ethanol. The non-telomeric <i>ARO1</i> locus was used to normalize the relative levels.</p>", "links"=>[], "tags"=>["elongation", "mutants", "grown"], "article_id"=>789791, "categories"=>["Biological Sciences"], "users"=>["Gal Hagit Romano", "Yaniv Harari", "Tal Yehuda", "Ariel Podhorzer", "Linda Rubinstein", "Ron Shamir", "Assaf Gottlieb", "Yael Silberberg", "Dana Pe'er", "Eytan Ruppin", "Roded Sharan", "Martin Kupiec"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003721.g004", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Telomere_elongation_of_different_mutants_grown_in_the_presence_of_ethanol_/789791", "title"=>"Telomere elongation of different mutants grown in the presence of ethanol.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-05 02:31:17"}

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• {"unique-ip"=>"40", "full-text"=>"41", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2018", "month"=>"5"}
• {"unique-ip"=>"24", "full-text"=>"26", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
• {"unique-ip"=>"27", "full-text"=>"30", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
• {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
• {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
• {"unique-ip"=>"29", "full-text"=>"31", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
• {"unique-ip"=>"34", "full-text"=>"32", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
• {"unique-ip"=>"29", "full-text"=>"33", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
• {"unique-ip"=>"23", "full-text"=>"28", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
• {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
• {"unique-ip"=>"49", "full-text"=>"57", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"9", "cited-by"=>"1", "year"=>"2019", "month"=>"4"}
• {"unique-ip"=>"28", "full-text"=>"31", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
• {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
• {"unique-ip"=>"25", "full-text"=>"26", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[284, 491, 620, 738, 843, 945, 1043, 1137, 1225, 1315, 1400, 1479, 1555]}, {"subject_area"=>"/Physical sciences/Chemistry", "average_usage"=>[247, 429, 544, 647, 747, 842, 929, 1012, 1099, 1179, 1263, 1339, 1409]}, {"subject_area"=>"/Physical sciences/Physics", "average_usage"=>[254, 421, 527, 626, 720, 813, 900, 983, 1063, 1136, 1210, 1283, 1342]}]}

F1000Prime