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{"title"=>"Prolonged Activation of Virus-Specific CD8+T Cells after Acute B19 Infection", "type"=>"journal", "authors"=>[{"first_name"=>"Adiba", "last_name"=>"Isa"}, {"first_name"=>"Victoria", "last_name"=>"Kasprowicz"}, {"first_name"=>"Oscar", "last_name"=>"Norbeck"}, {"first_name"=>"Andrew", "last_name"=>"Loughry"}, {"first_name"=>"Katie", "last_name"=>"Jeffery"}, {"first_name"=>"Kristina", "last_name"=>"Broliden"}, {"first_name"=>"Paul", "last_name"=>"Klenerman"}, {"first_name"=>"Thomas", "last_name"=>"Tolfvenstam"}, {"first_name"=>"Paul", "last_name"=>"Bowness"}], "year"=>2005, "source"=>"PLoS Medicine", "identifiers"=>{"pmid"=>"16253012", "doi"=>"10.1371/journal.pmed.0020343", "issn"=>"1549-1676"}, "id"=>"e3335dac-c0a3-34b2-b6c8-9ac6df668347", "abstract"=>"BACKGROUND: Human parvovirus B19 (B19) is a ubiquitous and clinically significant pathogen, causing erythema infectiosum, arthropathy, transient aplastic crisis, and intrauterine fetal death. The phenotype of CD8+ T cells in acute B19 infection has not been studied previously.\\n\\nMETHODS AND FINDINGS: The number and phenotype of B19-specific CD8+ T cell responses during and after acute adult infection was studied using HLA-peptide multimeric complexes. Surprisingly, these responses increased in magnitude over the first year post-infection despite resolution of clinical symptoms and control of viraemia, with T cell populations specific for individual epitopes comprising up to 4% of CD8+ T cells. B19-specific T cells developed and maintained an activated CD38+ phenotype, with strong expression of perforin and CD57 and downregulation of CD28 and CD27. These cells possessed strong effector function and intact proliferative capacity. Individuals tested many years after infection exhibited lower frequencies of B19-specific cytotoxic T lymphocytes, typically 0.05%-0.5% of CD8+ T cells, which were perforin, CD38, and CCR7 low.\\n\\nCONCLUSION: This is the first example to our knowledge of an \"acute\" human viral infection inducing a persistent activated CD8+ T cell response. The likely explanation--analogous to that for cytomegalovirus infection--is that this persistent response is due to low-level antigen exposure. CD8+ T cells may contribute to the long-term control of this significant pathogen and should be considered during vaccine development.", "link"=>"http://www.mendeley.com/research/prolonged-activation-virusspecific-cd8t-cells-after-acute-b19-infection", "reader_count"=>9, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>4, "Student > Ph. D. Student"=>1, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>4, "Student > Ph. D. Student"=>1, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>3, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>1}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/961425"], "description"=>"<div><p>(A) Representative A24 FYT tetramer staining of individual O3\\′s PBMCs. Plots are gated on live CD8⁺ lymphocytes stained directly ex vivo. Percentages shown are those of tetramer-positive CD8⁺ T cells. Time points indicated refer to the number of months after first symptoms reported. Symptoms in this individual lasted 5 wk.</p>\n <p>(B) Frequency of B19-specific responses over time for six acutely infected individuals in the Oxford cohort (O1–O5) and five remotely infected individuals (OR1–OR5). In one case, two epitopes were studied.</p>\n <p>(C) Frequency of B19-specific responses over time for five acutely infected individuals in the Stockholm cohort (S1–S5). In two cases, two epitopes were studied.</p></div>", "links"=>[], "tags"=>["cells", "months", "acute"], "article_id"=>631408, "categories"=>["Cell Biology", "Microbiology", "Hematology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Adiba Isa", "Victoria Kasprowicz", "Oscar Norbeck", "Andrew Loughry", "Katie Jeffery", "Kristina Broliden", "Paul Klenerman", "Thomas Tolfvenstam", "Paul Bowness"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.0020343.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_B19_Specific_CD8_T_Cells_Persist_at_High_Levels_for_Many_Months_after_Acute_Infection_/631408", "title"=>"B19-Specific CD8⁺ T Cells Persist at High Levels for Many Months after Acute Infection", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 08:57:12"}
• {"files"=>["https://ndownloader.figshare.com/files/961832"], "description"=>"<div><p>(A) Blood from patient S1 was stained with the two tetramers A2 LLH and A2 GLC.</p>\n <p>(B) Blood from patient S2 was stained with tetramers A2 GLC and the Pro5 B40 TEA pentamer. The top panels show the frequency of tetramer-positive cells over time for the two different responses in each individual (data equivalent to those in <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0020343#pmed-0020343-g001\" target=\"_blank\">Figure 1</a>C). The subsequent panels show the frequency of B19-specific CD8⁺ cells positive for perforin, CD38, CD57, and CD62L in both patients.</p></div>", "links"=>[], "tags"=>["phenotype", "b19-specific", "responses", "acutely", "infected", "individuals", "stockholm"], "article_id"=>631808, "categories"=>["Cell Biology", "Microbiology", "Hematology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Adiba Isa", "Victoria Kasprowicz", "Oscar Norbeck", "Andrew Loughry", "Katie Jeffery", "Kristina Broliden", "Paul Klenerman", "Thomas Tolfvenstam", "Paul Bowness"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.0020343.g004", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Longitudinal_Phenotype_Analysis_of_B19_Specific_CD8_T_Cell_Responses_in_Acutely_Infected_Individuals_in_Stockholm_Cohort_/631808", "title"=>"Longitudinal Phenotype Analysis of B19-Specific CD8⁺ T Cell Responses in Acutely Infected Individuals in Stockholm Cohort", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 08:59:58"}
• {"files"=>["https://ndownloader.figshare.com/files/961958"], "description"=>"<div><p>(A) Left panel shows that PBMCs from acutely infected patient O1 secrete IFNγ ex vivo after 18 h of FYTPLADQF peptide stimulation. Negative control (zero spots) and two peptide-stimulated wells from an ELISpot plate are shown. Numbers represent IFNγ-secreting cells per 250,000 PBMCs. Right panel shows A24 FYT tetramer staining of PBMCs at same time point, displaying the number of tetramer-positive cells expressed as a percentage of CD8⁺ T cells.</p>\n <p>(B) Tetramer staining of patient S2\\′s PBMCs ex vivo (left) and after short-term TEADVQQWL peptide stimulation in vitro (right).</p>\n <p>(C) Ex vivo IFNγ ELISpot results for remotely infected individual OR3. Mean and standard deviations of triplicates are shown. Cells were stimulated for 18 h with no peptide, GLCPHCINV, or TEADVQQWL.</p>\n <p>(D) ⁵¹Cr release assay using HLA-A2-restricted GLCPHCINV-specific CTLs from individual OR1. PBMCs were stimulated for 14 d with GLCPHCINV peptide and cytolysis was tested against HLA-A*0201-transfected LBL.721.220 target cells at various effector-to-target-cell (E:T) ratios.</p></div>", "links"=>[], "tags"=>["cells", "secrete", "ex", "cytolytic"], "article_id"=>631936, "categories"=>["Cell Biology", "Microbiology", "Hematology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Adiba Isa", "Victoria Kasprowicz", "Oscar Norbeck", "Andrew Loughry", "Katie Jeffery", "Kristina Broliden", "Paul Klenerman", "Thomas Tolfvenstam", "Paul Bowness"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.0020343.g005", "stats"=>{"downloads"=>0, "page_views"=>32, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_B19_Specific_CD8_T_Cells_Secrete_IFN_947_Ex_Vivo_Proliferate_and_Show_Cytolytic_Function_In_Vitro_/631936", "title"=>"B19-Specific CD8⁺ T Cells Secrete IFNγ Ex Vivo, Proliferate, and Show Cytolytic Function In Vitro", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 09:00:55"}
• {"files"=>["https://ndownloader.figshare.com/files/961528"], "description"=>"<div><p>Percentages shown are the frequency of marker-positive cells amongst multimer-positive cells (plots gated on live CD8⁺ lymphocytes ex vivo).</p>\n <p>(A) Patient S2 B40 TEA pentamer staining at 4 mo (left) and 21 mo (right), showing perforin and CD62L levels.</p>\n <p>(B) Patient O3 A24 FYT tetramer staining at 2 mo (left) and 20 mo (right), showing CD27 and CD28 staining.</p>\n <p>(C) Patient O5 A2 GLC tetramer staining at 4 mo (left) and 18 mo (right), showing CD38 and CD57 staining.</p></div>", "links"=>[], "tags"=>["ex", "vivo", "phenotyping", "b19-specific", "populations"], "article_id"=>631508, "categories"=>["Cell Biology", "Microbiology", "Hematology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Adiba Isa", "Victoria Kasprowicz", "Oscar Norbeck", "Andrew Loughry", "Katie Jeffery", "Kristina Broliden", "Paul Klenerman", "Thomas Tolfvenstam", "Paul Bowness"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.0020343.g002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_Ex_Vivo_Phenotyping_of_B19_Specific_CD8_T_Cell_Populations_over_Time_/631508", "title"=>"Representative Ex Vivo Phenotyping of B19-Specific CD8⁺ T Cell Populations over Time", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 08:57:53"}
• {"files"=>["https://ndownloader.figshare.com/files/961669"], "description"=>"<p>Remotely infected individuals show a less mature/activated phenotype but express only low levels of CCR7 and CD62L (Oxford cohort). The y-axis show the frequency of marker-positive cells amongst tetramer-positive CD8⁺ cells, while the x-axis show the number of months after symptom onset. Data are shown in perforin, CD38, CD57, CD27, CD28, and CCR7: data are derived from six acutely infected individuals in the Oxford cohort (O1–O3, O5, and O6; insufficient cells available for O4) and five remotely infected individuals (OR1–OR5).</p>", "links"=>[], "tags"=>["infected", "individuals", "activated", "mature", "effector", "cells", "acute"], "article_id"=>631646, "categories"=>["Cell Biology", "Microbiology", "Hematology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Adiba Isa", "Victoria Kasprowicz", "Oscar Norbeck", "Andrew Loughry", "Katie Jeffery", "Kristina Broliden", "Paul Klenerman", "Thomas Tolfvenstam", "Paul Bowness"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.0020343.g003", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Acutely_infected_individuals_Maintain_Activated_Mature_Effector_Cells_after_Resolution_of_Acute_Infection_/631646", "title"=>"Acutely infected individuals Maintain Activated Mature Effector Cells after Resolution of Acute Infection", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 08:58:51"}

PMC Usage Stats | Further Information

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Relative Metric

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F1000Prime | Further Information

• {"year"=>2014, "month"=>5, "doi"=>"10.1371/journal.pmed.0020343", "f1000_id"=>"1029057", "url"=>"http://f1000.com/prime/1029057", "score"=>1, "classifications"=>["new_finding"], "updated_at"=>"2014-05-26T08:30:29Z"}
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