Mendeley | Further Information

{"title"=>"Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis", "type"=>"journal", "authors"=>[{"first_name"=>"Marcin J.", "last_name"=>"Skwark", "scopus_author_id"=>"25824446200"}, {"first_name"=>"Nicholas J.", "last_name"=>"Croucher", "scopus_author_id"=>"26326753500"}, {"first_name"=>"Santeri", "last_name"=>"Puranen", "scopus_author_id"=>"6504216128"}, {"first_name"=>"Claire", "last_name"=>"Chewapreecha", "scopus_author_id"=>"55249688500"}, {"first_name"=>"Maiju", "last_name"=>"Pesonen", "scopus_author_id"=>"57193453845"}, {"first_name"=>"Ying Ying", "last_name"=>"Xu", "scopus_author_id"=>"57193453488"}, {"first_name"=>"Paul", "last_name"=>"Turner", "scopus_author_id"=>"37011586200"}, {"first_name"=>"Simon R.", "last_name"=>"Harris", "scopus_author_id"=>"35277976300"}, {"first_name"=>"Stephen B.", "last_name"=>"Beres", "scopus_author_id"=>"6602638769"}, {"first_name"=>"James M.", "last_name"=>"Musser", "scopus_author_id"=>"7103224550"}, {"first_name"=>"Julian", "last_name"=>"Parkhill", "scopus_author_id"=>"7005397039"}, {"first_name"=>"Stephen D.", "last_name"=>"Bentley", "scopus_author_id"=>"7102548116"}, {"first_name"=>"Erik", "last_name"=>"Aurell", "scopus_author_id"=>"55884846500"}, {"first_name"=>"Jukka", "last_name"=>"Corander", "scopus_author_id"=>"6603490546"}], "year"=>2017, "source"=>"PLoS Genetics", "identifiers"=>{"scopus"=>"2-s2.0-85014119857", "isbn"=>"1111111111", "doi"=>"10.1371/journal.pgen.1006508", "pui"=>"614650961", "sgr"=>"85014119857", "issn"=>"15537404", "pmid"=>"28207813"}, "id"=>"566baa60-3c16-367c-9365-6e762d540ae7", "abstract"=>"Recent advances in the scale and diversity of population genomic datasets for bacteria now provide the potential for genome-wide patterns of co-evolution to be studied at the resolution of individual bases. Here we describe a new statistical method, genomeDCA, which uses recent advances in computational structural biology to identify the polymorphic loci under the strongest co-evolutionary pressures. We apply genomeDCA to two large population data sets representing the major human pathogens Streptococcus pneumoniae (pneumococcus) and Streptococcus pyogenes (group A Streptococcus). For pneumococcus we identified 5,199 putative epistatic interactions between 1,936 sites. Over three-quarters of the links were between sites within the pbp2x, pbp1a and pbp2b genes, the sequences of which are critical in determining non-susceptibility to beta-lactam antibiotics. A network-based analysis found these genes were also coupled to that encoding dihydrofolate reductase, changes to which underlie trimethoprim resistance. Distinct from these antibiotic resistance genes, a large network component of 384 protein coding sequences encompassed many genes critical in basic cellular functions, while another distinct component included genes associated with virulence. The group A Streptococcus (GAS) data set population represents a clonal population with relatively little genetic variation and a high level of linkage disequilibrium across the genome. Despite this, we were able to pinpoint two RNA pseudouridine synthases, which were each strongly linked to a separate set of loci across the chromosome, representing biologically plausible targets of co-selection. The population genomic analysis method applied here identifies statistically significantly co-evolving locus pairs, potentially arising from fitness selection interdependence reflecting underlying protein-protein interactions, or genes whose product activities contribute to the same phenotype. This discovery approach greatly enhances the future potential of epistasis analysis for systems biology, and can complement genome-wide association studies as a means of formulating hypotheses for targeted experimental work.", "link"=>"http://www.mendeley.com/research/interacting-networks-resistance-virulence-core-machinery-genes-identified-genomewide-epistasis-analy", "reader_count"=>77, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>6, "Researcher"=>18, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>5, "Other"=>1, "Student > Master"=>9, "Student > Bachelor"=>8, "Lecturer"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>6, "Researcher"=>18, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>5, "Other"=>1, "Student > Master"=>9, "Student > Bachelor"=>8, "Lecturer"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Engineering"=>3, "Biochemistry, Genetics and Molecular Biology"=>13, "Agricultural and Biological Sciences"=>38, "Medicine and Dentistry"=>3, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Physics and Astronomy"=>1, "Computer Science"=>3, "Immunology and Microbiology"=>8}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>8}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>38}, "Computer Science"=>{"Computer Science"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>13}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1, "China"=>1, "United Kingdom"=>1, "France"=>1}, "group_count"=>3}

CrossRef

• http://doi.org/10.1093/molbev/msz225
• http://doi.org/10.1111/mec.15067
• http://doi.org/10.1016/j.mgene.2018.01.013
• http://doi.org/10.1088/1478-3975/aafbe0
• http://doi.org/10.1007/s13353-019-00482-2
• http://doi.org/10.1007/s00285-021-01555-9
• http://doi.org/10.1038/s41564-018-0309-1
• http://doi.org/10.1093/infdis/jiz687
• http://doi.org/10.1093/genetics/iyab003
• http://doi.org/10.1016/j.meegid.2020.104609
• http://doi.org/10.1093/bib/bbz056
• http://doi.org/10.1088/1674-1056/ab8da6
• http://doi.org/10.1038/s41396-020-00867-w
• http://doi.org/10.1021/acs.jcim.8b00690
• http://doi.org/10.1093/database/baz113
• http://doi.org/10.1103/PhysRevE.97.062112
• http://doi.org/10.1186/s13040-019-0195-y
• http://doi.org/10.1093/nar/gkz656
• http://doi.org/10.1103/PhysRevE.98.032407
• http://doi.org/10.1016/j.tim.2020.12.002
• http://doi.org/10.1128/JCM.01405-18
• http://doi.org/10.1089/mdr.2020.0233
• http://doi.org/10.1099/mgen.0.000184
• http://doi.org/10.1103/PhysRevE.101.052409
• http://doi.org/10.1093/bioinformatics/btx339
• http://doi.org/10.1534/genetics.117.300662
• http://doi.org/10.1111/eva.12900
• http://doi.org/10.1089/mdr.2020.0204
• http://doi.org/10.1038/nrmicro.2017.95
• http://doi.org/10.1016/j.csda.2019.06.012
• http://doi.org/10.1093/femsre/fuaa055
• http://doi.org/10.1371/journal.pgen.1007525
• http://doi.org/10.1073/pnas.2012331117
• http://doi.org/10.1038/s41576-018-0032-z
• http://doi.org/10.1016/j.sbi.2019.03.024
• http://doi.org/10.1111/omi.12192
• http://doi.org/10.1093/cid/ciy417
• http://doi.org/10.1186/s12859-020-3360-x
• http://doi.org/10.1128/mBio.02882-20
• http://doi.org/10.1016/j.meegid.2018.07.039
• http://doi.org/10.1099/mgen.0.000305

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85014119857"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85014119857?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85014119857&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85014119857&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85014119857", "dc:identifier"=>"SCOPUS_ID:85014119857", "eid"=>"2-s2.0-85014119857", "dc:title"=>"Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis", "dc:creator"=>"Skwark M.J.", "prism:publicationName"=>"PLoS Genetics", "prism:issn"=>"15537390", "prism:eIssn"=>"15537404", "prism:volume"=>"13", "prism:issueIdentifier"=>"2", "prism:pageRange"=>nil, "prism:coverDate"=>"2017-02-01", "prism:coverDisplayDate"=>"February 2017", "prism:doi"=>"10.1371/journal.pgen.1006508", "citedby-count"=>"38", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Vanderbilt University", "affiliation-city"=>"Nashville", "affiliation-country"=>"United States"}], "pubmed-id"=>"28207813", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1006508", "source-id"=>"4000151808", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}, {"$"=>"repositoryam"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}

Web of Science®

Article Coverage Curated

• {"referral"=>"http://blogs.plos.org/publichealth/?p=4807", "language"=>"English", "title"=>"Police-related killings are countable public health data | Public Health", "type"=>"Blog", "publication"=>"Public Health", "published_on"=>"", "link_state"=>"APPROVED", "id"=>67058, "created"=>"2017-05-01T06:50:57.000Z", "crowdsourced"=>false, "article"=>{"id"=>21881, "doi"=>"10.1371/journal.pgen.1006508", "title"=>"<article-title xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis</article-title>", "published_on"=>"2017-02-15T00:00:00.000Z"}}

Twitter

• {"id"=>"1025421853676863489", "text"=>"@seattle_lex @aldertzomer @johnlees6 Any time! these papers seem super relevant -- https://t.co/iJLNljDy4R &amp;… https://t.co/MXPWNAxfS8", "created_at"=>"2018-08-03T16:43:15Z", "user"=>"hamesjadfield", "user_name"=>"james hadfield", "user_profile_image"=>"http://pbs.twimg.com/profile_images/694219118728331264/Z3E8i2WO_normal.jpg"}
• {"id"=>"832340914920103936", "text"=>"#PLOSGenetics: Interacting networks of resistance, virulence and core machinery genes identified by genome-wi ... https://t.co/xKm6AahOnN", "created_at"=>"2017-02-16T21:28:32Z", "user"=>"mjskwark", "user_name"=>"Marcin J. Skwark", "user_profile_image"=>"http://pbs.twimg.com/profile_images/522096847242801152/3I6kPe_N_normal.jpeg"}
• {"id"=>"832544620198363137", "text"=>"From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T10:58:00Z", "user"=>"alanmcn1", "user_name"=>"Alan McNally", "user_profile_image"=>"http://pbs.twimg.com/profile_images/667376681489932288/lGkImWiG_normal.jpg"}
• {"id"=>"832550905413304320", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T11:22:58Z", "user"=>"widdowquinn", "user_name"=>"Leighton Pritchard", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2361874280/z7co0zrwaump7iptht1s_normal.jpeg"}
• {"id"=>"832555055727390720", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T11:39:28Z", "user"=>"LaurenCowley4", "user_name"=>"Lauren Cowley", "user_profile_image"=>"http://pbs.twimg.com/profile_images/801203165618196480/vfCZAgOy_normal.jpg"}
• {"id"=>"832562465460346880", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T12:08:54Z", "user"=>"Evol_Molly", "user_name"=>"Dr Mary J. O'Connell", "user_profile_image"=>"http://pbs.twimg.com/profile_images/560096879359164416/c-f6hELN_normal.jpeg"}
• {"id"=>"832574038551756800", "text"=>"Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis https://t.co/vlAq2lrZqu", "created_at"=>"2017-02-17T12:54:53Z", "user"=>"rasmusmarvig", "user_name"=>"Rasmus Lykke Marvig", "user_profile_image"=>"http://pbs.twimg.com/profile_images/523920480323895296/8ELhC8c1_normal.png"}
• {"id"=>"832584291649482752", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T13:35:38Z", "user"=>"BrockhurstLab", "user_name"=>"Michael Brockhurst", "user_profile_image"=>"http://pbs.twimg.com/profile_images/572723709928960000/1C9fxMUo_normal.jpeg"}
• {"id"=>"832585604055564290", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T13:40:51Z", "user"=>"jomcinerney", "user_name"=>"James McInerney", "user_profile_image"=>"http://pbs.twimg.com/profile_images/821802499027988480/3N0ZD1nc_normal.jpg"}
• {"id"=>"832617739416014850", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T15:48:33Z", "user"=>"timrich", "user_name"=>"timrich", "user_profile_image"=>"http://pbs.twimg.com/profile_images/810934757039214592/hKYJ9bfT_normal.jpg"}
• {"id"=>"832628944046223360", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T16:33:04Z", "user"=>"tatumdmortimer", "user_name"=>"Tatum Mortimer", "user_profile_image"=>"http://pbs.twimg.com/profile_images/688089618927910916/k2acNCZn_normal.jpg"}
• {"id"=>"832659684603621378", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T18:35:13Z", "user"=>"GcRox1", "user_name"=>"Hank S Seifert", "user_profile_image"=>"http://pbs.twimg.com/profile_images/497828015091351552/f25rqBh__normal.jpeg"}
• {"id"=>"832663835609739265", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T18:51:43Z", "user"=>"tdread_emory", "user_name"=>"Timothy Read PhD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/768828282338967552/pPPssx8v_normal.jpg"}
• {"id"=>"832664329056948224", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T18:53:40Z", "user"=>"GreatCthoolhoo", "user_name"=>"Great Cthulhu", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3672610701/4502dcdcda11e8d76c19495c6d025956_normal.jpeg"}
• {"id"=>"832670543539081216", "text"=>"#Epistasis Analysis Goes Genome-Wide @PLOSGenetics https://t.co/qyLCY7mUAA &amp; https://t.co/jEMyCy3P8R #genomics… https://t.co/ve4o1LU62u", "created_at"=>"2017-02-17T19:18:22Z", "user"=>"westr", "user_name"=>"Robert West PhD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/500040415697833989/p8hvJ9_i_normal.jpeg"}
• {"id"=>"832674477846597634", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T19:34:00Z", "user"=>"LBarquist", "user_name"=>"Lars Barquist", "user_profile_image"=>"http://pbs.twimg.com/profile_images/814460280801464320/3Yz1fZmp_normal.jpg"}
• {"id"=>"832675705477435393", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T19:38:53Z", "user"=>"cjblondel", "user_name"=>"Carlos J. Blondel", "user_profile_image"=>"http://pbs.twimg.com/profile_images/560296001806680064/baIXgrQ5_normal.jpeg"}
• {"id"=>"832676856486768641", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T19:43:27Z", "user"=>"GCAGATGCAATG", "user_name"=>"Adam P Roberts", "user_profile_image"=>"http://pbs.twimg.com/profile_images/728482282332368897/LJVB6fvb_normal.jpg"}
• {"id"=>"832677557279416322", "text"=>"We should have a read of this before submitting ours @UnintendedSci https://t.co/MRy0VRyx1S", "created_at"=>"2017-02-17T19:46:14Z", "user"=>"MasseyLab", "user_name"=>"ruth massey", "user_profile_image"=>"http://pbs.twimg.com/profile_images/813493479582171144/VZsPF-Ck_normal.jpg"}
• {"id"=>"832678460459868160", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T19:49:50Z", "user"=>"Sara_E_Boyd", "user_name"=>"Sara Boyd", "user_profile_image"=>"http://pbs.twimg.com/profile_images/800620620069400577/uVxjArO0_normal.jpg"}
• {"id"=>"832683906050752512", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T20:11:28Z", "user"=>"tarawa62", "user_name"=>"awatif aljudaibi", "user_profile_image"=>"http://pbs.twimg.com/profile_images/646360013435351040/a75S6EOg_normal.jpg"}
• {"id"=>"832687931143774208", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T20:27:28Z", "user"=>"DrKatHolt", "user_name"=>"Kat Holt", "user_profile_image"=>"http://pbs.twimg.com/profile_images/687586000277655552/QzSRDX7P_normal.jpg"}
• {"id"=>"832688545324290048", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T20:29:54Z", "user"=>"vallenet", "user_name"=>"David Vallenet", "user_profile_image"=>"http://pbs.twimg.com/profile_images/620021377706233856/6tAgTLgj_normal.jpg"}
• {"id"=>"832703490753323008", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T21:29:17Z", "user"=>"lindseylbohr", "user_name"=>"Lindsey Bohr", "user_profile_image"=>"http://pbs.twimg.com/profile_images/694734798502260737/0sLd1hel_normal.jpg"}
• {"id"=>"832738094537256960", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T23:46:47Z", "user"=>"mgalactus", "user_name"=>"Marco Galardini", "user_profile_image"=>"http://pbs.twimg.com/profile_images/724711785417302016/n-9hcOMO_normal.jpg"}
• {"id"=>"832739519598309377", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-17T23:52:27Z", "user"=>"leosanbu", "user_name"=>"Leo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000238640027/239f71e9c29cb97012059e7139dab172_normal.jpeg"}
• {"id"=>"832877872759070720", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-18T09:02:13Z", "user"=>"ABpreservation", "user_name"=>"Adrian Brink", "user_profile_image"=>"http://pbs.twimg.com/profile_images/664331195639984128/TjNg0ev-_normal.jpg"}
• {"id"=>"832941843801395200", "text"=>"Great article on identifying epistatic links from sequences of strep populations:\nhttps://t.co/l18FwkHVK1\nsure we'll be seeing more of this", "created_at"=>"2017-02-18T13:16:25Z", "user"=>"johnlees6", "user_name"=>"John Lees", "user_profile_image"=>"http://pbs.twimg.com/profile_images/742789761438515205/avsBz7jo_normal.jpg"}
• {"id"=>"832942495092781057", "text"=>"RT @johnlees6: Great article on identifying epistatic links from sequences of strep populations:\nhttps://t.co/l18FwkHVK1\nsure we'll be seei…", "created_at"=>"2017-02-18T13:19:00Z", "user"=>"hlcao", "user_name"=>"Huiluo Cao", "user_profile_image"=>"http://pbs.twimg.com/profile_images/793457609143484416/3E5emsY__normal.jpg"}
• {"id"=>"833025814719459328", "text"=>"Using a comp struct biology approach, population geneticists predict interdependence between all genes of Strep-A. https://t.co/uRLOyUAcku", "created_at"=>"2017-02-18T18:50:05Z", "user"=>"dev2death", "user_name"=>"Matt Gruner", "user_profile_image"=>"http://pbs.twimg.com/profile_images/772594533489971200/4jvso0sF_normal.jpg"}
• {"id"=>"833417648335577088", "text"=>"Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis ana https://t.co/q9SrPmr4Sp", "created_at"=>"2017-02-19T20:47:06Z", "user"=>"CayleyAerospace", "user_name"=>"Chartered Engineer", "user_profile_image"=>"http://pbs.twimg.com/profile_images/527561411946229760/XDhwvvH5_normal.jpeg"}
• {"id"=>"833816271338749952", "text"=>"To-read list:\n\nInteracting networks of resistance, virulence and core machinery genes identified by genome-wi ... https://t.co/gqh7xDuuTS", "created_at"=>"2017-02-20T23:11:05Z", "user"=>"EpicBear", "user_name"=>"EpicBear", "user_profile_image"=>"http://pbs.twimg.com/profile_images/584603930010583041/rQYbbhC3_normal.png"}
• {"id"=>"835589181237825536", "text"=>"RT @alanmcn1: From the incredible Croucher and Corander. Genome wide epistasis analysis in bacteria https://t.co/4Gh7NoTIl1", "created_at"=>"2017-02-25T20:35:59Z", "user"=>"abraham_moller", "user_name"=>"Abraham Moller", "user_profile_image"=>"http://pbs.twimg.com/profile_images/738905294240120832/lZ7PQnMm_normal.jpg"}
• {"id"=>"837363498032193537", "text"=>"Networks of virulence &amp; resistance genes identified by genome-wide epistasis analysis https://t.co/68NgBBVJBs via… https://t.co/qhScT2kcI8", "created_at"=>"2017-03-02T18:06:30Z", "user"=>"TweetNTD", "user_name"=>"Paul L. Maurizio", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1876013297/347px-Phlebotomus_pappatasi_bloodmeal_finished_normal.jpg"}

Wikipedia

Counter

• {"month"=>"2", "year"=>"2017", "pdf_views"=>"269", "xml_views"=>"9", "html_views"=>"1962"}
• {"month"=>"3", "year"=>"2017", "pdf_views"=>"240", "xml_views"=>"3", "html_views"=>"1780"}
• {"month"=>"4", "year"=>"2017", "pdf_views"=>"114", "xml_views"=>"12", "html_views"=>"609"}
• {"month"=>"5", "year"=>"2017", "pdf_views"=>"61", "xml_views"=>"1", "html_views"=>"340"}
• {"month"=>"6", "year"=>"2017", "pdf_views"=>"40", "xml_views"=>"0", "html_views"=>"138"}
• {"month"=>"7", "year"=>"2017", "pdf_views"=>"43", "xml_views"=>"0", "html_views"=>"120"}
• {"month"=>"8", "year"=>"2017", "pdf_views"=>"71", "xml_views"=>"0", "html_views"=>"169"}
• {"month"=>"9", "year"=>"2017", "pdf_views"=>"51", "xml_views"=>"2", "html_views"=>"180"}
• {"month"=>"10", "year"=>"2017", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"177"}
• {"month"=>"11", "year"=>"2017", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"150"}
• {"month"=>"12", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"152"}
• {"month"=>"1", "year"=>"2018", "pdf_views"=>"59", "xml_views"=>"0", "html_views"=>"130"}
• {"month"=>"2", "year"=>"2018", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"87"}
• {"month"=>"3", "year"=>"2018", "pdf_views"=>"33", "xml_views"=>"4", "html_views"=>"80"}
• {"month"=>"4", "year"=>"2018", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"75"}
• {"month"=>"5", "year"=>"2018", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"67"}
• {"month"=>"6", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"57"}
• {"month"=>"7", "year"=>"2018", "pdf_views"=>"21", "xml_views"=>"5", "html_views"=>"61"}
• {"month"=>"8", "year"=>"2018", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"50"}
• {"month"=>"9", "year"=>"2018", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"54"}
• {"month"=>"10", "year"=>"2018", "pdf_views"=>"53", "xml_views"=>"0", "html_views"=>"102"}
• {"month"=>"11", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"37"}
• {"month"=>"12", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"46"}
• {"month"=>"1", "year"=>"2019", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"47"}
• {"month"=>"2", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"30"}
• {"month"=>"3", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"26"}
• {"month"=>"4", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"2", "html_views"=>"34"}
• {"month"=>"5", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"30"}
• {"month"=>"6", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"26"}
• {"month"=>"7", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"29"}
• {"month"=>"8", "year"=>"2019", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"33"}
• {"month"=>"9", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"38"}
• {"month"=>"10", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"47"}
• {"month"=>"11", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"32"}
• {"month"=>"12", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"29"}
• {"month"=>"1", "year"=>"2020", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"40"}
• {"month"=>"2", "year"=>"2020", "pdf_views"=>"24", "xml_views"=>"2", "html_views"=>"15"}
• {"month"=>"3", "year"=>"2020", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"16"}
• {"month"=>"4", "year"=>"2020", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"9"}
• {"month"=>"5", "year"=>"2020", "pdf_views"=>"63", "xml_views"=>"0", "html_views"=>"26"}
• {"month"=>"6", "year"=>"2020", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"13"}
• {"month"=>"7", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"20"}
• {"month"=>"8", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"20"}
• {"month"=>"9", "year"=>"2020", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"31"}
• {"month"=>"10", "year"=>"2020", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"24"}
• {"month"=>"11", "year"=>"2020", "pdf_views"=>"59", "xml_views"=>"0", "html_views"=>"29"}
• {"month"=>"12", "year"=>"2020", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"23"}
• {"month"=>"1", "year"=>"2021", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"34"}
• {"month"=>"2", "year"=>"2021", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"28"}
• {"month"=>"3", "year"=>"2021", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"2"}

PMC Usage Stats

• {"unique-ip"=>"37", "full-text"=>"29", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
• {"unique-ip"=>"22", "full-text"=>"24", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
• {"unique-ip"=>"32", "full-text"=>"29", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
• {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
• {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
• {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
• {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
• {"unique-ip"=>"29", "full-text"=>"17", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
• {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
• {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
• {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
• {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
• {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
• {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"4", "year"=>"2018", "month"=>"4"}
• {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
• {"unique-ip"=>"10", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
• {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
• {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
• {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
• {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
• {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2018", "month"=>"10"}
• {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
• {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
• {"unique-ip"=>"14", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
• {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
• {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
• {"unique-ip"=>"23", "full-text"=>"15", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
• {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
• {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
• {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
• {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
• {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
• {"unique-ip"=>"12", "full-text"=>"18", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
• {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
• {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
• {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
• {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
• {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
• {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
• {"unique-ip"=>"7", "full-text"=>"2", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
• {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2021", "month"=>"1"}

F1000Prime