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• {"link"=>{"url"=>"http://www.citeulike.org/user/bmezmer/article/5778366"}, "post_time"=>"2009-09-12 18:13:12", "tag"=>["accidental_contamination", "disease", "human", "prion"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pone.0003017"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/18714385"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=18714385"}], "username"=>"bmezmer", "article_id"=>"5778366"}

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{"title"=>"Atypical BSE (BASE) transmitted from asymptomatic aging cattle to a primate", "type"=>"journal", "authors"=>[{"first_name"=>"Emmanuel E.", "last_name"=>"Comoy", "scopus_author_id"=>"7004669353"}, {"first_name"=>"Cristina", "last_name"=>"Casalone", "scopus_author_id"=>"16177404700"}, {"first_name"=>"Nathalie", "last_name"=>"Lescoutra-Etchegaray", "scopus_author_id"=>"12770426500"}, {"first_name"=>"Gianluigi", "last_name"=>"Zanusso", "scopus_author_id"=>"6701822555"}, {"first_name"=>"Sophie", "last_name"=>"Freire", "scopus_author_id"=>"24779567400"}, {"first_name"=>"Dominique", "last_name"=>"Marcé", "scopus_author_id"=>"6602405205"}, {"first_name"=>"Frédéric", "last_name"=>"Auvré", "scopus_author_id"=>"6506462381"}, {"first_name"=>"Marie Magdeleine", "last_name"=>"Ruchoux", "scopus_author_id"=>"35429848300"}, {"first_name"=>"Sergio", "last_name"=>"Ferrari", "scopus_author_id"=>"7201818430"}, {"first_name"=>"Salvatore", "last_name"=>"Monaco", "scopus_author_id"=>"9736421900"}, {"first_name"=>"Nicole", "last_name"=>"Salès", "scopus_author_id"=>"17137353800"}, {"first_name"=>"Maria", "last_name"=>"Caramelli", "scopus_author_id"=>"55890943700"}, {"first_name"=>"Philippe", "last_name"=>"Leboulch", "scopus_author_id"=>"7003644385"}, {"first_name"=>"Paul", "last_name"=>"Brown", "scopus_author_id"=>"35371555600"}, {"first_name"=>"Corinne I.", "last_name"=>"Lasmézas", "scopus_author_id"=>"7004275131"}, {"first_name"=>"Jean Philippe", "last_name"=>"Deslys", "scopus_author_id"=>"7006973315"}], "year"=>2008, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"352327517", "sgr"=>"51549111981", "pmid"=>"18714385", "scopus"=>"2-s2.0-51549111981", "isbn"=>"1932-6203 (Electronic)", "doi"=>"10.1371/journal.pone.0003017", "issn"=>"19326203"}, "id"=>"cfd6694a-5910-351e-9be9-f1afb38e9a13", "abstract"=>"BACKGROUND: Human variant Creutzfeldt-Jakob Disease (vCJD) results from foodborne transmission of prions from slaughtered cattle with classical Bovine Spongiform Encephalopathy (cBSE). Atypical forms of BSE, which remain mostly asymptomatic in aging cattle, were recently identified at slaughterhouses throughout Europe and North America, raising a question about human susceptibility to these new prion strains. METHODOLOGY/PRINCIPAL FINDINGS: Brain homogenates from cattle with classical BSE and atypical (BASE) infections were inoculated intracerebrally into cynomolgus monkeys (Macacca fascicularis), a non-human primate model previously demonstrated to be susceptible to the original strain of cBSE. The resulting diseases were compared in terms of clinical signs, histology and biochemistry of the abnormal prion protein (PrPres). The single monkey infected with BASE had a shorter survival, and a different clinical evolution, histopathology, and prion protein (PrPres) pattern than was observed for either classical BSE or vCJD-inoculated animals. Also, the biochemical signature of PrPres in the BASE-inoculated animal was found to have a higher proteinase K sensitivity of the octa-repeat region. We found the same biochemical signature in three of four human patients with sporadic CJD and an MM type 2 PrP genotype who lived in the same country as the infected bovine. CONCLUSION/SIGNIFICANCE: Our results point to a possibly higher degree of pathogenicity of BASE than classical BSE in primates and also raise a question about a possible link to one uncommon subset of cases of apparently sporadic CJD. Thus, despite the waning epidemic of classical BSE, the occurrence of atypical strains should temper the urge to relax measures currently in place to protect public health from accidental contamination by BSE-contaminated products.", "link"=>"http://www.mendeley.com/research/atypical-bse-base-transmitted-asymptomatic-aging-cattle-primate", "reader_count"=>27, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>3, "Researcher"=>12, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>4, "Student > Master"=>2, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>3, "Researcher"=>12, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>4, "Student > Master"=>2, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>15, "Medicine and Dentistry"=>2, "Veterinary Science and Veterinary Medicine"=>5, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>5}}, "reader_count_by_country"=>{"France"=>1}, "group_count"=>2}

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• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0003017", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

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• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/6cd1b30c-8a12-4fbc-913b-1cb9e08c05b8", "title"=>"BSE-L and BASE", "body"=>"For the sake of clarity, I think that it would be suitable in future publications to state somewhere in the paper that BASE and BSE-L type involve the same TSE agent, as far as the evidence goes. \nNot going this way inevitably - if not deliberately - results into providing truncated and misleading information to a reader unaware of this fact.\nReaders interested in further information on this matter are invited to read the paper \"A Bovine Prion Acquires an Epidemic Bovine Spongiform Encephalopathy Strain-Like Phenotype on\nInterspecies Transmission\" published by Beringue et al in J Neurosci 2007. In this study, we show that i) BASE and BSE-L isolates behave similarly upon transmission to mice; ii) both have a tendency to shift to a BSE phenotype upon transmission to a heterologous PrP genotype. Furthermore, we provide here the first evidence that this type of atypical BSE agent replicates faster than the classical one on mice expressing human PrP. ", "isRemoved"=>false, "created"=>"2008-09-04T14:16:27Z", "lastModified"=>"2008-09-04T14:16:27Z", "creator"=>{"userId"=>"21693"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>false, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0003017", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2008-09-04T14:16:27Z", "replies"=>[]}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/455577", "https://ndownloader.figshare.com/files/455643"], "description"=>"<div><h3>Background</h3><p>Human variant Creutzfeldt-Jakob Disease (vCJD) results from foodborne transmission of prions from slaughtered cattle with classical Bovine Spongiform Encephalopathy (cBSE). Atypical forms of BSE, which remain mostly asymptomatic in aging cattle, were recently identified at slaughterhouses throughout Europe and North America, raising a question about human susceptibility to these new prion strains.</p><h3>Methodology/Principal Findings</h3><p>Brain homogenates from cattle with classical BSE and atypical (BASE) infections were inoculated intracerebrally into cynomolgus monkeys (<em>Macacca fascicularis</em>), a non-human primate model previously demonstrated to be susceptible to the original strain of cBSE. The resulting diseases were compared in terms of clinical signs, histology and biochemistry of the abnormal prion protein (PrPres). The single monkey infected with BASE had a shorter survival, and a different clinical evolution, histopathology, and prion protein (PrPres) pattern than was observed for either classical BSE or vCJD-inoculated animals. Also, the biochemical signature of PrPres in the BASE-inoculated animal was found to have a higher proteinase K sensitivity of the octa-repeat region. We found the same biochemical signature in three of four human patients with sporadic CJD and an MM type 2 PrP genotype who lived in the same country as the infected bovine.</p><h3>Conclusion/Significance</h3><p>Our results point to a possibly higher degree of pathogenicity of BASE than classical BSE in primates and also raise a question about a possible link to one uncommon subset of cases of apparently sporadic CJD. Thus, despite the waning epidemic of classical BSE, the occurrence of atypical strains should temper the urge to relax measures currently in place to protect public health from accidental contamination by BSE-contaminated products.</p></div>", "links"=>[], "tags"=>["atypical", "bse", "transmitted", "asymptomatic", "aging", "primate"], "article_id"=>149730, "categories"=>["Biochemistry", "Biological Sciences", "Medicine", "Neuroscience"], "users"=>["Emmanuel E. Comoy", "Cristina Casalone", "Nathalie Lescoutra-Etchegaray", "Gianluigi Zanusso", "Sophie Freire", "Dominique Marcé", "Frédéric Auvré", "Marie-Magdeleine Ruchoux", "Sergio Ferrari", "Salvatore Monaco", "Nicole Salès", "Maria Caramelli", "Philippe Leboulch", "Paul Brown", "Corinne I. Lasmézas", "Jean-Philippe Deslys"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003017.s001", "https://dx.doi.org/10.1371/journal.pone.0003017.s002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Atypical_BSE_BASE_Transmitted_from_Asymptomatic_Aging_Cattle_to_a_Primate/149730", "title"=>"Atypical BSE (BASE) Transmitted from Asymptomatic Aging Cattle to a Primate", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-08-20 02:42:10"}
• {"files"=>["https://ndownloader.figshare.com/files/923843"], "description"=>"<p>Topographic distribution of spongiosis (a and b) or gliosis (c and d) in BASE and cBSE-infected primates. The lesions were scored from 0 to 4 (negative, light, mild, moderate, and severe).</p>", "links"=>[], "tags"=>["histologic"], "article_id"=>594278, "categories"=>["Biochemistry", "Computational Biology", "Medicine", "Neuroscience"], "users"=>["Emmanuel E. Comoy", "Cristina Casalone", "Nathalie Lescoutra-Etchegaray", "Gianluigi Zanusso", "Sophie Freire", "Dominique Marcé", "Frédéric Auvré", "Marie-Magdeleine Ruchoux", "Sergio Ferrari", "Salvatore Monaco", "Nicole Salès", "Maria Caramelli", "Philippe Leboulch", "Paul Brown", "Corinne I. Lasmézas", "Jean-Philippe Deslys"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003017.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Diagrammatic_representation_of_histologic_lesions_/594278", "title"=>"Diagrammatic representation of histologic lesions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-08-20 01:11:18"}
• {"files"=>["https://ndownloader.figshare.com/files/924042"], "description"=>"<p>Spongiosis, gliosis (GFAP staining) and PrPres deposition in frontal cortex and obex in BASE- and cBSE-infected primates (original magnification ×200 for spongiosis and gliosis, ×400 for PrPres staining). Immunostaining of PrPres was performed with 3F4 monoclonal anti-PrP antibody after proteinase K treatment as previously described <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003017#pone.0003017-Herzog1\" target=\"_blank\">[11]</a>. No staining was observed in the brain of control healthy primates (data not shown) in these conditions.</p>", "links"=>[], "tags"=>["prpres"], "article_id"=>594481, "categories"=>["Biochemistry", "Computational Biology", "Medicine", "Neuroscience"], "users"=>["Emmanuel E. Comoy", "Cristina Casalone", "Nathalie Lescoutra-Etchegaray", "Gianluigi Zanusso", "Sophie Freire", "Dominique Marcé", "Frédéric Auvré", "Marie-Magdeleine Ruchoux", "Sergio Ferrari", "Salvatore Monaco", "Nicole Salès", "Maria Caramelli", "Philippe Leboulch", "Paul Brown", "Corinne I. Lasmézas", "Jean-Philippe Deslys"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003017.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histopathology_and_PrPres_immunostaining_/594481", "title"=>"Histopathology and PrPres immunostaining.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-08-20 01:14:41"}
• {"files"=>["https://ndownloader.figshare.com/files/924201"], "description"=>"<p>PrPres from brain homogenates (MM1 or VV2 sCJD, vCJD in humans, or primates experimentally infected with BASE, cBSE or vCJD inocula) were purified under high concentrations of proteinase K, and detected with monoclonal antibodies recognizing either the core (3F4, panel A) or the octapeptide region (panel B and C) of the protein. Frontal cortex and obex regions of BASE-infected primate were both analysed (lanes 3 and 4 respectively). Panel C is an overexposure of the autoradiography of Panel B to detect weak signals. The absence of octarepeat region reactivity in the PrPres of the BASE in Panel C indicates a proportion at least ten fold lower than that of the vCJD or cBSE samples on the basis of a quantitative analysis of chemiluminescence signal intensities.</p>", "links"=>[], "tags"=>["differential", "proteolysis", "prpres", "prion", "diseases", "primates"], "article_id"=>594635, "categories"=>["Biochemistry", "Computational Biology", "Medicine", "Neuroscience"], "users"=>["Emmanuel E. Comoy", "Cristina Casalone", "Nathalie Lescoutra-Etchegaray", "Gianluigi Zanusso", "Sophie Freire", "Dominique Marcé", "Frédéric Auvré", "Marie-Magdeleine Ruchoux", "Sergio Ferrari", "Salvatore Monaco", "Nicole Salès", "Maria Caramelli", "Philippe Leboulch", "Paul Brown", "Corinne I. Lasmézas", "Jean-Philippe Deslys"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003017.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Electrophoretic_analysis_and_differential_sensitivity_to_proteolysis_of_PrPres_in_various_prion_diseases_of_primates_and_humans_/594635", "title"=>"Electrophoretic analysis and differential sensitivity to proteolysis of PrPres in various prion diseases of primates and humans.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-08-20 01:17:15"}
• {"files"=>["https://ndownloader.figshare.com/files/924326"], "description"=>"<p>PrPres from human brain homogenates (MM1, MV1, VV1, MM2, MV2 or VV2 subtypes of sCJD, and vCJD) were purified under high concentrations of proteinase K, and detected with monoclonal antibodies that recognize either the core (3F4, Panel A) or the octapeptide region (Panel B) of the protein. The proportion of PrPres with an intact octarepeat region after PK exposure in VV2 and human (or macaque) vCJD was estimated to be only one-tenth and one-twentieth as high as in an MM1 sub-type of sCJD, respectively.</p>", "links"=>[], "tags"=>["differential", "proteolysis", "prpres", "subtypes"], "article_id"=>594759, "categories"=>["Biochemistry", "Computational Biology", "Medicine", "Neuroscience"], "users"=>["Emmanuel E. Comoy", "Cristina Casalone", "Nathalie Lescoutra-Etchegaray", "Gianluigi Zanusso", "Sophie Freire", "Dominique Marcé", "Frédéric Auvré", "Marie-Magdeleine Ruchoux", "Sergio Ferrari", "Salvatore Monaco", "Nicole Salès", "Maria Caramelli", "Philippe Leboulch", "Paul Brown", "Corinne I. Lasmézas", "Jean-Philippe Deslys"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003017.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Electrophoretic_analysis_and_differential_sensitivity_to_proteolysis_of_PrPres_in_different_subtypes_of_CJD_/594759", "title"=>"Electrophoretic analysis and differential sensitivity to proteolysis of PrPres in different subtypes of CJD.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-08-20 01:19:19"}
• {"files"=>["https://ndownloader.figshare.com/files/924431"], "description"=>"<p>PrPres from human brain homogenates (MM2 or MV2 subtypes of sCJD) and from primate experimentally infected with BASE were purified under high concentrations of proteinase K, and detected with monoclonal antibodies that recognize either the core (3F4, Panel A) or the octapeptide region (Panel B) of the protein.</p>", "links"=>[], "tags"=>["differential", "proteolysis", "prpres", "mm2", "cjd"], "article_id"=>594863, "categories"=>["Biochemistry", "Computational Biology", "Medicine", "Neuroscience"], "users"=>["Emmanuel E. Comoy", "Cristina Casalone", "Nathalie Lescoutra-Etchegaray", "Gianluigi Zanusso", "Sophie Freire", "Dominique Marcé", "Frédéric Auvré", "Marie-Magdeleine Ruchoux", "Sergio Ferrari", "Salvatore Monaco", "Nicole Salès", "Maria Caramelli", "Philippe Leboulch", "Paul Brown", "Corinne I. Lasmézas", "Jean-Philippe Deslys"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003017.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Electrophoretic_analysis_and_differential_sensitivity_to_proteolysis_of_PrPres_in_different_MM2_CJD_patients_/594863", "title"=>"Electrophoretic analysis and differential sensitivity to proteolysis of PrPres in different MM2 CJD patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-08-20 01:21:03"}
• {"files"=>["https://ndownloader.figshare.com/files/924555"], "description"=>"<p>Summary of MM2 subtype sporadic CJD patients.</p>", "links"=>[], "tags"=>["mm2", "subtype", "sporadic", "cjd"], "article_id"=>594987, "categories"=>["Biochemistry", "Computational Biology", "Medicine", "Neuroscience"], "users"=>["Emmanuel E. Comoy", "Cristina Casalone", "Nathalie Lescoutra-Etchegaray", "Gianluigi Zanusso", "Sophie Freire", "Dominique Marcé", "Frédéric Auvré", "Marie-Magdeleine Ruchoux", "Sergio Ferrari", "Salvatore Monaco", "Nicole Salès", "Maria Caramelli", "Philippe Leboulch", "Paul Brown", "Corinne I. Lasmézas", "Jean-Philippe Deslys"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003017.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_MM2_subtype_sporadic_CJD_patients_/594987", "title"=>"Summary of MM2 subtype sporadic CJD patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-08-20 01:23:07"}
• {"files"=>["https://ndownloader.figshare.com/files/924595"], "description"=>"*<p>Amount of crude brain in 10% brain suspension inoculated intracerebrally. BSE brain had a 10-fold greater concentration of PrPres than the BASE brain). Animals inoculated with vCJD also received the equivalent of 8 mg of brain by intra-tonsillar injection.</p>", "links"=>[], "tags"=>["times", "macaques", "inoculated", "intracerebrally", "homogenates", "humans"], "article_id"=>595029, "categories"=>["Biochemistry", "Computational Biology", "Medicine", "Neuroscience"], "users"=>["Emmanuel E. Comoy", "Cristina Casalone", "Nathalie Lescoutra-Etchegaray", "Gianluigi Zanusso", "Sophie Freire", "Dominique Marcé", "Frédéric Auvré", "Marie-Magdeleine Ruchoux", "Sergio Ferrari", "Salvatore Monaco", "Nicole Salès", "Maria Caramelli", "Philippe Leboulch", "Paul Brown", "Corinne I. Lasmézas", "Jean-Philippe Deslys"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003017.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Survival_times_of_macaques_inoculated_intracerebrally_with_brain_homogenates_from_cattle_with_BASE_or_BSE_and_from_humans_with_vCJD_/595029", "title"=>"Survival times of macaques inoculated intracerebrally with brain homogenates from cattle with BASE or BSE, and from humans with vCJD.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-08-20 01:23:49"}

PMC Usage Stats | Further Information

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• {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"15", "year"=>"2011", "pdf"=>"5", "unique-ip"=>"15", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"2"}
• {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "unique-ip"=>"9", "pdf"=>"3", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
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• {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"223", "year"=>"2008", "pdf"=>"90", "unique-ip"=>"105", "figure"=>"27", "scanned-summary"=>"0", "supp-data"=>"16"}
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• {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"36", "year"=>"2009", "pdf"=>"16", "unique-ip"=>"32", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"2"}
• {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"33", "unique-ip"=>"33", "pdf"=>"26", "year"=>"2009", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"19", "year"=>"2009", "pdf"=>"8", "unique-ip"=>"22", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"62", "unique-ip"=>"12", "pdf"=>"25", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
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• {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"6", "full-text"=>"14", "year"=>"2009", "pdf"=>"5", "unique-ip"=>"15", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
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• {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"24", "year"=>"2009", "pdf"=>"18", "unique-ip"=>"24", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"27", "unique-ip"=>"22", "pdf"=>"14", "year"=>"2009", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"2", "abstract"=>"0", "full-text"=>"17", "year"=>"2012", "pdf"=>"10", "unique-ip"=>"11", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
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• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
• {"unique-ip"=>"14", "full-text"=>"8", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
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Relative Metric

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F1000Prime