The Vast and Varied Global Burden of Norovirus: Prospects for Prevention and Control
- Publication Date
- April 26, 2016
- Journal
- PLOS Medicine
- Authors
- Benjamin A. Lopman, Duncan Steele, Carl D. Kirkwood & Umesh D. Parashar
- Volume
- 13
- Issue
- 4
- Pages
- e1001999
- DOI
- https://dx.plos.org/10.1371/journal.pmed.1001999
- Publisher URL
- http://journals.plos.org/plosmedicine/article?id=10.1371%2Fjournal.pmed.1001999
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/27115709
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846155
- Europe PMC
- http://europepmc.org/abstract/MED/27115709
- Scopus
- 84964725770
- Mendeley
- http://www.mendeley.com/research/vast-varied-global-burden-norovirus-prospects-prevention-control
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Mendeley | Further Information
{"title"=>"The Vast and Varied Global Burden of Norovirus: Prospects for Prevention and Control", "type"=>"generic", "authors"=>[{"first_name"=>"Benjamin A.", "last_name"=>"Lopman", "scopus_author_id"=>"6701349763"}, {"first_name"=>"Duncan", "last_name"=>"Steele", "scopus_author_id"=>"7102383229"}, {"first_name"=>"Carl D.", "last_name"=>"Kirkwood", "scopus_author_id"=>"7005904534"}, {"first_name"=>"Umesh D.", "last_name"=>"Parashar", "scopus_author_id"=>"7006315208"}], "year"=>2016, "source"=>"PLoS Medicine", "identifiers"=>{"scopus"=>"2-s2.0-84964725770", "sgr"=>"84964725770", "doi"=>"10.1371/journal.pmed.1001999", "pui"=>"610202040", "pmid"=>"27115709", "isbn"=>"10.1371/journal.pmed.1001999", "issn"=>"15491676"}, "id"=>"f3839aec-5b22-354c-b76b-94a473997219", "abstract"=>"Globally, norovirus is associated with approximately one-fifth of all diarrhea cases, with similar prevalence in both children and adults, and is estimated to cause over 200,000 deaths annually in developing countries. Norovirus is an important pathogen in a number of high-priority domains: it is themost common cause of diarrheal episodes globally, the principal cause of foodborne disease outbreaks in the United States, a key health care–acquired infection, a common cause of travel-associated diarrhea, and a bane for deployedmilitary troops. Partly as a result of this ubiquity and burden across a range of different populations, identifying target groups and strategies for intervention has been challenging. And, on top of the breadth of this public health problem, there remain impor- tant gaps in scientific knowledge regarding norovirus, especially with respect to disease in low-income settings. Many pathogens can cause acute gastroenteritis. Historically, rotavirus was the most common cause of severe disease in young children globally. Now, vaccines are available for rotavirus and are universally recommended by theWorld Health Organization. In countries with effective rotavirus vaccination programs, disease due to that pathogen has decreased markedly, but norovirus persists and is now themost common cause of pediatric gastroenteritis requiring medical attention. However, the data supporting the precise role of norovirus in low- andmiddle-income settings are sparse.With vaccines in the pipeline, addressing these and other important knowledge gaps is increasingly pressing. We assembled an expert group to assess the evidence for the global burden of norovirus and to consider the prospects for norovirus vaccine development. The group assessed the evidence in the areas of burden of disease, epidemiology, diagnostics, disease attribution, acquired immunity, and innate susceptibility, and the group considered how to bring norovi- rus vaccines from their current state of development to a viable product that will benefit global health.", "link"=>"http://www.mendeley.com/research/vast-varied-global-burden-norovirus-prospects-prevention-control", "reader_count"=>101, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>1, "Researcher"=>19, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>5, "Other"=>4, "Student > Master"=>23, "Student > Bachelor"=>16, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>1, "Researcher"=>19, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>5, "Other"=>4, "Student > Master"=>23, "Student > Bachelor"=>16, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Agricultural and Biological Sciences"=>28, "Arts and Humanities"=>1, "Business, Management and Accounting"=>1, "Veterinary Science and Veterinary Medicine"=>4, "Economics, Econometrics and Finance"=>2, "Engineering"=>5, "Environmental Science"=>5, "Biochemistry, Genetics and Molecular Biology"=>8, "Nursing and Health Professions"=>3, "Mathematics"=>1, "Medicine and Dentistry"=>19, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>2, "Social Sciences"=>3, "Immunology and Microbiology"=>11}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>19}, "Social Sciences"=>{"Social Sciences"=>3}, "Psychology"=>{"Psychology"=>2}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>7}, "Environmental Science"=>{"Environmental Science"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>5}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>11}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>28}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>4}}, "reader_count_by_country"=>{"Bangladesh"=>2, "Brazil"=>1, "United Kingdom"=>1}, "group_count"=>8}CrossRef
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Counter
- {"month"=>"4", "year"=>"2016", "pdf_views"=>"99", "xml_views"=>"0", "html_views"=>"853"}
- {"month"=>"5", "year"=>"2016", "pdf_views"=>"207", "xml_views"=>"0", "html_views"=>"1893"}
- {"month"=>"6", "year"=>"2016", "pdf_views"=>"79", "xml_views"=>"0", "html_views"=>"741"}
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- {"month"=>"12", "year"=>"2016", "pdf_views"=>"65", "xml_views"=>"3", "html_views"=>"315"}
- {"month"=>"1", "year"=>"2017", "pdf_views"=>"69", "xml_views"=>"2", "html_views"=>"289"}
- {"month"=>"2", "year"=>"2017", "pdf_views"=>"50", "xml_views"=>"3", "html_views"=>"248"}
- {"month"=>"3", "year"=>"2017", "pdf_views"=>"78", "xml_views"=>"1", "html_views"=>"227"}
- {"month"=>"4", "year"=>"2017", "pdf_views"=>"309", "xml_views"=>"6", "html_views"=>"1036"}
- {"month"=>"5", "year"=>"2017", "pdf_views"=>"45", "xml_views"=>"1", "html_views"=>"171"}
- {"month"=>"6", "year"=>"2017", "pdf_views"=>"49", "xml_views"=>"4", "html_views"=>"177"}
- {"month"=>"7", "year"=>"2017", "pdf_views"=>"48", "xml_views"=>"5", "html_views"=>"141"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"4", "html_views"=>"113"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"23", "xml_views"=>"3", "html_views"=>"107"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"24", "xml_views"=>"4", "html_views"=>"129"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"183"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"132"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"62", "xml_views"=>"2", "html_views"=>"157"}
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- {"month"=>"3", "year"=>"2018", "pdf_views"=>"50", "xml_views"=>"2", "html_views"=>"77"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"82", "xml_views"=>"3", "html_views"=>"120"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"54", "xml_views"=>"6", "html_views"=>"89"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"53", "xml_views"=>"10", "html_views"=>"59"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"36", "xml_views"=>"8", "html_views"=>"58"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"31", "xml_views"=>"8", "html_views"=>"89"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"27", "xml_views"=>"1", "html_views"=>"48"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"88"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"101"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"37", "xml_views"=>"1", "html_views"=>"62"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"76"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"98"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"39", "xml_views"=>"2", "html_views"=>"90"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"71"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"68"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"59"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"37", "xml_views"=>"0", "html_views"=>"57"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"47", "xml_views"=>"0", "html_views"=>"58"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"69"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"55", "xml_views"=>"2", "html_views"=>"90"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"42", "xml_views"=>"2", "html_views"=>"59"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"61"}
- {"month"=>"1", "year"=>"2020", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"85"}
- {"month"=>"2", "year"=>"2020", "pdf_views"=>"30", "xml_views"=>"2", "html_views"=>"70"}
- {"month"=>"3", "year"=>"2020", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"108"}
- {"month"=>"4", "year"=>"2020", "pdf_views"=>"32", "xml_views"=>"2", "html_views"=>"44"}
- {"month"=>"5", "year"=>"2020", "pdf_views"=>"62", "xml_views"=>"6", "html_views"=>"21"}
- {"month"=>"6", "year"=>"2020", "pdf_views"=>"50", "xml_views"=>"5", "html_views"=>"36"}
- {"month"=>"7", "year"=>"2020", "pdf_views"=>"59", "xml_views"=>"2", "html_views"=>"47"}
- {"month"=>"8", "year"=>"2020", "pdf_views"=>"39", "xml_views"=>"3", "html_views"=>"40"}
- {"month"=>"9", "year"=>"2020", "pdf_views"=>"76", "xml_views"=>"1", "html_views"=>"73"}
- {"month"=>"10", "year"=>"2020", "pdf_views"=>"93", "xml_views"=>"2", "html_views"=>"89"}
- {"month"=>"11", "year"=>"2020", "pdf_views"=>"46", "xml_views"=>"1", "html_views"=>"62"}
- {"month"=>"12", "year"=>"2020", "pdf_views"=>"45", "xml_views"=>"2", "html_views"=>"47"}
- {"month"=>"1", "year"=>"2021", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"37"}
PMC Usage Stats | Further Information
- {"unique-ip"=>"64", "full-text"=>"74", "pdf"=>"43", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
- {"unique-ip"=>"45", "full-text"=>"49", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
- {"unique-ip"=>"49", "full-text"=>"52", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
- {"unique-ip"=>"63", "full-text"=>"75", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"8"}
- {"unique-ip"=>"80", "full-text"=>"95", "pdf"=>"53", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
- {"unique-ip"=>"105", "full-text"=>"115", "pdf"=>"49", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
- {"unique-ip"=>"84", "full-text"=>"105", "pdf"=>"53", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2016", "month"=>"11"}
- {"unique-ip"=>"84", "full-text"=>"98", "pdf"=>"43", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
- {"unique-ip"=>"88", "full-text"=>"98", "pdf"=>"56", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
- {"unique-ip"=>"74", "full-text"=>"84", "pdf"=>"41", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
- {"unique-ip"=>"81", "full-text"=>"97", "pdf"=>"57", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
- {"unique-ip"=>"76", "full-text"=>"94", "pdf"=>"34", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"4"}
- {"unique-ip"=>"57", "full-text"=>"72", "pdf"=>"33", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
- {"unique-ip"=>"43", "full-text"=>"57", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
- {"unique-ip"=>"38", "full-text"=>"53", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
- {"unique-ip"=>"47", "full-text"=>"64", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
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- {"unique-ip"=>"49", "full-text"=>"55", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
- {"unique-ip"=>"50", "full-text"=>"56", "pdf"=>"29", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
- {"unique-ip"=>"35", "full-text"=>"46", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
- {"unique-ip"=>"62", "full-text"=>"66", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
- {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
- {"unique-ip"=>"51", "full-text"=>"56", "pdf"=>"32", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"3"}
- {"unique-ip"=>"59", "full-text"=>"72", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
- {"unique-ip"=>"63", "full-text"=>"77", "pdf"=>"32", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
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- {"unique-ip"=>"70", "full-text"=>"77", "pdf"=>"18", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
- {"unique-ip"=>"36", "full-text"=>"39", "pdf"=>"17", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
- {"unique-ip"=>"40", "full-text"=>"41", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2018", "month"=>"8"}
- {"unique-ip"=>"23", "full-text"=>"26", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
- {"unique-ip"=>"43", "full-text"=>"45", "pdf"=>"17", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
- {"unique-ip"=>"38", "full-text"=>"45", "pdf"=>"16", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
- {"unique-ip"=>"38", "full-text"=>"53", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
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- {"unique-ip"=>"48", "full-text"=>"59", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"3"}
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- {"unique-ip"=>"51", "full-text"=>"60", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
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Relative Metric
{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}F1000Prime | Further Information
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