The Transacting Factor CBF-A/Hnrnpab Binds to the A2RE/RTS Element of Protamine 2 mRNA and Contributes to Its Translational Regulation during Mouse Spermatogenesis
- Publication Date
- October 17, 2013
- Journal
- PLOS Genetics
- Authors
- Nanaho Fukuda, Tomoyuki Fukuda, John Sinnamon, Abrahan Hernandez Hernandez, et al
- Volume
- 9
- Issue
- 10
- Pages
- e1003858
- DOI
- https://dx.plos.org/10.1371/journal.pgen.1003858
- Publisher URL
- http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1003858
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/24146628
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798277
- Europe PMC
- http://europepmc.org/abstract/MED/24146628
- Web of Science
- 000330367200037
- Scopus
- 84887296803
- Mendeley
- http://www.mendeley.com/research/transacting-factor-cbfahnrnpab-binds-a2rerts-element-protamine-2-mrna-contributes-translational-regu
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Mendeley | Further Information
{"title"=>"The Transacting Factor CBF-A/Hnrnpab Binds to the A2RE/RTS Element of Protamine 2 mRNA and Contributes to Its Translational Regulation during Mouse Spermatogenesis", "type"=>"journal", "authors"=>[{"first_name"=>"Nanaho", "last_name"=>"Fukuda", "scopus_author_id"=>"35483663300"}, {"first_name"=>"Tomoyuki", "last_name"=>"Fukuda", "scopus_author_id"=>"7404415138"}, {"first_name"=>"John", "last_name"=>"Sinnamon", "scopus_author_id"=>"49361984300"}, {"first_name"=>"Abrahan", "last_name"=>"Hernandez-Hernandez", "scopus_author_id"=>"56002744400"}, {"first_name"=>"Manizheh", "last_name"=>"Izadi", "scopus_author_id"=>"55921753200"}, {"first_name"=>"Chandrasekhar S.", "last_name"=>"Raju", "scopus_author_id"=>"24776701700"}, {"first_name"=>"Kevin", "last_name"=>"Czaplinski", "scopus_author_id"=>"6603353220"}, {"first_name"=>"Piergiorgio", "last_name"=>"Percipalle", "scopus_author_id"=>"6603316700"}], "year"=>2013, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537390", "scopus"=>"2-s2.0-84887296803", "sgr"=>"84887296803", "pui"=>"370217920", "isbn"=>"1553-7404 (Electronic)\\r1553-7390 (Linking)", "pmid"=>"24146628", "doi"=>"10.1371/journal.pgen.1003858"}, "id"=>"307e43a5-4f40-3b7c-879e-2ec624d254a9", "abstract"=>"During spermatogenesis, mRNA localization and translation are believed to be regulated in a stage-specific manner. We report here that the Protamine2 (Prm2) mRNA transits through chromatoid bodies of round spermatids and localizes to cytosol of elongating spermatids for translation. The transacting factor CBF-A, also termed Hnrnpab, contributes to temporal regulation of Prm2 translation. We found that CBF-A co-localizes with the Prm2 mRNA during spermatogenesis, directly binding to the A2RE/RTS element in the 3' UTR. Although both p37 and p42 CBF-A isoforms interacted with RTS, they associated with translationally repressed and de-repressed Prm2 mRNA, respectively. Only p42 was found to interact with the 5'cap complex, and to co-sediment with the Prm2 mRNA in polysomes. In CBF-A knockout mice, expression of protamine 2 (PRM2) was reduced and the Prm2 mRNA was prematurely translated in a subset of elongating spermatids. Moreover, a high percentage of sperm from the CBF-A knockout mouse showed abnormal DNA morphology. We suggest that CBF-A plays an important role in spermatogenesis by regulating stage-specific translation of testicular mRNAs.", "link"=>"http://www.mendeley.com/research/transacting-factor-cbfahnrnpab-binds-a2rerts-element-protamine-2-mrna-contributes-translational-regu", "reader_count"=>10, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>6, "Psychology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}CrossRef
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Europe PMC Database Citations | Further Information
{"UNIPROT"=>22}Scopus | Further Information
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Relative Metric
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