The Rise and Fall of an Evolutionary Innovation: Contrasting Strategies of Venom Evolution in Ancient and Young Animals
- Publication Date
- October 22, 2015
- Journal
- PLOS Genetics
- Authors
- Kartik Sunagar & Yehu Moran
- Volume
- 11
- Issue
- 10
- Pages
- e1005596
- DOI
- https://dx.plos.org/10.1371/journal.pgen.1005596
- Publisher URL
- http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1005596
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/26492532
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619613
- Europe PMC
- http://europepmc.org/abstract/MED/26492532
- Web of Science
- 000364401600060
- Scopus
- 84946592944
- Mendeley
- http://www.mendeley.com/research/rise-fall-evolutionary-innovation-contrasting-strategies-venom-evolution-ancient-young-animals
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Mendeley | Further Information
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- http://doi.org/10.3390/toxins8100303
- http://doi.org/10.3390/toxins8100286
- http://doi.org/10.3390/toxins8040117
- http://doi.org/10.3390/toxins10030096
- http://doi.org/10.1093/icb/icw112
- http://doi.org/10.1039/C6MB00516K
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- http://doi.org/10.1093/icb/icw070
- http://doi.org/10.1111/mec.15084
- http://doi.org/10.1016/j.jprot.2018.05.009
- http://doi.org/10.1016/j.cbpc.2017.07.005
- http://doi.org/10.1007/s12080-017-0354-z
- http://doi.org/10.1016/j.cub.2017.05.091
- http://doi.org/10.3389/fevo.2019.00320
- http://doi.org/10.1038/s41598-017-18355-1
- http://doi.org/10.3390/toxins11020104
- http://doi.org/10.3390/toxins9100312
- http://doi.org/10.7717/peerj.3142
- http://doi.org/10.1016/j.cretres.2016.11.013
- http://doi.org/10.1074/mcp.M116.063321
- http://doi.org/10.1016/j.jprot.2017.07.007
- http://doi.org/10.3390/toxins8110309
- http://doi.org/10.1016/j.peptides.2017.03.007
- http://doi.org/10.1016/j.toxicon.2018.11.433
- http://doi.org/10.1093/molbev/msz181
- http://doi.org/10.1093/molbev/msv350
- http://doi.org/10.3390/toxins10010029
- http://doi.org/10.3390/vetsci5020053
- http://doi.org/10.1007/s00018-018-2768-1
- http://doi.org/10.1093/molbev/msw174
- http://doi.org/10.1016/j.ympev.2019.106573
- http://doi.org/10.3390/toxins10120518
- http://doi.org/10.1016/j.jprot.2017.04.018
- http://doi.org/10.1007/s00239-018-9860-x
- http://doi.org/10.1002/ece3.5633
- http://doi.org/10.1016/j.toxicon.2017.01.014
- http://doi.org/10.1007/s00359-017-1183-7
- http://doi.org/10.1007/s00018-018-2897-6
- http://doi.org/10.2139/ssrn.3396502
- http://doi.org/10.1016/j.ibmb.2018.12.011
Scopus | Further Information
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Relative Metric
{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}Loading … 

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