Vitamin D Status Is Positively Correlated with Regulatory T Cell Function in Patients with Multiple Sclerosis
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis", "type"=>"journal", "authors"=>[{"first_name"=>"Joost", "last_name"=>"Smolders", "scopus_author_id"=>"23101501900"}, {"first_name"=>"Mariëlle", "last_name"=>"Thewissen", "scopus_author_id"=>"16204164800"}, {"first_name"=>"Evelyn", "last_name"=>"Peelen", "scopus_author_id"=>"26041037500"}, {"first_name"=>"Paul", "last_name"=>"Menheere", "scopus_author_id"=>"7003768785"}, {"first_name"=>"Jan Willem Cohen", "last_name"=>"Tervaert", "scopus_author_id"=>"7003559165"}, {"first_name"=>"Jan", "last_name"=>"Damoiseaux", "scopus_author_id"=>"55313943700"}, {"first_name"=>"Raymond", "last_name"=>"Hupperts", "scopus_author_id"=>"57190082411"}], "year"=>2009, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-68949140898", "sgr"=>"68949140898", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0006635", "pmid"=>"19675671", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"355113839"}, "id"=>"be5b8fcb-7daf-3f65-89a9-c0a05cab7644", "abstract"=>"BACKGROUND: In several autoimmune diseases, including multiple sclerosis (MS), a compromised regulatory T cell (Treg) function is believed to be critically involved in the disease process. In vitro, the biologically active metabolite of vitamin D has been shown to promote Treg development. A poor vitamin D status has been linked with MS incidence and MS disease activity. In the present study, we assess a potential in vivo correlation between vitamin D status and Treg function in relapsing remitting MS (RRMS) patients.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: Serum levels of 25-hydroxyvitamin D (25(OH)D) were measured in 29 RRMS patients. The number of circulating Tregs was assessed by flow-cytometry, and their functionality was tested in vitro in a CFSE-based proliferation suppression assay. Additionally, the intracellular cytokine profile of T helper cells was determined directly ex-vivo by flow-cytometry. Serum levels of 25(OH)D correlated positively with the ability of Tregs to suppress T cell proliferation (R = 0.590, P = 0.002). No correlation between 25(OH)D levels and the number of Tregs was found. The IFN-gamma/IL-4 ratio (Th1/Th2-balance) was more directed towards IL-4 in patients with favourable 25(OH)D levels (R = -0.435, P = 0.023).\\n\\nCONCLUSIONS/SIGNIFICANCE: These results show an association of high 25(OH)D levels with an improved Treg function, and with skewing of the Th1/Th2 balance towards Th2. These findings suggest that vitamin D is an important promoter of T cell regulation in vivo in MS patients. It is tempting to speculate that our results may not only hold for MS, but also for other autoimmune diseases. Future intervention studies will show whether modulation of vitamin D status results in modulation of the T cell response and subsequent amelioration of disease activity.", "link"=>"http://www.mendeley.com/research/vitamin-d-status-positively-correlated-regulatory-t-cell-function-patients-multiple-sclerosis-1", "reader_count"=>86, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>4, "Librarian"=>3, "Researcher"=>11, "Student > Doctoral Student"=>7, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>6, "Student > Master"=>14, "Other"=>3, "Student > Bachelor"=>15, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>4, "Librarian"=>3, "Researcher"=>11, "Student > Doctoral Student"=>7, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>6, "Student > Master"=>14, "Other"=>3, "Student > Bachelor"=>15, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Engineering"=>1, "Nursing and Health Professions"=>4, "Biochemistry, Genetics and Molecular Biology"=>6, "Agricultural and Biological Sciences"=>21, "Medicine and Dentistry"=>40, "Neuroscience"=>2, "Psychology"=>1, "Social Sciences"=>2, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>40}, "Neuroscience"=>{"Neuroscience"=>2}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>21}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>5}}, "reader_count_by_country"=>{"Canada"=>2, "Austria"=>1, "Brazil"=>1, "Mexico"=>1, "Portugal"=>1}, "group_count"=>3}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/68949140898"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/68949140898?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=68949140898&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=68949140898&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/68949140898", "dc:identifier"=>"SCOPUS_ID:68949140898", "eid"=>"2-s2.0-68949140898", "dc:title"=>"Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis", "dc:creator"=>"Smolders J.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"4", "prism:issueIdentifier"=>"8", "prism:pageRange"=>nil, "prism:coverDate"=>"2009-08-13", "prism:coverDisplayDate"=>"13 August 2009", "prism:doi"=>"10.1371/journal.pone.0006635", "citedby-count"=>"210", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University Hospital Maastricht", "affiliation-city"=>"Maastricht", "affiliation-country"=>"Netherlands"}], "pubmed-id"=>"19675671", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e6635", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0006635", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"169", "xml_views"=>"1", "html_views"=>"621"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"91", "xml_views"=>"0", "html_views"=>"155"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"43", "xml_views"=>"2", "html_views"=>"178"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"134"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"125"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"40", "xml_views"=>"1", "html_views"=>"125"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"110"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"131"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"116"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"153"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"133"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"145"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"118"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"119"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"41", "xml_views"=>"2", "html_views"=>"180"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"122"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"96"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"96"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"148"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"125"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"107"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"63"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"102"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"118"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"130"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"173"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"110"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"173"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"146"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"34", "xml_views"=>"1", "html_views"=>"179"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"150"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"148"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"123"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"100"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"5", "html_views"=>"100"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"94"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"128"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"146"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"121"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"136"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"120"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"110"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"173"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"136"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"98"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"111"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"87"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"2", "html_views"=>"84"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"101"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"93"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"100"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"83"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"3", "html_views"=>"54"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"66"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"108"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"3", "html_views"=>"92"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"83"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"89"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"71"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"104"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"103"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"153"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"118"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"100"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"69"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"99"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"112"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"65"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"69"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"48"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"78"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"18"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"3", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"3", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"36"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"3", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"12"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/887783"], "description"=>"<p>(A–D) Correlation of relative and absolute number of Tregs with 25(OH)D levels. The Pearson correlation coefficient and corresponding regression line are shown.</p>", "links"=>[], "tags"=>["circulating", "tregs", "serum"], "article_id"=>558240, "categories"=>["Immunology", "Neuroscience", "Medicine"], "users"=>["Joost Smolders", "Mariëlle Thewissen", "Evelyn Peelen", "Paul Menheere", "Jan Willem Cohen Tervaert", "Jan Damoiseaux", "Raymond Hupperts"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006635.g004", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_of_the_number_of_circulating_Tregs_with_serum_25_OH_D_levels_/558240", "title"=>"Correlation of the number of circulating Tregs with serum 25(OH)D levels.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 05:00:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/887631"], "description"=>"<p>Within the CD3<sup>+</sup>CD4<sup>+</sup> lymphogate, Tregs were defined as either being (A) CD25<sup>+</sup>FoxP3<sup>+</sup> or being (B) CD25<sup>+</sup>CD127<sup>−</sup>. (C) The percentages of Tregs within the CD4<sup>+</sup> T cell compartment. (D) Absolute number of circulating Tregs. The lines indicate the median values.</p>", "links"=>[], "tags"=>["circulating"], "article_id"=>558088, "categories"=>["Immunology", "Neuroscience", "Medicine"], "users"=>["Joost Smolders", "Mariëlle Thewissen", "Evelyn Peelen", "Paul Menheere", "Jan Willem Cohen Tervaert", "Jan Damoiseaux", "Raymond Hupperts"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006635.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relative_and_absolute_number_of_circulating_Tregs_/558088", "title"=>"Relative and absolute number of circulating Tregs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:59:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/887912"], "description"=>"<p>(A) The percentages of IFN-γ<sup>+</sup>, IL-4<sup>+</sup>, IL-17<sup>+</sup> and IL-10<sup>+</sup> CD4<sup>+</sup> T cells. The lines show the median values. (B) The correlation between IFN-γ/IL-4 ratio and serum 25(OH)D levels. The Pearson correlation coefficient and corresponding regression line are shown.</p>", "links"=>[], "tags"=>["helper", "subsets", "serum"], "article_id"=>558365, "categories"=>["Immunology", "Neuroscience", "Medicine"], "users"=>["Joost Smolders", "Mariëlle Thewissen", "Evelyn Peelen", "Paul Menheere", "Jan Willem Cohen Tervaert", "Jan Damoiseaux", "Raymond Hupperts"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006635.g005", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_of_T_helper_cell_subsets_with_serum_25_OH_D_levels_/558365", "title"=>"Correlation of T helper cell subsets with serum 25(OH)D levels.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 05:01:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/887470"], "description"=>"<p>(A) The correlation between ED50 and serum 25(OH)D levels. (B–E) Correlation between inhibition of suppression and 25(OH)D levels for the individual Treg/Tresp ratios. The Spearman correlation coefficient is shown. The regression line illustrates the direction of the association. The closed dots represent the Beta Interferon-treated patients, the open dots the untreated patients.</p>", "links"=>[], "tags"=>["treg", "suppressive", "serum"], "article_id"=>557925, "categories"=>["Immunology", "Neuroscience", "Medicine"], "users"=>["Joost Smolders", "Mariëlle Thewissen", "Evelyn Peelen", "Paul Menheere", "Jan Willem Cohen Tervaert", "Jan Damoiseaux", "Raymond Hupperts"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006635.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_Treg_suppressive_function_and_serum_25_OH_D_levels_/557925", "title"=>"Correlation between Treg suppressive function and serum 25(OH)D levels.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:58:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/888000"], "description"=>"*<p>Expanded Disability Status Scale.</p>", "links"=>[], "tags"=>["immunology/autoimmunity", "neurological disorders/multiple sclerosis and related disorders", "nutrition/deficiencies"], "article_id"=>558454, "categories"=>["Immunology", "Neuroscience", "Medicine"], "users"=>["Joost Smolders", "Mariëlle Thewissen", "Evelyn Peelen", "Paul Menheere", "Jan Willem Cohen Tervaert", "Jan Damoiseaux", "Raymond Hupperts"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006635.t001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_characteristics_/558454", "title"=>"Patient characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 05:01:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/887360"], "description"=>"<p>(A) Representative dot-plot of the sorting protocol. CD25<sup>+</sup>CD127<sup>−</sup> cells within the CD4<sup>+</sup> lymphogate were sorted as Tregs, CD25<sup>−</sup> cells were sorted as Tresps. (B) The percentages of suppression which were achieved for the respective Treg/Tresp ratios of the individual patients are shown. The Treg/Tresp ratio at which 50% inhibition of proliferation was achieved is defined as ED50 of suppression. The distribution of ED50 is shown in the rightmost column. The lines show the median values. The closed dots represent the Beta Interferon-treated patients, the open dots the untreated patients.</p>", "links"=>[], "tags"=>["proliferation", "suppression"], "article_id"=>557811, "categories"=>["Immunology", "Neuroscience", "Medicine"], "users"=>["Joost Smolders", "Mariëlle Thewissen", "Evelyn Peelen", "Paul Menheere", "Jan Willem Cohen Tervaert", "Jan Damoiseaux", "Raymond Hupperts"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006635.g001", "stats"=>{"downloads"=>1, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_proliferation_suppression_assay_/557811", "title"=>"Results proliferation suppression assay.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:58:21"}

PMC Usage Stats | Further Information

  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"87", "year"=>"2010", "pdf"=>"56", "unique-ip"=>"82", "figure"=>"15", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"112", "unique-ip"=>"102", "pdf"=>"84", "year"=>"2010", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"97", "year"=>"2010", "pdf"=>"62", "unique-ip"=>"93", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"108", "unique-ip"=>"87", "pdf"=>"47", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"79", "year"=>"2010", "pdf"=>"48", "unique-ip"=>"72", "figure"=>"19", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"58", "unique-ip"=>"60", "pdf"=>"47", "year"=>"2010", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"54", "year"=>"2010", "pdf"=>"35", "unique-ip"=>"49", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"61", "unique-ip"=>"56", "pdf"=>"32", "year"=>"2010", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"7", "full-text"=>"65", "year"=>"2010", "pdf"=>"47", "unique-ip"=>"59", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"75", "unique-ip"=>"64", "pdf"=>"49", "year"=>"2010", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"62", "year"=>"2010", "pdf"=>"81", "unique-ip"=>"61", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"50", "unique-ip"=>"40", "pdf"=>"18", "year"=>"2010", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"2", "full-text"=>"53", "year"=>"2011", "pdf"=>"29", "unique-ip"=>"42", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"39", "unique-ip"=>"37", "pdf"=>"22", "year"=>"2011", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"59", "year"=>"2011", "pdf"=>"53", "unique-ip"=>"58", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"45", "unique-ip"=>"35", "pdf"=>"19", "year"=>"2011", "figure"=>"15", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"46", "year"=>"2011", "pdf"=>"23", "unique-ip"=>"41", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"32", "unique-ip"=>"32", "pdf"=>"22", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"26", "year"=>"2011", "pdf"=>"10", "unique-ip"=>"25", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"13", "unique-ip"=>"17", "pdf"=>"11", "year"=>"2011", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"24", "year"=>"2011", "pdf"=>"17", "unique-ip"=>"24", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"16", "unique-ip"=>"20", "pdf"=>"16", "year"=>"2011", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"24", "year"=>"2011", "pdf"=>"11", "unique-ip"=>"19", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "unique-ip"=>"22", "pdf"=>"12", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"27", "year"=>"2012", "pdf"=>"9", "unique-ip"=>"23", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"25", "unique-ip"=>"23", "pdf"=>"17", "year"=>"2012", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"30", "year"=>"2012", "pdf"=>"13", "unique-ip"=>"28", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"23", "unique-ip"=>"24", "pdf"=>"13", "year"=>"2012", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "year"=>"2012", "pdf"=>"6", "unique-ip"=>"17", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"182", "unique-ip"=>"153", "pdf"=>"100", "year"=>"2009", "figure"=>"25", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"159", "year"=>"2009", "pdf"=>"102", "unique-ip"=>"149", "figure"=>"34", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"75", "unique-ip"=>"63", "pdf"=>"51", "year"=>"2009", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"10", "full-text"=>"148", "year"=>"2009", "pdf"=>"92", "unique-ip"=>"126", "figure"=>"38", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"90", "unique-ip"=>"77", "pdf"=>"50", "year"=>"2009", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"18", "year"=>"2012", "pdf"=>"10", "unique-ip"=>"18", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"12", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"50", "full-text"=>"46", "pdf"=>"15", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"29", "full-text"=>"29", "pdf"=>"10", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"8", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"24", "full-text"=>"31", "pdf"=>"9", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"3", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"11", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"16", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"20", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"23", "full-text"=>"20", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"25", "full-text"=>"29", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"29", "full-text"=>"25", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"4", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"24", "full-text"=>"28", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"23", "full-text"=>"28", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"34", "full-text"=>"34", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"19", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"23", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"29", "full-text"=>"33", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"21", "full-text"=>"27", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"27", "full-text"=>"41", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"17", "full-text"=>"48", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"29", "full-text"=>"33", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"24", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"30", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"20", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"25", "full-text"=>"21", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"21", "full-text"=>"17", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"5", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}

Relative Metric

{"start_date"=>"2009-01-01T00:00:00Z", "end_date"=>"2009-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[302, 541, 669, 778, 878, 978, 1080, 1163, 1254, 1345, 1432, 1510, 1575, 1651, 1711, 1789, 1861, 1916, 1961, 2020, 2083, 2135, 2199, 2233, 2281, 2332, 2387, 2432, 2481, 2540, 2583, 2626, 2680, 2718, 2759, 2810, 2868, 2918, 2962, 3007, 3062, 3113, 3174, 3252, 3315, 3356, 3401, 3468, 3520, 3557, 3617, 3674, 3728, 3781, 3824, 3873, 3929, 3981, 4041, 4088, 4138]}, {"subject_area"=>"/Biology and life sciences/Nutrition", "average_usage"=>[316, 553, 708, 766, 859, 941, 1070, 1156, 1269, 1365, 1497, 1574, 1669, 1763, 1812, 1908, 1984, 2060, 2142, 2190, 2281, 2339, 2409, 2470, 2557, 2661, 2741, 2805, 2845, 2876, 2909, 2939, 2993, 3109, 3184, 3252, 3337, 3398, 3459, 3531, 3606, 3661, 3726, 3798, 3844, 3900, 3946, 3999, 4061, 4116, 4244, 4291, 4358, 4441, 4499, 4562, 4622, 4668, 4736, 4795, 4857, 4902]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[306, 552, 683, 801, 902, 1004, 1103, 1192, 1279, 1350, 1434, 1503, 1564, 1641, 1705, 1779, 1833, 1887, 1946, 2001, 2054, 2105, 2167, 2218, 2270, 2307, 2358, 2410, 2454, 2504, 2560, 2608, 2656, 2713, 2757, 2807, 2856, 2912, 2959, 3010, 3059, 3111, 3162, 3216, 3282, 3336, 3393, 3453, 3512, 3569, 3623, 3687, 3746, 3792, 3838, 3888, 3938, 3997, 4059, 4114, 4152]}, {"subject_area"=>"/Medicine and health sciences/Inflammatory diseases", "average_usage"=>[255, 486, 633, 765, 884, 993, 1135, 1233, 1375, 1502, 1623, 1704, 1781, 1846, 1955, 2065, 2177, 2296, 2386, 2455, 2534, 2613, 2681, 2748, 2829, 2905, 2974, 3058, 3144, 3221, 3308, 3397, 3471, 3549, 3621, 3709, 3807, 3897, 3969, 4054, 4134, 4196, 4295, 4368, 4475, 4664, 4748, 4817, 4877, 4946, 5003, 5071, 5126, 5166, 5226, 5296, 5357, 5426, 5497, 5545, 5609]}, {"subject_area"=>"/Medicine and health sciences/Nutrition", "average_usage"=>[336, 587, 740, 840, 916, 996, 1138, 1280, 1400, 1492, 1573, 1646, 1739, 1823, 1926, 2014, 2097, 2194, 2272, 2371, 2437, 2511, 2562, 2644, 2693, 2730, 2764, 2812, 2849, 2931, 2986, 3031, 3107, 3232, 3267, 3308, 3374, 3496, 3578, 3684, 3746, 3800, 3857, 3924, 3988, 4037, 4111, 4162, 4200, 4236, 4280, 4340, 4389, 4442, 4519, 4569, 4631, 4683, 4757, 4850, 4916, 4951]}]}
Loading … Spinner
There are currently no alerts