Whole Blood Gene Expression Profiles to Assess Pathogenesis and Disease Severity in Infants with Respiratory Syncytial Virus Infection
- Publication Date
- November 12, 2013
- Journal
- PLOS Medicine
- Authors
- Asuncion Mejias, Blerta Dimo, Nicolas M. Suarez, Carla Garcia, et al
- Volume
- 10
- Issue
- 11
- Pages
- e1001549
- DOI
- https://dx.plos.org/10.1371/journal.pmed.1001549
- Publisher URL
- http://journals.plos.org/plosmedicine/article?id=10.1371%2Fjournal.pmed.1001549
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/24265599
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825655
- Europe PMC
- http://europepmc.org/abstract/MED/24265599
- Web of Science
- 000330371600006
- Scopus
- 84888990746
- Mendeley
- http://www.mendeley.com/research/whole-blood-gene-expression-profiles-assess-pathogenesis-disease-severity-infants-respiratory-syncyt-2
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Mendeley | Further Information
{"title"=>"Whole Blood Gene Expression Profiles to Assess Pathogenesis and Disease Severity in Infants with Respiratory Syncytial Virus Infection", "type"=>"journal", "authors"=>[{"first_name"=>"Asuncion", "last_name"=>"Mejias", "scopus_author_id"=>"8533427800"}, {"first_name"=>"Blerta", "last_name"=>"Dimo", "scopus_author_id"=>"36015128000"}, {"first_name"=>"Nicolas M.", "last_name"=>"Suarez", "scopus_author_id"=>"7003499062"}, {"first_name"=>"Carla", "last_name"=>"Garcia", "scopus_author_id"=>"37033850700"}, {"first_name"=>"M. Carmen", "last_name"=>"Suarez-Arrabal", "scopus_author_id"=>"55648565700"}, {"first_name"=>"Tuomas", "last_name"=>"Jartti", "scopus_author_id"=>"6603865579"}, {"first_name"=>"Derek", "last_name"=>"Blankenship", "scopus_author_id"=>"23007592400"}, {"first_name"=>"Alejandro", "last_name"=>"Jordan-Villegas", "scopus_author_id"=>"15727774900"}, {"first_name"=>"Monica I.", "last_name"=>"Ardura", "scopus_author_id"=>"20733525300"}, {"first_name"=>"Zhaohui", "last_name"=>"Xu", "scopus_author_id"=>"55547136146"}, {"first_name"=>"Jacques", "last_name"=>"Banchereau", "scopus_author_id"=>"7103212992"}, {"first_name"=>"Damien", "last_name"=>"Chaussabel", "scopus_author_id"=>"6602320002"}, {"first_name"=>"Octavio", "last_name"=>"Ramilo", "scopus_author_id"=>"7003527418"}], "year"=>2013, "source"=>"PLoS Medicine", "identifiers"=>{"issn"=>"15491277", "scopus"=>"2-s2.0-84888990746", "sgr"=>"84888990746", "pui"=>"370401976", "isbn"=>"1549-1676 (Electronic)\\r1549-1277 (Linking)", "pmid"=>"24265599", "doi"=>"10.1371/journal.pmed.1001549"}, "id"=>"21950c02-52c0-34cc-b364-8ad2a73c130c", "abstract"=>"BACKGROUND: Respiratory syncytial virus (RSV) is the leading cause of viral lower respiratory tract infection (LRTI) and hospitalization in infants. Mostly because of the incomplete understanding of the disease pathogenesis, there is no licensed vaccine, and treatment remains symptomatic. We analyzed whole blood transcriptional profiles to characterize the global host immune response to acute RSV LRTI in infants, to characterize its specificity compared with influenza and human rhinovirus (HRV) LRTI, and to identify biomarkers that can objectively assess RSV disease severity. METHODS AND FINDINGS: This was a prospective observational study over six respiratory seasons including a cohort of infants hospitalized with RSV (n = 135), HRV (n = 30), and influenza (n = 16) LRTI, and healthy age- and sex-matched controls (n = 39). A specific RSV transcriptional profile was identified in whole blood (training cohort, n = 45 infants; Dallas, Texas, US) and validated in three different cohorts (test cohort, n = 46, Dallas, Texas, US; validation cohort A, n = 16, Turku, Finland; validation cohort B, n = 28, Columbus, Ohio, US) with high sensitivity (94% [95% CI 87%-98%]) and specificity (98% [95% CI 88%-99%]). It classified infants with RSV LRTI versus HRV or influenza LRTI with 95% accuracy. The immune dysregulation induced by RSV (overexpression of neutrophil, inflammation, and interferon genes, and suppression of T and B cell genes) persisted beyond the acute disease, and immune dysregulation was greatly impaired in younger infants (<6 mo). We identified a genomic score that significantly correlated with outcomes of care including a clinical disease severity score and, more importantly, length of hospitalization and duration of supplemental O2. CONCLUSIONS: Blood RNA profiles of infants with RSV LRTI allow specific diagnosis, better understanding of disease pathogenesis, and assessment of disease severity. This study opens new avenues for biomarker discovery and identification of potential therapeutic or preventive targets, and demonstrates that large microarray datasets can be translated into a biologically meaningful context and applied to the clinical setting. Please see later in the article for the Editors' Summary.", "link"=>"http://www.mendeley.com/research/whole-blood-gene-expression-profiles-assess-pathogenesis-disease-severity-infants-respiratory-syncyt-2", "reader_count"=>60, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Librarian"=>1, "Researcher"=>18, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>4, "Other"=>4, "Student > Master"=>6, "Student > Bachelor"=>5, "Professor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Librarian"=>1, "Researcher"=>18, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>4, "Other"=>4, "Student > Master"=>6, "Student > Bachelor"=>5, "Professor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Mathematics"=>1, "Medicine and Dentistry"=>25, "Agricultural and Biological Sciences"=>18, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Business, Management and Accounting"=>1, "Chemistry"=>2, "Computer Science"=>3, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>25}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>18}, "Computer Science"=>{"Computer Science"=>3}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Canada"=>3, "Netherlands"=>1, "United States"=>1, "Qatar"=>1, "Taiwan"=>1, "Brazil"=>1, "Kenya"=>1, "India"=>1, "Spain"=>1}, "group_count"=>6}CrossRef
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Scopus | Further Information
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- {"id"=>"400664165401899008", "text"=>"Can we use genetic analysis to predict which infants will have chronic problems from RSV infection? #PLOSMedicine: http://t.co/XSajra9s93", "created_at"=>"2013-11-13T16:39:15Z", "user"=>"ZacharyHoy", "user_name"=>"Zachary Hoy, MD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3356182288/5b9d7f1712f27d2512d01b7c20281dc3_normal.jpeg"}
- {"id"=>"400665372204232705", "text"=>"Fascinating work from @PIDSociety member Octavio Ramilo MT @ZacharyHoy: genetic analysis predicts problems from RSV? http://t.co/AWih9DytHR", "created_at"=>"2013-11-13T16:44:03Z", "user"=>"IDDocHymes", "user_name"=>"Saul Hymes, MD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1696871361/headshot_normal.jpg"}
- {"id"=>"400666400038993920", "text"=>"Gene expression profiling might provide strategy for triaging patients w/ respiratory syncytial virus infections http://t.co/SH71NJWPRL", "created_at"=>"2013-11-13T16:48:08Z", "user"=>"PLOSMedicine", "user_name"=>"PLOS Medicine", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2436335697/k93oob5au2gllc775hk5_normal.jpeg"}
- {"id"=>"402127585615699968", "text"=>"Genomic signature of RSV infection in children delineated #digitalhealth #digitalmedicine #genomics #PLOSMedicine http://t.co/mvhnSPYimG", "created_at"=>"2013-11-17T17:34:22Z", "user"=>"arharper17", "user_name"=>"Andrew Harper", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000435987810/944927b100ef7cd196c45617b4cda920_normal.jpeg"}
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- {"month"=>"1", "year"=>"2017", "pdf_views"=>"40", "xml_views"=>"0", "html_views"=>"70"}
- {"month"=>"2", "year"=>"2017", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"81"}
- {"month"=>"3", "year"=>"2017", "pdf_views"=>"42", "xml_views"=>"1", "html_views"=>"110"}
- {"month"=>"4", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"79"}
- {"month"=>"5", "year"=>"2017", "pdf_views"=>"32", "xml_views"=>"1", "html_views"=>"144"}
- {"month"=>"6", "year"=>"2017", "pdf_views"=>"30", "xml_views"=>"2", "html_views"=>"105"}
- {"month"=>"7", "year"=>"2017", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"71"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"73"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"67"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"51", "xml_views"=>"3", "html_views"=>"89"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"83"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"75"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"58"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"60"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"26"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"29"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"36"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"4", "html_views"=>"28"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"5", "html_views"=>"36"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"48"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"61", "xml_views"=>"1", "html_views"=>"35"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"46"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"29"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"29"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"36"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"37"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"34"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"26"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"49"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"44"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"43"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"23"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"23"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"36"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"46"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
PMC Usage Stats | Further Information
- {"unique-ip"=>"37", "full-text"=>"41", "pdf"=>"33", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
- {"unique-ip"=>"112", "full-text"=>"113", "pdf"=>"75", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"70", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
- {"unique-ip"=>"67", "full-text"=>"70", "pdf"=>"44", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"41", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
- {"unique-ip"=>"47", "full-text"=>"45", "pdf"=>"23", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
- {"unique-ip"=>"48", "full-text"=>"51", "pdf"=>"25", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"34", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
- {"unique-ip"=>"42", "full-text"=>"42", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
- {"unique-ip"=>"52", "full-text"=>"56", "pdf"=>"31", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
- {"unique-ip"=>"56", "full-text"=>"54", "pdf"=>"35", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"39", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
- {"unique-ip"=>"40", "full-text"=>"37", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2014", "month"=>"7"}
- {"unique-ip"=>"33", "full-text"=>"52", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"22", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2014", "month"=>"8"}
- {"unique-ip"=>"31", "full-text"=>"26", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
- {"unique-ip"=>"41", "full-text"=>"33", "pdf"=>"11", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"27", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
- {"unique-ip"=>"23", "full-text"=>"20", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
- {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
- {"unique-ip"=>"27", "full-text"=>"33", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
- {"unique-ip"=>"30", "full-text"=>"28", "pdf"=>"45", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
- {"unique-ip"=>"45", "full-text"=>"45", "pdf"=>"30", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
- {"unique-ip"=>"31", "full-text"=>"34", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
- {"unique-ip"=>"38", "full-text"=>"42", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2015", "month"=>"5"}
- {"unique-ip"=>"26", "full-text"=>"25", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
- {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
- {"unique-ip"=>"32", "full-text"=>"33", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
- {"unique-ip"=>"27", "full-text"=>"34", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"5", "cited-by"=>"1", "year"=>"2015", "month"=>"9"}
- {"unique-ip"=>"38", "full-text"=>"36", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
- {"unique-ip"=>"37", "full-text"=>"32", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
- {"unique-ip"=>"33", "full-text"=>"23", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
- {"unique-ip"=>"31", "full-text"=>"41", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"7", "cited-by"=>"1", "year"=>"2016", "month"=>"1"}
- {"unique-ip"=>"23", "full-text"=>"27", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
- {"unique-ip"=>"22", "full-text"=>"18", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
- {"unique-ip"=>"27", "full-text"=>"25", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
- {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
- {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
- {"unique-ip"=>"30", "full-text"=>"21", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
- {"unique-ip"=>"28", "full-text"=>"34", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
- {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
- {"unique-ip"=>"26", "full-text"=>"27", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
- {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
- {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
- {"unique-ip"=>"28", "full-text"=>"22", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
- {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
- {"unique-ip"=>"21", "full-text"=>"25", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
- {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
- {"unique-ip"=>"22", "full-text"=>"27", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
- {"unique-ip"=>"21", "full-text"=>"19", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
- {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
- {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"34", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
- {"unique-ip"=>"27", "full-text"=>"29", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"22", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
- {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
- {"unique-ip"=>"14", "full-text"=>"19", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
- {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
- {"unique-ip"=>"24", "full-text"=>"29", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
- {"unique-ip"=>"23", "full-text"=>"19", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
- {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
- {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
- {"unique-ip"=>"22", "full-text"=>"16", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
- {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
- {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
- {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
- {"unique-ip"=>"21", "full-text"=>"9", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
- {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
- {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
- {"unique-ip"=>"15", "full-text"=>"20", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"12"}
- {"unique-ip"=>"20", "full-text"=>"24", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
- {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
- {"unique-ip"=>"18", "full-text"=>"26", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
- {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
- {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
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Relative Metric
{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[238, 424, 545, 650, 749, 839, 926, 1006, 1090, 1167, 1243, 1316, 1380]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[262, 463, 587, 693, 790, 882, 965, 1051, 1135, 1218, 1300, 1376, 1438]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[258, 449, 572, 679, 775, 866, 956, 1041, 1124, 1211, 1291, 1371, 1437]}, {"subject_area"=>"/People and places", "average_usage"=>[270, 456, 573, 676, 773, 867, 955, 1037, 1120, 1205, 1286, 1363, 1436]}]}Loading … 

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