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Definitions and Standardization of a New Grading Scheme for Eyelid Contour Abnormalities after Trichiasis Surgery

Publication Date: June 26, 2012
Journal: PLOS Neglected Tropical Diseases
Authors: Emily W. Gower, Sheila K. West, Sandra D. Cassard, Beatriz E. Munoz, et al
Volume: 6
Issue: 6
Pages: e1713
DOI: https://dx.plos.org/10.1371/journal.pntd.0001713
Publisher URL: http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0001713
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/22745845
PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383763
Europe PMC: http://europepmc.org/abstract/MED/22745845
Web of Science: 000305945300051
Scopus: 84863637327
Mendeley: http://www.mendeley.com/research/definitions-standardization-new-grading-scheme-eyelid-contour-abnormalities-after-trichiasis-surgery

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{"title"=>"Definitions and standardization of a new grading scheme for eyelid contour abnormalities after trichiasis surgery", "type"=>"journal", "authors"=>[{"first_name"=>"Emily W.", "last_name"=>"Gower", "scopus_author_id"=>"16229793200"}, {"first_name"=>"Sheila K.", "last_name"=>"West", "scopus_author_id"=>"35463160200"}, {"first_name"=>"Sandra D.", "last_name"=>"Cassard", "scopus_author_id"=>"6603740528"}, {"first_name"=>"Beatriz E.", "last_name"=>"Munoz", "scopus_author_id"=>"7004763528"}, {"first_name"=>"Jennifer C.", "last_name"=>"Harding", "scopus_author_id"=>"55309105500"}, {"first_name"=>"Shannath L.", "last_name"=>"Merbs", "scopus_author_id"=>"6603940850"}], "year"=>2012, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"sgr"=>"84863637327", "doi"=>"10.1371/journal.pntd.0001713", "issn"=>"19352727", "pui"=>"365220767", "pmid"=>"22745845", "scopus"=>"2-s2.0-84863637327"}, "id"=>"90d6c49b-f222-3100-a59a-e2b91255111c", "abstract"=>"BACKGROUND: Clear definitions of outcomes following trichiasis surgery are critical for planning program evaluations and for identifying ways to improve trichiasis surgery. Eyelid contour abnormality is an important adverse outcome of surgery; however, no standard method has been described to categorize eyelid contour abnormalities.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: A classification system for eyelid contour abnormalities following surgery for trachomatous trichiasis was developed. To determine whether the grading was reproducible using the classification system, six-week postoperative photographs were reviewed by two senior graders to characterize severity of contour abnormalities. Sample photographs defining each contour abnormality category were compiled and used to train four new graders. All six graders independently graded a Standardization Set of 75 eyelids, which included a roughly equal distribution across the severity scale, and weighted kappa scores were calculated. Two hundred forty six-week postoperative photographs from an ongoing clinical trial were randomly selected for evaluating agreement across graders. Two months after initial grading, one grader regraded a subset of the 240 photographs to measure longer-term intra-observer agreement. The weighted kappa for agreement between the two senior graders was 0.80 (95% CI: 0.71-0.89). Among the Standardization Set, agreement between the senior graders and the 4 new graders showed weighted kappa scores ranging from 0.60-0.80. Among 240 eyes comprising the clinical trial dataset, agreement ranged from weighted kappa 0.70-0.71. Longer-term intra-observer agreement was weighted kappa 0.86 (95% CI: 0.80-0.92).\\n\\nCONCLUSIONS/SIGNIFICANCE: The standard eyelid contour grading system we developed reproducibly delineates differing levels of contour abnormality. This grading system could be useful both for helping to evaluate trichiasis surgery outcomes in clinical trials and for evaluating trichiasis surgery programs.", "link"=>"http://www.mendeley.com/research/definitions-standardization-new-grading-scheme-eyelid-contour-abnormalities-after-trichiasis-surgery", "reader_count"=>13, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>8, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>2}

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Figshare07 Jan 11:24 UTC

Figshare

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PMC Usage Stats 104517 Feb 13:59 UTC

PMC Usage Stats | Further Information

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Relative Metric 33297910 May 16:20 UTC

Relative Metric

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F1000Prime12 Feb 11:57 UTC

F1000Prime

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