Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function
- Publication Date
- October 31, 2013
- Journal
- PLOS Genetics
- Authors
- Ivana Murfuni, Giorgia Basile, Shyamal Subramanyam, Eva Malacaria, et al
- Volume
- 9
- Issue
- 10
- Pages
- e1003910
- DOI
- https://dx.plos.org/10.1371/journal.pgen.1003910
- Publisher URL
- http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1003910
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/24204313
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814295
- Europe PMC
- http://europepmc.org/abstract/MED/24204313
- Web of Science
- 000330367200073
- Scopus
- 84887283315
- Mendeley
- http://www.mendeley.com/research/survival-replication-checkpoint-deficient-cells-requires-mus81rad52-function
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Mendeley | Further Information
{"title"=>"Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function", "type"=>"journal", "authors"=>[{"first_name"=>"Ivana", "last_name"=>"Murfuni", "scopus_author_id"=>"24335793600"}, {"first_name"=>"Giorgia", "last_name"=>"Basile", "scopus_author_id"=>"55920886400"}, {"first_name"=>"Shyamal", "last_name"=>"Subramanyam", "scopus_author_id"=>"55893085600"}, {"first_name"=>"Eva", "last_name"=>"Malacaria", "scopus_author_id"=>"55920801400"}, {"first_name"=>"Margherita", "last_name"=>"Bignami", "scopus_author_id"=>"7006515247"}, {"first_name"=>"Maria", "last_name"=>"Spies", "scopus_author_id"=>"8152365600"}, {"first_name"=>"Annapaola", "last_name"=>"Franchitto", "scopus_author_id"=>"56260219900"}, {"first_name"=>"Pietro", "last_name"=>"Pichierri", "scopus_author_id"=>"57190310465"}], "year"=>2013, "source"=>"PLoS Genetics", "identifiers"=>{"sgr"=>"84887283315", "doi"=>"10.1371/journal.pgen.1003910", "issn"=>"15537390", "pui"=>"370217956", "isbn"=>"1553-7404 (Electronic)\\r1553-7390 (Linking)", "pmid"=>"24204313", "scopus"=>"2-s2.0-84887283315"}, "id"=>"43494a25-0d0a-3fcb-a50e-5fca7d279c94", "abstract"=>"In checkpoint-deficient cells, DNA double-strand breaks (DSBs) are produced during replication by the structure-specific endonuclease MUS81. The mechanism underlying MUS81-dependent cleavage, and the effect on chromosome integrity and viability of checkpoint deficient cells is only partly understood, especially in human cells. Here, we show that MUS81-induced DSBs are specifically triggered by CHK1 inhibition in a manner that is unrelated to the loss of RAD51, and does not involve formation of a RAD51 substrate. Indeed, CHK1 deficiency results in the formation of a RAD52-dependent structure that is cleaved by MUS81. Moreover, in CHK1-deficient cells depletion of RAD52, but not of MUS81, rescues chromosome instability observed after replication fork stalling. However, when RAD52 is down-regulated, recovery from replication stress requires MUS81, and loss of both these proteins results in massive cell death that can be suppressed by RAD51 depletion. Our findings reveal a novel RAD52/MUS81-dependent mechanism that promotes cell viability and genome integrity in checkpoint-deficient cells, and disclose the involvement of MUS81 to multiple processes after replication stress.", "link"=>"http://www.mendeley.com/research/survival-replication-checkpoint-deficient-cells-requires-mus81rad52-function", "reader_count"=>40, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Librarian"=>1, "Researcher"=>13, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>2, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Librarian"=>1, "Researcher"=>13, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>2, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>15, "Agricultural and Biological Sciences"=>20, "Medicine and Dentistry"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>20}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>15}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Denmark"=>1, "United Kingdom"=>1}, "group_count"=>2}CrossRef
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Europe PMC Database Citations | Further Information
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Relative Metric
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