Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies
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{"title"=>"Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: Meta-analysis of three genome-wide association studies", "type"=>"journal", "authors"=>[{"first_name"=>"Ilja M.", "last_name"=>"Nolte", "scopus_author_id"=>"7102054770"}, {"first_name"=>"Chris", "last_name"=>"Wallace", "scopus_author_id"=>"8931612300"}, {"first_name"=>"Stephen J.", "last_name"=>"Newhouse", "scopus_author_id"=>"8931613700"}, {"first_name"=>"Daryl", "last_name"=>"Waggott", "scopus_author_id"=>"27268054300"}, {"first_name"=>"Jingyuan", "last_name"=>"Fu", "scopus_author_id"=>"8633742800"}, {"first_name"=>"Nicole", "last_name"=>"Soranzo", "scopus_author_id"=>"55800239500"}, {"first_name"=>"Rhian", "last_name"=>"Gwilliam", "scopus_author_id"=>"7006302366"}, {"first_name"=>"Panos", "last_name"=>"Deloukas", "scopus_author_id"=>"7003287098"}, {"first_name"=>"Irina", "last_name"=>"Savelieva", "scopus_author_id"=>"6701768664"}, {"first_name"=>"Dongling", "last_name"=>"Zheng", "scopus_author_id"=>"7202567092"}, {"first_name"=>"Chrysoula", "last_name"=>"Dalageorgou", "scopus_author_id"=>"6506484507"}, {"first_name"=>"Martin", "last_name"=>"Farrall", "scopus_author_id"=>"7006468255"}, {"first_name"=>"Nilesh J.", "last_name"=>"Samani", "scopus_author_id"=>"7004345054"}, {"first_name"=>"John", "last_name"=>"Connell", "scopus_author_id"=>"7201843996"}, {"first_name"=>"Morris", "last_name"=>"Brown", "scopus_author_id"=>"7405387005"}, {"first_name"=>"Anna", "last_name"=>"Dominiczak", "scopus_author_id"=>"7005462773"}, {"first_name"=>"Mark", "last_name"=>"Lathrop", "scopus_author_id"=>"7006495387"}, {"first_name"=>"Eleftheria", "last_name"=>"Zeginni", "scopus_author_id"=>"6602598642"}, {"first_name"=>"Louise V.", "last_name"=>"Wain", "scopus_author_id"=>"57195273227"}, {"first_name"=>"Christopher", "last_name"=>"Newton-Cheh", "scopus_author_id"=>"56962776100"}, {"first_name"=>"Mark", "last_name"=>"Eijgelsheim", "scopus_author_id"=>"57200296851"}, {"first_name"=>"Kenneth", "last_name"=>"Rice", "scopus_author_id"=>"14120284900"}, {"first_name"=>"Paul I.W.", "last_name"=>"De Bakker", "scopus_author_id"=>"6701510692"}, {"first_name"=>"Arne", "last_name"=>"Pfeufer", "scopus_author_id"=>"6602795696"}, {"first_name"=>"Serena", "last_name"=>"Sanna", "scopus_author_id"=>"16646989300"}, {"first_name"=>"Dan E.", "last_name"=>"Arking", "scopus_author_id"=>"6507688292"}, {"first_name"=>"Folkert W.", "last_name"=>"Asselbergs", "scopus_author_id"=>"7006736234"}, {"first_name"=>"Tim D.", "last_name"=>"Spector", "scopus_author_id"=>"35351391300"}, {"first_name"=>"Nicholas D.", "last_name"=>"Carter", "scopus_author_id"=>"7201454523"}, {"first_name"=>"Steve", "last_name"=>"Jeffery", "scopus_author_id"=>"7005949136"}, {"first_name"=>"Martin", "last_name"=>"Tobin", "scopus_author_id"=>"7202893448"}, {"first_name"=>"Mark", "last_name"=>"Caulfield", "scopus_author_id"=>"7102853527"}, {"first_name"=>"Harold", "last_name"=>"Snieder", "scopus_author_id"=>"7006990967"}, {"first_name"=>"Andrew D.", "last_name"=>"Paterson", "scopus_author_id"=>"55554856400"}, {"first_name"=>"Patricia B.", "last_name"=>"Munroe", "scopus_author_id"=>"7005376453"}, {"first_name"=>"Yalda", "last_name"=>"Jamshidi", "scopus_author_id"=>"57195074187"}], "year"=>2009, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"354894283", "sgr"=>"67650280679", "pmid"=>"19587794", "scopus"=>"2-s2.0-67650280679", "isbn"=>"2200820186", "doi"=>"10.1371/journal.pone.0006138", "issn"=>"19326203"}, "id"=>"af3da06c-8894-3f24-860f-7a16ce5a0138", "abstract"=>"To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS) including 3,558 subjects from the TwinsUK and BRIGHT cohorts in the UK and the DCCT/EDIC cohort from North America. Five loci were significantly associated with QT interval at P<1x10(-6). To validate these findings we performed an in silico comparison with data from two QT consortia: QTSCD (n = 15,842) and QTGEN (n = 13,685). Analysis confirmed the association between common variants near NOS1AP (P = 1.4x10(-83)) and the phospholamban (PLN) gene (P = 1.9x10(-29)). The most associated SNP near NOS1AP (rs12143842) explains 0.82% variance; the SNP near PLN (rs11153730) explains 0.74% variance of QT interval duration. We found no evidence for interaction between these two SNPs (P = 0.99). PLN is a key regulator of cardiac diastolic function and is involved in regulating intracellular calcium cycling, it has only recently been identified as a susceptibility locus for QT interval. These data offer further mechanistic insights into genetic influence on the QT interval which may predispose to life threatening arrhythmias and sudden cardiac death.", "link"=>"http://www.mendeley.com/research/common-genetic-variation-near-phospholamban-gene-associated-cardiac-repolarisation-metaanalysis-thre-3", "reader_count"=>54, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>23, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>2, "Student > Master"=>3, "Other"=>3, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>23, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>2, "Student > Master"=>3, "Other"=>3, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Mathematics"=>1, "Agricultural and Biological Sciences"=>22, "Medicine and Dentistry"=>22, "Computer Science"=>2, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>22}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>22}, "Computer Science"=>{"Computer Science"=>2}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Japan"=>1, "Denmark"=>1, "United Kingdom"=>2, "Switzerland"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/441804", "https://ndownloader.figshare.com/files/441849", "https://ndownloader.figshare.com/files/441894", "https://ndownloader.figshare.com/files/441927", "https://ndownloader.figshare.com/files/441947", "https://ndownloader.figshare.com/files/442002"], "description"=>"<div><p>To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS) including 3,558 subjects from the TwinsUK and BRIGHT cohorts in the UK and the DCCT/EDIC cohort from North America. Five loci were significantly associated with QT interval at P<1×10<sup>−6</sup>. To validate these findings we performed an <em>in silico</em> comparison with data from two QT consortia: QTSCD (n = 15,842) and QTGEN (n = 13,685). Analysis confirmed the association between common variants near <em>NOS1AP</em> (P = 1.4×10<sup>−83</sup>) and the phospholamban (<em>PLN</em>) gene (P = 1.9×10<sup>−29</sup>). The most associated SNP near <em>NOS1AP</em> (rs12143842) explains 0.82% variance; the SNP near <em>PLN</em> (rs11153730) explains 0.74% variance of QT interval duration. We found no evidence for interaction between these two SNPs (P = 0.99). PLN is a key regulator of cardiac diastolic function and is involved in regulating intracellular calcium cycling, it has only recently been identified as a susceptibility locus for QT interval. These data offer further mechanistic insights into genetic influence on the QT interval which may predispose to life threatening arrhythmias and sudden cardiac death.</p></div>", "links"=>[], "tags"=>["cardiac", "meta-analysis", "genome-wide", "studies"], "article_id"=>147072, "categories"=>["Cancer", "Genetics", "Medicine"], "users"=>["Ilja M. Nolte", "Chris Wallace", "Stephen J. Newhouse", "Daryl Waggott", "Jingyuan Fu", "Nicole Soranzo", "Rhian Gwilliam", "Panos Deloukas", "Irina Savelieva", "Dongling Zheng", "Chrysoula Dalageorgou", "Martin Farrall", "Nilesh J. Samani", "John Connell", "Morris Brown", "Anna Dominiczak", "Mark Lathrop", "Eleftheria Zeggini", "Louise V. Wain", "Christopher Newton-Cheh", "Mark Eijgelsheim", "Kenneth Rice", "Paul I. W. de Bakker", "Arne Pfeufer", "Serena Sanna", "Dan E. Arking", "Folkert W. Asselbergs", "Tim D. Spector", "Nicholas D. Carter", "Steve Jeffery", "Martin Tobin", "Mark Caulfield", "Harold Snieder", "Andrew D. Paterson", "Patricia B. Munroe", "Yalda Jamshidi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006138.s001", "https://dx.doi.org/10.1371/journal.pone.0006138.s002", "https://dx.doi.org/10.1371/journal.pone.0006138.s003", "https://dx.doi.org/10.1371/journal.pone.0006138.s004", "https://dx.doi.org/10.1371/journal.pone.0006138.s005", "https://dx.doi.org/10.1371/journal.pone.0006138.s006"], "stats"=>{"downloads"=>6, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Common_Genetic_Variation_Near_the_Phospholamban_Gene_Is_Associated_with_Cardiac_Repolarisation_Meta_Analysis_of_Three_Genome_Wide_Association_Studies/147072", "title"=>"Common Genetic Variation Near the <em>Phospholamban</em> Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2009-07-09 01:57:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/892219"], "description"=>"<p>Shown is the region extending to 500 kb either side of the most associated SNP rs11153730. The SNPs are illustrated on −log10(<i>P</i>) scale as a function of chromosomal position (NCBI build36.3). The sentinel SNP is illustrated in blue. Surrounding SNPs are coloured according to their r<sup>2</sup> with rs11153730 (red indicates an r<sup>2</sup>>0.8, orange an r<sup>2</sup> of 0.5–0.8, yellow an r<sup>2</sup> of 0.2–0.5 and grey an r<sup>2</sup> of less than 0.2).</p>", "links"=>[], "tags"=>["locus", "chromosome"], "article_id"=>562622, "categories"=>["Cancer", "Genetics", "Medicine"], "users"=>["Ilja M. Nolte", "Chris Wallace", "Stephen J. Newhouse", "Daryl Waggott", "Jingyuan Fu", "Nicole Soranzo", "Rhian Gwilliam", "Panos Deloukas", "Irina Savelieva", "Dongling Zheng", "Chrysoula Dalageorgou", "Martin Farrall", "Nilesh J. Samani", "John Connell", "Morris Brown", "Anna Dominiczak", "Mark Lathrop", "Eleftheria Zeggini", "Louise V. Wain", "Christopher Newton-Cheh", "Mark Eijgelsheim", "Kenneth Rice", "Paul I. W. de Bakker", "Arne Pfeufer", "Serena Sanna", "Dan E. Arking", "Folkert W. Asselbergs", "Tim D. Spector", "Nicholas D. Carter", "Steve Jeffery", "Martin Tobin", "Mark Caulfield", "Harold Snieder", "Andrew D. Paterson", "Patricia B. Munroe", "Yalda Jamshidi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006138.g003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regional_association_plot_for_the_SLC35F1_C6orf204_PLN_locus_on_chromosome_6_/562622", "title"=>"Regional association plot for the <i>SLC35F1/C6orf204/PLN</i> locus on chromosome 6.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-09 00:43:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/892324"], "description"=>"<p>HWE: Hardy-Weinberg equilibrium test; SE: standard error; N/A: not applicable.</p>a<p>Percentage of explained variance.</p>", "links"=>[], "tags"=>["snp", "regions", "qt", "GWAS", "meta-analysis"], "article_id"=>562732, "categories"=>["Cancer", "Genetics", "Medicine"], "users"=>["Ilja M. Nolte", "Chris Wallace", "Stephen J. Newhouse", "Daryl Waggott", "Jingyuan Fu", "Nicole Soranzo", "Rhian Gwilliam", "Panos Deloukas", "Irina Savelieva", "Dongling Zheng", "Chrysoula Dalageorgou", "Martin Farrall", "Nilesh J. Samani", "John Connell", "Morris Brown", "Anna Dominiczak", "Mark Lathrop", "Eleftheria Zeggini", "Louise V. Wain", "Christopher Newton-Cheh", "Mark Eijgelsheim", "Kenneth Rice", "Paul I. W. de Bakker", "Arne Pfeufer", "Serena Sanna", "Dan E. Arking", "Folkert W. Asselbergs", "Tim D. Spector", "Nicholas D. Carter", "Steve Jeffery", "Martin Tobin", "Mark Caulfield", "Harold Snieder", "Andrew D. Paterson", "Patricia B. Munroe", "Yalda Jamshidi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006138.t002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_the_most_significant_SNP_from_the_five_regions_associated_with_QT_interval_in_GWAS_meta_analysis_of_TwinsUK_BRIGHT_and_DCCT_EDIC_cohorts_/562732", "title"=>"Results of the most significant SNP from the five regions associated with QT interval in GWAS meta-analysis of TwinsUK, BRIGHT and DCCT/EDIC cohorts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-09 00:45:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/892417"], "description"=>"<p>Freq: allele frequency.</p>a<p>NCBI Genome build 36.3.</p>", "links"=>[], "tags"=>["loci", "GWAS", "meta-analysis", "cohorts", "qtgen", "qtscd", "consortia"], "article_id"=>562810, "categories"=>["Cancer", "Genetics", "Medicine"], "users"=>["Ilja M. Nolte", "Chris Wallace", "Stephen J. Newhouse", "Daryl Waggott", "Jingyuan Fu", "Nicole Soranzo", "Rhian Gwilliam", "Panos Deloukas", "Irina Savelieva", "Dongling Zheng", "Chrysoula Dalageorgou", "Martin Farrall", "Nilesh J. Samani", "John Connell", "Morris Brown", "Anna Dominiczak", "Mark Lathrop", "Eleftheria Zeggini", "Louise V. Wain", "Christopher Newton-Cheh", "Mark Eijgelsheim", "Kenneth Rice", "Paul I. W. de Bakker", "Arne Pfeufer", "Serena Sanna", "Dan E. Arking", "Folkert W. Asselbergs", "Tim D. Spector", "Nicholas D. Carter", "Steve Jeffery", "Martin Tobin", "Mark Caulfield", "Harold Snieder", "Andrew D. Paterson", "Patricia B. Munroe", "Yalda Jamshidi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006138.t003", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_the_five_most_significant_loci_from_GWAS_meta_analysis_of_TwinsUK_BRIGHT_and_DCCT_EDIC_cohorts_and_in_silico_comparison_with_the_QTGEN_and_QTSCD_consortia_data_/562810", "title"=>"Results of the five most significant loci from GWAS meta-analysis of TwinsUK, BRIGHT and DCCT/EDIC cohorts and <i>in silico</i> comparison with the QTGEN and QTSCD consortia data.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-09 00:46:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/892491"], "description"=>"a<p>Systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg or taking anti-hypertensive drugs.</p>b<p>Type 1 or type 2 diabetes.</p>", "links"=>[], "tags"=>["characteristics"], "article_id"=>562905, "categories"=>["Cancer", "Genetics", "Medicine"], "users"=>["Ilja M. Nolte", "Chris Wallace", "Stephen J. Newhouse", "Daryl Waggott", "Jingyuan Fu", "Nicole Soranzo", "Rhian Gwilliam", "Panos Deloukas", "Irina Savelieva", "Dongling Zheng", "Chrysoula Dalageorgou", "Martin Farrall", "Nilesh J. Samani", "John Connell", "Morris Brown", "Anna Dominiczak", "Mark Lathrop", "Eleftheria Zeggini", "Louise V. Wain", "Christopher Newton-Cheh", "Mark Eijgelsheim", "Kenneth Rice", "Paul I. W. de Bakker", "Arne Pfeufer", "Serena Sanna", "Dan E. Arking", "Folkert W. Asselbergs", "Tim D. Spector", "Nicholas D. Carter", "Steve Jeffery", "Martin Tobin", "Mark Caulfield", "Harold Snieder", "Andrew D. Paterson", "Patricia B. Munroe", "Yalda Jamshidi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006138.t001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_characteristics_of_the_TwinsUK_BRIGHT_and_DCCT_EDIC_cohorts_/562905", "title"=>"Study characteristics of the TwinsUK, BRIGHT and DCCT/EDIC cohorts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-09 00:48:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/891979"], "description"=>"<p>SNPs are ordered along the chromosomes on the x-axis. The −log10 (P) results are plotted for 2,399,142 SNPs of the meta-analysis of TwinsUK, BRIGHT and DCCT/EDIC cohorts for 3,558 individuals. The red dots indicate SNPs with P<10<sup>−6</sup>.</p>", "links"=>[], "tags"=>["qt", "GWAS", "meta-analysis"], "article_id"=>562390, "categories"=>["Cancer", "Genetics", "Medicine"], "users"=>["Ilja M. Nolte", "Chris Wallace", "Stephen J. Newhouse", "Daryl Waggott", "Jingyuan Fu", "Nicole Soranzo", "Rhian Gwilliam", "Panos Deloukas", "Irina Savelieva", "Dongling Zheng", "Chrysoula Dalageorgou", "Martin Farrall", "Nilesh J. Samani", "John Connell", "Morris Brown", "Anna Dominiczak", "Mark Lathrop", "Eleftheria Zeggini", "Louise V. Wain", "Christopher Newton-Cheh", "Mark Eijgelsheim", "Kenneth Rice", "Paul I. W. de Bakker", "Arne Pfeufer", "Serena Sanna", "Dan E. Arking", "Folkert W. Asselbergs", "Tim D. Spector", "Nicholas D. Carter", "Steve Jeffery", "Martin Tobin", "Mark Caulfield", "Harold Snieder", "Andrew D. Paterson", "Patricia B. Munroe", "Yalda Jamshidi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006138.g001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Manhattan_plot_for_QT_interval_based_on_GWAS_meta_analysis_of_TwinsUK_BRIGHT_and_DCCT_EDIC_cohorts_/562390", "title"=>"Manhattan plot for QT interval based on GWAS meta-analysis of TwinsUK, BRIGHT, and DCCT/EDIC cohorts.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-09 00:39:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/892099"], "description"=>"<p>Based on 2,399,142 SNPs in 3,558 individuals from the combined cohorts. The −log10(P) plot of association test for QT interval is shown for all SNPs (black diamonds) and for all SNPs except those located within 1 Mb of the most significant SNPs of our five associated regions (dark grey) <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006138#pone.0006138-Pfeufer2\" target=\"_blank\">[26]</a>. Genomic Control λ was 1.016 <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006138#pone.0006138-NewtonCheh2\" target=\"_blank\">[25]</a>. The lower horizontal line denotes the 95% percentile of the results of all SNPs, values lower than this threshold were used for calculating the λ. The upper line indicates the point from where P-values of the complete dataset deviate from the expected line.</p>", "links"=>[], "tags"=>["plots", "meta-analysis"], "article_id"=>562500, "categories"=>["Cancer", "Genetics", "Medicine"], "users"=>["Ilja M. Nolte", "Chris Wallace", "Stephen J. Newhouse", "Daryl Waggott", "Jingyuan Fu", "Nicole Soranzo", "Rhian Gwilliam", "Panos Deloukas", "Irina Savelieva", "Dongling Zheng", "Chrysoula Dalageorgou", "Martin Farrall", "Nilesh J. Samani", "John Connell", "Morris Brown", "Anna Dominiczak", "Mark Lathrop", "Eleftheria Zeggini", "Louise V. Wain", "Christopher Newton-Cheh", "Mark Eijgelsheim", "Kenneth Rice", "Paul I. W. de Bakker", "Arne Pfeufer", "Serena Sanna", "Dan E. Arking", "Folkert W. Asselbergs", "Tim D. Spector", "Nicholas D. Carter", "Steve Jeffery", "Martin Tobin", "Mark Caulfield", "Harold Snieder", "Andrew D. Paterson", "Patricia B. Munroe", "Yalda Jamshidi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006138.g002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantile_quantile_plots_of_association_results_of_the_meta_analysis_from_TwinsUK_BRIGHT_and_DCCT_EDIC_cohorts_/562500", "title"=>"Quantile-quantile plots of association results of the meta-analysis from TwinsUK, BRIGHT and DCCT/EDIC cohorts.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-09 00:41:40"}

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Relative Metric

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