Is Antiretroviral Therapy Causing Long-Term Liver Damage? A Comparative Analysis of HIV-Mono-Infected and HIV/Hepatitis C Co-Infected Cohorts
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Mendeley | Further Information

{"title"=>"Is antiretroviral therapy causing long-term liver damage? A comparative analysis of HIV-mono-infected and HIV/hepatitis C co-infected cohorts", "type"=>"journal", "authors"=>[{"first_name"=>"Erica E M", "last_name"=>"Moodie", "scopus_author_id"=>"18434676900"}, {"first_name"=>"Nitika Pant", "last_name"=>"Pai", "scopus_author_id"=>"55576637900"}, {"first_name"=>"Marina B.", "last_name"=>"Klein", "scopus_author_id"=>"7404419562"}], "year"=>2009, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"354229994", "sgr"=>"84887212517", "pmid"=>"19223976", "scopus"=>"2-s2.0-84887212517", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0004517", "issn"=>"19326203"}, "id"=>"82263e80-1452-3365-9b67-c2d864db559d", "abstract"=>"The effects of highly active antiretroviral therapy (HAART) on progression of hepatic fibrosis in HIV-hepatitis C virus (HCV) co-infection are not well understood. Deaths from liver diseases have risen in the post-HAART era, yet some cross-sectional studies have suggested that HAART use is associated with improved fibrosis rates. In a retrospective cohort of 533 HIV mono-infected and 127 HIV/HCV co-infected patients, followed between January 1991 and July 2005 at a university-based HIV clinic, we investigated the relationship between cumulative HAART exposure and hepatic fibrosis, as measured by the aspartate aminotransferase-to-platelet ratio index (APRI). We used a novel methodological approach to estimate the dose-response relationship of the effect of HAART exposure on APRI. HAART was associated with increasing APRI over time in HIV/HCV co-infected patients suggesting that they may be experiencing cumulative hepatotoxicity from antiretrovirals. The estimated median change (95% confidence interval) in APRI per one year of HAART intake was of -0.46% (-1.61% to 0.71%) in HIV mono-infected compared to 2.54% (-1.77% to 7.03%) in HIV/HCV co-infected patients. Similar results were found when the direct effect of HAART intake since the last visit was estimated on the change in APRI. HAART use associated is with increased APRI in patients with HIV/HCV co-infection. Therefore treatment for HCV infection may be required to slow the growing epidemic of end-stage liver disease in this population.", "link"=>"http://www.mendeley.com/research/antiretroviral-therapy-causing-longterm-liver-damage-comparative-analysis-hivmonoinfected-hivhepatit", "reader_count"=>26, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>3, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>3, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Nursing and Health Professions"=>2, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>11, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>1, "Decision Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Decision Sciences"=>{"Decision Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1, "United Kingdom"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/907652"], "description"=>"<p>The plot includes point-wise 95% confidence bands for HIV mono-infected patients (solid line) and HIV/HCV co-infected patients (dashed line).</p>", "links"=>[], "tags"=>["dose-response", "apri", "haart", "intake"], "article_id"=>578107, "categories"=>["Computational Biology", "Medicine", "Neuroscience"], "users"=>["Erica E. M. Moodie", "Nitika Pant Pai", "Marina B. Klein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0004517.g003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Estimated_dose_response_function_change_in_APRI_due_to_HAART_intake_between_clinical_visits_/578107", "title"=>"Estimated dose-response function: change in APRI due to HAART intake between clinical visits.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-02-18 02:15:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/448987"], "description"=>"<div><p>The effects of highly active antiretroviral therapy (HAART) on progression of hepatic fibrosis in HIV-hepatitis C virus (HCV) co-infection are not well understood. Deaths from liver diseases have risen in the post-HAART era, yet some cross-sectional studies have suggested that HAART use is associated with improved fibrosis rates. In a retrospective cohort of 533 HIV mono-infected and 127 HIV/HCV co-infected patients, followed between January 1991 and July 2005 at a university-based HIV clinic, we investigated the relationship between cumulative HAART exposure and hepatic fibrosis, as measured by the aspartate aminotransferase-to-platelet ratio index (APRI). We used a novel methodological approach to estimate the dose-response relationship of the effect of HAART exposure on APRI. HAART was associated with increasing APRI over time in HIV/HCV co-infected patients suggesting that they may be experiencing cumulative hepatotoxicity from antiretrovirals. The estimated median change (95% confidence interval) in APRI per one year of HAART intake was of −0.46% (−1.61% to 0.71%) in HIV mono-infected compared to 2.54% (−1.77% to 7.03%) in HIV/HCV co-infected patients. Similar results were found when the direct effect of HAART intake since the last visit was estimated on the change in APRI. HAART use associated is with increased APRI in patients with HIV/HCV co-infection. Therefore treatment for HCV infection may be required to slow the growing epidemic of end-stage liver disease in this population.</p></div>", "links"=>[], "tags"=>["antiretroviral", "causing", "comparative", "hiv-mono-infected", "co-infected", "cohorts"], "article_id"=>148484, "categories"=>["Biological Sciences", "Medicine", "Neuroscience"], "users"=>["Erica E. M. Moodie", "Nitika Pant Pai", "Marina B. Klein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0004517", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Is_Antiretroviral_Therapy_Causing_Long_Term_Liver_Damage_A_Comparative_Analysis_of_HIV_Mono_Infected_and_HIV_Hepatitis_C_Co_Infected_Cohorts/148484", "title"=>"Is Antiretroviral Therapy Causing Long-Term Liver Damage? A Comparative Analysis of HIV-Mono-Infected and HIV/Hepatitis C Co-Infected Cohorts", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-02-18 02:21:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/907445"], "description"=>"<p>A directed acyclic graph of the relationship between HAART exposure and APRI over time, where potentially confounding variables such as, for example, CD4+ T-cell counts, are represented by X. The Generalized Propensity Score permits unbiased estimation of the direct (or cross-sectional) effect, α, of most recent HAART intake on the response.</p>", "links"=>[], "tags"=>["causal"], "article_id"=>577903, "categories"=>["Computational Biology", "Medicine", "Neuroscience"], "users"=>["Erica E. M. Moodie", "Nitika Pant Pai", "Marina B. Klein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0004517.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Postulated_causal_diagram_/577903", "title"=>"Postulated causal diagram.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-02-18 02:11:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/907904"], "description"=>"<p>For continuous variables, statistics reported are median (range). For categorical variables statistics reported are count (%).</p><p>Abbreviations: APRI, AST to platelet ratio index; HAART, highly active antiretroviral therapy; HCV, hepatitis C infection.</p>", "links"=>[], "tags"=>["characteristics", "viral", "co-infection", "by-interval"], "article_id"=>578359, "categories"=>["Computational Biology", "Medicine", "Neuroscience"], "users"=>["Erica E. M. Moodie", "Nitika Pant Pai", "Marina B. Klein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0004517.t002", "stats"=>{"downloads"=>5, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_according_viral_co_infection_status_individuals_used_to_assess_the_by_interval_effects_/578359", "title"=>"Baseline characteristics according viral co-infection status (individuals used to assess the by-interval effects).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-02-18 02:19:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/907930"], "description"=>"<p>For continuous variables, statistics reported are median (range). For categorical variables statistics reported are count (%).</p><p>Abbreviations: APRI, AST to platelet ratio index; HAART, highly active antiretroviral therapy; HCV, hepatitis C infection.</p>", "links"=>[], "tags"=>["characteristics", "viral", "co-infection"], "article_id"=>578392, "categories"=>["Computational Biology", "Medicine", "Neuroscience"], "users"=>["Erica E. M. Moodie", "Nitika Pant Pai", "Marina B. Klein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0004517.t001", "stats"=>{"downloads"=>3, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_according_viral_co_infection_status_/578392", "title"=>"Baseline characteristics according viral co-infection status.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-02-18 02:19:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/907754"], "description"=>"<p>The plot includes point-wise 95% confidence bands for HIV mono-infected patients (solid line) and HIV/HCV co-infected patients (dashed line).</p>", "links"=>[], "tags"=>["dose-response", "apri", "cumulative", "haart"], "article_id"=>578212, "categories"=>["Computational Biology", "Medicine", "Neuroscience"], "users"=>["Erica E. M. Moodie", "Nitika Pant Pai", "Marina B. Klein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0004517.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Estimated_dose_response_function_APRI_due_to_cumulative_HAART_intake_/578212", "title"=>"Estimated dose-response function: APRI due to cumulative HAART intake.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-02-18 02:16:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/907525"], "description"=>"<p>The figure on the left is HIV-infected and on the right is the HIV/HCV co-infected patients; 15 data points in mono-infected persons and 39 points in co-infected persons have APRI scores above 4.0.</p>", "links"=>[], "tags"=>["cumulative", "haart", "years"], "article_id"=>577983, "categories"=>["Computational Biology", "Medicine", "Neuroscience"], "users"=>["Erica E. M. Moodie", "Nitika Pant Pai", "Marina B. Klein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0004517.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_APRI_by_cumulative_HAART_exposure_in_years_over_the_course_of_the_study_/577983", "title"=>"APRI by cumulative HAART exposure in years over the course of the study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-02-18 02:13:03"}

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