Genetic Evidence That Captured Retroviral Envelope syncytins Contribute to Myoblast Fusion and Muscle Sexual Dimorphism in Mice
Publication Date
September 02, 2016
Journal
PLOS Genetics
Authors
François Redelsperger, Najat Raddi, Agathe Bacquin, Cécile Vernochet, et al
Volume
12
Issue
9
Pages
e1006289
DOI
https://dx.plos.org/10.1371/journal.pgen.1006289
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1006289
Web of Science
000386069000023
Scopus
84990250719
Mendeley
http://www.mendeley.com/research/genetic-evidence-captured-retroviral-envelope-syncytins-contribute-myoblast-fusion-muscle-sexual-dim
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Mendeley | Further Information

{"title"=>"Genetic Evidence That Captured Retroviral Envelope syncytins Contribute to Myoblast Fusion and Muscle Sexual Dimorphism in Mice", "type"=>"journal", "authors"=>[{"first_name"=>"François", "last_name"=>"Redelsperger", "scopus_author_id"=>"55233696400"}, {"first_name"=>"Najat", "last_name"=>"Raddi", "scopus_author_id"=>"57133182700"}, {"first_name"=>"Agathe", "last_name"=>"Bacquin", "scopus_author_id"=>"55800388700"}, {"first_name"=>"Cécile", "last_name"=>"Vernochet", "scopus_author_id"=>"6603333137"}, {"first_name"=>"Virginie", "last_name"=>"Mariot", "scopus_author_id"=>"6507639974"}, {"first_name"=>"Vincent", "last_name"=>"Gache", "scopus_author_id"=>"23472382100"}, {"first_name"=>"Nicolas", "last_name"=>"Blanchard-Gutton", "scopus_author_id"=>"23988571300"}, {"first_name"=>"Stéphanie", "last_name"=>"Charrin", "scopus_author_id"=>"6602868905"}, {"first_name"=>"Laurent", "last_name"=>"Tiret", "scopus_author_id"=>"55730149500"}, {"first_name"=>"Julie", "last_name"=>"Dumonceaux", "scopus_author_id"=>"6506439253"}, {"first_name"=>"Anne", "last_name"=>"Dupressoir", "scopus_author_id"=>"6602397356"}, {"first_name"=>"Thierry", "last_name"=>"Heidmann", "scopus_author_id"=>"7006152051"}], "year"=>2016, "source"=>"PLoS Genetics", "identifiers"=>{"sgr"=>"84990250719", "scopus"=>"2-s2.0-84990250719", "doi"=>"10.1371/journal.pgen.1006289", "pui"=>"612628290", "issn"=>"15537404", "isbn"=>"1553-7404 (Electronic) 1553-7390 (Linking)", "pmid"=>"27589388"}, "id"=>"b63a0378-121b-3beb-8a9e-d464477ba4d2", "abstract"=>"Syncytins are envelope genes from endogenous retroviruses, “captured” for a role in placentation. They mediate cell-cell fusion, resulting in the formation of a syncytium (the syncytiotrophoblast) at the fetomaternal interface. These genes have been found in all placental mammals in which they have been searched for. Cell-cell fusion is also pivotal for muscle fiber formation and repair, where the myotubes are formed from the fusion of mononucleated myoblasts into large multinucleated structures. Here we show, taking advantage of mice knocked out for syncytins, that these captured genes contribute to myoblast fusion, with a >20% reduction in muscle mass, mean muscle fiber area and number of nuclei per fiber in knocked out mice for one of the two murine syncytin genes. Remarkably, this reduction is only observed in males, which subsequently show muscle quantitative traits more similar to those of females. In addition, we show that syncytins also contribute to muscle repair after cardiotoxin-induced injury, with again a male-specific effect on the rate and extent of regeneration. Finally, ex vivo experiments carried out on murine myoblasts demonstrate the direct involvement of syncytins in fusion, with a >40% reduction in fusion index upon addition of siRNA against both syncytins. Importantly, similar effects are observed with primary myoblasts from sheep, dog and human, with a 20–40% reduction upon addition of siRNA against the corresponding syncytins. Altogether, these results show a direct contribution of the fusogenic syncytins to myogenesis, with a demonstrated male-dependence of the effect in mice, suggesting that these captured genes could be responsible for the muscle sexual dimorphism observed in placental mammals.", "link"=>"http://www.mendeley.com/research/genetic-evidence-captured-retroviral-envelope-syncytins-contribute-myoblast-fusion-muscle-sexual-dim", "reader_count"=>48, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>10, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>3, "Student > Master"=>4, "Other"=>6, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>10, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>3, "Student > Master"=>4, "Other"=>6, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>9, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>22, "Neuroscience"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>22}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>9}, "Unspecified"=>{"Unspecified"=>6}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Iran"=>1, "United Kingdom"=>2}, "group_count"=>1}

Scopus | Further Information

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