Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias
- Publication Date
- February 21, 2012
- Journal
- PLOS Medicine
- Authors
- Robert Clarke, Derrick A. Bennett, Sarah Parish, Petra Verhoef, et al
- Volume
- 9
- Issue
- 2
- Pages
- e1001177
- DOI
- https://dx.plos.org/10.1371/journal.pmed.1001177
- Publisher URL
- http://journals.plos.org/plosmedicine/article?id=10.1371%2Fjournal.pmed.1001177
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/22363213
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283559
- Europe PMC
- http://europepmc.org/abstract/MED/22363213
- Web of Science
- 000301222600009
- Scopus
- 84857711683
- Mendeley
- http://www.mendeley.com/research/homocysteine-coronary-heart-disease-metaanalysis-mthfr-casecontrol-studies-avoiding-publication-bias
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Mendeley | Further Information
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When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so \"Mendelian randomization\" studies using this variant as an instrumental variable could help test causality.\\n\\nMETHODS AND FINDINGS: Nineteen unpublished datasets were obtained (total 48,175 CHD cases and 67,961 controls) in which multiple genetic variants had been measured, including MTHFR C677T. These datasets did not include measurements of blood homocysteine, but homocysteine levels would be expected to be about 20% higher with TT than with CC genotype in the populations studied. In meta-analyses of these unpublished datasets, the case-control CHD odds ratio (OR) and 95% CI comparing TT versus CC homozygotes was 1.02 (0.98-1.07; p = 0.28) overall, and 1.01 (0.95-1.07) in unsupplemented low-folate populations. By contrast, in a slightly updated meta-analysis of the 86 published studies (28,617 CHD cases and 41,857 controls), the OR was 1.15 (1.09-1.21), significantly discrepant (p = 0.001) with the OR in the unpublished datasets. Within the meta-analysis of published studies, the OR was 1.12 (1.04-1.21) in the 14 larger studies (those with variance of log OR<0.05; total 13,119 cases) and 1.18 (1.09-1.28) in the 72 smaller ones (total 15,498 cases).\\n\\nCONCLUSIONS: The CI for the overall result from large unpublished datasets shows lifelong moderate homocysteine elevation has little or no effect on CHD. The discrepant overall result from previously published studies reflects publication bias or methodological problems.", "link"=>"http://www.mendeley.com/research/homocysteine-coronary-heart-disease-metaanalysis-mthfr-casecontrol-studies-avoiding-publication-bias", "reader_count"=>112, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>7, "Librarian"=>3, "Researcher"=>24, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>8, "Student > Master"=>19, "Other"=>5, "Student > Bachelor"=>13, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>3, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>7, "Librarian"=>3, "Researcher"=>24, "Student > Doctoral Student"=>2, "Student > Ph. D. 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Scopus | Further Information
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- {"month"=>"3", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"122"}
- {"month"=>"4", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"158"}
- {"month"=>"5", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"119"}
- {"month"=>"6", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"104"}
- {"month"=>"7", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"89"}
- {"month"=>"8", "year"=>"2016", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"83"}
- {"month"=>"9", "year"=>"2016", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"116"}
- {"month"=>"10", "year"=>"2016", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"181"}
- {"month"=>"11", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"133"}
- {"month"=>"12", "year"=>"2016", "pdf_views"=>"54", "xml_views"=>"1", "html_views"=>"98"}
- {"month"=>"1", "year"=>"2017", "pdf_views"=>"97", "xml_views"=>"1", "html_views"=>"93"}
- {"month"=>"2", "year"=>"2017", "pdf_views"=>"48", "xml_views"=>"1", "html_views"=>"176"}
- {"month"=>"3", "year"=>"2017", "pdf_views"=>"27", "xml_views"=>"1", "html_views"=>"171"}
- {"month"=>"4", "year"=>"2017", "pdf_views"=>"25", "xml_views"=>"2", "html_views"=>"160"}
- {"month"=>"5", "year"=>"2017", "pdf_views"=>"29", "xml_views"=>"4", "html_views"=>"101"}
- {"month"=>"6", "year"=>"2017", "pdf_views"=>"35", "xml_views"=>"3", "html_views"=>"178"}
- {"month"=>"7", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"85"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"110"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"87"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"142"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"127"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"82"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"81"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"117"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"27", "xml_views"=>"1", "html_views"=>"53"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"2", "html_views"=>"64"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"89"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"53", "xml_views"=>"6", "html_views"=>"91"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"5", "html_views"=>"58"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"38"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"44"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"70"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"75"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"34"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"3", "html_views"=>"43"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"43"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"4", "html_views"=>"58"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"49"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"83"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"33", "xml_views"=>"4", "html_views"=>"95"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"80"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"31", "xml_views"=>"2", "html_views"=>"72"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"54"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"44"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"76"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"3", "html_views"=>"54"}
- {"month"=>"1", "year"=>"2020", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"49"}
- {"month"=>"2", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"54"}
- {"month"=>"3", "year"=>"2020", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"53"}
- {"month"=>"4", "year"=>"2020", "pdf_views"=>"58", "xml_views"=>"0", "html_views"=>"43"}
- {"month"=>"5", "year"=>"2020", "pdf_views"=>"75", "xml_views"=>"0", "html_views"=>"42"}
- {"month"=>"6", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"38"}
- {"month"=>"7", "year"=>"2020", "pdf_views"=>"22", "xml_views"=>"2", "html_views"=>"47"}
- {"month"=>"8", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"3", "html_views"=>"40"}
- {"month"=>"9", "year"=>"2020", "pdf_views"=>"24", "xml_views"=>"4", "html_views"=>"37"}
- {"month"=>"10", "year"=>"2020", "pdf_views"=>"40", "xml_views"=>"1", "html_views"=>"45"}
- {"month"=>"11", "year"=>"2020", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"41"}
- {"month"=>"12", "year"=>"2020", "pdf_views"=>"27", "xml_views"=>"5", "html_views"=>"29"}
- {"month"=>"1", "year"=>"2021", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"21"}
PMC Usage Stats | Further Information
- {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"133", "unique-ip"=>"128", "pdf"=>"75", "year"=>"2012", "figure"=>"28", "scanned-summary"=>"0", "supp-data"=>"1"}
- {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"114", "year"=>"2012", "pdf"=>"88", "unique-ip"=>"112", "figure"=>"25", "scanned-summary"=>"0", "supp-data"=>"12"}
- {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"80", "unique-ip"=>"80", "pdf"=>"48", "year"=>"2012", "figure"=>"17", "scanned-summary"=>"0", "supp-data"=>"2"}
- {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"105", "year"=>"2012", "pdf"=>"65", "unique-ip"=>"96", "figure"=>"18", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"unique-ip"=>"71", "full-text"=>"75", "pdf"=>"53", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
- {"unique-ip"=>"68", "full-text"=>"72", "pdf"=>"58", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2012", "month"=>"8"}
- {"unique-ip"=>"52", "full-text"=>"60", "pdf"=>"36", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2012", "month"=>"9"}
- {"unique-ip"=>"86", "full-text"=>"85", "pdf"=>"56", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"1", "cited-by"=>"3", "year"=>"2012", "month"=>"10"}
- {"unique-ip"=>"47", "full-text"=>"53", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2012", "month"=>"12"}
- {"unique-ip"=>"60", "full-text"=>"86", "pdf"=>"30", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
- {"unique-ip"=>"58", "full-text"=>"68", "pdf"=>"30", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
- {"unique-ip"=>"59", "full-text"=>"65", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
- {"unique-ip"=>"43", "full-text"=>"52", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2013", "month"=>"4"}
- {"unique-ip"=>"73", "full-text"=>"100", "pdf"=>"39", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"2", "year"=>"2012", "month"=>"11"}
- {"unique-ip"=>"45", "full-text"=>"44", "pdf"=>"17", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
- {"unique-ip"=>"32", "full-text"=>"34", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
- {"unique-ip"=>"26", "full-text"=>"41", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
- {"unique-ip"=>"43", "full-text"=>"54", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2013", "month"=>"8"}
- {"unique-ip"=>"29", "full-text"=>"38", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
- {"unique-ip"=>"45", "full-text"=>"31", "pdf"=>"42", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
- {"unique-ip"=>"45", "full-text"=>"43", "pdf"=>"17", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2013", "month"=>"11"}
- {"unique-ip"=>"31", "full-text"=>"32", "pdf"=>"23", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
- {"unique-ip"=>"48", "full-text"=>"60", "pdf"=>"36", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
- {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
- {"unique-ip"=>"32", "full-text"=>"32", "pdf"=>"16", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
- {"unique-ip"=>"45", "full-text"=>"35", "pdf"=>"41", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
- {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
- {"unique-ip"=>"37", "full-text"=>"32", "pdf"=>"22", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
- {"unique-ip"=>"27", "full-text"=>"19", "pdf"=>"16", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
- {"unique-ip"=>"36", "full-text"=>"22", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2014", "month"=>"8"}
- {"unique-ip"=>"32", "full-text"=>"24", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
- {"unique-ip"=>"37", "full-text"=>"32", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
- {"unique-ip"=>"27", "full-text"=>"20", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
- {"unique-ip"=>"27", "full-text"=>"27", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"6", "cited-by"=>"1", "year"=>"2014", "month"=>"12"}
- {"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
- {"unique-ip"=>"28", "full-text"=>"30", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
- {"unique-ip"=>"38", "full-text"=>"52", "pdf"=>"33", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"22", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
- {"unique-ip"=>"35", "full-text"=>"31", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2015", "month"=>"4"}
- {"unique-ip"=>"33", "full-text"=>"35", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
- {"unique-ip"=>"29", "full-text"=>"30", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
- {"unique-ip"=>"58", "full-text"=>"65", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
- {"unique-ip"=>"48", "full-text"=>"48", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
- {"unique-ip"=>"36", "full-text"=>"34", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
- {"unique-ip"=>"52", "full-text"=>"56", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
- {"unique-ip"=>"38", "full-text"=>"36", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
- {"unique-ip"=>"46", "full-text"=>"46", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
- {"unique-ip"=>"41", "full-text"=>"42", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
- {"unique-ip"=>"39", "full-text"=>"40", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
- {"unique-ip"=>"53", "full-text"=>"61", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
- {"unique-ip"=>"57", "full-text"=>"66", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"7", "cited-by"=>"2", "year"=>"2016", "month"=>"4"}
- {"unique-ip"=>"39", "full-text"=>"40", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
- {"unique-ip"=>"28", "full-text"=>"26", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"6"}
- {"unique-ip"=>"33", "full-text"=>"39", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2016", "month"=>"7"}
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Relative Metric
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