MicroRNA Expression Patterns and Function in Endodermal Differentiation of Human Embryonic Stem Cells
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{"title"=>"MicroRNA expression patterns and function in endodermal differentiation of human embryonic stem cells", "type"=>"journal", "authors"=>[{"first_name"=>"Galit", "last_name"=>"Tzur", "scopus_author_id"=>"25655567100"}, {"first_name"=>"Asaf", "last_name"=>"Levy", "scopus_author_id"=>"23995615200"}, {"first_name"=>"Eti", "last_name"=>"Meiri", "scopus_author_id"=>"9745812100"}, {"first_name"=>"Omer", "last_name"=>"Barad", "scopus_author_id"=>"9747325000"}, {"first_name"=>"Yael", "last_name"=>"Spector", "scopus_author_id"=>"9745642600"}, {"first_name"=>"Zvi", "last_name"=>"Bentwich", "scopus_author_id"=>"7005510294"}, {"first_name"=>"Lina", "last_name"=>"Mizrahi", "scopus_author_id"=>"36878513200"}, {"first_name"=>"Mark", "last_name"=>"Katzenellenbogen", "scopus_author_id"=>"6506866680"}, {"first_name"=>"Etti", "last_name"=>"Ben-Shushan", "scopus_author_id"=>"6602302202"}, {"first_name"=>"Benjamin E.", "last_name"=>"Reubinoff", "scopus_author_id"=>"7003526389"}, {"first_name"=>"Eithan", "last_name"=>"Galun", "scopus_author_id"=>"35453167900"}], "year"=>2008, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"19015728", "doi"=>"10.1371/journal.pone.0003726", "sgr"=>"56749176517", "isbn"=>"2005018961", "scopus"=>"2-s2.0-56749176517", "issn"=>"19326203", "pui"=>"352728908"}, "id"=>"7a5139d3-593b-3cb0-85c8-f8a90ab83749", "abstract"=>"BACKGROUND/AIMS: microRNAs (miRNAs) are small noncoding RNAs that regulate cognate mRNAs post-transcriptionally. Human embryonic stem cells (hESC), which exhibit the characteristics of pluripotency and self-renewal, may serve as a model to study the role of miRNAs in early human development. We aimed to determine whether endodermally-differentiated hESC demonstrate a unique miRNA expression pattern, and whether overexpression of endoderm-specific miRNA may affect hESC differentiation.\\n\\nMETHODS: miRNA expression was profiled in undifferentiated and NaButyrate-induced differentiated hESC of two lines, using microarray and quantitative RT-PCR. Then, the effect of lentiviral-based overexpression of liver-specific miR-122 on hESC differentiation was analyzed, using genomewide gene microarrays.\\n\\nRESULTS: The miRNA profiling revealed expression of three novel miRNAs in undifferentiated and differentiated hESC. Upon NaButyrate induction, two of the most upregulated miRNAs common to both cell lines were miR-24 and miR-10a, whose target genes have been shown to inhibit endodermal differentiation. Furthermore, induction of several liver-enriched miRNAs, including miR-122 and miR-192, was observed in parallel to induction of endodermal gene expression. Stable overexpression of miR-122 in hESC was unable to direct spontaneous differentiation towards a clear endodermal fate, but rather, delayed general differentiation of these cells.\\n\\nCONCLUSIONS: Our results demonstrate that expression of specific miRNAs correlates with that of specific genes upon differentiation, and highlight the potential role of miRNAs in endodermal differentiation of hESC.", "link"=>"http://www.mendeley.com/research/microrna-expression-patterns-function-endodermal-differentiation-human-embryonic-stem-cells-2", "reader_count"=>42, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>16, "Student > Ph. D. Student"=>16, "Student > Master"=>5, "Other"=>3, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>16, "Student > Ph. D. Student"=>16, "Student > Master"=>5, "Other"=>3, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>7, "Agricultural and Biological Sciences"=>30, "Medicine and Dentistry"=>3, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>30}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>2, "Denmark"=>1, "France"=>2, "Germany"=>3}, "group_count"=>0}

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  • {"month"=>"2", "year"=>"2021", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"4"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/916534"], "description"=>"<p>QRT-PCR results of gene expression in 14d-differentiated HES2 cells expressing mutant (mut) or wt miR-122. The reactions were performed on the same RNA samples that were analyzed on the microarrays. Results are expressed as relative quantification of the gene level in each sample relative to undifferentiated cells transduced with the relevant miRNA (wt or mutant), and normalized to GUSB. Each reaction was performed in triplicates and the average RQ of 3 independent experiments is shown with the SD and the p value between mut diff and wt diff cells when significant.</p>", "links"=>[], "tags"=>["mir-122", "overexpression"], "article_id"=>586981, "categories"=>["Genetics", "Chemistry", "Virology"], "users"=>["Galit Tzur", "Asaf Levy", "Eti Meiri", "Omer Barad", "Yael Spector", "Zvi Bentwich", "Lina Mizrahi", "Mark Katzenellenbogen", "Etti Ben-Shushan", "Benjamin E. Reubinoff", "Eithan Galun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003726.g007", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_miR_122_overexpression_on_gene_expression_in_hESC_/586981", "title"=>"Effect of miR-122 overexpression on gene expression in hESC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-18 01:56:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/916410"], "description"=>"<p>QRT-PCR results of miRNA expression levels in undifferentiated (undiff) untransduced (un-trans) HES2 cells, and in cells transduced with wt or mutant (mut) miR-122 vector either undifferentiated, or spontaneously differentiated for 14d. Results are expressed as relative quantification of the miRNA expression levels in each sample relative to untransduced cells, and normalized to RNU43. Each reaction was performed in triplicate, and the average ct was used for RQ calculation. For differentiated cells, average RQ of 3 independent experiments is shown with the SD and the p value between mut diff and wt diff cells.</p>", "links"=>[], "tags"=>["mir-122", "overexpression", "mirna"], "article_id"=>586857, "categories"=>["Genetics", "Chemistry", "Virology"], "users"=>["Galit Tzur", "Asaf Levy", "Eti Meiri", "Omer Barad", "Yael Spector", "Zvi Bentwich", "Lina Mizrahi", "Mark Katzenellenbogen", "Etti Ben-Shushan", "Benjamin E. Reubinoff", "Eithan Galun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003726.g006", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_miR_122_overexpression_on_miRNA_expression_in_hESC_/586857", "title"=>"Effect of miR-122 overexpression on miRNA expression in hESC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-18 01:54:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/915738"], "description"=>"<p>A–C. Scatter plots representing miRNA expression profiles of 436 miRNAs in undifferentiated and 14d-differentiated HES1 and HES2 cells. Names of outlier miRNAs are indicated. miRNA names in the format MIDxxx are predictions of Rosetta Genomics. D. Unsupervised hierarchical cluster analysis was performed on expression signature of 436 human miRNAs in undifferentiated (undiff) HES1 and HES2 cells, and in cells differentiated (diff) with NaB for 7d or 14d (Cluster 3.0 software, log transformed data, average linkage). A dendogram demonstrating similarity level in miRNA expression between the various samples is shown. E. Venn diagrams of 20% of the miRNAs with the highest expression level for each cell line in undifferentiated (undiff), 7d-differentiated (7d diff) and 14d-differentiated (14d diff) HES1 and HES2 cells. Number of miRNAs included in each circle is denoted in parentheses.</p>", "links"=>[], "tags"=>["undifferentiated", "differentiated"], "article_id"=>586186, "categories"=>["Genetics", "Chemistry", "Virology"], "users"=>["Galit Tzur", "Asaf Levy", "Eti Meiri", "Omer Barad", "Yael Spector", "Zvi Bentwich", "Lina Mizrahi", "Mark Katzenellenbogen", "Etti Ben-Shushan", "Benjamin E. Reubinoff", "Eithan Galun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003726.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_miRNA_expression_analysis_in_undifferentiated_and_differentiated_hESC_/586186", "title"=>"miRNA expression analysis in undifferentiated and differentiated hESC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-18 01:43:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/452716", "https://ndownloader.figshare.com/files/452729", "https://ndownloader.figshare.com/files/452759"], "description"=>"<div><h3>Background/Aims</h3><p>microRNAs (miRNAs) are small noncoding RNAs that regulate cognate mRNAs post-transcriptionally. Human embryonic stem cells (hESC), which exhibit the characteristics of pluripotency and self-renewal, may serve as a model to study the role of miRNAs in early human development. We aimed to determine whether endodermally-differentiated hESC demonstrate a unique miRNA expression pattern, and whether overexpression of endoderm-specific miRNA may affect hESC differentiation.</p><h3>Methods</h3><p>miRNA expression was profiled in undifferentiated and NaButyrate-induced differentiated hESC of two lines, using microarray and quantitative RT-PCR. Then, the effect of lentiviral-based overexpression of liver-specific miR-122 on hESC differentiation was analyzed, using genomewide gene microarrays.</p><h3>Results</h3><p>The miRNA profiling revealed expression of three novel miRNAs in undifferentiated and differentiated hESC. Upon NaButyrate induction, two of the most upregulated miRNAs common to both cell lines were miR-24 and miR-10a, whose target genes have been shown to inhibit endodermal differentiation. Furthermore, induction of several liver-enriched miRNAs, including miR-122 and miR-192, was observed in parallel to induction of endodermal gene expression. Stable overexpression of miR-122 in hESC was unable to direct spontaneous differentiation towards a clear endodermal fate, but rather, delayed general differentiation of these cells.</p><h3>Conclusions</h3><p>Our results demonstrate that expression of specific miRNAs correlates with that of specific genes upon differentiation, and highlight the potential role of miRNAs in endodermal differentiation of hESC.</p></div>", "links"=>[], "tags"=>["microrna", "patterns", "endodermal", "differentiation", "embryonic", "cells"], "article_id"=>149175, "categories"=>["Genetics", "Chemistry", "Cancer"], "users"=>["Galit Tzur", "Asaf Levy", "Eti Meiri", "Omer Barad", "Yael Spector", "Zvi Bentwich", "Lina Mizrahi", "Mark Katzenellenbogen", "Etti Ben-Shushan", "Benjamin E. Reubinoff", "Eithan Galun"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003726.s001", "https://dx.doi.org/10.1371/journal.pone.0003726.s002", "https://dx.doi.org/10.1371/journal.pone.0003726.s003"], "stats"=>{"downloads"=>10, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/MicroRNA_Expression_Patterns_and_Function_in_Endodermal_Differentiation_of_Human_Embryonic_Stem_Cells/149175", "title"=>"MicroRNA Expression Patterns and Function in Endodermal Differentiation of Human Embryonic Stem Cells", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-11-18 02:32:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/915975"], "description"=>"<p>Summary of miRNA expression in endodermal differentiation of hESC.</p>", "links"=>[], "tags"=>["mirna", "endodermal", "differentiation"], "article_id"=>586423, "categories"=>["Genetics", "Chemistry", "Virology"], "users"=>["Galit Tzur", "Asaf Levy", "Eti Meiri", "Omer Barad", "Yael Spector", "Zvi Bentwich", "Lina Mizrahi", "Mark Katzenellenbogen", "Etti Ben-Shushan", "Benjamin E. Reubinoff", "Eithan Galun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003726.g003", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_miRNA_expression_in_endodermal_differentiation_of_hESC_/586423", "title"=>"Summary of miRNA expression in endodermal differentiation of hESC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-18 01:47:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/915879"], "description"=>"<p>QRT-PCR results of miRNA expression level in undifferentiated HES1 and HES2 cells or cells differentiated with NaB for 7d or 14d. Results are expressed as relative quantification of the miRNA expression level in each sample relative to undifferentiated cells of the respective line, and normalized to RNU43. Each reaction was performed in triplicate and the average ct was used for RQ calculation. RQ–Relative Quantification; Con–control cells grown with the same media as treated cells, but without NaB; NaB–0.5 mM Na Butyrate; F–Feeder, mitotically arrested foreskin cells (feeder cells of hESC); EC–Embryonal Carcinoma 2102Ep cell line; EL–human embryonic liver of stage 7w from gestation; AL–human normal adult liver; NS–Neurospheres, HES1 cells differentiated for 4.5w towards neural fate.</p>", "links"=>[], "tags"=>["mirna", "microarray"], "article_id"=>586327, "categories"=>["Genetics", "Chemistry", "Virology"], "users"=>["Galit Tzur", "Asaf Levy", "Eti Meiri", "Omer Barad", "Yael Spector", "Zvi Bentwich", "Lina Mizrahi", "Mark Katzenellenbogen", "Etti Ben-Shushan", "Benjamin E. Reubinoff", "Eithan Galun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003726.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Verification_of_the_miRNA_microarray_results_by_qRT_PCR_/586327", "title"=>"Verification of the miRNA microarray results by qRT-PCR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-18 01:45:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/916769"], "description"=>"a<p>Nucleotides that were optional during sequencing are in parenthesis.</p>b<p>of all variants.</p>", "links"=>[], "tags"=>["mirnas"], "article_id"=>587217, "categories"=>["Genetics", "Chemistry", "Virology"], "users"=>["Galit Tzur", "Asaf Levy", "Eti Meiri", "Omer Barad", "Yael Spector", "Zvi Bentwich", "Lina Mizrahi", "Mark Katzenellenbogen", "Etti Ben-Shushan", "Benjamin E. Reubinoff", "Eithan Galun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003726.t001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Novel_miRNAs_identified_in_hESC_/587217", "title"=>"Novel miRNAs identified in hESC", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-11-18 02:00:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/916282"], "description"=>"<p>A. Schematic representation of the lentiviral vector expressing the wt and mutant hsa-miR-122. The H1 and EF1α promoters are marked by an arrow. The sequence of mature wt miR-122 and mutant miR-122 carrying 3 mutations in the seed sequence (underlined) are shown below. RFP-Red Fluorescent Protein; cPPT-central PolyPurine Tract; WPRE-Woodchuck hepatitis virus Posttranscriptional Regulatory Element. B. HEK-293 cells were co-transfected with a lentiviral plasmid encoding EYFP fused to the 3′UTR of hsa-miR-122 target gene CAT-1 (EYFP-CAT-1) and lentiviral plasmids encoding wt hsa-miR-122, mutant (mut) hsa-miR-122 or empty vector (ev). 48 hr later, the cells were analyzed for EYFP expression by FACS. Each transfection was performed in triplicate and the average mean fluorescence intensity of each triplicate is presented with the SD. C. FACS histogram showing transduction efficiency of HES2 cells with lentiviral vector expressing hsa-miR-122 (wt or mutant) and a RFP reporter. A representative histogram of two independent experiments is shown. D. QRT-PCR results of hsa-miR-122 expression levels in undifferentiated untransduced HES2 cells, or cells transduced with lentiviral vector encoding wt or mutant (mut) hsa-miR-122. Results are expressed as relative quantification of the miRNA expression level in each sample relative to untransduced cells, and normalized to RNU43. Each reaction was performed in triplicate and the average ct was used for RQ calculation.</p>", "links"=>[], "tags"=>["hsa-mir-122"], "article_id"=>586730, "categories"=>["Genetics", "Chemistry", "Virology"], "users"=>["Galit Tzur", "Asaf Levy", "Eti Meiri", "Omer Barad", "Yael Spector", "Zvi Bentwich", "Lina Mizrahi", "Mark Katzenellenbogen", "Etti Ben-Shushan", "Benjamin E. Reubinoff", "Eithan Galun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003726.g005", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overexpression_of_hsa_miR_122_in_hESC_/586730", "title"=>"Overexpression of hsa-miR-122 in hESC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-18 01:52:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/916808"], "description"=>"<p>TSS–transcription start site.</p><p>TFBS–transcription factor binding site (predicted).</p>a<p>-Z score of TF binding site prediction, according to the UCSC browser.</p>b<p>-hsa-mir-125b which is also derived from this cluster was not co-expressed with CEBPA, however, this miRNA is derived from two different genomic loci, which may mask the expression of hsa-miR-125b from the current cluster (since the other copy is not predicted to be regulated by CEBPA).</p>c<p>-hsa-mir-99a was not expressed in any of the samples, yet, co-expression of two out of the three members of the cluster, which are different in sequence (and therefore cross-hybridization to the microarray was not likely to have occurred), together with CEBPA gene, supports this prediction.</p>", "links"=>[], "tags"=>["factors", "mirna", "differentiated"], "article_id"=>587253, "categories"=>["Genetics", "Chemistry", "Virology"], "users"=>["Galit Tzur", "Asaf Levy", "Eti Meiri", "Omer Barad", "Yael Spector", "Zvi Bentwich", "Lina Mizrahi", "Mark Katzenellenbogen", "Etti Ben-Shushan", "Benjamin E. Reubinoff", "Eithan Galun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003726.t004", "stats"=>{"downloads"=>4, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Transcription_factors_predicted_to_regulate_miRNA_expression_in_differentiated_hESC_/587253", "title"=>"Transcription factors predicted to regulate miRNA expression in differentiated hESC", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-11-18 02:00:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/916727"], "description"=>"<p>List of the top ten miRNAs upregulated or downregulated at least 2-folds in each line upon differentiation. Expression is presented as fold of change in 7d and 14d differentiated (diff) versus undifferentiated (undiff) cells. miRNAs designated as MIDxxx are predictions of Rosetta Genomics.</p>", "links"=>[], "tags"=>["upregulated", "downregulated", "hesc"], "article_id"=>587177, "categories"=>["Genetics", "Chemistry", "Virology"], "users"=>["Galit Tzur", "Asaf Levy", "Eti Meiri", "Omer Barad", "Yael Spector", "Zvi Bentwich", "Lina Mizrahi", "Mark Katzenellenbogen", "Etti Ben-Shushan", "Benjamin E. Reubinoff", "Eithan Galun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003726.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_miRNAs_upregulated_and_downregulated_upon_hESC_differentiation_/587177", "title"=>"miRNAs upregulated and downregulated upon hESC differentiation", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-11-18 01:59:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/916076"], "description"=>"<p>cDNA macroarray results of gene expression analysis in undifferentiated (undiff) HES1 and HES2 cells or cells treated with NaB for 7 or 14d, or with the basic medium only (con). The same RNA samples that were utilized for miRNA profiling were used for this analysis. The average results of two independent experiments are presented as gene expression level in arbitrary units. CK8-cytokeratin 8; CK18–cytokeratin 18; CK19–cytokeratin 19; AFP-alpha-fetoprotein; TTR-transthyretin; ALB–albumin; ASGR1-asialoglycoprotein receptor 1; TDO2-tryptophan 2,3 dioxygenase; DLK1-Delta-like 1 Homolog.</p>", "links"=>[], "tags"=>["hepatic", "markers", "hesc", "differentiated"], "article_id"=>586523, "categories"=>["Genetics", "Chemistry", "Virology"], "users"=>["Galit Tzur", "Asaf Levy", "Eti Meiri", "Omer Barad", "Yael Spector", "Zvi Bentwich", "Lina Mizrahi", "Mark Katzenellenbogen", "Etti Ben-Shushan", "Benjamin E. Reubinoff", "Eithan Galun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003726.g004", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characterization_of_hepatic_markers_expression_in_hESC_differentiated_with_NaB_/586523", "title"=>"Characterization of hepatic markers expression in hESC differentiated with NaB.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-18 01:48:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/916688"], "description"=>"<p>The top 10% of miRNAs expressed at the highest level are shown for each cell line, in a descending order of expression. miRNAs that appear in both cell lines are <b>bolded</b>.</p>", "links"=>[], "tags"=>["mirnas", "undifferentiated"], "article_id"=>587133, "categories"=>["Genetics", "Chemistry", "Virology"], "users"=>["Galit Tzur", "Asaf Levy", "Eti Meiri", "Omer Barad", "Yael Spector", "Zvi Bentwich", "Lina Mizrahi", "Mark Katzenellenbogen", "Etti Ben-Shushan", "Benjamin E. Reubinoff", "Eithan Galun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003726.t002", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_top_10_miRNAs_expressed_in_undifferentiated_hESC_/587133", "title"=>"The top 10% miRNAs expressed in undifferentiated hESC", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-11-18 01:58:53"}

PMC Usage Stats | Further Information

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Relative Metric

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