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Characteristics and Impact of Drug Detailing for Gabapentin

Publication Date: April 24, 2007
Journal: PLOS Medicine
Authors: Michael A Steinman, G. Michael Harper, Mary Margaret Chren, C. Seth Landefeld, et al
Volume: 4
Issue: 4
Pages: e134
DOI: https://dx.plos.org/10.1371/journal.pmed.0040134
Publisher URL: http://journals.plos.org/plosmedicine/article?id=10.1371%2Fjournal.pmed.0040134
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/17455990
PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855692
Europe PMC: http://europepmc.org/abstract/MED/17455990
Web of Science: 000245947000023
Scopus: 34247486946
Mendeley: http://www.mendeley.com/research/characteristics-impact-drug-detailing-gabapentin

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{"title"=>"Characteristics and impact of drug detailing for gabapentin", "type"=>"journal", "authors"=>[{"first_name"=>"Michael A.", "last_name"=>"Steinman", "scopus_author_id"=>"7003750140"}, {"first_name"=>"G. Michael", "last_name"=>"Harper", "scopus_author_id"=>"35554311200"}, {"first_name"=>"Mary Margaret", "last_name"=>"Chren", "scopus_author_id"=>"7005446805"}, {"first_name"=>"C. Seth", "last_name"=>"Landefeld", "scopus_author_id"=>"7006718432"}, {"first_name"=>"Lisa A.", "last_name"=>"Bero", "scopus_author_id"=>"7006671378"}], "year"=>2007, "source"=>"PLoS Medicine", "identifiers"=>{"isbn"=>"1549-1676 (Electronic)\\r1549-1277 (Linking)", "doi"=>"10.1371/journal.pmed.0040134", "sgr"=>"34247486946", "issn"=>"15491277", "pui"=>"46658775", "pmid"=>"17455990", "scopus"=>"2-s2.0-34247486946"}, "id"=>"e3fcfb96-fabd-33e4-8017-64114e02b00f", "abstract"=>"BACKGROUND: Sales visits by pharmaceutical representatives (\"drug detailing\") are common, but little is known about the content of these visits or about the impact of visit characteristics on prescribing behavior. In this study, we evaluated the content and impact of detail visits for gabapentin by analyzing market research forms completed by physicians after receiving a detail visit for this drug. METHODS AND FINDINGS: Market research forms that describe detail visits for gabapentin became available through litigation that alleged that gabapentin was promoted for \"off-label\" uses. Forms were available for 97 physicians reporting on 116 detail visits between 1995 and 1999. Three-quarters of recorded visits (91/116) occurred in 1996. Two-thirds of visits (72/107) were 5 minutes or less in duration, 65% (73/113) were rated of high informational value, and 39% (42/107) were accompanied by the delivery or promise of samples. During the period of this study, gabapentin was approved by the US Food and Drug Administration only for the adjunctive treatment of partial seizures, but in 38% of visits (44/115) the \"main message\" of the visit involved at least one off-label use. After receiving the detail visit, 46% (50/108) of physicians reported the intention to increase their prescribing or recommending of gabapentin in the future. In multivariable analysis, intent to increase future use or recommendation of gabapentin was associated with receiving the detail in a small group (versus one-on-one) setting and with low or absent baseline use of the drug, but not with other factors such as visit duration, discussion of \"on-label\" versus \"off-label\" content, and the perceived informational value of the presentation. CONCLUSIONS: Detail visits for gabapentin were of high perceived informational value and often involved messages about unapproved uses. Despite their short duration, detail visits were frequently followed by physician intentions to increase their future recommending or prescribing of the drug.", "link"=>"http://www.mendeley.com/research/characteristics-impact-drug-detailing-gabapentin", "reader_count"=>30, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>5, "Librarian"=>2, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Other"=>5, "Student > Master"=>5, "Professor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>5, "Librarian"=>2, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Other"=>5, "Student > Master"=>5, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>21, "Design"=>1, "Business, Management and Accounting"=>1, "Social Sciences"=>2, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>21}, "Social Sciences"=>{"Social Sciences"=>2}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Sweden"=>1, "United States"=>2, "United Kingdom"=>1, "Germany"=>1}, "group_count"=>1}

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Figshare 1303 May 11:23 UTC

Figshare

{"files"=>["https://ndownloader.figshare.com/files/950620"], "description"=>"<p>Excerpt from a detailing reporting form providing information on a detail visit for gabapentin. Some markings (e.g., “032417 Neuro” and “12233” next to “Product: Neurontin”) were annotations entered by Verispan employees to assist with coding and data entry of completed forms.</p>", "links"=>[], "tags"=>["anesthesiology and pain management", "Mental health", "Non-clinical medicine"], "article_id"=>620945, "categories"=>["Medicine", "Genetics", "Mental Health"], "users"=>["Michael A Steinman", "G. Michael Harper", "Mary-Margaret Chren", "C. Seth Landefeld", "Lisa A Bero"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.0040134.g001", "stats"=>{"downloads"=>4, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Detailing_Reporting_Form_/620945", "title"=>"Detailing Reporting Form", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 12:33:38"}

PMC Usage Stats 323117 Feb 13:59 UTC

PMC Usage Stats | Further Information

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Relative Metric 134420810 May 16:06 UTC

Relative Metric

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F1000Prime03 Mar 11:30 UTC

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