CiteULike | Further Information

• {"link"=>{"url"=>"http://www.citeulike.org/user/rossmounce/article/11420943"}, "post_time"=>"2012-10-08 23:51:15", "tag"=>"openscience", "linkout"=>{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pntd.0001260"}, "username"=>"rossmounce", "article_id"=>"11420943"}

Mendeley | Further Information

{"title"=>"Resolution of praziquantel", "type"=>"journal", "authors"=>[{"first_name"=>"Michael", "last_name"=>"Woelfle", "scopus_author_id"=>"51666336200"}, {"first_name"=>"Jean Paul", "last_name"=>"Seerden", "scopus_author_id"=>"57194678004"}, {"first_name"=>"Jesse", "last_name"=>"de Gooijer", "scopus_author_id"=>"36945944200"}, {"first_name"=>"Kees", "last_name"=>"Pouwer", "scopus_author_id"=>"6506316843"}, {"first_name"=>"Piero", "last_name"=>"Olliaro", "scopus_author_id"=>"7005144054"}, {"first_name"=>"Matthew H.", "last_name"=>"Todd", "scopus_author_id"=>"7202805944"}], "year"=>2011, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"issn"=>"19352727", "pui"=>"362681173", "doi"=>"10.1371/journal.pntd.0001260", "sgr"=>"80053458170", "scopus"=>"2-s2.0-80053458170", "isbn"=>"1935-2735 (Electronic)\\r1935-2727 (Linking)", "pmid"=>"21949890"}, "id"=>"a244edff-dfb5-32f4-a48b-45c290ca6380", "abstract"=>"BACKGROUND: Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate. Use of the pure active enantiomer would be desirable since the inactive enantiomer is associated with side effects and is responsible for the extremely bitter taste of the pill.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: We have identified two resolution approaches toward the production of praziquantel as a single enantiomer. One approach starts with commercially available praziquantel and involves a hydrolysis to an intermediate amine, which is resolved with a derivative of tartaric acid. This method was discovered through an open collaboration on the internet. The second method, identified by a contract research organisation, employs a different intermediate that may be resolved with tartaric acid itself.\\n\\nCONCLUSIONS/SIGNIFICANCE: Both resolution procedures identified show promise for the large-scale, economically viable production of praziquantel as a single enantiomer for a low price. Additionally, they may be employed by laboratories for the production of smaller amounts of enantiopure drug for research purposes that should be useful in, for example, elucidation of the drug's mechanism of action.", "link"=>"http://www.mendeley.com/research/resolution-praziquantel", "reader_count"=>64, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Librarian"=>2, "Researcher"=>15, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>3, "Student > Master"=>10, "Student > Bachelor"=>10, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Librarian"=>2, "Researcher"=>15, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>3, "Student > Master"=>10, "Student > Bachelor"=>10, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>4, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>12, "Agricultural and Biological Sciences"=>16, "Pharmacology, Toxicology and Pharmaceutical Science"=>5, "Chemical Engineering"=>1, "Chemistry"=>17, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Chemistry"=>{"Chemistry"=>17}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>5}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "reader_count_by_country"=>{"Brazil"=>4, "Zimbabwe"=>1, "United Kingdom"=>1, "Australia"=>1, "Switzerland"=>1}, "group_count"=>5}

ORCID

CrossRef

• http://doi.org/10.1074/jbc.AC119.011093
• http://doi.org/10.4155/cli.13.128
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PubMed Central

• 4135865
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• 3784487
• 3477162
• 3447952
• 4199547
• 4805296
• 3884843
• 3247111

Scopus | Further Information

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Article Coverage

• {"referral"=>"http://openwetware.org/wiki/Todd", "language"=>"", "title"=>"Todd - OpenWetWare", "type"=>"Blog", "publication"=>"", "published_on"=>"", "link_state"=>""}

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• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosntds%2Farticle%3Fid%3D10.1371%252Fjournal.pntd.0001260", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments | Further Information

• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/182930a6-8c3a-41c6-beeb-77d9f666cae4", "title"=>"Resolution?", "body"=>"Sirs,\n\nThe report on the progress made to find a convenient route for preparing industrial-scale quantities of levo-praziquantel is an interesting academic exercise which in isolation appears to be a significant step forward for schistosomiasis treatment. However the concept of development of this isomer seems to disregard the context in which schistosomiasis control takes place and, in particular, it omits to mention the following points: \n\n- there are insufficient quantities of quality-assured praziquantel to treat those who should receive it; as a result, over half of all people in sub Saharan Africa at risk have never been treated, and regular treatment reaches less than 20% of those who should receive the drug according to WHA resolution 54.19 of 2001”\n\n- affected populations would not be able to pay for praziquantel even if enough quantities were available today; this no-market situation makes most manufacturers uninterested in producing praziquantel; it is unlikely that the situation would be different if a convenient route to produce levo-praziquantel existed; \n\n- most praziquantel currently made available to populations in need is either donated by Merck-Serono, procured through privately donated funds or more recently funded directly by a two governments (USA and UK); it is possible that an increase in the price of praziquantel would reduce these commitments. \n\nIt is within this context that the hypothetical advantages of levo-praziquantel and the small progress made during the past 10 years in developing viable economic and ecological ways for its production should be weighed. In addition, if and when such a new synthetic route becomes available, several years and important resources would be required to overcome non-clinical testing, clinical trials and other necessary regulatory steps before levo-praziquantel could be safely used in populations affected by schistosomiasis. \n\nIt is extremely important to ensure that any additional research effort should not divert much-needed resources from providing praziquantel - a safe medicine of proven efficacy - to populations in need. Finally, an amendment is needed to the Acknowledgements: racemic praziquantel was donated by Merck Serono S.A.; the World Health Organization's Department of Control of Neglected Tropical Diseases was simply a conduit. \n\nValerio Reggi, Denis Daumerie, Dirk Engels, Lorenzo Savioli - Department of Control of Neglected Tropical Diseases, WHO, Geneva, Switzerland\nAlan Fenwick - School of Public Health, Imperial College, London, UK\n", "isRemoved"=>false, "created"=>"2011-09-26T15:25:13Z", "lastModified"=>"2011-09-26T15:25:13Z", "creator"=>{"userId"=>"135883"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pntd.0001260", "state"=>"published", "journals"=>{"PLoSNTD"=>{"journalKey"=>"PLoSNTD", "eIssn"=>"1935-2735", "title"=>"PLOS Neglected Tropical Diseases"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2011-09-26T15:25:13Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/8e5ce476-8a01-4540-9c08-efc380ef8e16", "title"=>"Great job for opening big science for looking to resolve big problems in neglected diseases", "body"=>"I was really excited on my field after reading this interesting paper. In addition, after knowing that a open forum was open for the interested scientific, I immediately revised the comment on Nature Chemistry. Great job!!! TDR has a page that is indicating that there is a need for applying excelent science to resolve neglected diseases that are affecting a huge numbers of persons and pharmaceutical interests are not sufficient for pushing these kind of efforts. However, these kind of efforts are showing us that there is a good opportunity for share common feelings in order to help to resolve this kind of problems.\n\nI wonder how is the pharmacological action of the enantiomer versus the racemic compound. Other helminths are treated clinically with the same drug. One example are Taenia solium parasites and maybe a good way for evaluating this question is performing in vitro assays in parasite models. Our group is ready for that. \n\nYours \n\nDr. Javier Ambrosio\nMicrobiology and Parasitology Department\nSchool of Medicine\nUniversidad Nacional Autonoma de Mexico\nMexico city.", "isRemoved"=>false, "created"=>"2011-11-17T15:22:59Z", "lastModified"=>"2011-11-17T15:22:59Z", "creator"=>{"userId"=>"60369"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pntd.0001260", "state"=>"published", "journals"=>{"PLoSNTD"=>{"journalKey"=>"PLoSNTD", "eIssn"=>"1935-2735", "title"=>"PLOS Neglected Tropical Diseases"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2011-11-17T15:22:59Z", "replies"=>[]}

Nature

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ScienceSeeker | Further Information

Twitter

• {"id"=>"351703949532868609", "text"=>"@mwpeczuh @OSDDMalaria Not sure there's a how-to, but this was our 1st one: http://t.co/V8X2PRVsJd", "created_at"=>"2013-07-01T14:08:50Z", "user"=>"MatToddChem", "user_name"=>"Matthew Todd", "user_profile_image"=>"http://a0.twimg.com/profile_images/1417112463/LA_from_Twitter_normal.JPG"}
• {"id"=>"363430271888011265", "text"=>"@all_isee @victoriastodden Oh, yes, we did that direct link between papers and data here, right? http://t.co/V8X2PRVsJd Paper<->Lab book", "created_at"=>"2013-08-02T22:45:03Z", "user"=>"MatToddChem", "user_name"=>"Matthew Todd", "user_profile_image"=>"http://a0.twimg.com/profile_images/1417112463/LA_from_Twitter_normal.JPG"}
• {"id"=>"641180132565196800", "text"=>"Talk at #ECTMIH2015 on #praziquantel disappointingly doesn't cite the relevant open source project http://t.co/wN37TpORN8", "created_at"=>"2015-09-08T09:23:50Z", "user"=>"MatToddChem", "user_name"=>"Matthew Todd", "user_profile_image"=>"http://pbs.twimg.com/profile_images/459301747970682882/21LQ-k33_normal.png"}
• {"id"=>"705568467080994816", "text"=>".@cdsouthan @B_resnick Lovely stuff! But sure, open drug work from 2010 https://t.co/wN37Tpxgoy and Synaptic Leap 10 y ago other precedents", "created_at"=>"2016-03-04T01:40:06Z", "user"=>"MatToddChem", "user_name"=>"Matthew Todd", "user_profile_image"=>"http://pbs.twimg.com/profile_images/459301747970682882/21LQ-k33_normal.png"}
• {"id"=>"718314202612547585", "text"=>"@MikeDFrench @elimin8schisto For sure, as are Cipla and the Paed PZQ Consortium. See https://t.co/V8X2PSd47N Will enantiopure be enough..?", "created_at"=>"2016-04-08T05:47:06Z", "user"=>"MatToddChem", "user_name"=>"Matthew Todd", "user_profile_image"=>"http://pbs.twimg.com/profile_images/459301747970682882/21LQ-k33_normal.png"}
• {"id"=>"718315420063809536", "text"=>"RT @MatToddChem: @MikeDFrench @elimin8schisto For sure, as are Cipla and the Paed PZQ Consortium. See https://t.co/V8X2PSd47N Will enantiop…", "created_at"=>"2016-04-08T05:51:56Z", "user"=>"MikeDFrench", "user_name"=>"Michael French", "user_profile_image"=>"http://pbs.twimg.com/profile_images/695319975242899456/v1vF94KI_normal.jpg"}

Wikipedia | Further Information

• {"title"=>"Praziquantel", "url"=>"http://en.wikipedia.org/wiki/Praziquantel", "timestamp"=>"2018-12-17T14:42:38Z"}
• {"title"=>"Open-notebook science", "url"=>"http://en.wikipedia.org/wiki/Open-notebook_science", "timestamp"=>"2019-02-06T04:29:12Z"}
• {"title"=>"Open notebook", "url"=>"http://it.wikipedia.org/wiki/Open_notebook", "timestamp"=>"2019-01-10T01:05:23Z"}
• {"title"=>"Open notebook science", "url"=>"http://es.wikipedia.org/wiki/Open_notebook_science", "timestamp"=>"2018-01-08T03:41:50Z"}
• {"title"=>"吡喹酮", "url"=>"http://zh.wikipedia.org/wiki/吡喹酮", "timestamp"=>"2018-09-16T09:12:18Z"}

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Figshare

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• {"files"=>["https://ndownloader.figshare.com/files/370337", "https://ndownloader.figshare.com/files/370364", "https://ndownloader.figshare.com/files/370400", "https://ndownloader.figshare.com/files/370470", "https://ndownloader.figshare.com/files/370523", "https://ndownloader.figshare.com/files/370554", "https://ndownloader.figshare.com/files/370576", "https://ndownloader.figshare.com/files/370619", "https://ndownloader.figshare.com/files/370656", "https://ndownloader.figshare.com/files/370697", "https://ndownloader.figshare.com/files/370734", "https://ndownloader.figshare.com/files/370753", "https://ndownloader.figshare.com/files/370784", "https://ndownloader.figshare.com/files/370820", "https://ndownloader.figshare.com/files/371010"], "description"=>"<div><h3>Background</h3><p>Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate. Use of the pure active enantiomer would be desirable since the inactive enantiomer is associated with side effects and is responsible for the extremely bitter taste of the pill.</p> <h3>Methodology/Principal Findings</h3><p>We have identified two resolution approaches toward the production of praziquantel as a single enantiomer. One approach starts with commercially available praziquantel and involves a hydrolysis to an intermediate amine, which is resolved with a derivative of tartaric acid. This method was discovered through an open collaboration on the internet. The second method, identified by a contract research organisation, employs a different intermediate that may be resolved with tartaric acid itself.</p> <h3>Conclusions/Significance</h3><p>Both resolution procedures identified show promise for the large-scale, economically viable production of praziquantel as a single enantiomer for a low price. Additionally, they may be employed by laboratories for the production of smaller amounts of enantiopure drug for research purposes that should be useful in, for example, elucidation of the drug's mechanism of action.</p> </div>", "links"=>[], "tags"=>["praziquantel"], "article_id"=>133166, "categories"=>["Cancer", "Chemistry"], "users"=>["Michael Woelfle", "Jean-Paul Seerden", "Jesse de Gooijer", "Kees Pouwer", "Piero Olliaro", "Matthew H. Todd"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0001260.s001", "https://dx.doi.org/10.1371/journal.pntd.0001260.s002", "https://dx.doi.org/10.1371/journal.pntd.0001260.s003", "https://dx.doi.org/10.1371/journal.pntd.0001260.s004", "https://dx.doi.org/10.1371/journal.pntd.0001260.s005", "https://dx.doi.org/10.1371/journal.pntd.0001260.s006", "https://dx.doi.org/10.1371/journal.pntd.0001260.s007", "https://dx.doi.org/10.1371/journal.pntd.0001260.s008", "https://dx.doi.org/10.1371/journal.pntd.0001260.s009", "https://dx.doi.org/10.1371/journal.pntd.0001260.s010", "https://dx.doi.org/10.1371/journal.pntd.0001260.s011", "https://dx.doi.org/10.1371/journal.pntd.0001260.s012", "https://dx.doi.org/10.1371/journal.pntd.0001260.s013", "https://dx.doi.org/10.1371/journal.pntd.0001260.s014", "https://dx.doi.org/10.1371/journal.pntd.0001260.s015"], "stats"=>{"downloads"=>26, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Resolution_of_Praziquantel/133166", "title"=>"Resolution of Praziquantel", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-09-20 00:52:46"}

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Relative Metric

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F1000Prime | Further Information

• {"year"=>2014, "month"=>5, "doi"=>"10.1371/journal.pntd.0001260", "f1000_id"=>"13328002", "url"=>"http://f1000.com/prime/13328002", "score"=>2, "classifications"=>["new_finding", "technical_advance"], "updated_at"=>"2014-05-26T08:33:28Z"}
• {"year"=>2014, "month"=>6, "doi"=>"10.1371/journal.pntd.0001260", "f1000_id"=>"13328002", "url"=>"http://f1000.com/prime/13328002", "score"=>2, "classifications"=>["new_finding", "technical_advance"], "updated_at"=>"2014-06-30T08:33:23Z"}
• {"year"=>2014, "month"=>7, "doi"=>"10.1371/journal.pntd.0001260", "f1000_id"=>"13328002", "url"=>"http://f1000.com/prime/13328002", "score"=>2, "classifications"=>["new_finding", "technical_advance"], "updated_at"=>"2014-07-28T08:33:29Z"}
• {"year"=>2014, "month"=>8, "doi"=>"10.1371/journal.pntd.0001260", "f1000_id"=>"13328002", "url"=>"http://f1000.com/prime/13328002", "score"=>2, "classifications"=>["new_finding", "technical_advance"], "updated_at"=>"2014-08-25T08:33:30Z"}
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