CiteULike

Mendeley | Further Information

{"title"=>"The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans", "type"=>"journal", "authors"=>[{"first_name"=>"Yi", "last_name"=>"Zhang", "scopus_author_id"=>"7601333059"}, {"first_name"=>"Zhiyong", "last_name"=>"Shao", "scopus_author_id"=>"14627922400"}, {"first_name"=>"Zhiwei", "last_name"=>"Zhai", "scopus_author_id"=>"14629791600"}, {"first_name"=>"Chuan", "last_name"=>"Shen", "scopus_author_id"=>"8603630400"}, {"first_name"=>"Jo Anne", "last_name"=>"Powell-Coffman", "scopus_author_id"=>"6602086693"}], "year"=>2009, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"355035949", "doi"=>"10.1371/journal.pone.0006348", "sgr"=>"68149149835", "scopus"=>"2-s2.0-68149149835", "isbn"=>"1932-6203 (Electronic)", "pmid"=>"19633713"}, "id"=>"de62ba3b-3317-3dde-a55c-a64dd0699250", "abstract"=>"During normal development or during disease, animal cells experience hypoxic (low oxygen) conditions, and the hypoxia-inducible factor (HIF) transcription factors implement most of the critical changes in gene expression that enable animals to adapt to this stress. Here, we examine the roles of HIF-1 in post-mitotic aging. We examined the effects of HIF-1 over-expression and of hif-1 loss-of-function mutations on longevity in C. elegans, a powerful genetic system in which adult somatic cells are post-mitotic. We constructed transgenic lines that expressed varying levels of HIF-1 protein and discovered a positive correlation between HIF-1 expression levels and lifespan. The data further showed that HIF-1 acted in parallel to the SKN-1/NRF and DAF-16/FOXO transcription factors to promote longevity. HIF-1 over-expression also conferred increased resistance to heat and oxidative stress. We isolated and characterized additional hif-1 mutations, and we found that each of 3 loss-of-function mutations conferred increased longevity in normal lab culture conditions, but, unlike HIF-1 over-expression, a hif-1 deletion mutation did not extend the lifespan of daf-16 or skn-1 mutants. We conclude that HIF-1 over-expression and hif-1 loss-of-function mutations promote longevity by different pathways. These data establish HIF-1 as one of the key stress-responsive transcription factors that modulate longevity in C. elegans and advance our understanding of the regulatory networks that link oxygen homeostasis and aging.", "link"=>"http://www.mendeley.com/research/hif1-hypoxiainducible-factor-modulates-lifespan-c-elegans", "reader_count"=>89, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>7, "Student > Doctoral Student"=>5, "Researcher"=>18, "Student > Ph. D. Student"=>25, "Student > Postgraduate"=>4, "Other"=>4, "Student > Master"=>9, "Student > Bachelor"=>10, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>7, "Student > Doctoral Student"=>5, "Researcher"=>18, "Student > Ph. D. Student"=>25, "Student > Postgraduate"=>4, "Other"=>4, "Student > Master"=>9, "Student > Bachelor"=>10, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>11, "Agricultural and Biological Sciences"=>67, "Medicine and Dentistry"=>2, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Psychology"=>1, "Chemical Engineering"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>67}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>11}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "reader_count_by_country"=>{"Sweden"=>1, "United States"=>3, "United Kingdom"=>1, "Switzerland"=>1, "Germany"=>1}, "group_count"=>4}

ORCID

CrossRef

• http://doi.org/10.7600/jpfsm.1.5
• http://doi.org/10.1080/0284186X.2017.1301680
• http://doi.org/10.1016/j.tem.2010.02.006
• http://doi.org/10.1096/fj.201903235R
• http://doi.org/10.20286/nova-jmbs-040347
• http://doi.org/10.1016/j.cbpa.2013.04.003
• http://doi.org/10.1186/s12864-018-5230-8
• http://doi.org/10.1093/gerona/glw105
• http://doi.org/10.1111/acel.12569
• http://doi.org/10.1016/j.aquatox.2019.02.014
• http://doi.org/10.1016/j.molcel.2010.05.023
• http://doi.org/10.2527/jas.2009-2381
• http://doi.org/10.1016/j.cub.2015.05.059
• http://doi.org/10.4161/worm.29868
• http://doi.org/10.1038/465554a
• http://doi.org/10.1007/s11357-016-9936-8
• http://doi.org/10.1073/pnas.1411199111
• http://doi.org/10.1517/17460441.2012.660144
• http://doi.org/10.1534/genetics.120.303219
• http://doi.org/10.1097/MNH.0b013e3283471a22
• http://doi.org/10.1111/j.1474-9726.2011.00672.x
• http://doi.org/10.1038/npjamd.2016.10
• http://doi.org/10.1007/s00018-015-1978-z
• http://doi.org/10.1096/fj.09-152223
• http://doi.org/10.1016/j.cub.2010.10.057
• http://doi.org/10.1515/bc.2010.123
• http://doi.org/10.1111/j.1474-9726.2010.00618.x
• http://doi.org/10.2203/dose-response.13-035.Ristow
• http://doi.org/10.3389/fgene.2015.00316
• http://doi.org/10.1371/journal.pgen.1002498
• http://doi.org/10.1371/journal.ppat.1001075
• http://doi.org/10.1017/S0007114511000614
• http://doi.org/10.1016/j.cmet.2010.05.001
• http://doi.org/10.1016/j.exger.2014.02.002
• http://doi.org/10.1016/j.jaut.2009.11.009
• http://doi.org/10.1128/MCB.00390-18
• http://doi.org/10.1093/gerona/glq036
• http://doi.org/10.1371/journal.pgen.1002394
• http://doi.org/10.1096/fj.10-162941
• http://doi.org/10.1038/nature11861
• http://doi.org/10.1016/j.freeradbiomed.2017.05.007
• http://doi.org/10.1186/s12915-018-0615-3
• http://doi.org/10.1016/j.molcel.2010.06.015
• http://doi.org/10.1111/acel.12390
• http://doi.org/10.1016/j.mad.2011.07.001
• http://doi.org/10.1126/science.aac9257
• http://doi.org/10.1517/17460441.2014.885014
• http://doi.org/10.1016/j.lssr.2016.06.003
• http://doi.org/10.1515/hsz-2019-0385
• http://doi.org/10.1038/ncomms4483
• http://doi.org/10.1007/s10522-016-9655-7
• http://doi.org/10.1016/j.phymed.2019.153132
• http://doi.org/10.1016/j.freeradbiomed.2018.12.006
• http://doi.org/10.1371/journal.pgen.1004972
• http://doi.org/10.1111/acel.12081
• http://doi.org/10.4161/21624046.2014.959404
• http://doi.org/10.1007/s12640-020-00207-y
• http://doi.org/10.18632/aging.100292
• http://doi.org/10.1534/genetics.109.107284
• http://doi.org/10.1134/S0006297916120075
• http://doi.org/10.1111/j.1474-9726.2009.00522.x
• http://doi.org/10.1038/nrm.2016.23
• http://doi.org/10.1371/journal.pone.0113865
• http://doi.org/10.1038/onc.2011.37
• http://doi.org/10.7554/eLife.36828
• http://doi.org/10.1038/emboj.2013.75
• http://doi.org/10.1016/j.freeradbiomed.2017.02.007
• http://doi.org/10.1016/j.exger.2014.03.028
• http://doi.org/10.1080/21624054.2016.1176823
• http://doi.org/10.1371/journal.pone.0016790
• http://doi.org/10.1172/JCI71749
• http://doi.org/10.1016/j.exger.2011.11.001
• http://doi.org/10.1016/j.redox.2019.101359
• http://doi.org/10.1039/C4LC01377H
• http://doi.org/10.18632/aging.101267
• http://doi.org/10.1098/rstb.2010.0198
• http://doi.org/10.4161/23723556.2014.975027
• http://doi.org/10.1186/s12860-016-0112-x
• http://doi.org/10.1016/j.celrep.2014.08.075
• http://doi.org/10.1016/j.freeradbiomed.2013.07.003
• http://doi.org/10.1371/journal.pone.0025476
• http://doi.org/10.1038/s41467-018-06624-0
• http://doi.org/10.1096/fj.10.162941
• http://doi.org/10.1016/j.jprot.2015.07.032
• http://doi.org/10.1111/acel.12439
• http://doi.org/10.1111/imb.12189
• http://doi.org/10.1371/journal.ppat.1000689
• http://doi.org/10.1038/s41598-019-47891-1
• http://doi.org/10.1038/nm0610-641
• http://doi.org/10.1016/j.cmet.2014.05.006
• http://doi.org/10.1016/j.mad.2018.08.001
• http://doi.org/10.1016/j.arr.2016.12.005
• http://doi.org/10.7554/eLife.19130
• http://doi.org/10.18632/aging.100683
• http://doi.org/10.1111/mec.15557
• http://doi.org/10.1016/j.arr.2010.04.001
• http://doi.org/10.1038/nature13264
• http://doi.org/10.1016/j.exger.2014.03.016
• http://doi.org/10.1016/j.isci.2019.11.039
• http://doi.org/10.1186/s12863-015-0167-2
• http://doi.org/10.3390/toxins7083344
• http://doi.org/10.1016/j.tem.2012.05.003
• http://doi.org/10.3390/genes11091043
• http://doi.org/10.1007/s11357-020-00194-0
• http://doi.org/10.7554/eLife.08833
• http://doi.org/10.1093/gerona/glt016
• http://doi.org/10.1093/jb/mvr026
• http://doi.org/10.1017/S0029665120007910

DataCite

Europe PMC Citations | Further Information

Europe PMC Database Citations | Further Information

{"UNIPROT"=>4}

PubMed Central | Further Information

• 4210294
• 4328591
• 3671255
• 4038567
• 3001303
• 2778979
• 2885591
• 2917906
• 2941539
• 2943975
• 3058811
• 3084006
• 3984390
• 4018576
• 4263271
• 4274350
• 3245324
• 3673879
• 3687363
• 3980873
• 4632857
• 4048780
• 4077615
• 4104296
• 4194168
• 3240588
• 3291539
• 4335496
• 2785477
• 2928816
• 3033420
• 3183046
• 4242664
• 3468884
• 3468885
• 2887269
• 2992375
• 4036400
• 2854889
• 3779632
• 3101847
• 3134877
• 3091522
• 3091523
• 4169858
• 4549754
• 3481051
• 3516179
• 3644678
• 4621483
• 3084006
• 4720515
• 4588544
• 4693473
• 4783347

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/68149149835"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/68149149835?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=68149149835&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=68149149835&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/68149149835", "dc:identifier"=>"SCOPUS_ID:68149149835", "eid"=>"2-s2.0-68149149835", "dc:title"=>"The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans", "dc:creator"=>"Zhang Y.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"4", "prism:issueIdentifier"=>"7", "prism:pageRange"=>nil, "prism:coverDate"=>"2009-07-27", "prism:coverDisplayDate"=>"27 July 2009", "prism:doi"=>"10.1371/journal.pone.0006348", "citedby-count"=>"129", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Iowa State University", "affiliation-city"=>"Ames", "affiliation-country"=>"United States"}], "pubmed-id"=>"19633713", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e6348", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}, {"$"=>"repositoryam"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}

Web of Science® | Further Information

Article Coverage

Article Coverage Curated

Facebook

• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0006348", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments

Nature

Reddit

Research Blogging | Further Information

ScienceSeeker | Further Information

Twitter

Wikipedia

Wordpress.com | Further Information

Counter

• {"month"=>"7", "year"=>"2009", "pdf_views"=>"121", "xml_views"=>"1", "html_views"=>"394"}
• {"month"=>"8", "year"=>"2009", "pdf_views"=>"86", "xml_views"=>"0", "html_views"=>"192"}
• {"month"=>"9", "year"=>"2009", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"91"}
• {"month"=>"10", "year"=>"2009", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"78"}
• {"month"=>"11", "year"=>"2009", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"69"}
• {"month"=>"12", "year"=>"2009", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"80"}
• {"month"=>"1", "year"=>"2010", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"67"}
• {"month"=>"2", "year"=>"2010", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"62"}
• {"month"=>"3", "year"=>"2010", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"68"}
• {"month"=>"4", "year"=>"2010", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"74"}
• {"month"=>"5", "year"=>"2010", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"102"}
• {"month"=>"6", "year"=>"2010", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"75"}
• {"month"=>"7", "year"=>"2010", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"66"}
• {"month"=>"8", "year"=>"2010", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"67"}
• {"month"=>"9", "year"=>"2010", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"59"}
• {"month"=>"10", "year"=>"2010", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"72"}
• {"month"=>"11", "year"=>"2010", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"62"}
• {"month"=>"12", "year"=>"2010", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"41"}
• {"month"=>"1", "year"=>"2011", "pdf_views"=>"17", "xml_views"=>"2", "html_views"=>"38"}
• {"month"=>"2", "year"=>"2011", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"47"}
• {"month"=>"3", "year"=>"2011", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"73"}
• {"month"=>"4", "year"=>"2011", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"47"}
• {"month"=>"5", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"41"}
• {"month"=>"6", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"31"}
• {"month"=>"7", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"38"}
• {"month"=>"8", "year"=>"2011", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"49"}
• {"month"=>"9", "year"=>"2011", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"72"}
• {"month"=>"10", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"51"}
• {"month"=>"11", "year"=>"2011", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"69"}
• {"month"=>"12", "year"=>"2011", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"49"}
• {"month"=>"1", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"62"}
• {"month"=>"2", "year"=>"2012", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"73"}
• {"month"=>"3", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"59"}
• {"month"=>"4", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"55"}
• {"month"=>"5", "year"=>"2012", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"72"}
• {"month"=>"6", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"65"}
• {"month"=>"7", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"73"}
• {"month"=>"8", "year"=>"2012", "pdf_views"=>"16", "xml_views"=>"5", "html_views"=>"86"}
• {"month"=>"9", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"57"}
• {"month"=>"10", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"60"}
• {"month"=>"11", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"80"}
• {"month"=>"12", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"80"}
• {"month"=>"1", "year"=>"2013", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"116"}
• {"month"=>"2", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"95"}
• {"month"=>"3", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"81"}
• {"month"=>"4", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"79"}
• {"month"=>"5", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"55"}
• {"month"=>"6", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"58"}
• {"month"=>"7", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
• {"month"=>"8", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"80"}
• {"month"=>"9", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"80"}
• {"month"=>"10", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"87"}
• {"month"=>"11", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"76"}
• {"month"=>"12", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"75"}
• {"month"=>"1", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"42"}
• {"month"=>"2", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"53"}
• {"month"=>"3", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"466"}
• {"month"=>"4", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"4", "html_views"=>"143"}
• {"month"=>"5", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"108"}
• {"month"=>"6", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"82"}
• {"month"=>"7", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"116"}
• {"month"=>"8", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"3", "html_views"=>"62"}
• {"month"=>"9", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"80"}
• {"month"=>"10", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"72"}
• {"month"=>"11", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"54"}
• {"month"=>"12", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"98"}
• {"month"=>"1", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"66"}
• {"month"=>"2", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"40"}
• {"month"=>"3", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"49"}
• {"month"=>"4", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"51"}
• {"month"=>"5", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"59"}
• {"month"=>"6", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"47"}
• {"month"=>"7", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"45"}
• {"month"=>"8", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"37"}
• {"month"=>"9", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"70"}
• {"month"=>"10", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"109"}
• {"month"=>"11", "year"=>"2015", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"123"}
• {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"124"}
• {"month"=>"1", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"100"}
• {"month"=>"2", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"58"}
• {"month"=>"3", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"64"}
• {"month"=>"4", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"74"}
• {"month"=>"5", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"46"}
• {"month"=>"6", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"43"}
• {"month"=>"7", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"43"}
• {"month"=>"8", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"47"}
• {"month"=>"9", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"65"}
• {"month"=>"10", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"52"}
• {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"45"}
• {"month"=>"12", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
• {"month"=>"1", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"53"}
• {"month"=>"2", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"80"}
• {"month"=>"3", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"85"}
• {"month"=>"4", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"53"}
• {"month"=>"5", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"78"}
• {"month"=>"6", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"60"}
• {"month"=>"7", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"56"}
• {"month"=>"8", "year"=>"2017", "pdf_views"=>"21", "xml_views"=>"4", "html_views"=>"48"}
• {"month"=>"9", "year"=>"2017", "pdf_views"=>"23", "xml_views"=>"3", "html_views"=>"58"}
• {"month"=>"10", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"59"}
• {"month"=>"11", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"41"}
• {"month"=>"12", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"58"}
• {"month"=>"1", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"52"}
• {"month"=>"2", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"43"}
• {"month"=>"3", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"33"}
• {"month"=>"4", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"26"}
• {"month"=>"5", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"50"}
• {"month"=>"6", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"40"}
• {"month"=>"7", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"5", "html_views"=>"40"}
• {"month"=>"8", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"33"}
• {"month"=>"9", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"31"}
• {"month"=>"10", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"47"}
• {"month"=>"11", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"42"}
• {"month"=>"12", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"44"}
• {"month"=>"1", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"50"}
• {"month"=>"2", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"37"}
• {"month"=>"3", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"32"}
• {"month"=>"4", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"4", "html_views"=>"30"}
• {"month"=>"5", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"26"}
• {"month"=>"6", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"34"}
• {"month"=>"7", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"22"}
• {"month"=>"8", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"9"}
• {"month"=>"9", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"21"}
• {"month"=>"10", "year"=>"2019", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"29"}
• {"month"=>"11", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"21"}
• {"month"=>"12", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"14"}
• {"month"=>"1", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"6", "html_views"=>"24"}
• {"month"=>"2", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"22"}
• {"month"=>"3", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"24"}
• {"month"=>"4", "year"=>"2020", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"19"}
• {"month"=>"5", "year"=>"2020", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"18"}
• {"month"=>"6", "year"=>"2020", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"27"}
• {"month"=>"7", "year"=>"2020", "pdf_views"=>"20", "xml_views"=>"3", "html_views"=>"3"}
• {"month"=>"8", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"12"}
• {"month"=>"9", "year"=>"2020", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"28"}
• {"month"=>"10", "year"=>"2020", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"18"}
• {"month"=>"11", "year"=>"2020", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"12"}
• {"month"=>"12", "year"=>"2020", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"23"}
• {"month"=>"1", "year"=>"2021", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
• {"month"=>"2", "year"=>"2021", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"20"}
• {"month"=>"3", "year"=>"2021", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"3"}

Figshare

• {"files"=>["https://ndownloader.figshare.com/files/890022"], "description"=>"<p>(A, B) <i>hif-1(P621G)</i> transgenes (<i>iaIs32</i> or <i>iaIs34</i>) extend the lifespan of animals carrying loss-of-function mutations in (A) <i>daf-16</i> (<i>p</i><0.0001) or (B) <i>skn-1</i> (<i>p</i><0.0001). (C) The longevity of <i>daf-2(e1370)</i> animals carrying a <i>hif-1 (P621G)</i> transgene is equivalent to that of <i>daf-2(e1370)</i> single mutants.</p>", "links"=>[], "tags"=>["over-expression", "extends", "lifespan"], "article_id"=>560480, "categories"=>["Cell Biology", "Genetics", "Medicine"], "users"=>["Yi Zhang", "Zhiyong Shao", "Zhiwei Zhai", "Chuan Shen", "Jo Anne Powell-Coffman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006348.g003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HIF_1_over_expression_extends_the_lifespan_of_daf_16_deficient_and_skn_1_deficient_mutants_/560480", "title"=>"HIF-1 over-expression extends the lifespan of <i>daf-16</i>-deficient and <i>skn-1</i>-deficient mutants.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-27 00:08:00"}
• {"files"=>["https://ndownloader.figshare.com/files/890160"], "description"=>"<p>(A,B) Characterization of <i>hif-1</i> mutation alleles. (A) The <i>hif-1</i> locus encodes 4 mRNA isoforms (<a href=\"http://www.wormbase.org\" target=\"_blank\">www.wormbase.org</a>). Exons are depicted as boxes, with coding sequences in black and untranslated regions in grey. The positions of two deletion alleles (<i>ia04</i> and <i>ok2564</i>) and one nonsense mutation (<i>ia07</i>) are shown. (B) The <i>hif-1 (ia07)</i> point mutation introduces an early stop codon; (C) Protein blots show that all three mutations in <i>hif-1</i> repress expression of the <i>Pnhr-57</i>::GFP reporter <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006348#pone.0006348-Shen2\" target=\"_blank\">[20]</a>. Expression was assayed in <i>vhl-1 (ok161)</i> mutants, which are defective in oxygen-dependent degradation of HIF-1. (D) <i>C. elegans</i> carrying <i>hif-1</i> loss-of-function mutations live longer than wild-type N2 (<i>p</i><0.0001). (E) <i>hif-1(ia04);daf-16(mu86)</i> double mutant animals do not live longer than <i>daf-16(mu86)</i> single mutants. (F) <i>daf-2 (e1370)</i> single mutants and <i>daf-2 (e1370); hif-1(ia04)</i> double mutants have equivalent lifespans. (G) <i>hif-1(ia04);skn-1(zu67)</i> double mutant animals do not live longer than <i>skn-1(zu67)</i> single mutants.</p>", "links"=>[], "tags"=>["loss-of-function", "mutations", "lifespan", "wild-type"], "article_id"=>560610, "categories"=>["Cell Biology", "Genetics", "Medicine"], "users"=>["Yi Zhang", "Zhiyong Shao", "Zhiwei Zhai", "Chuan Shen", "Jo Anne Powell-Coffman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006348.g005", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_hif_1_loss_of_function_mutations_extend_the_lifespan_of_wild_type_animals_via_pathway_s_that_require_daf_16_and_skn_1_/560610", "title"=>"<i>hif-1</i> loss-of-function mutations extend the lifespan of wild-type animals, via pathway(s) that require <i>daf-16</i> and <i>skn-1</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-27 00:10:10"}
• {"files"=>["https://ndownloader.figshare.com/files/890325"], "description"=>"*<p>The <i>p</i> value was calculated by log-rank test as a comparison to <i>daf-16(mu86)</i> worms.</p>†<p>The <i>p</i> value was calculated by log-rank test as a comparison to <i>skn-1(zu67)</i> worms.</p>‡<p>The <i>p</i> value was calculated by log-rank test as a comparison to <i>daf-2(e1370)</i> worms.</p><p>Longevity assays for <i>daf-2</i>-deficient strains were performed at 25°C. All other lifespan assays were conducted at 20°C.</p>", "links"=>[], "tags"=>["hif-1", "over-expression", "loss-of-function", "mutations", "longevity"], "article_id"=>560773, "categories"=>["Cell Biology", "Genetics", "Medicine"], "users"=>["Yi Zhang", "Zhiyong Shao", "Zhiwei Zhai", "Chuan Shen", "Jo Anne Powell-Coffman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006348.t002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_HIF_1_over_expression_or_hif_1_loss_of_function_mutations_on_the_longevity_of_daf_16_or_skn_1_mutants_/560773", "title"=>"Effects of HIF-1 over-expression or <i>hif-1</i> loss-of-function mutations on the longevity of <i>daf-16</i> or <i>skn-1</i> mutants.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-27 00:12:53"}
• {"files"=>["https://ndownloader.figshare.com/files/890092"], "description"=>"<p>(A) A reduction of function mutation in <i>daf-2</i> does not change the protein levels of epitope-tagged HIF-1 (<i>iaIs28</i>) or HIF-1(P621G) (<i>iaIs32</i>) in young adult animals (<i>p</i>>0.2 from three independent experiments). (B,C) The expression of two HIF-1 targets were assayed in wild-type animals and in animals carrying a loss-of-function mutation in <i>daf-2</i>. (B) <i>Pnhr-57</i>:GFP expression was assayed by protein blots and was not significantly different in these genetic backgrounds (<i>p</i>>0.2 from three independent experiments) (B) Quantitative RT-PCR revealed a marginal differences in the levels of K10H10.2 mRNA (<i>p</i> = 0.09).</p>", "links"=>[], "tags"=>["insulin-like", "receptor", "hif-1"], "article_id"=>560551, "categories"=>["Cell Biology", "Genetics", "Medicine"], "users"=>["Yi Zhang", "Zhiyong Shao", "Zhiwei Zhai", "Chuan Shen", "Jo Anne Powell-Coffman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006348.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_daf_2_insulin_like_receptor_does_not_regulate_expression_of_HIF_1_protein_or_its_targets_/560551", "title"=>"The <i>daf-2</i> insulin-like receptor does not regulate expression of HIF-1 protein or its targets.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-27 00:09:11"}
• {"files"=>["https://ndownloader.figshare.com/files/889879"], "description"=>"<p>(A) Diagram of the minigenes that express epitope-tagged HIF-1. Genomic sequence including the <i>hif-1</i> promoter sequence, exon 1, and intron 1, was fused to cDNA including exons 2–9 for the predominant <i>hif-1</i> mRNA isoform (<i>hif-1a</i>). A myc epitope tag was inserted. A proline to glycine conversion at amino acid residue 621 prevents VHL-1-mediated degradation <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006348#pone.0006348-Epstein1\" target=\"_blank\">[17]</a>. (B) Representative protein blots show that epitope-tagged HIF-1 is stabilized by loss-of-function mutations in <i>vhl-1</i> or <i>egl-9</i>. AHA-1 is ortholgous to HIFβ/ARNT <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006348#pone.0006348-PowellCoffman1\" target=\"_blank\">[48]</a>, and the abundance of AHA-1 does not vary significantly in these strains. (C) Western blots show the transgene restores HIF-1-mediated gene expression. <i>Pnhr-57</i>:GFP is a reporter for HIF-1 activity <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006348#pone.0006348-Shen2\" target=\"_blank\">[20]</a>. Its expression is dramatically reduced in <i>hif-1(ia04)</i> mutants and is restored by the <i>iaIs28</i> integrated <i>hif-1</i> transgene. (D) Oxygen-dependent degradation via the <i>vhl-1/egl-9</i> pathway is abolished when the HIF-1 proline residue 621 is mutated to glycine.</p>", "links"=>[], "tags"=>["genetics and genomics", "cell biology/cellular death and stress responses", "cell biology/gene expression", "developmental biology/aging"], "article_id"=>560330, "categories"=>["Cell Biology", "Genetics", "Medicine"], "users"=>["Yi Zhang", "Zhiyong Shao", "Zhiwei Zhai", "Chuan Shen", "Jo Anne Powell-Coffman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006348.g001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characterization_of_the_hif_1_and_hif_1_P621G_transgenes_/560330", "title"=>"Characterization of the <i>hif-1</i> and <i>hif-1(P621G)</i> transgenes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-27 00:05:30"}
• {"files"=>["https://ndownloader.figshare.com/files/441019", "https://ndownloader.figshare.com/files/441076", "https://ndownloader.figshare.com/files/441116"], "description"=>"<div><p>During normal development or during disease, animal cells experience hypoxic (low oxygen) conditions, and the hypoxia-inducible factor (HIF) transcription factors implement most of the critical changes in gene expression that enable animals to adapt to this stress. Here, we examine the roles of HIF-1 in post-mitotic aging. We examined the effects of HIF-1 over-expression and of <em>hif-1</em> loss-of-function mutations on longevity in <em>C. elegans</em>, a powerful genetic system in which adult somatic cells are post-mitotic. We constructed transgenic lines that expressed varying levels of HIF-1 protein and discovered a positive correlation between HIF-1 expression levels and lifespan. The data further showed that HIF-1 acted in parallel to the SKN-1/NRF and DAF-16/FOXO transcription factors to promote longevity. HIF-1 over-expression also conferred increased resistance to heat and oxidative stress. We isolated and characterized additional <em>hif-1</em> mutations, and we found that each of 3 loss-of-function mutations conferred increased longevity in normal lab culture conditions, but, unlike HIF-1 over-expression, a <em>hif-1</em> deletion mutation did not extend the lifespan of <em>daf-16</em> or <em>skn-1</em> mutants. We conclude that HIF-1 over-expression and <em>hif-1</em> loss-of-function mutations promote longevity by different pathways. These data establish HIF-1 as one of the key stress-responsive transcription factors that modulate longevity in <em>C. elegans</em> and advance our understanding of the regulatory networks that link oxygen homeostasis and aging.</p></div>", "links"=>[], "tags"=>["hif-1", "hypoxia-inducible", "modulates", "lifespan"], "article_id"=>146927, "categories"=>["Cell Biology", "Genetics", "Medicine"], "users"=>["Yi Zhang", "Zhiyong Shao", "Zhiwei Zhai", "Chuan Shen", "Jo Anne Powell-Coffman"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006348.s001", "https://dx.doi.org/10.1371/journal.pone.0006348.s002", "https://dx.doi.org/10.1371/journal.pone.0006348.s003"], "stats"=>{"downloads"=>19, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_HIF_1_Hypoxia_Inducible_Factor_Modulates_Lifespan_in_C_elegans_/146927", "title"=>"The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in <em>C. elegans</em>", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2009-07-27 01:55:27"}
• {"files"=>["https://ndownloader.figshare.com/files/890245"], "description"=>"<p>(A, B) Resistance to (A) t-butyl peroxide or (B) heat stress was assayed in <i>hif-1</i> loss-of-function mutants and in animals over-expressing HIF-1. The <i>daf-2 (e1370)</i> and <i>daf-16 (mu86)</i> strains were included as a basis for comparison. Error bars represent the standard error of the means from at least 3 experiments. (*, <i>p</i><0.0001 compared to wild type N2 worms using z-test).</p>", "links"=>[], "tags"=>["loss-of-function", "mutations", "hif-1", "over-expression", "oxidative"], "article_id"=>560696, "categories"=>["Cell Biology", "Genetics", "Medicine"], "users"=>["Yi Zhang", "Zhiyong Shao", "Zhiwei Zhai", "Chuan Shen", "Jo Anne Powell-Coffman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006348.g006", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_hif_1_loss_of_function_mutations_and_HIF_1_over_expression_increase_oxidative_stress_resistance_and_thermotolerance_/560696", "title"=>"<i>hif-1</i> loss-of-function mutations and HIF-1 over-expression increase oxidative stress resistance and thermotolerance.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-27 00:11:36"}
• {"files"=>["https://ndownloader.figshare.com/files/889959"], "description"=>"<p>(A) Protein blots quantitate expression of HIF-1 and HIF-1(P621G) transgenes (tagged with the myc epitope). <i>iaIs27</i> and <i>iaIs28</i> contain integrated copies of the <i>hif-1</i> minigene. <i>iaIs32</i>, <i>iaIs33</i>, and <i>iaIs34</i> carry integrated copies of <i>hif-1 (P621G)</i>. (B) Strains carrying <i>hif-1</i> transgenes live longer (<i>p</i><0.0001). Proportion alive is plotted over time. (C) The mean adult lifespans of strains over-expressing HIF-1 are positively correlated with the HIF-1 expression levels. Error bars represent the standard errors of the means.</p>", "links"=>[], "tags"=>["over-expression", "extends", "longevity", "dose-dependent"], "article_id"=>560411, "categories"=>["Cell Biology", "Genetics", "Medicine"], "users"=>["Yi Zhang", "Zhiyong Shao", "Zhiwei Zhai", "Chuan Shen", "Jo Anne Powell-Coffman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006348.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HIF_1_over_expression_extends_longevity_in_a_dose_dependent_manner_/560411", "title"=>"HIF-1 over-expression extends longevity in a dose-dependent manner.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-27 00:06:51"}
• {"files"=>["https://ndownloader.figshare.com/files/890360"], "description"=>"*<p>The longevity of each strain was compared to wild-type, and the <i>p</i> values were calculated by log-rank tests.</p>", "links"=>[], "tags"=>["hif-1", "loss-of-function", "mutations", "lifespan"], "article_id"=>560815, "categories"=>["Cell Biology", "Genetics", "Medicine"], "users"=>["Yi Zhang", "Zhiyong Shao", "Zhiwei Zhai", "Chuan Shen", "Jo Anne Powell-Coffman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006348.t001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Over_expression_of_HIF_1_protein_or_hif_1_loss_of_function_mutations_extend_adult_lifespan_in_C_elegans_in_standard_lab_culture_conditions_/560815", "title"=>"Over-expression of HIF-1 protein or <i>hif-1</i> loss-of-function mutations extend adult lifespan in <i>C. elegans</i> in standard lab culture conditions.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-27 00:13:35"}

PMC Usage Stats | Further Information

• {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"35", "unique-ip"=>"36", "pdf"=>"22", "year"=>"2010", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"28", "year"=>"2010", "pdf"=>"22", "unique-ip"=>"31", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"22", "unique-ip"=>"27", "pdf"=>"19", "year"=>"2010", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"27", "year"=>"2010", "pdf"=>"21", "unique-ip"=>"28", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"39", "unique-ip"=>"30", "pdf"=>"13", "year"=>"2010", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"3"}
• {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"38", "year"=>"2010", "pdf"=>"24", "unique-ip"=>"33", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"39", "unique-ip"=>"38", "pdf"=>"23", "year"=>"2010", "figure"=>"18", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"19", "year"=>"2010", "pdf"=>"11", "unique-ip"=>"16", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"1", "abstract"=>"1", "full-text"=>"28", "unique-ip"=>"31", "pdf"=>"26", "year"=>"2010", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"3", "full-text"=>"42", "year"=>"2010", "pdf"=>"16", "unique-ip"=>"30", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"5"}
• {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"27", "unique-ip"=>"28", "pdf"=>"9", "year"=>"2010", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"15", "year"=>"2010", "pdf"=>"13", "unique-ip"=>"19", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "unique-ip"=>"18", "pdf"=>"10", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"2"}
• {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"18", "year"=>"2011", "pdf"=>"16", "unique-ip"=>"22", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "unique-ip"=>"20", "pdf"=>"10", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"17", "year"=>"2011", "pdf"=>"13", "unique-ip"=>"14", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"6", "full-text"=>"5", "unique-ip"=>"10", "pdf"=>"4", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"19", "year"=>"2011", "pdf"=>"16", "unique-ip"=>"22", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"14", "unique-ip"=>"13", "pdf"=>"8", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"2"}
• {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"10", "year"=>"2011", "pdf"=>"4", "unique-ip"=>"9", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"14", "unique-ip"=>"13", "pdf"=>"6", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"18", "year"=>"2011", "pdf"=>"4", "unique-ip"=>"18", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"10", "unique-ip"=>"12", "pdf"=>"3", "year"=>"2011", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"11", "year"=>"2011", "pdf"=>"4", "unique-ip"=>"13", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"22", "unique-ip"=>"20", "pdf"=>"7", "year"=>"2012", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"24", "year"=>"2012", "pdf"=>"8", "unique-ip"=>"21", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "unique-ip"=>"16", "pdf"=>"6", "year"=>"2012", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"8", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"13", "unique-ip"=>"15", "pdf"=>"4", "year"=>"2012", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"42", "year"=>"2009", "pdf"=>"21", "unique-ip"=>"35", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"4"}
• {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"108", "unique-ip"=>"101", "pdf"=>"65", "year"=>"2009", "figure"=>"20", "scanned-summary"=>"0", "supp-data"=>"8"}
• {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"69", "year"=>"2009", "pdf"=>"51", "unique-ip"=>"66", "figure"=>"17", "scanned-summary"=>"0", "supp-data"=>"3"}
• {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"20", "unique-ip"=>"19", "pdf"=>"11", "year"=>"2009", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"57", "year"=>"2009", "pdf"=>"26", "unique-ip"=>"46", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"43", "unique-ip"=>"37", "pdf"=>"15", "year"=>"2009", "figure"=>"21", "scanned-summary"=>"0", "supp-data"=>"4"}
• {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"11", "year"=>"2012", "pdf"=>"6", "unique-ip"=>"15", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
• {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
• {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
• {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
• {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
• {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
• {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
• {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
• {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
• {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
• {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
• {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
• {"unique-ip"=>"19", "full-text"=>"30", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
• {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
• {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
• {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
• {"unique-ip"=>"17", "full-text"=>"21", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
• {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
• {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
• {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
• {"unique-ip"=>"15", "full-text"=>"8", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
• {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
• {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
• {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
• {"unique-ip"=>"11", "full-text"=>"24", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
• {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
• {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
• {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
• {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
• {"unique-ip"=>"21", "full-text"=>"25", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
• {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
• {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
• {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
• {"unique-ip"=>"22", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
• {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
• {"unique-ip"=>"13", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
• {"unique-ip"=>"32", "full-text"=>"24", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
• {"unique-ip"=>"29", "full-text"=>"19", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
• {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
• {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"12"}
• {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"1"}
• {"unique-ip"=>"30", "full-text"=>"36", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
• {"unique-ip"=>"24", "full-text"=>"22", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
• {"unique-ip"=>"31", "full-text"=>"13", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
• {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"3"}
• {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
• {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
• {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"6"}
• {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
• {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
• {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
• {"unique-ip"=>"19", "full-text"=>"24", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
• {"unique-ip"=>"18", "full-text"=>"24", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
• {"unique-ip"=>"18", "full-text"=>"28", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
• {"unique-ip"=>"21", "full-text"=>"27", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"2", "year"=>"2017", "month"=>"1"}
• {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
• {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
• {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
• {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
• {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
• {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
• {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
• {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
• {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
• {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
• {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
• {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
• {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
• {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
• {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
• {"unique-ip"=>"24", "full-text"=>"22", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
• {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
• {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
• {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
• {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
• {"unique-ip"=>"20", "full-text"=>"27", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
• {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
• {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
• {"unique-ip"=>"31", "full-text"=>"36", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"2", "year"=>"2018", "month"=>"12"}
• {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
• {"unique-ip"=>"16", "full-text"=>"21", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
• {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
• {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
• {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
• {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
• {"unique-ip"=>"26", "full-text"=>"25", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"3", "cited-by"=>"3", "year"=>"2019", "month"=>"10"}
• {"unique-ip"=>"19", "full-text"=>"10", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
• {"unique-ip"=>"17", "full-text"=>"13", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
• {"unique-ip"=>"35", "full-text"=>"32", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
• {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
• {"unique-ip"=>"24", "full-text"=>"29", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
• {"unique-ip"=>"26", "full-text"=>"26", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
• {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
• {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
• {"unique-ip"=>"30", "full-text"=>"36", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
• {"unique-ip"=>"34", "full-text"=>"45", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
• {"unique-ip"=>"27", "full-text"=>"27", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
• {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
• {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2021", "month"=>"1"}

Relative Metric

{"start_date"=>"2009-01-01T00:00:00Z", "end_date"=>"2009-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[349, 614, 744, 851, 955, 1059, 1167, 1262, 1352, 1431, 1516, 1593, 1668, 1746, 1817, 1883, 1950, 2017, 2075, 2141, 2198, 2254, 2313, 2368, 2424, 2474, 2534, 2591, 2651, 2710, 2776, 2837, 2892, 2953, 3014, 3072, 3130, 3186, 3251, 3307, 3366, 3427, 3500, 3561, 3627, 3688, 3759, 3821, 3888, 3950, 4010, 4070, 4131, 4189, 4242, 4307, 4370, 4431, 4491, 4549, 4608]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[335, 600, 731, 835, 935, 1034, 1138, 1230, 1320, 1399, 1485, 1570, 1643, 1714, 1791, 1859, 1928, 1987, 2040, 2104, 2157, 2210, 2261, 2320, 2373, 2432, 2486, 2543, 2603, 2655, 2720, 2787, 2844, 2901, 2952, 3005, 3065, 3119, 3176, 3236, 3305, 3373, 3432, 3492, 3558, 3614, 3676, 3736, 3801, 3869, 3930, 3973, 4031, 4096, 4176, 4234, 4283, 4338, 4405, 4464, 4512]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[336, 588, 721, 826, 931, 1029, 1138, 1224, 1311, 1395, 1477, 1555, 1632, 1704, 1774, 1847, 1919, 1987, 2039, 2089, 2149, 2204, 2264, 2319, 2370, 2424, 2481, 2535, 2593, 2645, 2702, 2765, 2816, 2865, 2932, 2992, 3045, 3105, 3159, 3208, 3259, 3316, 3374, 3430, 3490, 3542, 3602, 3654, 3720, 3783, 3851, 3919, 3981, 4038, 4096, 4151, 4197, 4235, 4297, 4372, 4437]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[366, 637, 775, 896, 999, 1118, 1230, 1322, 1416, 1516, 1602, 1685, 1767, 1849, 1914, 1982, 2049, 2120, 2185, 2246, 2303, 2363, 2409, 2473, 2535, 2599, 2655, 2717, 2777, 2842, 2906, 2977, 3021, 3088, 3144, 3199, 3253, 3317, 3379, 3456, 3508, 3567, 3634, 3716, 3781, 3853, 3911, 3974, 4040, 4118, 4170, 4218, 4285, 4341, 4404, 4467, 4527, 4584, 4631, 4689, 4725]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[306, 556, 687, 796, 910, 1010, 1116, 1207, 1291, 1370, 1458, 1539, 1613, 1694, 1768, 1842, 1905, 1965, 2034, 2097, 2148, 2198, 2253, 2307, 2349, 2409, 2462, 2516, 2562, 2614, 2666, 2723, 2779, 2833, 2895, 2961, 3009, 3061, 3119, 3183, 3232, 3303, 3367, 3414, 3464, 3516, 3588, 3648, 3713, 3774, 3827, 3880, 3953, 4012, 4070, 4125, 4187, 4230, 4291, 4339, 4393]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[332, 584, 719, 824, 927, 1030, 1139, 1233, 1322, 1402, 1483, 1570, 1649, 1730, 1806, 1873, 1939, 2003, 2068, 2130, 2191, 2248, 2302, 2362, 2427, 2485, 2544, 2599, 2653, 2709, 2778, 2840, 2896, 2950, 3013, 3073, 3137, 3189, 3253, 3305, 3364, 3423, 3489, 3557, 3606, 3668, 3742, 3797, 3852, 3907, 3962, 4027, 4072, 4132, 4193, 4256, 4308, 4366, 4427, 4493, 4556]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[321, 578, 720, 834, 929, 1032, 1139, 1230, 1314, 1399, 1483, 1569, 1645, 1719, 1793, 1864, 1941, 2002, 2063, 2129, 2189, 2232, 2285, 2336, 2395, 2448, 2515, 2581, 2637, 2681, 2747, 2800, 2854, 2920, 2974, 3039, 3088, 3143, 3202, 3258, 3299, 3389, 3447, 3510, 3573, 3643, 3713, 3771, 3845, 3907, 3956, 4020, 4074, 4127, 4187, 4251, 4316, 4354, 4401, 4472, 4518]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[340, 575, 698, 803, 889, 974, 1077, 1169, 1245, 1318, 1398, 1468, 1540, 1608, 1679, 1748, 1819, 1877, 1937, 1999, 2044, 2100, 2148, 2198, 2250, 2306, 2357, 2414, 2458, 2517, 2572, 2636, 2690, 2749, 2799, 2861, 2914, 2970, 3026, 3102, 3143, 3237, 3303, 3373, 3441, 3500, 3553, 3608, 3679, 3733, 3791, 3856, 3908, 3962, 4033, 4096, 4149, 4187, 4229, 4281, 4336]}, {"subject_area"=>"/Physical sciences/Chemistry", "average_usage"=>[303, 516, 651, 762, 853, 944, 1048, 1140, 1218, 1291, 1366, 1449, 1509, 1593, 1663, 1726, 1797, 1856, 1906, 1958, 2018, 2083, 2128, 2175, 2235, 2294, 2354, 2403, 2452, 2502, 2558, 2617, 2672, 2730, 2794, 2857, 2913, 2970, 3036, 3087, 3155, 3216, 3270, 3336, 3390, 3450, 3508, 3568, 3623, 3705, 3762, 3812, 3895, 3938, 4026, 4083, 4137, 4187, 4235, 4292, 4348]}]}

F1000Prime