CiteULike | Further Information

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Mendeley | Further Information

{"title"=>"Seventy-five trials and eleven systematic reviews a day: How will we ever keep up?", "type"=>"journal", "authors"=>[{"first_name"=>"Hilda", "last_name"=>"Bastian", "scopus_author_id"=>"7005698433"}, {"first_name"=>"Paul", "last_name"=>"Glasziou", "scopus_author_id"=>"55382766300"}, {"first_name"=>"Iain", "last_name"=>"Chalmers", "scopus_author_id"=>"7102392251"}], "year"=>2010, "source"=>"PLoS Medicine", "identifiers"=>{"sgr"=>"77957859521", "doi"=>"10.1371/journal.pmed.1000326", "pui"=>"359754398", "issn"=>"15491277", "pmid"=>"20877712", "isbn"=>"1549-1676 (Electronic)\\n1549-1277 (Linking)", "scopus"=>"2-s2.0-77957859521"}, "id"=>"a41182ab-5e00-379c-aae9-824fabae6c8e", "abstract"=>"When Archie Cochrane reproached the medical profession for not having critical summaries of all randomised controlled trials, about 14 reports of trials were being published per day. There are now 75 trials, and 11 systematic reviews of trials, per day and a plateau in growth has not yet been reached. Although trials, reviews, and health technology assessments have undoubtedly had major impacts, the staple of medical literature synthesis remains the non-systematic narrative review. Only a small minority of trial reports are being analysed in up-to-date systematic reviews. Given the constraints, Archie Cochrane's vision will not be achieved without some serious changes in course. To meet the needs of patients, clinicians, and policymakers, unnecessary trials need to be reduced, and systematic reviews need to be prioritised. Streamlining and innovation in methods of systematic reviewing are necessary to enable valid answers to be found for most patient questions. Finally, clinicians and patients require open access to these important resources.", "link"=>"http://www.mendeley.com/research/seventyfive-trials-eleven-systematic-reviews-day-we-ever-keep-up-1", "reader_count"=>370, "reader_count_by_academic_status"=>{"Unspecified"=>7, "Professor > Associate Professor"=>31, "Librarian"=>33, "Researcher"=>57, "Student > Doctoral Student"=>24, "Student > Ph. D. Student"=>68, "Student > Postgraduate"=>15, "Other"=>30, "Student > Master"=>51, "Student > Bachelor"=>17, "Lecturer"=>12, "Lecturer > Senior Lecturer"=>3, "Professor"=>22}, "reader_count_by_user_role"=>{"Unspecified"=>7, "Professor > Associate Professor"=>31, "Librarian"=>33, "Researcher"=>57, "Student > Doctoral Student"=>24, "Student > Ph. D. Student"=>68, "Student > Postgraduate"=>15, "Other"=>30, "Student > Master"=>51, "Student > Bachelor"=>17, "Lecturer"=>12, "Lecturer > Senior Lecturer"=>3, "Professor"=>22}, "reader_count_by_subject_area"=>{"Unspecified"=>21, "Agricultural and Biological Sciences"=>24, "Philosophy"=>4, "Arts and Humanities"=>5, "Business, Management and Accounting"=>2, "Chemistry"=>2, "Computer Science"=>24, "Decision Sciences"=>1, "Economics, Econometrics and Finance"=>3, "Engineering"=>1, "Environmental Science"=>4, "Biochemistry, Genetics and Molecular Biology"=>5, "Nursing and Health Professions"=>12, "Materials Science"=>1, "Medicine and Dentistry"=>209, "Neuroscience"=>3, "Sports and Recreations"=>5, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Psychology"=>17, "Social Sciences"=>23, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>209}, "Social Sciences"=>{"Social Sciences"=>23}, "Decision Sciences"=>{"Decision Sciences"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>5}, "Psychology"=>{"Psychology"=>17}, "Unspecified"=>{"Unspecified"=>21}, "Environmental Science"=>{"Environmental Science"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}, "Arts and Humanities"=>{"Arts and Humanities"=>5}, "Engineering"=>{"Engineering"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Neuroscience"=>{"Neuroscience"=>3}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>24}, "Computer Science"=>{"Computer Science"=>24}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>12}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Philosophy"=>{"Philosophy"=>4}}, "reader_count_by_country"=>{"United States"=>16, "Egypt"=>1, "United Kingdom"=>13, "Spain"=>7, "India"=>1, "New Zealand"=>1, "Canada"=>6, "Norway"=>1, "Denmark"=>4, "Brazil"=>3, "Mexico"=>1, "France"=>4, "Australia"=>3, "Germany"=>2}, "group_count"=>33}

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• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosmedicine%2Farticle%3Fid%3D10.1371%252Fjournal.pmed.1000326", "share_count"=>1, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>1}

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• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/3d9365e2-c2b5-4849-bbeb-e6481e5b84c2", "title"=>"Too Canute like?", "body"=>"The article by Hilda Bastian and others is rightly attracting a lot of attention, and I wanted to add a few thoughts.\n\n1. Many people reading their article might reach the conclusion that Archie Cochrane's dream is unachievable and ought perhaps be replaced by something less Utopian.\n\n2. Have the authors noticed something of a swing away from evidence based practice? I have--despite being an enthusiast since the very beginning. Many people, including many doctors, most policy makers, and even some statisticians, have come to see it as too reductionist, unhelpful in answering the complex questions of a world dominated by people with polypathology.\n\n3. Their tendency to be sceptical about the inclusion of non-randomised trials and other evidence in systematic reviews puts them at risk of becoming pure but irrelevant.\n\n4. They need a more sophisticated prescription for achieving their goal. In their next article they should analyse the incentives, many of them perverse, that leads to our present circumstances and propose ways of changing the incentives.\n", "isRemoved"=>false, "created"=>"2010-09-28T10:07:08Z", "lastModified"=>"2010-09-28T10:07:08Z", "creator"=>{"userId"=>"107797"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"1. I regard all three authors as friends, even though Iain disapproves of my career path.\n\n2. I am the chair of the Cochrane Library Oversight Committee.\n\n3. I am on the board of the Public Library of Science."}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pmed.1000326", "state"=>"published", "journals"=>{"PLoSMedicine"=>{"journalKey"=>"PLoSMedicine", "eIssn"=>"1549-1676", "title"=>"PLOS Medicine"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2010-09-28T10:07:08Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/831907ce-7b15-4f6b-b65d-285fab72755c", "title"=>"Authors' (Canutes?) respond", "body"=>"A less utopian version of Cochrane’s challenge is unnecessary: rather only a precise reading of it. We need to concentrate on trials that are “relevant” [1]. The information needs of clinicians and patients will not be well served by removing the floodgates and admitting non-randomised studies of questionable relevance, any more than they are being well served by the plethora of randomised studies of questionable relevance. \r\n\r\nRandomised and non-randomised studies frequently give different answers to the same question, and choices are required based on logic. It is a choice whether or not to recommend that postmenopausal women should take hormones to prevent cardiovascular disease, but the choice has mortal consequences. \r\n\r\nWe suggest that practice should be informed by non-randomised evidence in three main situations: (i) when estimates of the effects of an intervention are so large that it is inconceivable that they reflect bias [2]; (ii) when trials are of insufficient size to address questions about important possible uncommon adverse effects [3]; and (iii) that it really is inconceivable that randomised trials would ever be feasible, for example, to address uncertainties about how to treat white phosphorous burns sustained during an intensive bombing campaign. \r\n\r\nAs illustrated by numerous examples, acquiescing in lack of randomised trials when controlled experiments are, in principle, feasible, has resulted in unacceptable suffering and death. Cochrane’s suggestion offers protection against error – but also a vital and increasingly important triage principle for coping with information. The current bias and waste in the medical research enterprise has multiple layers [4]. But understanding causes and cures of our ignorance despite a flood of information is still worth more attention and effort than it currently gets. Like Canute, we are well aware that we cannot stop the tide. Getting more selective, though, and finding new ways to cooperate, might help us stay afloat. \r\n\r\n1. Bastian H, Glasziou P, Chalmers I. Seventy-five trials and eleven systematic reviews a day: how will we ever keep up? PLoS Med 7(9): e1000326.\r\n\r\n2. Glasziou P, Chalmers I, Rawlins M, McCulloch P. When are randomised trials unnecessary? Picking signal from noise. BMJ. 2007 Feb 17;334(7589):349-351.\r\n\r\n3. Vandenbroucke JP, Psaty BM. Benefits and risks of drug treatments: how to combine the best evidence on benefits with the best data about adverse effects. JAMA 2008; 300(20):2417-2419.\r\n\r\n4. Chalmers I, Glasziou P. Avoidable waste in the production and reporting of research evidence. Lancet. 2009 Jul 4;374(9683):86-89.\r\n", "isRemoved"=>false, "created"=>"2010-10-04T07:44:13Z", "lastModified"=>"2010-10-04T07:44:13Z", "creator"=>{"userId"=>"137985"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"Authors' response."}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pmed.1000326", "state"=>"published", "journals"=>{"PLoSMedicine"=>{"journalKey"=>"PLoSMedicine", "eIssn"=>"1549-1676", "title"=>"PLOS Medicine"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2010-10-04T07:44:13Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/bb03f188-a0aa-41e1-a76d-b970097c43f8", "title"=>"What type of review is needed? ", "body"=>"The paper by Bastian et al. [1] contains the seeds of another debate: what type of systematic review is needed to decide which study needs to be done next? Should the review aim at helping medical doctors to decide which treatment is best for their patients, or should it be a summary of studies with one type of design (RCTs)? In a decision oriented review, RCTs that use an obsolete comparison treatment or placebo might be discarded when a reasonable standard treatment is available. If no RCTs with a relevant comparator exist, and if it is unlikely that the relevant comparison will ever be done, the review might attempt network meta-analysis, or might search for observational comparative studies of effectiveness in large data-bases - provided the circumstances make it possible [2]. Given newer insights, the right circumstances in which data-bases might give an answer to some therapeutic questions may be less utopian as Bastian et al. seem to think in their response to Richard Smith [3]. \r\n\r\nIn the decision to prefer one treatment over another, adverse effects may play a large role. RCTs do not only fail to be informative about adverse effects when these effects are rare or occur late - in contrast to what is stated by Bastian et al., and repeated in their response to Richard Smith [3]. RCTs commonly fail because they study selected populations and because interventions are carried out in extraordinary circumstances. Observational studies on adverse effects study the real life application of the intervention and may therefore lead to strongly different estimates of common adverse effects. For instance, when the patient population enrolled in the trials was screened for risks of adverse effects, or when concomitant medications that may trigger an adverse effect were ruled out, or when special skills need to be learned to apply the intervention. Thus, a systematic review aimed at making decisions needs to have the best evidence about adverse effects – which will often be observational [4].\r\n\r\nA decision oriented approach is the reason why an organization like NICE prefers to look for the best possible evidence, inclusive of observational data and insight in the mechanism of action of the interventions [5]. Likewise, AHRQ states that inclusion of observational data will almost always be necessary to study adverse effects, and adds that the potential for confounding by indication is much less for adverse effects – which obviates the need for randomization [6]. These views are echoed in a recent Institute of Medicine letter on ethical issues in studying the safety of approved drugs [7]. Such insights may have evolved from a paper that was written with two of the present authors and that was critical of the usual ‘hiearchy’ of study designs [8]. \r\n\r\nThe current procedures of the Cochrane collaboration are best suited for the second type of review: a compilation of RCTs, as also advocated by Bastian et al., who see the inclusion of observational studies as a distraction. In a commentary about the status of Cochrane in the US, the current Cochrane Editor-in-chief cites the opinions of US medical researchers: that current practices may place too much emphasis on the methodology and that newer sophisticated skills are needed to produce reviews that are relevant for Comparative Effectiveness Research [9]. \r\n\r\n\r\nJan P Vandenbroucke, MD, PhD\r\nDepartment of Clinical Epidemiology \r\nLeiden University Medical Center, The Netherlands\r\n\r\n\r\n1. Bastian H, Glasziou P, Chalmers I. Seventy-five trials and eleven systematic reviews a day: how will we ever keep up? PLoS Med. 2010;7(9):e1000326.\r\n\r\n2. Schneeweiss S, Patrick AR, Stürmer T, Brookhart MA, Avorn J, Maclure M, Rothman KJ, Glynn RJ. Increasing levels of restriction in pharmacoepidemiologic database studies of elderly and comparison with randomized trial results. Med\r\nCare. 2007;45(10 Supl 2):S131-42. \r\n\r\n3. Bastian H. Authors’ (Canute?) respond to: Smith R. Too Canute like? Comment on: Bastian H, Glasziou P, Chalmers I. Seventy-five trials and eleven systematic reviews a day: how will we ever keep up? PLoS Med. 2010;7(9):e1000326.\r\n\r\n4. Vandenbroucke JP, Psaty BM. Benefits and risks of drug treatments: how to combine the best evidence on benefits with the best data about adverse effects.\r\nJAMA. 2008;300:2417-9. \r\n\r\n5. Rawlins M. De Testimonio: on the evidence for decisions about the use of therapeutic interventions. Lancet. 2008;372:2152-61. \r\n\r\n6. Agency for Healthcare Research and Quality. Methods Reference Guide for Effectiveness and Comparative Effectiveness Reviews, Version 1.0 [draft posted\r\nOctober 2007]. Rockville, MD: Agency for Healthcare Research and Quality; 2007.\r\nhttp://effectivehealthcare.ahrq.gov/repFiles/2007_10DraftMethodsGuide.pdf.\r\n\r\n7. Ethical and Scientific Issues in Studying the Safety of Approved Drugs; Institute of Medicine 2010. http://www.nap.edu/catalog.php?record_id=12948 \r\n\r\n8. Glasziou P, Vandenbroucke JP, Chalmers I. Assessing the quality of research. BMJ. 2004;328:39-41. Erratum in: BMJ. 2004;329:621.\r\n\r\n9. Tovey D, Dellavalle R. Cochrane in the United States of Amcerica. The Cochrane Collaboration. http://www.thecochranelibrary.com/details/editorial/847239/Cochrane-in-the-United-States-of-America-by-Dr-David-Tovey--Dr-Robert-Dellavalle.html\r\n", "isRemoved"=>false, "created"=>"2010-10-18T16:23:57Z", "lastModified"=>"2010-10-18T16:23:57Z", "creator"=>{"userId"=>"29109"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"Having written reference [8] with two of the authors of the paper, and having greatly enjoyed the collaboration.\r\n"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pmed.1000326", "state"=>"published", "journals"=>{"PLoSMedicine"=>{"journalKey"=>"PLoSMedicine", "eIssn"=>"1549-1676", "title"=>"PLOS Medicine"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2010-10-18T16:23:57Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/fb95fbc7-ba3a-4a8a-be82-5a722770ecf0", "title"=>"Vitamin C and the common cold: early systematic reviews and the justification for new trials", "body"=>"Vitamin C and the common cold is a particularly important topic in the history of systematic reviews because three of the earliest systematic reviews examined that topic [1-3]. Nevertheless, Bastian et al.'s brief mention of this issue is misleading [4].\r\n\r\nThere has been a long-lasting belief in the mainstream medicine that vitamin C has effect only on scurvy. Linus Pauling's 1971 systematic review of 4 placebo-controlled studies on vitamin C and the common cold challenged this view [1]. Pauling pooled P-values of the 4 trials by using the Fisher method and calculated that it was highly unlikely that the decrease in common cold morbidity in vitamin C groups was explained by random variation (pooled P = 0.000022). Among the 4 trials included in Pauling’s meta-analysis, the greatest benefit was found by Ritzel who studied Swiss schoolchildren in a skiing camp [5]. Ritzel used the highest dose, 1 g/day, and this led Pauling to propose that gram doses of vitamin C might decrease common cold morbidity [1].\r\n\r\nThomas Chalmers' 1975 systematic review [3] challenged the validity of Pauling's conclusions. Chalmers selected 8 placebo-controlled trials and calculated that the common cold episodes were on average 0.11 ± 0.24 (SE) days shorter in the vitamin C groups than in the placebo groups. Even if real, a 0.11 day (= 2.6 hours) decrease in the duration of colds would have no clinical relevance, Furthermore, the great variation in the results indicates that the slight difference is explained by chance. Chalmers concluded that “the conclusion drawn from this analysis of the published controlled trials is the opposite of that drawn from the analysis carried out by Pauling [1], of four trials, published before 1971.”\r\n\r\nHowever, Chalmers’ systematic review [3] contains a large number of serious errors, such as the data presented was inconsistent with the original published data, there were errors in calculation, the selection of trials was inconsistent, and in some trials a clinically less meaningful outcome was selected. I re-analyzed those trials that were known to Chalmers which had used ≥1 g/day of vitamin C, i.e., which were testing Pauling’s proposal. I found that the common cold episodes were 0.93 ± 0.22 (SE) (P = 0.01) days shorter in the vitamin C groups [6,7]. Thus, an estimate of more than 8 times Chalmers’ estimate was obtained by employing correct values and keeping to trials which used doses as high as Pauling had proposed. Furthermore, a more useful estimate of vitamin C effect from the same trials is a 21% ± 3% (SE) decrease in common cold duration (P = 0.001) [6].\r\n\r\nIn our Cochrane review on vitamin C and the common cold [8,9], Ritzel's trial [5] is included in the subgroup of studies with participants under heavy acute physical stress. In this subgroup vitamin C supplementation halved the incidence of colds. Evidently, it was not a misjudgment by Pauling to put the greatest weight on Ritzel's randomized double-blind trial, but when Pauling extrapolated Ritzel's results to all people (i.e., to children at school and to adults), he took a bold step and went wrong [10]. In any case, the data Pauling presented was consistent with the original published data and he did not make errors in calculations.\r\n\r\nIn their Box 1, Bastian et al. list Chalmers' 1975 systematic review as one of the early systematic reviews, without mentioning that the review was shown to be seriously flawed over a decade ago [6]. At the same time Bastian et al. ignore Pauling's 1971 systematic reviews [1,2] although they were methodologically sound and published 3 years before the first systematic review mentioned in Box 1. Given that the primary purpose of systematic reviews is to minimize the likelihood of being misled by the effects of biases, Bastian et al.'s biased presentation of the early systematic reviews is amazing.\r\n\r\nI dont see much justification for Bastian et al.'s proposal that a new controlled trial should not be carried out unless a systematic review has shown the trial to be necessary [4, p. 5]. If researchers had been following Bastian et al.'s way of reasoning, no new vitamin C common cold trials would have been carried out after Chalmers' 1975 systematic review was published. Although that review largely quelled interest in vitamin C, it is fortunate that some new trials were still carried out. Our Cochrane review shows that even more new trials are needed [8,9]. I have read many poor quality systematic reviews and it would be a pity if all of them had such a great influence that the justification for new trials was based on them. Given that Bastian et al. cannot see that the highly influential Chalmers' 1975 systematic review is seriously flawed, how could less experienced researchers evaluate whether some of the recent systematic reviews is reliable or not when they are contemplating the rationale for a new trial.\r\n\r\nHarri Hemilä, MD, PhD\r\nUniversity of Helsinki\r\nHelsinki, Finland\r\n\r\nReferences\r\n\r\n1. Pauling L. The significance of the evidence about ascorbic acid and the common cold. Proc Natl Acad Sci USA. 1971;68:2678-2681. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC389499\r\n\r\n2. Pauling L. Ascorbic acid and the common cold. Am J Clin Nutr. 1971;24:1294-1299. http://www.ajcn.org/cgi/reprint/24/11/1294\r\n\r\n3. Chalmers TC. Effects of ascorbic acid on the common cold: an evaluation of the evidence. Am J Med. 1975;58:532-536. doi:10.1016/0002-9343(75)90127-8\r\n\r\n4. Bastian H, Glasziou P, Chalmers I. Seventy-five trials and eleven systematic reviews a day: how will we ever keep up? PLoS Med. 2010;7:e1000326. http://dx.doi.org/10.1371/journal.pmed.1000326\r\n\r\n5. Ritzel G. Critical analysis of the role of vitamin C in the treatment of the common cold (in German). Helv Med Acta. 1961;28:63-68. Translation: http://www.ltdk.helsinki.fi/users/hemila/T3.pdf\r\n\r\n6. Hemilä H, Herman ZS. Vitamin C and the common cold: a retrospective analysis of Chalmers’ review. J Am Coll Nutr. 1995;14:116-123.\r\n\r\n7. Hemilä H. Chalmers’ meta-analysis (1975). In: Do vitamins C and E affect respiratory infections? [PhD Thesis]. Helsinki, Finland: University of Helsinki; 2006, pp 36-38. http://ethesis.helsinki.fi/julkaisut/laa/kansa/vk/hemila/ and http://www.ltdk.helsinki.fi/users/hemila/reviews/chalmers\r\n\r\n8. Hemilä H, Chalker EB, Douglas RM. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2007;(3):CD000980. http://dx.doi.org/10.1002/14651858.CD000980.pub3\r\n\r\n9. Douglas RM, Hemilä H. Vitamin C for preventing and treating the common cold. PLoS Med. 2005;2:e168. http://dx.doi.org/10.1371/journal.pmed.0020168\r\n\r\n10. Hemilä H. Pauling's meta-analyses (1971a,b). In: Do vitamins C and E affect respiratory infections? [PhD Thesis]. Helsinki, Finland: University of Helsinki; 2006, pp 35-36. http://ethesis.helsinki.fi/julkaisut/laa/kansa/vk/hemila/ and http://www.ltdk.helsinki.fi/users/hemila/reviews/pauling", "isRemoved"=>false, "created"=>"2010-10-27T21:17:15Z", "lastModified"=>"2010-10-27T21:17:15Z", "creator"=>{"userId"=>"23731"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pmed.1000326", "state"=>"published", "journals"=>{"PLoSMedicine"=>{"journalKey"=>"PLoSMedicine", "eIssn"=>"1549-1676", "title"=>"PLOS Medicine"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2010-10-27T21:17:15Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/93351a63-3a3c-4290-ab44-5abe287a15b0", "title"=>"Blog on this article", "body"=>"Annabel Bentley has written a thoughtful blog on this article and subject. The blog has elicited many comments, and you can access it at:\n\nhttp://blogs.bmj.com/bmj/2010/11/03/annabel-bentley-information-overload-are-you-waving-or-drowning/", "isRemoved"=>false, "created"=>"2010-11-04T16:42:57Z", "lastModified"=>"2010-11-04T16:42:57Z", "creator"=>{"userId"=>"107797"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pmed.1000326", "state"=>"published", "journals"=>{"PLoSMedicine"=>{"journalKey"=>"PLoSMedicine", "eIssn"=>"1549-1676", "title"=>"PLOS Medicine"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2010-11-04T16:42:57Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/bd47bbf5-1d10-450b-8ff7-a1d29f60d0f8", "title"=>"Another blog post", "body"=>"I have written a (critical) review on this paper a while ago.\n\nhttp://laikaspoetnik.wordpress.com/2010/10/06/how-will-we-ever-keep-up-with-75-trials-and-11-systematic-reviews-a-day/", "isRemoved"=>false, "created"=>"2010-11-07T14:33:50Z", "lastModified"=>"2010-11-07T14:33:50Z", "creator"=>{"userId"=>"161151"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pmed.1000326", "state"=>"published", "journals"=>{"PLoSMedicine"=>{"journalKey"=>"PLoSMedicine", "eIssn"=>"1549-1676", "title"=>"PLOS Medicine"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2010-11-07T14:33:50Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/416c5a8b-6a77-445c-91f6-ce26aadf38e3", "title"=>"It's easy to keep up: Stop depending on human analysts", "body"=>"Although human analysts obviously cannot keep up with the need for updated meta-analyses, computers can very easily. All that's needed is for the reporters of trials to report the their results in a computer-understandable format (which they pretty much already do!), and then use automated meta-analysis to summarize the results on a continuous basis. This method can incorporate all sort of results, including case studies (cf. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011965), and the results can be reported out in the form of web-based applications (cf. http://therapy.collabrx.com/). ", "isRemoved"=>false, "created"=>"2010-12-30T04:21:47Z", "lastModified"=>"2010-12-30T04:21:47Z", "creator"=>{"userId"=>"81771"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pmed.1000326", "state"=>"published", "journals"=>{"PLoSMedicine"=>{"journalKey"=>"PLoSMedicine", "eIssn"=>"1549-1676", "title"=>"PLOS Medicine"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2010-12-30T04:21:47Z", "replies"=>[]}

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• {"id"=>"1065946708524363777", "text"=>"#PLOSMedicine: Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? https://t.co/d805TDSx2U", "created_at"=>"2018-11-23T12:34:34Z", "user"=>"Danelle_Pettman", "user_name"=>"Danelle Pettman", "user_profile_image"=>"http://pbs.twimg.com/profile_images/720971965377482753/YLa2LOUO_normal.jpg"}
• {"id"=>"1069682908800172032", "text"=>"Setenta y cinco ensayos cl?nicos y once revisiones sistem?ticos por d?a: ?C?mo mantenerse al d?a? | PLOS Medicine\nhttps://t.co/2mkkplw9BX", "created_at"=>"2018-12-03T20:00:53Z", "user"=>"IlindelatorreMD", "user_name"=>"Dr Ilin Gilberto dlT", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1063154360933326848/dtkgaANY_normal.jpg"}
• {"id"=>"1268804172360581123", "text"=>"@ChristosArgyrop Time for a change in title and search terms https://t.co/T1triH6Mwg", "created_at"=>"2020-06-05T07:17:42Z", "user"=>"DonDonRic", "user_name"=>"Ricardo Fernandes", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2204941705/IMG_0741-1_2_normal.jpg"}
• {"id"=>"233299889189179395", "text"=>"#PLOS: Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? http://t.co/ify0aiin", "created_at"=>"2012-08-08T20:33:22Z", "user"=>"SMHealthSciLib", "user_name"=>"Health Sci Library", "user_profile_image"=>"http://a0.twimg.com/profile_images/2281566026/tocvr6wo48l4pwcmfgf7_normal.png"}
• {"id"=>"233309795279597568", "text"=>"RT @SMHealthSciLib: #PLOS: Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? http://t.co/HgYMsvAH", "created_at"=>"2012-08-08T21:12:44Z", "user"=>"UHNLibraries", "user_name"=>"UHN Libraries", "user_profile_image"=>"http://a0.twimg.com/profile_images/1317632005/uhnlogo2_normal.gif"}
• {"id"=>"233362807603740673", "text"=>"@bogdanrau A question answered definitively here: http://t.co/fgTG8IxP and here: http://t.co/Bo32uvbh", "created_at"=>"2012-08-09T00:43:23Z", "user"=>"adamgdunn", "user_name"=>"Adam Dunn", "user_profile_image"=>"http://a0.twimg.com/profile_images/2242359678/adam_normal.jpg"}
• {"id"=>"256350027784523777", "text"=>"@PLOSMedicine 75 Trials & 11 SRs a Day: How Will We Ever Keep Up? http://t.co/ydPAWBwR mentioned by Iain Chalmers at #equatorACT", "created_at"=>"2012-10-11T11:06:24Z", "user"=>"GinnyBarbour", "user_name"=>"Ginny Barbour", "user_profile_image"=>"http://a0.twimg.com/profile_images/1019520057/Clipboard02_normal.bmp"}
• {"id"=>"256350336263000064", "text"=>"RT @GinnyBarbour: @PLOSMedicine 75 Trials & 11 SRs a Day: How Will We Ever Keep Up? http://t.co/ydPAWBwR mentioned by Iain Chalmers ...", "created_at"=>"2012-10-11T11:07:37Z", "user"=>"trished", "user_name"=>"Trish Groves", "user_profile_image"=>"http://a0.twimg.com/profile_images/62749001/trish2_normal.jpg"}
• {"id"=>"256358769896849408", "text"=>"RT @GinnyBarbour: @PLOSMedicine 75 Trials & 11 SRs a Day: How Will We Ever Keep Up? http://t.co/ydPAWBwR mentioned by Iain Chalmers ...", "created_at"=>"2012-10-11T11:41:08Z", "user"=>"hildabast", "user_name"=>"Hilda Bastian", "user_profile_image"=>"http://a0.twimg.com/profile_images/1612898309/July_2011_Washington_DC_normal.png"}
• {"id"=>"256373502834270208", "text"=>"RT @GinnyBarbour: @PLOSMedicine 75 Trials & 11 SRs a Day: How Will We Ever Keep Up? http://t.co/ydPAWBwR mentioned by Iain Chalmers ...", "created_at"=>"2012-10-11T12:39:40Z", "user"=>"Ezzoef", "user_name"=>"Esther van Zuuren", "user_profile_image"=>"http://a0.twimg.com/profile_images/2673561307/8c1e7934f0a802d9d9f3fba5f6090aa3_normal.jpeg"}
• {"id"=>"256430686729273344", "text"=>"RT @GinnyBarbour: @PLOSMedicine 75 Trials & 11 SRs a Day: How Will We Ever Keep Up? http://t.co/ydPAWBwR mentioned by Iain Chalmers ...", "created_at"=>"2012-10-11T16:26:54Z", "user"=>"PLOS", "user_name"=>"PLOS", "user_profile_image"=>"http://a0.twimg.com/profile_images/2424363764/2etoq0zjwxicokm1woge_normal.jpeg"}
• {"id"=>"256431992634220545", "text"=>"RT @GinnyBarbour: @PLOSMedicine 75 Trials & 11 SRs a Day: How Will We Ever Keep Up? http://t.co/ydPAWBwR mentioned by Iain Chalmers ...", "created_at"=>"2012-10-11T16:32:05Z", "user"=>"marc_rr", "user_name"=>"Marc RobinsonRechavi", "user_profile_image"=>"http://a0.twimg.com/profile_images/1751744306/mrr_caricature_normal.jpg"}
• {"id"=>"258268352852676608", "text"=>"Hilda Bastian @Pubmedhealth #NIHMiM12 #evidenceoverload 75 Trials + 11 Syst Reviews a Day: How Will We Ever Keep Up? http://t.co/chs6t9kZ", "created_at"=>"2012-10-16T18:09:08Z", "user"=>"trished", "user_name"=>"Trish Groves", "user_profile_image"=>"http://a0.twimg.com/profile_images/62749001/trish2_normal.jpg"}
• {"id"=>"267102273790963712", "text"=>"一日あたり世界中で何本の臨床論文が発表されているか見当がつきますか？ランダム化比較試験が75本。システマティック・レビューが11件。それもまだ指数関数的に増え続けているそうです。http://t.co/DkXnLcVq", "created_at"=>"2012-11-10T03:11:59Z", "user"=>"itokouta", "user_name"=>"Kouta Ito", "user_profile_image"=>"http://a0.twimg.com/profile_images/2583034120/4k4s425thu2cjom6yf6i_normal.jpeg"}
• {"id"=>"267102510702030848", "text"=>"一日あたり世界中で何本の臨床論文が発表されているか見当がつきますか？ランダム化比較試験が75本。システマティック・レビューが11本。それもまだ指数関数的に増え続けているそうです。http://t.co/DkXnLcVq", "created_at"=>"2012-11-10T03:12:55Z", "user"=>"itokouta", "user_name"=>"Kouta Ito", "user_profile_image"=>"http://a0.twimg.com/profile_images/2583034120/4k4s425thu2cjom6yf6i_normal.jpeg"}
• {"id"=>"267251622697136128", "text"=>"RT @itokouta: 一日あたり世界中で何本の臨床論文が発表されているか見当がつきますか？ランダム化比較試験が75本。システマティック・レビューが11本。それもまだ指数関数的に増え続けているそうです。http://t.co/DkXnLcVq", "created_at"=>"2012-11-10T13:05:26Z", "user"=>"hm0612", "user_name"=>"hideki", "user_profile_image"=>"http://a0.twimg.com/sticky/default_profile_images/default_profile_5_normal.png"}
• {"id"=>"268721247834230785", "text"=>"RT @itokouta: 一日あたり世界中で何本の臨床論文が発表されているか見当がつきますか？ランダム化比較試験が75本。システマティック・レビューが11本。それもまだ指数関数的に増え続けているそうです。http://t.co/DkXnLcVq", "created_at"=>"2012-11-14T14:25:12Z", "user"=>"Anesth_Earth", "user_name"=>"地球に麻酔", "user_profile_image"=>"http://a0.twimg.com/profile_images/869407609/platina_ash_normal.jpg"}
• {"id"=>"268746847760310274", "text"=>"RT @itokouta: 一日あたり世界中で何本の臨床論文が発表されているか見当がつきますか？ランダム化比較試験が75本。システマティック・レビューが11本。それもまだ指数関数的に増え続けているそうです。http://t.co/DkXnLcVq", "created_at"=>"2012-11-14T16:06:56Z", "user"=>"med_bed_med", "user_name"=>"こう見えてかなり人見知りするほうです。", "user_profile_image"=>"http://a0.twimg.com/profile_images/2800306699/66f2d89302e924290c00ce99b4193023_normal.jpeg"}
• {"id"=>"275095905265414145", "text"=>"@LorenaGroo here -> http://t.co/Ztb1BJlX", "created_at"=>"2012-12-02T04:35:49Z", "user"=>"CharlieNeck", "user_name"=>"Carlos Cuello", "user_profile_image"=>"http://a0.twimg.com/profile_images/2849822519/c9a199bd750592187d4e5a0e89ac9425_normal.jpeg"}
• {"id"=>"286638197902036993", "text"=>"PLOS Medicine: Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? http://t.co/CkGivkNv", "created_at"=>"2013-01-03T01:00:46Z", "user"=>"fsayre", "user_name"=>"Franklin Sayre", "user_profile_image"=>"http://a0.twimg.com/profile_images/2803156614/1442e8af010e7ba7cc42a52365f2afca_normal.jpeg"}
• {"id"=>"299863201166811136", "text"=>".@JRBtrip Less than half of Cochrane SRs are up-to-date http://t.co/kwrT89az", "created_at"=>"2013-02-08T12:52:13Z", "user"=>"hildabast", "user_name"=>"Hilda Bastian", "user_profile_image"=>"http://a0.twimg.com/profile_images/1612898309/July_2011_Washington_DC_normal.png"}
• {"id"=>"299863705984835584", "text"=>"RT @hildabast: .@JRBtrip Less than half of Cochrane SRs are up-to-date http://t.co/kwrT89az", "created_at"=>"2013-02-08T12:54:13Z", "user"=>"jevans7", "user_name"=>"jennifer evans", "user_profile_image"=>"http://a0.twimg.com/profile_images/1596118323/jevans_normal.jpg"}
• {"id"=>"299863868816101376", "text"=>"RT @hildabast: .@JRBtrip Less than half of Cochrane SRs are up-to-date http://t.co/kwrT89az", "created_at"=>"2013-02-08T12:54:52Z", "user"=>"JRBtrip", "user_name"=>"Jon Brassey", "user_profile_image"=>"http://a0.twimg.com/profile_images/2588387175/6yzgt248u7ef0x9k02kb_normal.jpeg"}
• {"id"=>"299876138333917186", "text"=>"RT @hildabast: .@JRBtrip Less than half of Cochrane SRs are up-to-date http://t.co/kwrT89az", "created_at"=>"2013-02-08T13:43:37Z", "user"=>"alanfricker", "user_name"=>"Alan Fricker", "user_profile_image"=>"http://a0.twimg.com/profile_images/1397653931/82e5d1f0-1ee0-4b06-8d66-6b322047beae_normal.JPG"}
• {"id"=>"300217990509629441", "text"=>"RT @hildabast: .@JRBtrip Less than half of Cochrane SRs are up-to-date http://t.co/kwrT89az", "created_at"=>"2013-02-09T12:22:01Z", "user"=>"khresmoi", "user_name"=>"Khresmoi project", "user_profile_image"=>"http://a0.twimg.com/profile_images/1111355586/Logo_KHRESMOI_2010-300-twitter_normal.png"}
• {"id"=>"300314643296051202", "text"=>"PLOS Medicine: Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? http://t.co/TQaZ9luW", "created_at"=>"2013-02-09T18:46:05Z", "user"=>"doc_RT", "user_name"=>"radioterapia@pt", "user_profile_image"=>"http://a0.twimg.com/profile_images/602568278/logo1_normal.gif"}
• {"id"=>"300646978549841921", "text"=>"RT @hildabast: .@JRBtrip Less than half of Cochrane SRs are up-to-date http://t.co/uA2dUeRg", "created_at"=>"2013-02-10T16:46:40Z", "user"=>"MJBwrites", "user_name"=>"Melissa J Bodeau", "user_profile_image"=>"http://a0.twimg.com/profile_images/1321587517/P6050052_normal.JPG"}
• {"id"=>"314336083288674304", "text"=>"75 trials and 11 Systematic reviews are published EVERY DAY (circa 2010) http://t.co/d9F1kUFdwb Need for text-mining in medical research?", "created_at"=>"2013-03-20T11:22:16Z", "user"=>"dataJujitsu", "user_name"=>"David Springate", "user_profile_image"=>"http://a0.twimg.com/profile_images/3094300984/ff647084431d08fa5d417b0aa682346f_normal.jpeg"}
• {"id"=>"314338913382699009", "text"=>"RT @dataJujitsu: 75 trials and 11 Systematic reviews are published EVERY DAY (circa 2010) http://t.co/d9F1kUFdwb Need for text-mining i ...", "created_at"=>"2013-03-20T11:33:31Z", "user"=>"chlalanne", "user_name"=>"Christophe Lalanne", "user_profile_image"=>"http://a0.twimg.com/profile_images/1135754268/chl2bgv2_normal.png"}
• {"id"=>"328805573879558145", "text"=>"@PeterDLROW Have you read this @iainchalmersTTi classic? '75Trials&11Syst Revs a Day:How Will We Ever Keep Up?' http://t.co/qp6fGTYFRv", "created_at"=>"2013-04-29T09:38:52Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://a0.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"330275840359280641", "text"=>"Heaven help Patients if the NHS doesn't come up with a better system of knowledge gathering than in recent times.http://t.co/cWPn1HkVHd", "created_at"=>"2013-05-03T11:01:11Z", "user"=>"b12unme", "user_name"=>"B12 unme", "user_profile_image"=>"http://a0.twimg.com/profile_images/2780871087/dbf2e33ea82e8b87677148bf52d6d213_normal.jpeg"}
• {"id"=>"353903840208232449", "text"=>"We live with two problems — an overload of information & lack of open access to information relevant to patients. http://t.co/vS13tnkHuZ", "created_at"=>"2013-07-07T15:50:25Z", "user"=>"mrgunn", "user_name"=>"mrgunn", "user_profile_image"=>"http://a0.twimg.com/profile_images/1583656465/William_Gunn_headshot_square_683x680_normal.png"}
• {"id"=>"354312559811231744", "text"=>"Oldie but goodie: '75 Trials + 11 Systematic Reviews a Day: How Will We Ever Keep Up?' by @hildabast in @PLOSMedicine http://t.co/c2UVxz1FCi", "created_at"=>"2013-07-08T18:54:31Z", "user"=>"jocalynclark", "user_name"=>"Jocalyn Clark", "user_profile_image"=>"http://a0.twimg.com/profile_images/3320446396/b0c186ee9129e96f7ad5e722b4278046_normal.jpeg"}
• {"id"=>"354314662097068032", "text"=>"Worth revisiting this from 2010: Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? http://t.co/6p75sx4VpG", "created_at"=>"2013-07-08T19:02:52Z", "user"=>"UHNLibraries", "user_name"=>"UHN Libraries", "user_profile_image"=>"http://a0.twimg.com/profile_images/1317632005/uhnlogo2_normal.gif"}
• {"id"=>"354320024116273153", "text"=>"Medisch onderzoek: 75 trials + 11 systematische reviews per dag. Beperk overbodige trials; stimuleer system. reviews http://t.co/SjbpWUpqnG", "created_at"=>"2013-07-08T19:24:11Z", "user"=>"KabosVdVliet", "user_name"=>"Kabos-Van der Vliet ", "user_profile_image"=>"http://a0.twimg.com/profile_images/1531502488/uil_normal.jpg"}
• {"id"=>"354856965907808256", "text"=>".@PLOSONE 75 Trials, 11 Systematic Reviews/Day: How Will We Ever Keep Up? Good question, punchline end to abstract. http://t.co/iy7LdzInkh", "created_at"=>"2013-07-10T06:57:48Z", "user"=>"CoyneoftheRealm", "user_name"=>"James C.Coyne", "user_profile_image"=>"http://a0.twimg.com/profile_images/1508296653/Paris_Au_Revoir_normal.JPG"}
• {"id"=>"354858963319275521", "text"=>"MT “@CoyneoftheRealm: @PLOSONE 75 trials, 11 syst revs/day: overload http://t.co/d6wy9fHyj1” By @iainchalmersTTi @hildabast @PaulGlasziou", "created_at"=>"2013-07-10T07:05:44Z", "user"=>"trished", "user_name"=>"Trish Groves", "user_profile_image"=>"http://a0.twimg.com/profile_images/3626756853/305796f28705f12b01ac74fd8fc83bc1_normal.jpeg"}
• {"id"=>"354896502797250560", "text"=>"75 trials and 11 syst reviews a day. Thoughtful article on info overload. http://t.co/gVsbD13rZK", "created_at"=>"2013-07-10T09:34:54Z", "user"=>"glbryson", "user_name"=>"Greg Bryson", "user_profile_image"=>"http://a0.twimg.com/profile_images/2297481989/image_normal.jpg"}
• {"id"=>"354957947215937538", "text"=>"Inabarcable ciencia: 75 estudios y 11 revisiones sistemáticas publicadas cada día http://t.co/4xG1zy75U3 hace 30 años eran 14 estudios/día", "created_at"=>"2013-07-10T13:39:04Z", "user"=>"cgblanch1", "user_name"=>"C. González-Blanch", "user_profile_image"=>"http://a0.twimg.com/profile_images/2443026895/jz80nefbx45q932az9rb_normal.jpeg"}
• {"id"=>"354963205350637569", "text"=>"RT @cgblanch1: Inabarcable ciencia: 75 estudios y 11 revisiones sistemáticas publicadas cada día http://t.co/4xG1zy75U3 hace 30 años eran 1…", "created_at"=>"2013-07-10T13:59:57Z", "user"=>"psicomagister", "user_name"=>"Javi", "user_profile_image"=>"http://a0.twimg.com/profile_images/2993966124/8e6459de9460b3b403462661afd9efb7_normal.jpeg"}
• {"id"=>"354972368583663616", "text"=>"RT @cgblanch1: Inabarcable ciencia: 75 estudios y 11 revisiones sistemáticas publicadas cada día http://t.co/4xG1zy75U3 hace 30 años eran 1…", "created_at"=>"2013-07-10T14:36:22Z", "user"=>"psynthesisblog", "user_name"=>"PSY'N'THESIS Blog", "user_profile_image"=>"http://a0.twimg.com/profile_images/2677255614/cfc7559a8e41d0c4548d0fdc9b00d5c9_normal.jpeg"}
• {"id"=>"355001318097690624", "text"=>"RT @cgblanch1: Inabarcable ciencia: 75 estudios y 11 revisiones sistemáticas publicadas cada día http://t.co/4xG1zy75U3 hace 30 años eran 1…", "created_at"=>"2013-07-10T16:31:24Z", "user"=>"Salud_Mental", "user_name"=>"Salud Mental", "user_profile_image"=>"http://a0.twimg.com/profile_images/3447004333/8b31d8f914f9e6b151df61a539e569b0_normal.jpeg"}
• {"id"=>"355006465414676481", "text"=>"RT @cgblanch1: Inabarcable ciencia: 75 estudios y 11 revisiones sistemáticas publicadas cada día http://t.co/4xG1zy75U3 hace 30 años eran 1…", "created_at"=>"2013-07-10T16:51:51Z", "user"=>"mariamdeoz", "user_name"=>"Mariam Antoniles", "user_profile_image"=>"http://a0.twimg.com/profile_images/2571511518/3qUn98U2_normal"}
• {"id"=>"355040072053166080", "text"=>"RT @cgblanch1: Inabarcable ciencia: 75 estudios y 11 revisiones sistemáticas publicadas cada día http://t.co/4xG1zy75U3 hace 30 años eran 1…", "created_at"=>"2013-07-10T19:05:24Z", "user"=>"SergioMr88", "user_name"=>"Sergio Molina ", "user_profile_image"=>"http://a0.twimg.com/profile_images/2277629038/47vb3vvy0w73va5im0xc_normal.jpeg"}
• {"id"=>"355807331407241216", "text"=>"Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? @PLOSMedicine http://t.co/iy7LdzInkh", "created_at"=>"2013-07-12T21:54:13Z", "user"=>"CoyneoftheRealm", "user_name"=>"James C.Coyne", "user_profile_image"=>"http://a0.twimg.com/profile_images/1508296653/Paris_Au_Revoir_normal.JPG"}
• {"id"=>"361555250139774978", "text"=>"Do you know what I mean? http://t.co/XYKAXCOQHN No need for medic to feel ashamed.Read @iainchalmersTTi article http://t.co/qp6fGTYFRv", "created_at"=>"2013-07-28T18:34:23Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://a0.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"366888258824699906", "text"=>"Son 75 estudios clínicos y 11 revisiones sistemáticas diarias. Como mantenernos al día? http://t.co/nE0K2mAuwc", "created_at"=>"2013-08-12T11:45:52Z", "user"=>"saluduninorte", "user_name"=>"Salud Uninorte", "user_profile_image"=>"http://a0.twimg.com/profile_images/2490358664/fhtr1zyqm6kswmn15g9n_normal.jpeg"}
• {"id"=>"382135144213393408", "text"=>"Sir Ian Chalmers on keeping trials up to date: How will we ever keep up? At http://t.co/1lm3SpRuCU #CochraneQuebec @PLOSMedicine", "created_at"=>"2013-09-23T13:31:32Z", "user"=>"MargaretWinker", "user_name"=>"Margaret Winker", "user_profile_image"=>"http://a0.twimg.com/profile_images/2983052692/1b2a84d1eebafe82a7e439775128e8ef_normal.jpeg"}
• {"id"=>"382135628521308160", "text"=>"Sir Ian Chalmers on keeping reviews up to date: How will we ever keep up? At http://t.co/1lm3SpRuCU #CochraneQuebec @PLOSMedicine", "created_at"=>"2013-09-23T13:33:28Z", "user"=>"MargaretWinker", "user_name"=>"Margaret Winker", "user_profile_image"=>"http://a0.twimg.com/profile_images/2983052692/1b2a84d1eebafe82a7e439775128e8ef_normal.jpeg"}
• {"id"=>"382136329502724096", "text"=>"RT @MargaretWinker: Sir Ian Chalmers on keeping reviews up to date: How will we ever keep up? At http://t.co/1lm3SpRuCU #CochraneQuebec @PL…", "created_at"=>"2013-09-23T13:36:15Z", "user"=>"AlisonOMara", "user_name"=>"Alison O'Mara-Eves", "user_profile_image"=>"http://a0.twimg.com/profile_images/1365574366/website_image2_normal.jpg"}
• {"id"=>"382137028088827904", "text"=>"Article on keeping up with trials & systematic reviews @iainchalmersTTi talking about http://t.co/eGklEbfiIr #cochranequebec @PubMedHealth", "created_at"=>"2013-09-23T13:39:01Z", "user"=>"hildabast", "user_name"=>"Hilda Bastian", "user_profile_image"=>"http://a0.twimg.com/profile_images/1612898309/July_2011_Washington_DC_normal.png"}
• {"id"=>"382137224147791872", "text"=>"RT @hildabast: Article on keeping up with trials & systematic reviews @iainchalmersTTi talking about http://t.co/eGklEbfiIr #cochranequebec…", "created_at"=>"2013-09-23T13:39:48Z", "user"=>"Jo_KeeleIPCHS", "user_name"=>"Jo Jordan", "user_profile_image"=>"http://a0.twimg.com/profile_images/3666660629/3651fa8ff353042fee2dc658529d0712_normal.jpeg"}
• {"id"=>"382141257143042048", "text"=>"RT @hildabast: Article on keeping up with trials & systematic reviews @iainchalmersTTi talking about http://t.co/eGklEbfiIr #cochranequebec…", "created_at"=>"2013-09-23T13:55:50Z", "user"=>"TClifford71", "user_name"=>"Tammy Clifford", "user_profile_image"=>"http://a0.twimg.com/profile_images/3755129752/c94bde39c2de7e3ab7b90d9e3aa764ac_normal.jpeg"}
• {"id"=>"382161662595178496", "text"=>"RT @hildabast: Article on keeping up with trials & systematic reviews @iainchalmersTTi talking about http://t.co/eGklEbfiIr #cochranequebec…", "created_at"=>"2013-09-23T15:16:55Z", "user"=>"HugVai", "user_name"=>"Hugues Vaillancourt", "user_profile_image"=>"http://a0.twimg.com/profile_images/2386709048/image_normal.jpg"}
• {"id"=>"382190010994130944", "text"=>"RT @MargaretWinker: Sir Ian Chalmers on keeping reviews up to date: How will we ever keep up? At http://t.co/1lm3SpRuCU #CochraneQuebec @PL…", "created_at"=>"2013-09-23T17:09:34Z", "user"=>"drvalking", "user_name"=>"Valerie King", "user_profile_image"=>"http://a0.twimg.com/profile_images/2508774151/King_Val_800x714_122_3K_normal.jpg"}
• {"id"=>"382190500540723200", "text"=>"RT @hildabast: Article on keeping up with trials & systematic reviews @iainchalmersTTi talking about http://t.co/eGklEbfiIr #cochranequebec…", "created_at"=>"2013-09-23T17:11:30Z", "user"=>"drvalking", "user_name"=>"Valerie King", "user_profile_image"=>"http://a0.twimg.com/profile_images/2508774151/King_Val_800x714_122_3K_normal.jpg"}
• {"id"=>"390861059449290752", "text"=>"Systematic reviews in Therapeutic Evaluation: how far are we from Chochrane's objectives ? http://t.co/XAizUwbBna", "created_at"=>"2013-10-17T15:25:13Z", "user"=>"JusteRaimbault", "user_name"=>"Juste Raimbault", "user_profile_image"=>"http://a0.twimg.com/profile_images/2435810236/image_normal.jpg"}
• {"id"=>"397208240133402624", "text"=>"#PLOSMedicine: Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? http://t.co/2T5BmNsl7k", "created_at"=>"2013-11-04T03:46:38Z", "user"=>"hugotula", "user_name"=>"Hugo Tula", "user_profile_image"=>"http://pbs.twimg.com/profile_images/344513261580153176/7f26b0e729e29cd0194886ed4575c82d_normal.jpeg"}
• {"id"=>"397342622202998784", "text"=>"RT@HugoTula #PLOSMedicine: Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? http://t.co/jLno6AP6UQ", "created_at"=>"2013-11-04T12:40:38Z", "user"=>"TSC_OH", "user_name"=>"Anne Littlewood", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3054044064/645d389426d111dbfea34aa769044fec_normal.jpeg"}
• {"id"=>"411116858557734912", "text"=>"@parthaskar @WLancsGP No justification for changing practice based on one trial/paper. See @iainchalmersTTi article http://t.co/qp6fGTYFRv", "created_at"=>"2013-12-12T12:54:31Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"413852176104964096", "text"=>"Another barrier is the firehose prob of publications :75 Trials&11 Systematic Reviews a Day:How Will We Ever Keep Up?http://t.co/kMIqZEk6WP", "created_at"=>"2013-12-20T02:03:42Z", "user"=>"WePublicHealth", "user_name"=>"Ginny Barbour", "user_profile_image"=>"http://pbs.twimg.com/profile_images/412323247330304000/VZnCXv1-_normal.jpeg"}
• {"id"=>"431342760130387968", "text"=>"@HealthScoutBlog It's doubtful that generalist Dr's can actually do that due to the # and complexity of literature http://t.co/rk3B6XB6Jt", "created_at"=>"2014-02-06T08:25:02Z", "user"=>"Brent_Thoma", "user_name"=>"Brent Thoma", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000483681982/5592ee1bb6cc142bde4370709d0d6ce6_normal.jpeg"}
• {"id"=>"431404317544030208", "text"=>"RT @Brent_Thoma: @HealthScoutBlog It's doubtful that generalist Dr's can actually do that due to the # and complexity of literature http://…", "created_at"=>"2014-02-06T12:29:39Z", "user"=>"jvrbntz", "user_name"=>"Javier Benítez", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1907404713/image_normal.jpg"}
• {"id"=>"431406314925735936", "text"=>"RT @Brent_Thoma: @HealthScoutBlog It's doubtful that generalist Dr's can actually do that due to the # and complexity of literature http://…", "created_at"=>"2014-02-06T12:37:35Z", "user"=>"IVLINE", "user_name"=>"Aaron Sparshott", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000388006429/713828ef8a3e27db53edb093550fa62c_normal.jpeg"}
• {"id"=>"431425792464011264", "text"=>"RT @Brent_Thoma: @HealthScoutBlog It's doubtful that generalist Dr's can actually do that due to the # and complexity of literature http://…", "created_at"=>"2014-02-06T13:54:59Z", "user"=>"HealthScoutBlog", "user_name"=>"The Health Scout", "user_profile_image"=>"http://pbs.twimg.com/profile_images/419329884553351168/Wzdn2qq3_normal.jpeg"}
• {"id"=>"431426304248782849", "text"=>"RT @Brent_Thoma: @HealthScoutBlog It's doubtful that generalist Dr's can actually do that due to the # and complexity of literature http://…", "created_at"=>"2014-02-06T13:57:01Z", "user"=>"TheAngryElk", "user_name"=>"انجي/angyotensin", "user_profile_image"=>"http://pbs.twimg.com/profile_images/428045245763575808/OHmgKcaa_normal.jpeg"}
• {"id"=>"440500650258866176", "text"=>"@ChristosArgyrop There are 75 trials&11 sys reviews published every day. How will we cope? http://t.co/qp6fGTHCPv via @iainchalmersTTi", "created_at"=>"2014-03-03T14:55:13Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"456147622563045377", "text"=>"75 Trials & 11 Systematic Reviews a Day: How Will We Ever Keep Up? from @PLOSMedicine http://t.co/CW4EtDSBTT #WeNurses", "created_at"=>"2014-04-15T19:10:42Z", "user"=>"DGFoord", "user_name"=>"David Foord", "user_profile_image"=>"http://pbs.twimg.com/profile_images/423786771517026304/FZYmLj9b_normal.png"}
• {"id"=>"456147732478959616", "text"=>"RT @DGFoord: 75 Trials & 11 Systematic Reviews a Day: How Will We Ever Keep Up? from @PLOSMedicine http://t.co/CW4EtDSBTT #WeNurses", "created_at"=>"2014-04-15T19:11:08Z", "user"=>"WeNurses", "user_name"=>"WeNurses", "user_profile_image"=>"http://pbs.twimg.com/profile_images/434589034443067392/lhw7GNoH_normal.png"}
• {"id"=>"456147784739983361", "text"=>"RT @DGFoord: 75 Trials & 11 Systematic Reviews a Day: How Will We Ever Keep Up? from @PLOSMedicine http://t.co/CW4EtDSBTT #WeNurses", "created_at"=>"2014-04-15T19:11:21Z", "user"=>"MsNaughtyCheese", "user_name"=>"rebecca", "user_profile_image"=>"http://pbs.twimg.com/profile_images/437881344816054272/IdrOc36h_normal.jpeg"}
• {"id"=>"456147906857140224", "text"=>"RT @DGFoord: 75 Trials & 11 Systematic Reviews a Day: How Will We Ever Keep Up? from @PLOSMedicine http://t.co/CW4EtDSBTT #WeNurses", "created_at"=>"2014-04-15T19:11:50Z", "user"=>"AnnWilliams6", "user_name"=>"Angela Williams", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1912961244/1319307_xray_normal.jpg"}
• {"id"=>"456148129083977731", "text"=>"RT @DGFoord: 75 Trials & 11 Systematic Reviews a Day: How Will We Ever Keep Up? from @PLOSMedicine http://t.co/CW4EtDSBTT #WeNurses", "created_at"=>"2014-04-15T19:12:43Z", "user"=>"firecracker1305", "user_name"=>"Sian jackson", "user_profile_image"=>"http://pbs.twimg.com/profile_images/438387207221821441/w3IVNuJJ_normal.jpeg"}
• {"id"=>"456149359181062144", "text"=>"RT @DGFoord: 75 Trials & 11 Systematic Reviews a Day: How Will We Ever Keep Up? from @PLOSMedicine http://t.co/CW4EtDSBTT #WeNurses", "created_at"=>"2014-04-15T19:17:36Z", "user"=>"kpecky", "user_name"=>"kevin peck", "user_profile_image"=>"http://pbs.twimg.com/profile_images/417302361254936578/i5taR4zB_normal.png"}
• {"id"=>"456161354638823424", "text"=>"RT @DGFoord: 75 Trials & 11 Systematic Reviews a Day: How Will We Ever Keep Up? from @PLOSMedicine http://t.co/CW4EtDSBTT #WeNurses", "created_at"=>"2014-04-15T20:05:16Z", "user"=>"SUKBME", "user_name"=>"S I -29", "user_profile_image"=>"http://pbs.twimg.com/profile_images/440631067398373376/2aMQpIYD_normal.jpeg"}
• {"id"=>"479209714811953152", "text"=>"@amydlibrarian See also Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? \nhttp://t.co/ncLm7hRTjJ", "created_at"=>"2014-06-18T10:31:13Z", "user"=>"BrightonSx_LKS", "user_name"=>"Brighton Sx NHS LKS", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000123994851/7c23e2e37b0b7cdeb89a96b81b286a21_normal.gif"}
• {"id"=>"479211461861199872", "text"=>"RT @BrightonSx_LKS: @amydlibrarian See also Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? \nhttp://t.co…", "created_at"=>"2014-06-18T10:38:10Z", "user"=>"amydlibrarian", "user_name"=>"Amy Dunn", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2658727628/40208f1d551eba71d4aaf9d986882bbc_normal.jpeg"}
• {"id"=>"484617020747829248", "text"=>"Reminded of Bastian '75 Trials and 11 Systematic Reviews a Day: How Will We Ever Keep Up?' #hsrconf2014 #realebm http://t.co/fs4v7CnPEP", "created_at"=>"2014-07-03T08:37:56Z", "user"=>"berann", "user_name"=>"Anna Bergström", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000301090836/e72d99188611922d3b7491b0d9c3fa97_normal.jpeg"}
• {"id"=>"484620324622057472", "text"=>"RT @berann: Reminded of Bastian '75 Trials and 11 Systematic Reviews a Day: How Will We Ever Keep Up?' #hsrconf2014 #realebm http://t.co/fs…", "created_at"=>"2014-07-03T08:51:03Z", "user"=>"hsrconf", "user_name"=>"BMCHSRConference2014", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000410478834/5cc63d2803441055a87b19053e9d2351_normal.jpeg"}
• {"id"=>"484665753199976448", "text"=>"RT @berann: Reminded of Bastian '75 Trials and 11 Systematic Reviews a Day: How Will We Ever Keep Up?' #hsrconf2014 #realebm http://t.co/fs…", "created_at"=>"2014-07-03T11:51:34Z", "user"=>"trishgreenhalgh", "user_name"=>"Trisha Greenhalgh", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1749978296/TRISH_2010_cropped_normal.jpg"}
• {"id"=>"484682775858270208", "text"=>"RT @berann: Reminded of Bastian '75 Trials and 11 Systematic Reviews a Day: How Will We Ever Keep Up?' #hsrconf2014 #realebm http://t.co/fs…", "created_at"=>"2014-07-03T12:59:13Z", "user"=>"ruairidhm", "user_name"=>"Ruairidh Milne", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2674327498/b9078f29279cf3d93a8580dca11e1663_normal.jpeg"}
• {"id"=>"484683305271721984", "text"=>"RT @berann: Reminded of Bastian '75 Trials and 11 Systematic Reviews a Day: How Will We Ever Keep Up?' #hsrconf2014 #realebm http://t.co/fs…", "created_at"=>"2014-07-03T13:01:19Z", "user"=>"DrNo71", "user_name"=>"Dr No", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3663317991/ae9d11b93efaa7cd3b6caa5dd1c8a481_normal.jpeg"}
• {"id"=>"506570115375431680", "text"=>"RT @berann: Reminded of Bastian '75 Trials and 11 Systematic Reviews a Day: How Will We Ever Keep Up?' #hsrconf2014 #realebm http://t.co/fs…", "created_at"=>"2014-09-01T22:31:41Z", "user"=>"hildabast", "user_name"=>"Hilda Bastian", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1612898309/July_2011_Washington_DC_normal.png"}
• {"id"=>"506668668311601152", "text"=>"RT @berann: Reminded of Bastian '75 Trials and 11 Systematic Reviews a Day: How Will We Ever Keep Up?' #hsrconf2014 #realebm http://t.co/fs…", "created_at"=>"2014-09-02T05:03:18Z", "user"=>"mbmc_cmcm", "user_name"=>"Mont Behav Med Cent", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1369946520/smallheart_normal.jpg"}
• {"id"=>"506671687853940736", "text"=>"RT @berann: Reminded of Bastian '75 Trials and 11 Systematic Reviews a Day: How Will We Ever Keep Up?' #hsrconf2014 #realebm http://t.co/fs…", "created_at"=>"2014-09-02T05:15:18Z", "user"=>"sbacon20", "user_name"=>"Simon Bacon", "user_profile_image"=>"http://pbs.twimg.com/profile_images/478995647790456832/o1SrD2HT_normal.jpeg"}
• {"id"=>"520125071802003456", "text"=>"#PLOSMedicine: Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? http://t.co/Drq4bfJDB4", "created_at"=>"2014-10-09T08:14:15Z", "user"=>"DrSRPWilliams", "user_name"=>"Simon Williams", "user_profile_image"=>"http://pbs.twimg.com/profile_images/499227860045803520/UrkAm0s2_normal.jpeg"}
• {"id"=>"531515091699920897", "text"=>"@MHollander2628 @jimgthornton Don't go by just 1 article to come to conclusion. Read what Sir @iainchalmersTTi wrote http://t.co/Pfe5FK5jgI", "created_at"=>"2014-11-09T18:34:07Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"611792385014509569", "text"=>"@parthaskar @INESSS_Qc Also goes to prove u shud not rely on individ'l articles. Sir @iainchalmersTTi made it v clear http://t.co/cKPPQP0kWf", "created_at"=>"2015-06-19T07:07:25Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"615125934895726593", "text"=>"@VicPain1 @ketaminh @Robapark @brookmanknight @broomedocs @Fly_texan Why rely on 1 articl evid? @iainchalmersTTi Qs http://t.co/cKPPQOIK4H", "created_at"=>"2015-06-28T11:53:46Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"615126535872229376", "text"=>"RT @pash22: @VicPain1 @ketaminh @Robapark @brookmanknight @broomedocs @Fly_texan Why rely on 1 articl evid? @iainchalmersTTi Qs http://t.co…", "created_at"=>"2015-06-28T11:56:09Z", "user"=>"brookmanknight", "user_name"=>"Karen Price", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000838627700/57b1ca384abfc74843fa85e7b115b1b8_normal.jpeg"}
• {"id"=>"616946759240151040", "text"=>"@EJSMD @echungMD @drjohnm @cebmblog That's unwise IMO to base fundng decisns on single RCTs http://t.co/cKPPQOIK4H via Sir @iainchalmersTTi", "created_at"=>"2015-07-03T12:29:04Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"624138582953955329", "text"=>"@Hifistud @CaeruleanSea @markprigg @MailOnline See 75 Trials &11 Systematic Reviews a Day:How Will We Ever Keep Up? http://t.co/cKPPQOIK4H", "created_at"=>"2015-07-23T08:46:48Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"627485600711581696", "text"=>"@BCCCharles @Pharmed_Out @parthaskar Here is Sir @iainchalmersTTi 2010 article http://t.co/cKPPQOIK4H", "created_at"=>"2015-08-01T14:26:39Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"642530950556090368", "text"=>"@BCCCharles @trishgreenhalgh @kamleshkhunti Not convinced we shud go by results of 1 trial only. See @iainchalmersTTi http://t.co/cKPPQOIK4H", "created_at"=>"2015-09-12T02:51:30Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"650642142721929216", "text"=>"@docmdmartin @LJ_Ali1 Agree but it's not abt RCTs only. @iainchalmersTTi stresses imp of syst revs&meta-analyses http://t.co/cKPPQOIK4H", "created_at"=>"2015-10-04T12:02:29Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"657817325912109056", "text"=>"@Laconic_doc @carolinefiennes Yes indeed! @iainchalmersTTi @PaulGlasziou & @hildabast came to same conclusns in 2010\nhttps://t.co/cKPPQOIK4H", "created_at"=>"2015-10-24T07:14:06Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"658393062566051840", "text"=>"Automation badly needed when >75 trials and >11 systematic reviews are published every day in biomedicine alone. https://t.co/iVIxWBArv5", "created_at"=>"2015-10-25T21:21:53Z", "user"=>"lukeprog", "user_name"=>"Luke Muehlhauser", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1976032383/LukeFace_normal.png"}
• {"id"=>"662647931795849216", "text"=>"@SarahChapman30 One approach would be to search for articles citing this: https://t.co/3vuIYS6v6N", "created_at"=>"2015-11-06T15:09:13Z", "user"=>"tomroper", "user_name"=>"Tom Roper", "user_profile_image"=>"http://pbs.twimg.com/profile_images/646268640963207168/zLW_G3WN_normal.jpg"}
• {"id"=>"684989704123629568", "text"=>"@Borelmedwriter One swallow doesn't make a summer, one battle doesn't win a war! C @iainchalmersTTi & @PaulGlasziou https://t.co/cKPPQOIK4H", "created_at"=>"2016-01-07T06:47:26Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"715760693820190722", "text"=>"In ts context, no wonder keepng up w med evid=drinking from firehose @LindaRegber @hildabast https://t.co/u9l9ecvc7r https://t.co/7gzghAShuq", "created_at"=>"2016-04-01T04:40:22Z", "user"=>"eturnermd1", "user_name"=>"Erick Turner", "user_profile_image"=>"http://pbs.twimg.com/profile_images/667083632092143616/tYcc2zCO_normal.jpg"}
• {"id"=>"728344487332810756", "text"=>"@RogueRad @anishkoka @michelaccad C what Sir @iainchalmersTTi wrote https://t.co/cKPPQOIK4H", "created_at"=>"2016-05-05T22:03:52Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"731916798082359297", "text"=>"75 Trials & 11 Systematic Reviews a day: \nHow will we ever keep up? \nhttps://t.co/pZHXNvCXK0", "created_at"=>"2016-05-15T18:38:57Z", "user"=>"Damian_Roland", "user_name"=>"Damian Roland", "user_profile_image"=>"http://pbs.twimg.com/profile_images/655490444734803968/XtegEaYV_normal.png"}
• {"id"=>"731941056607059968", "text"=>"RT @Damian_Roland: 75 Trials & 11 Systematic Reviews a day: \nHow will we ever keep up? \nhttps://t.co/pZHXNvCXK0", "created_at"=>"2016-05-15T20:15:21Z", "user"=>"drpuppy1", "user_name"=>"Prabhakar", "user_profile_image"=>"http://pbs.twimg.com/profile_images/694485544823316483/KY_T0BFW_normal.jpg"}
• {"id"=>"732329633035718656", "text"=>"@anish_koka @RogueRad @VinayPrasad82 @JeanneLenzer1 @ShannonBrownlee Don't rely on 1 trial says Sir @iainchalmersTTi https://t.co/cKPPQOIK4H", "created_at"=>"2016-05-16T21:59:25Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"746199503804346368", "text"=>"No & neither is one study\nhttps://t.co/cKPPQP0kWf via @iainchalmersTTi @hildabast & @PaulGlasziou https://t.co/bkCvXWoseg", "created_at"=>"2016-06-24T04:33:20Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"780446187208015872", "text"=>"@adamcifu @MDaware 2010 Sir @iainchalmersTTi @PaulGlasziou & @hildabast wrote '75 Trials & 11 Syst Revs Daily ...' https://t.co/cKPPQOIK4H", "created_at"=>"2016-09-26T16:37:25Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"790193800471777280", "text"=>"@thebyrdlab @DrJohnCosgrove C Sir @iainchalmersTTi @hildabast & @PaulGlasziou articl on being wary of single studies https://t.co/cKPPQOIK4H", "created_at"=>"2016-10-23T14:10:57Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"797747645292941312", "text"=>"@parthaskar @GIMJClub Don't base ur clin mngtmnt on basis of single studies. C Sir @iainchalmersTTi https://t.co/cKPPQOIK4H", "created_at"=>"2016-11-13T10:27:14Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"798678472050679809", "text"=>"So much is published every day it can be a real challenge to keep up https://t.co/Ekg33U6xXC", "created_at"=>"2016-11-16T00:06:01Z", "user"=>"andrewjtagg", "user_name"=>"Andy Tagg", "user_profile_image"=>"http://pbs.twimg.com/profile_images/741705135768907776/TqafHo14_normal.jpg"}
• {"id"=>"803502487705702400", "text"=>"@docwas @vmontori Also, Sir @iainchalmersTTi pointed out that we shud not base clin decision-making on single trials https://t.co/cKPPQOIK4H", "created_at"=>"2016-11-29T07:34:56Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"809153795838115841", "text"=>"@benthebray @mellojonny @petbri @RichardLehman1 It's research vol which is overwhelming https://t.co/cKPPQOIK4H via @iainchalmersTTi", "created_at"=>"2016-12-14T21:51:12Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"809798451500371968", "text"=>"@alanfricker see https://t.co/7OrDe4Rlz8", "created_at"=>"2016-12-16T16:32:50Z", "user"=>"rapidreviews_i", "user_name"=>"Rapid Reviews Info", "user_profile_image"=>"http://pbs.twimg.com/profile_images/670614774636486656/VYCnuuk8_normal.png"}
• {"id"=>"816715879287320577", "text"=>"@DavidJohnsRD I know. Sir @iainchalmersTTi et al warned abt dangers of jumping to conclusions based on single trials https://t.co/cKPPQOIK4H", "created_at"=>"2017-01-04T18:40:14Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"840075065945276416", "text"=>"Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? - feeling stressed ? #IMSMelb17 https://t.co/bqRrIqA2Xt", "created_at"=>"2017-03-10T05:41:18Z", "user"=>"cancersolutions", "user_name"=>"matthew links", "user_profile_image"=>"http://pbs.twimg.com/profile_images/741784637/p023i029PictureA_normal.jpg"}
• {"id"=>"864114029379321857", "text"=>"Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up | PLOS https://t.co/uipe8RKfJf", "created_at"=>"2017-05-15T13:43:33Z", "user"=>"gbnayo", "user_name"=>"gnayowith", "user_profile_image"=>"http://pbs.twimg.com/profile_images/696735293836238848/rGgT3j1t_normal.jpg"}
• {"id"=>"866513868838895616", "text"=>"@BenMazer @pash22 Is that true?\n\nhttps://t.co/ZyiTr9ZaPf", "created_at"=>"2017-05-22T04:39:40Z", "user"=>"RSiemieniuk", "user_name"=>"ReedSiemieniuk.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/506638803319001088/szHrTJ_M_normal.jpeg"}
• {"id"=>"866514114868367360", "text"=>"RT @RSiemieniuk: @BenMazer @pash22 Is that true?\n\nhttps://t.co/ZyiTr9ZaPf", "created_at"=>"2017-05-22T04:40:38Z", "user"=>"pash22", "user_name"=>"Ash Paul", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3295856896/66ab958422d28c521d0143bddbb90233_normal.jpeg"}
• {"id"=>"876741083505479680", "text"=>"@angelamfevans Agree but even the higher quality research is overwhelming https://t.co/BOFN3Dtlao 2010 - 75 RCTs &… https://t.co/TUVCqO1EoM", "created_at"=>"2017-06-19T09:58:58Z", "user"=>"informpodiatry", "user_name"=>"Barry Matthews", "user_profile_image"=>"http://pbs.twimg.com/profile_images/701220381114236928/zzWXWDpm_normal.jpg"}
• {"id"=>"932126304832548866", "text"=>"#PLOSMedicine: Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? https://t.co/3nr3pBbVjN", "created_at"=>"2017-11-19T06:00:03Z", "user"=>"academia_kmu", "user_name"=>"Akhtar Sherin", "user_profile_image"=>"http://pbs.twimg.com/profile_images/721573102203904000/LiqDNn34_normal.jpg"}

Wikipedia | Further Information

• {"title"=>"Fallbericht (Medizin)", "url"=>"http://de.wikipedia.org/wiki/Fallbericht_(Medizin)", "timestamp"=>"2016-09-18T09:47:17Z"}

Wordpress.com | Further Information

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F1000Prime