Scaling Up Diarrhea Prevention and Treatment Interventions: A Lives Saved Tool Analysis
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Mendeley | Further Information

{"title"=>"Scaling up diarrhea prevention and treatment interventions: A lives saved tool analysis", "type"=>"journal", "authors"=>[{"first_name"=>"Christa L.Fischer", "last_name"=>"Walker", "scopus_author_id"=>"8966229800"}, {"first_name"=>"Ingrid K.", "last_name"=>"Friberg", "scopus_author_id"=>"6602123807"}, {"first_name"=>"Nancy", "last_name"=>"Binkin", "scopus_author_id"=>"7007018927"}, {"first_name"=>"Mark", "last_name"=>"Young", "scopus_author_id"=>"8514774900"}, {"first_name"=>"Neff", "last_name"=>"Walker", "scopus_author_id"=>"7201515530"}, {"first_name"=>"Olivier", "last_name"=>"Fontaine", "scopus_author_id"=>"55382768200"}, {"first_name"=>"Eva", "last_name"=>"Weissman", "scopus_author_id"=>"36351295100"}, {"first_name"=>"Akanksha", "last_name"=>"Gupta", "scopus_author_id"=>"56898364000"}, {"first_name"=>"Robert E.", "last_name"=>"Black", "scopus_author_id"=>"26541165000"}], "year"=>2011, "source"=>"PLoS Medicine", "identifiers"=>{"issn"=>"15491277", "scopus"=>"2-s2.0-79953694797", "pui"=>"361559651", "doi"=>"10.1371/journal.pmed.1000428", "isbn"=>"1549-1676 (Electronic)\\r1549-1277 (Linking)", "sgr"=>"79953694797", "pmid"=>"21445330"}, "id"=>"3728f9fd-6a0a-3315-b2ca-9a3346c978d5", "abstract"=>"Diarrhea remains a leading cause of mortality among young children in low- and middle-income countries. Although the evidence for individual diarrhea prevention and treatment interventions is solid, the effect a comprehensive scale-up effort would have on diarrhea mortality has not been estimated.", "link"=>"http://www.mendeley.com/research/scaling-up-diarrhea-prevention-treatment-interventions-lives-saved-tool-analysis", "reader_count"=>158, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>8, "Librarian"=>2, "Student > Doctoral Student"=>9, "Researcher"=>33, "Student > Ph. D. Student"=>22, "Student > Postgraduate"=>16, "Student > Master"=>43, "Other"=>2, "Student > Bachelor"=>10, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>3, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>8, "Librarian"=>2, "Student > Doctoral Student"=>9, "Researcher"=>33, "Student > Ph. D. Student"=>22, "Student > Postgraduate"=>16, "Student > Master"=>43, "Other"=>2, "Student > Bachelor"=>10, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>3, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Agricultural and Biological Sciences"=>20, "Arts and Humanities"=>3, "Business, Management and Accounting"=>4, "Computer Science"=>1, "Economics, Econometrics and Finance"=>4, "Engineering"=>7, "Environmental Science"=>10, "Nursing and Health Professions"=>8, "Biochemistry, Genetics and Molecular Biology"=>1, "Mathematics"=>1, "Medicine and Dentistry"=>62, "Sports and Recreations"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Physics and Astronomy"=>2, "Psychology"=>1, "Social Sciences"=>21, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>62}, "Social Sciences"=>{"Social Sciences"=>21}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Psychology"=>{"Psychology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>7}, "Environmental Science"=>{"Environmental Science"=>10}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Arts and Humanities"=>{"Arts and Humanities"=>3}, "Engineering"=>{"Engineering"=>7}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>20}, "Computer Science"=>{"Computer Science"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>4}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "United States"=>2, "South Africa"=>2, "United Kingdom"=>1, "France"=>1}, "group_count"=>9}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/789850"], "description"=>"<p>Number of child deaths averted in 2015 under the universal scale-up program\n for the 68 countries included in the analysis.</p>", "links"=>[], "tags"=>["deaths", "averted", "2015", "scale-up", "program", "68", "countries", "included"], "article_id"=>460208, "categories"=>["Immunology", "Engineering", "Cancer", "Medicine", "Computational Biology", "Information And Computing Sciences"], "users"=>["Christa L. Fischer Walker", "Ingrid K. Friberg", "Nancy Binkin", "Mark Young", "Neff Walker", "Olivier Fontaine", "Eva Weissman", "Akanksha Gupta", "Robert E. Black"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000428.g002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_child_deaths_averted_in_2015_under_the_universal_scale_up_program___for_the_68_countries_included_in_the_analysis_/460208", "title"=>"Number of child deaths averted in 2015 under the universal scale-up program\n for the 68 countries included in the analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-22 00:03:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/790030"], "description"=>"a<p>All interventions are applied to the 1–59 mo age group except ORS,\n which is applied to 0–59 mo and vitamin A, which is applied to\n 6–59 mo.</p>b<p>Applied to nondysentery diarrheal deaths assumed to be 95% of total\n diarrheal deaths.</p>c<p>Applied to dysentery diarrheal deaths assumed to be 5% of total\n diarrheal deaths.</p>d<p>Applied to rotavirus deaths assumed to be 39% of total diarrheal\n deaths.</p><p>RR, relative risk.</p>", "links"=>[], "tags"=>["rates", "scale-up", "plans", "for", "68"], "article_id"=>460386, "categories"=>["Immunology", "Engineering", "Cancer", "Medicine", "Computational Biology", "Information And Computing Sciences"], "users"=>["Christa L. Fischer Walker", "Ingrid K. Friberg", "Nancy Binkin", "Mark Young", "Neff Walker", "Olivier Fontaine", "Eva Weissman", "Akanksha Gupta", "Robert E. Black"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000428.t002", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Modeled_target_coverage_rates_by_intervention_for_two_scale_up_plans_for___the_68_priority_countries_/460386", "title"=>"Modeled target coverage rates by intervention for two scale-up plans for\n the 68 priority countries.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-03-22 00:06:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/789988"], "description"=>"a<p>Assumes maintaining 2010 coverage levels through 2015.</p>b<p>Interventions include vitamin A, rotavirus vaccine, and breastfeeding for\n prevention and ORS, zinc, and antibiotics for dysentery for treatment of\n diarrhea.</p>c<p>Interventions include hand-washing, improved sanitation, access to safe water,\n and home purification of water.</p><p>NA, not available.</p>", "links"=>[], "tags"=>["capita", "targeted", "rates", "the", "scale-up", "scenarios"], "article_id"=>460350, "categories"=>["Immunology", "Engineering", "Cancer", "Medicine", "Computational Biology", "Information And Computing Sciences"], "users"=>["Christa L. Fischer Walker", "Ingrid K. Friberg", "Nancy Binkin", "Mark Young", "Neff Walker", "Olivier Fontaine", "Eva Weissman", "Akanksha Gupta", "Robert E. Black"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000428.t003", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Additional_cost_per_capita_to_achieve_targeted_coverage_rates_for_the___ambitious_and_universal_scale_up_scenarios_by_2015_/460350", "title"=>"Additional cost per capita to achieve targeted coverage rates for the\n ambitious and universal scale-up scenarios by 2015.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-03-22 00:05:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/790074"], "description"=>"a<p>Data from JMP 2010.</p>b<p>Used piped water values from the JMP 2010 report.</p>c<p>Estimates based on work Curtis et al. <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000428#pmed.1000428-Curtis1\" target=\"_blank\">[31]</a>.</p>d<p>Most recent Demographic Health Survey (DHS)/Multiple Indicator Cluster\n Survey (MICS). Defined as percent of children with diarrhea in the past 2 wk\n who were treated with ORS or prepackaged ORS solutions.</p>e<p>Most recent DHS/MICS. Assumed to be the same as percent of children with\n symptoms suggestive of pneumonia treated with an antibiotic.</p>f<p>Most recent DHS/MICS. Defined as percent of children with diarrhea in the\n past 2 wk treated with zinc. If these data were not collected in the survey,\n 0 was the default value.</p>g<p>Estimates from WHO/UNICEF estimates of national immunization coverage <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000428#pmed.1000428-WHO3\" target=\"_blank\">[32]</a>.</p>h<p>UNICEF 2008 value or most recent. Countries listed as na are considered not\n to be Vitamin A deficient according to the Lancet Nutrition series and were\n excluded from the analysis.</p>", "links"=>[], "tags"=>["interventions", "except"], "article_id"=>460438, "categories"=>["Immunology", "Engineering", "Cancer", "Medicine", "Computational Biology", "Information And Computing Sciences"], "users"=>["Christa L. Fischer Walker", "Ingrid K. Friberg", "Nancy Binkin", "Mark Young", "Neff Walker", "Olivier Fontaine", "Eva Weissman", "Akanksha Gupta", "Robert E. Black"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000428.t001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_coverage_values_for_all_interventions_except___breastfeeding_/460438", "title"=>"Baseline coverage values for all interventions except\n breastfeeding.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-03-22 00:07:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/395085"], "description"=>"<div><h3>Background</h3><p>Diarrhea remains a leading cause of mortality among young children in low- and middle-income countries. Although the evidence for individual diarrhea prevention and treatment interventions is solid, the effect a comprehensive scale-up effort would have on diarrhea mortality has not been estimated.</p> <h3>Methods and Findings</h3><p>We use the Lives Saved Tool (<em>LiST</em>) to estimate the potential lives saved if two scale-up scenarios for key diarrhea interventions (oral rehydration salts [ORS], zinc, antibiotics for dysentery, rotavirus vaccine, vitamin A supplementation, basic water, sanitation, hygiene, and breastfeeding) were implemented in the 68 high child mortality countries. We also conduct a simple costing exercise to estimate cost per capita and total costs for each scale-up scenario. Under the ambitious (feasible improvement in coverage of all interventions) and universal (assumes near 100% coverage of all interventions) scale-up scenarios, we demonstrate that diarrhea mortality can be reduced by 78% and 92%, respectively. With universal coverage nearly 5 million diarrheal deaths could be averted during the 5-year scale-up period for an additional cost of US$12.5 billion invested across 68 priority countries for individual-level prevention and treatment interventions, and an additional US$84.8 billion would be required for the addition of all water and sanitation interventions.</p> <h3>Conclusion</h3><p>Using currently available interventions, we demonstrate that with improved coverage, diarrheal deaths can be drastically reduced. If delivery strategy bottlenecks can be overcome and the international community can collectively deliver on the key strategies outlined in these scenarios, we will be one step closer to achieving success for the United Nations' Millennium Development Goal 4 (MDG4) by 2015.</p> <h3></h3><p><em>Please see later in the article for the Editors' Summary</em></p> </div>", "links"=>[], "tags"=>["scaling", "diarrhea", "lives", "saved"], "article_id"=>138039, "categories"=>["Immunology", "Engineering", "Cancer", "Medicine", "Biological Sciences", "Information And Computing Sciences"], "users"=>["Christa L. Fischer Walker", "Ingrid K. Friberg", "Nancy Binkin", "Mark Young", "Neff Walker", "Olivier Fontaine", "Eva Weissman", "Akanksha Gupta", "Robert E. Black"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000428", "stats"=>{"downloads"=>1, "page_views"=>38, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Scaling_Up_Diarrhea_Prevention_and_Treatment_Interventions_A_Lives_Saved__Tool_Analysis/138039", "title"=>"Scaling Up Diarrhea Prevention and Treatment Interventions: A Lives Saved\n Tool Analysis", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-03-22 02:13:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/789765"], "description"=>"<p>Trends in number and proportion of diarrheal deaths, under ambitious and\n universal scale-up plans.</p>", "links"=>[], "tags"=>["diarrheal", "and", "scale-up"], "article_id"=>460126, "categories"=>["Immunology", "Engineering", "Cancer", "Medicine", "Computational Biology", "Information And Computing Sciences"], "users"=>["Christa L. Fischer Walker", "Ingrid K. Friberg", "Nancy Binkin", "Mark Young", "Neff Walker", "Olivier Fontaine", "Eva Weissman", "Akanksha Gupta", "Robert E. Black"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000428.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Trends_in_number_and_proportion_of_diarrheal_deaths_under_ambitious_and___universal_scale_up_plans_/460126", "title"=>"Trends in number and proportion of diarrheal deaths, under ambitious and\n universal scale-up plans.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-22 00:02:06"}

PMC Usage Stats | Further Information

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Relative Metric

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