Targeting the Wolbachia Cell Division Protein FtsZ as a New Approach for Antifilarial Therapy
- Publication Date
- November 29, 2011
- Journal
- PLOS Neglected Tropical Diseases
- Authors
- Zhiru Li, Amanda L. Garner, Christian Gloeckner, Kim D. Janda, et al
- Volume
- 5
- Issue
- 11
- Pages
- e1411
- DOI
- https://dx.plos.org/10.1371/journal.pntd.0001411
- Publisher URL
- http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0001411
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/22140592
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226453
- Europe PMC
- http://europepmc.org/abstract/MED/22140592
- Web of Science
- 000298134000032
- Scopus
- 82555173782
- Mendeley
- http://www.mendeley.com/research/targeting-wolbachia-cell-division-protein-ftsz-new-approach-antifilarial-therapy
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Mendeley | Further Information
{"title"=>"Targeting the Wolbachia cell division protein FtsZ as a new approach for antifilarial therapy", "type"=>"journal", "authors"=>[{"first_name"=>"Zhiru", "last_name"=>"Li", "scopus_author_id"=>"56075480000"}, {"first_name"=>"Amanda L.", "last_name"=>"Garner", "scopus_author_id"=>"22934020200"}, {"first_name"=>"Christian", "last_name"=>"Gloeckner", "scopus_author_id"=>"57190287825"}, {"first_name"=>"Kim D.", "last_name"=>"Janda", "scopus_author_id"=>"35500092800"}, {"first_name"=>"Clotilde K.", "last_name"=>"Carlow", "scopus_author_id"=>"6603794357"}], "year"=>2011, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"pmid"=>"22140592", "pui"=>"363024968", "issn"=>"19352727", "doi"=>"10.1371/journal.pntd.0001411", "isbn"=>"1935-2727", "scopus"=>"2-s2.0-82555173782", "sgr"=>"82555173782"}, "id"=>"7f3c60d1-123f-3d20-8aab-ac937188085c", "abstract"=>"The use of antibiotics targeting the obligate bacterial endosymbiont Wolbachia of filarial parasites has been validated as an approach for controlling filarial infection in animals and humans. Availability of genomic sequences for the Wolbachia (wBm) present in the human filarial parasite Brugia malayi has enabled genome-wide searching for new potential drug targets. In the present study, we investigated the cell division machinery of wBm and determined that it possesses the essential cell division gene ftsZ which was expressed in all developmental stages of B. malayi examined. FtsZ is a GTPase thereby making the protein an attractive Wolbachia drug target. We described the molecular characterization and catalytic properties of Wolbachia FtsZ. We also demonstrated that the GTPase activity was inhibited by the natural product, berberine, and small molecule inhibitors identified from a high-throughput screen. Furthermore, berberine was also effective in reducing motility and reproduction in B. malayi parasites in vitro. Our results should facilitate the discovery of selective inhibitors of FtsZ as a novel anti-symbiotic approach for controlling filarial infection. NOTE: The nucleotide sequences reported in this paper are available in GenBank™ Data Bank under the accession number wAlB-FtsZ (JN616286).", "link"=>"http://www.mendeley.com/research/targeting-wolbachia-cell-division-protein-ftsz-new-approach-antifilarial-therapy", "reader_count"=>33, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>3, "Student > Master"=>4, "Other"=>3, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>3, "Student > Master"=>4, "Other"=>3, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>25, "Chemistry"=>3, "Social Sciences"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Chemistry"=>{"Chemistry"=>3}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>25}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>2}CrossRef
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Scopus | Further Information
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Relative Metric
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