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{"title"=>"A new concept for medical imaging centered on cellular phone technology", "type"=>"journal", "authors"=>[{"first_name"=>"Yair", "last_name"=>"Granot", "scopus_author_id"=>"22979924000"}, {"first_name"=>"Antoni", "last_name"=>"Ivorra", "scopus_author_id"=>"16070282500"}, {"first_name"=>"Boris", "last_name"=>"Rubinsky", "scopus_author_id"=>"7006100650"}], "year"=>2008, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203", "pmid"=>"18446199", "scopus"=>"2-s2.0-44249128892", "doi"=>"10.1371/journal.pone.0002075", "sgr"=>"44249128892", "pui"=>"352025022"}, "id"=>"59d05a7c-1129-3478-9285-bd45838f88f8", "abstract"=>"According to World Health Organization reports, some three quarters of the world population does not have access to medical imaging. In addition, in developing countries over 50% of medical equipment that is available is not being used because it is too sophisticated or in disrepair or because the health personnel are not trained to use it. The goal of this study is to introduce and demonstrate the feasibility of a new concept in medical imaging that is centered on cellular phone technology and which may provide a solution to medical imaging in underserved areas. The new system replaces the conventional stand-alone medical imaging device with a new medical imaging system made of two independent components connected through cellular phone technology. The independent units are: a) a data acquisition device (DAD) at a remote patient site that is simple, with limited controls and no image display capability and b) an advanced image reconstruction and hardware control multiserver unit at a central site. The cellular phone technology transmits unprocessed raw data from the patient site DAD and receives and displays the processed image from the central site. (This is different from conventional telemedicine where the image reconstruction and control is at the patient site and telecommunication is used to transmit processed images from the patient site). The primary goal of this study is to demonstrate that the cellular phone technology can function in the proposed mode. The feasibility of the concept is demonstrated using a new frequency division multiplexing electrical impedance tomography system, which we have developed for dynamic medical imaging, as the medical imaging modality. The system is used to image through a cellular phone a simulation of breast cancer tumors in a medical imaging diagnostic mode and to image minimally invasive tissue ablation with irreversible electroporation in a medical imaging interventional mode.", "link"=>"http://www.mendeley.com/research/new-concept-medical-imaging-centered-cellular-phone-technology-3", "reader_count"=>61, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>5, "Researcher"=>8, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>2, "Other"=>3, "Student > Master"=>12, "Student > Bachelor"=>8, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>5, "Researcher"=>8, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>2, "Other"=>3, "Student > Master"=>12, "Student > Bachelor"=>8, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Agricultural and Biological Sciences"=>5, "Arts and Humanities"=>1, "Business, Management and Accounting"=>4, "Chemical Engineering"=>1, "Chemistry"=>1, "Computer Science"=>13, "Economics, Econometrics and Finance"=>1, "Engineering"=>16, "Medicine and Dentistry"=>12, "Design"=>1, "Physics and Astronomy"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Chemical Engineering"=>{"Chemical Engineering"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Design"=>{"Design"=>1}, "Engineering"=>{"Engineering"=>16}, "Chemistry"=>{"Chemistry"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Computer Science"=>{"Computer Science"=>13}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>4}}, "reader_count_by_country"=>{"Colombia"=>1, "United States"=>1, "Germany"=>1}, "group_count"=>4}

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• http://doi.org/10.1371/journal.pone.0159596
• http://doi.org/10.1016/j.cca.2014.08.019
• http://doi.org/10.1016/j.ijmedinf.2014.11.002
• http://doi.org/10.1089/tmj.2016.0149
• http://doi.org/10.1257/jep.24.3.207
• http://doi.org/10.1109/RBME.2012.2227703
• http://doi.org/10.1039/C4LC00523F
• http://doi.org/10.1016/j.addr.2014.05.015
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• http://doi.org/10.1002/jbio.201000050
• http://doi.org/10.1088/1742-6596/407/1/012014
• http://doi.org/10.1039/c1lc20479c
• http://doi.org/10.1371/journal.pone.0152351
• http://doi.org/10.1371/journal.pone.0055586
• http://doi.org/10.3790/vjh.81.3.85
• http://doi.org/10.1016/j.chroma.2014.12.041
• http://doi.org/10.4137/SART.S5025
• http://doi.org/10.1109/JPROC.2014.2378776
• http://doi.org/10.1088/0967-3334/31/11/N01
• http://doi.org/10.1007/s11465-011-0216-0
• http://doi.org/10.1007/s10916-009-9282-9
• http://doi.org/10.1021/nn4037706
• http://doi.org/10.1590/1414-431X20132978
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• http://doi.org/10.1016/j.aca.2014.08.006
• http://doi.org/10.1177/1357633X14566590
• http://doi.org/10.1371/journal.pone.0005178
• http://doi.org/10.1039/C0LC00358A
• http://doi.org/10.1016/j.bios.2018.05.050
• http://doi.org/10.2196/jmir.2959
• http://doi.org/10.1038/srep20459
• http://doi.org/10.1016/j.addr.2009.11.016
• http://doi.org/10.1177/1533034615601549
• http://doi.org/10.1089/tmj.2011.0018
• http://doi.org/10.5407/JKSV.2012.10.2.025
• http://doi.org/10.12968/hmed.2011.72.5.271

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• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/b211c068-5a71-48b5-8603-8315959808d1", "title"=>"Academic Editor Comments: H. Peter Soyer", "body"=>"Academic Editor's Review (H. Peter Soyer):\n\n**********\nN.B. These are the comments made by the referee when reviewing an earlier version of this paper. Prior to publication, the manuscript has been revised in light of these comments and to address other editorial requirements.\n**********\n\nReview of the original submission:\nThis is certainly an exciting manuscript on a cutting edge technology. As I am not a technology expert I cannot on the technical aspects.\n\nThe concept provided by the authors certainly sounds very promising and opens up new horizons. However, it has been outlined too lengthy in the introduction and in the result and discussion section.\n\nAdditional points:\n\n* Usually the patient site in telemedicine is meant to be the remote site. The advanced image reconstruction and hardware control unit is in my understanding the central site. In the first line of page 6 the authors write \"remote cutting edge central facility\". This is confusing. My proposal would be to simplify the wording. It is obvious that the signing out physician needs not to be physically at this central unit as shown in Fig. 1. It might well be that the authors see the location where the patient and the cellular phone is as the central site and the processing unit is then obviously the remote site. Anyhow, this is only a minor point which can be easily clarified.\n\n* For readers not familiar with the front end technology a better demonstration/explanation of the front end in Fig. 4 and Fig. 5 should be provided.\n\nReview of the first revised manuscript:\nThe authors certainly present an exciting new concept on medical imaging for patient-centered use in underserved areas.\n\nThe manuscript has been shortened considerable and reads now more conciser.\n\nThe second part of the first sentence of the results and discussion \"by imaging image a simulation of minimally invasive tissue ablation with irreversible electroporation in a medical imaging interventional mode\" still is difficult to understand and would need to be rephrased. The reviewer wonders why the authors focus not only on the medical imaging diagnostic mode.\n", "isRemoved"=>false, "created"=>"2008-05-05T23:33:04Z", "lastModified"=>"2008-05-05T23:33:04Z", "creator"=>{"userId"=>"80539"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>false, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0002075", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2008-05-05T23:33:04Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/625cfa67-b0db-406f-9376-d45189334a38", "title"=>"Transmitting data over cell phone voice channel", "body"=>"This idea is correct: it would be possible to convert the digital data into an \"audio\" signal, input the audio signal to the cell phone's microphone jack, and then the cell phone would transmit this \"audio\" to the remote side for analysis. Yes, it is true that the digital->\"audio\" conversion would introduce some loss. However the biggest obstacle is the encoding of the audio data in the cell phone network: cell phones today use digital speech encoding (not analog) and the digital speech encoding is both lossy and based on perceptual speech models. Even simple DTMF (touch tone) keypad tones do not transmit well when sent through a cell phone's digital speech encoding (GSM encoders, etc), and keypad tones are relatively simple (two sine waves summed together). Thus, the real bottleneck is the analog->compressed digital encoding->analog conversion. The D-A quantization isn't even that bad, in comparison to the perceptual voice encoders/decoders which will completely corrupt the data. (FYI, I am an electrical engineer with lots of telecom experience.)\n\nFax, for example, can not operate over a cell phone at any rate over 1200 baud reliably (even though the fax itself might operate at 9600 to 14400). In order to \"send fax over cell phone\", a separate re-encoding step is used, which bypasses the analog channel. In VoIP tests, which use better voice encoders than cell phone networks (more bandwidth is available), the maximum fax transmission speed using an analog channel, is 2400 bps, unless special processing is done.\n\nLong winded, though there it is... using the analog input of a cell phone to pass data over a cell phone network just won't work.\n\nUsing SMS is also unreliable in a cell phone network since there is no acknowledgement within the system or between networks; so data can be lost or delayed or re-ordered. This can be managed through redundancy, though it's best to use a standard data protocol (email, TCP/IP, etc). For this, an \"open\" cell phone provider is needed, which doesn't lock down services.", "highlightedText"=>"''In this case, the cell phone uses the voice channel to transmit an analog signal (much like a fax). This has the disadvantages of possible lost bits due to line quality and other problems that are characteristic of analog communications, but it is probably the best option in terms of cell phone compatibility.''\nhttp://plosone.org/article/info:doi/10.1371/journal.pone.0002075#article1.body1.sec3.p9", "isRemoved"=>false, "created"=>"2009-07-05T18:35:52Z", "lastModified"=>"2009-07-05T18:35:52Z", "creator"=>{"userId"=>"111885"}, "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0002075", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2009-07-05T18:35:52Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/ab592061-59e9-4138-abf4-1e8a7f900084", "title"=>"Protocols used .................", "body"=>"What are the various protocols used in this scenario where mobile phone is used as and imaging process???\n ", "isRemoved"=>false, "created"=>"2009-09-16T05:57:03Z", "lastModified"=>"2009-09-16T05:57:03Z", "creator"=>{"userId"=>"167515"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0002075", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2009-09-16T05:57:03Z", "replies"=>[]}

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• {"id"=>"208603521958952960", "text"=>"Medical imaging based off cellphone technology that would increase access in developing countries. http://t.co/qGm9PBH6", "created_at"=>"2012-06-01T16:58:49Z", "user"=>"InfabCorp", "user_name"=>"Infab", "user_profile_image"=>"http://a0.twimg.com/profile_images/2190636878/infab-avatar_normal.jpg"}

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Figshare

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• {"files"=>["https://ndownloader.figshare.com/files/932621"], "description"=>"<p>Outlined arrows indicate optional reporting of results to the patient.</p>", "links"=>[], "tags"=>["configuration", "cancer", "tumors", "self-test"], "article_id"=>603069, "categories"=>["Cell Biology"], "users"=>["Yair Granot", "Antoni Ivorra", "Boris Rubinsky"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002075.g001", "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_System_configuration_for_the_breast_cancer_tumors_patient_self_test_screening_/603069", "title"=>"System configuration for the breast cancer tumors patient self-test screening.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 10:34:43"}
• {"files"=>["https://ndownloader.figshare.com/files/932870"], "description"=>"<p>a) The DAD of the system with two types of gel representing an area treated with irreversible electroporation, marked in red, surrounded by normal tissue. b) Reconstructed result as it was displayed on the screen of a commercial cellular phone. Warm colors represent higher conductivity regions that denote an electroporated area.</p>", "links"=>[], "tags"=>["invasive"], "article_id"=>603322, "categories"=>["Cell Biology"], "users"=>["Yair Granot", "Antoni Ivorra", "Boris Rubinsky"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002075.g004", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Minimally_invasive_surgery_example_/603322", "title"=>"Minimally invasive surgery example.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 10:36:13"}

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Relative Metric

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F1000Prime