Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans
Publication Date
March 29, 2017
Authors
Christopher F. Bennett, Jane J. Kwon, Christine Chen, Joshua Russell, et al
Volume
13
Issue
3
Pages
e1006695
DOI
https://dx.plos.org/10.1371/journal.pgen.1006695
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1006695
Scopus
85016568166
Mendeley
http://www.mendeley.com/research/transaldolase-inhibition-impairs-mitochondrial-respiration-induces-starvationlike-longevity-response
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Mendeley | Further Information

{"title"=>"Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans", "type"=>"journal", "authors"=>[{"first_name"=>"Christopher F.", "last_name"=>"Bennett", "scopus_author_id"=>"55259472100"}, {"first_name"=>"Jane J.", "last_name"=>"Kwon", "scopus_author_id"=>"57193792425"}, {"first_name"=>"Christine", "last_name"=>"Chen", "scopus_author_id"=>"57193790293"}, {"first_name"=>"Joshua", "last_name"=>"Russell", "scopus_author_id"=>"56193913500"}, {"first_name"=>"Kathlyn", "last_name"=>"Acosta", "scopus_author_id"=>"57193791016"}, {"first_name"=>"Nikolay", "last_name"=>"Burnaevskiy", "scopus_author_id"=>"57194645465"}, {"first_name"=>"Matthew M.", "last_name"=>"Crane", "scopus_author_id"=>"24385265900"}, {"first_name"=>"Alessandro", "last_name"=>"Bitto", "scopus_author_id"=>"24173130900"}, {"first_name"=>"Helen", "last_name"=>"Vander Wende", "scopus_author_id"=>"55343423400"}, {"first_name"=>"Marissa", "last_name"=>"Simko", "scopus_author_id"=>"54586048600"}, {"first_name"=>"Victor", "last_name"=>"Pineda", "scopus_author_id"=>"7004119050"}, {"first_name"=>"Ryan", "last_name"=>"Rossner", "scopus_author_id"=>"56979149100"}, {"first_name"=>"Brian M.", "last_name"=>"Wasko", "scopus_author_id"=>"23993108400"}, {"first_name"=>"Haeri", "last_name"=>"Choi", "scopus_author_id"=>"56002368000"}, {"first_name"=>"Shiwen", "last_name"=>"Chen", "scopus_author_id"=>"56959618300"}, {"first_name"=>"Shirley", "last_name"=>"Park", "scopus_author_id"=>"56959599500"}, {"first_name"=>"Gholamali", "last_name"=>"Jafari", "scopus_author_id"=>"36134441200"}, {"first_name"=>"Bryan", "last_name"=>"Sands", "scopus_author_id"=>"7005180086"}, {"first_name"=>"Carissa", "last_name"=>"Perez Olsen", "scopus_author_id"=>"37038253000"}, {"first_name"=>"Alexander R.", "last_name"=>"Mendenhall", "scopus_author_id"=>"15073288200"}, {"first_name"=>"Philip G.", "last_name"=>"Morgan", "scopus_author_id"=>"7402394821"}, {"first_name"=>"Matt", "last_name"=>"Kaeberlein", "scopus_author_id"=>"6602710772"}], "year"=>2017, "source"=>"PLoS Genetics", "identifiers"=>{"sgr"=>"85016568166", "pmid"=>"28355222", "pui"=>"615141886", "isbn"=>"1553-7404 (Electronic)\r1553-7390 (Linking)", "scopus"=>"2-s2.0-85016568166", "doi"=>"10.1371/journal.pgen.1006695", "issn"=>"15537404"}, "id"=>"6f31a2d4-2313-353c-9f65-7bd2d8e653fd", "abstract"=>"Mitochondrial dysfunction can increase oxidative stress and extend lifespan in Caenorhabditis elegans. Homeostatic mechanisms exist to cope with disruptions to mitochondrial function that promote cellular health and organismal longevity. Previously, we determined that decreased expression of the cytosolic pentose phosphate pathway (PPP) enzyme transaldolase activates the mitochondrial unfolded protein response (UPRmt) and extends lifespan. Here we report that transaldolase (tald-1) deficiency impairs mitochondrial function in vivo, as evidenced by altered mitochondrial morphology, decreased respiration, and increased cellular H2O2 levels. Lifespan extension from knockdown of tald-1 is associated with an oxidative stress response involving p38 and c-Jun N-terminal kinase (JNK) MAPKs and a starvation-like response regulated by the transcription factor EB (TFEB) homolog HLH-30. The latter response promotes autophagy and increases expression of the flavin-containing monooxygenase 2 (fmo-2). We conclude that cytosolic redox established through the PPP is a key regulator of mitochondrial function and defines a new mechanism for mitochondrial regulation of longevity.", "link"=>"http://www.mendeley.com/research/transaldolase-inhibition-impairs-mitochondrial-respiration-induces-starvationlike-longevity-response", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>3, "Professor"=>2, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>3, "Professor"=>2, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>1, "Neuroscience"=>1, "Computer Science"=>1, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Computer Science"=>{"Computer Science"=>1}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>0}

Scopus | Further Information

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