Kinetic Modeling Reveals a Common Death Niche for Newly Formed and Mature B Cells
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{"title"=>"Kinetic modeling reveals a common death niche for newly formed and mature B cells", "type"=>"journal", "authors"=>[{"first_name"=>"Gitit", "last_name"=>"Shahaf", "scopus_author_id"=>"6506616575"}, {"first_name"=>"Michael P.", "last_name"=>"Cancro", "scopus_author_id"=>"7004335899"}, {"first_name"=>"Ramit", "last_name"=>"Mehr", "scopus_author_id"=>"7003356767"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-77949669230", "doi"=>"10.1371/journal.pone.0009497", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203", "pmid"=>"20209168", "pui"=>"358498871", "sgr"=>"77949669230"}, "id"=>"ae87e90e-07fb-3d9e-888c-6e9964567460", "abstract"=>"B lymphocytes are subject to elimination following strong BCR ligation in the absence of appropriate second signals, and this mechanism mediates substantial cell losses during late differentiation steps in the bone marrow and periphery. Mature B cells may also be eliminated through this mechanism as well as through normal turnover, but the population containing mature cells destined for elimination has not been identified. Herein, we asked whether the transitional 3 (T3) subset, which contains most newly formed cells undergoing anergic death, could also include mature B cells destined for elimination.", "link"=>"http://www.mendeley.com/research/kinetic-modeling-reveals-common-death-niche-newly-formed-mature-b-cells", "reader_count"=>17, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Ph. D. Student"=>7, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Ph. D. Student"=>7, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Mathematics"=>1, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>2}}, "reader_count_by_country"=>{"Afghanistan"=>1, "Ireland"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/860530"], "description"=>"<p>These kinetics were obtained by a simulation of the spleen population model <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009497#pone.0009497-Mehr1\" target=\"_blank\">[25]</a>–<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009497#pone.0009497-Shahaf1\" target=\"_blank\">[26]</a> with the parameter set that gave the best fit to the data <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009497#pone.0009497-Allman3\" target=\"_blank\">[28]</a>. Parameter values are given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009497#pone-0009497-t002\" target=\"_blank\">Table 2</a>. Simulation results (dashed lines) are presented along with the experimental results (symbols with error bars).</p>", "links"=>[], "tags"=>["labeling"], "article_id"=>530992, "categories"=>["Medicine", "Immunology"], "users"=>["Gitit Shahaf", "Michael P. Cancro", "Ramit Mehr"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009497.g003", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_BrdU_labeling_kinetics_/530992", "title"=>"BrdU labeling kinetics.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 02:26:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/860586"], "description"=>"<p>Here we plotted the mature B cell differentiation term (<i>δ<sub>m3</sub>*B<sub>m</sub></i>) in every time step (6 hours), obtained by a simulation of the new hypothesis. The figure shows the steady state that this number reaches within less than 2 months. Parameter values are given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009497#pone-0009497-t002\" target=\"_blank\">Table 2</a>.</p>", "links"=>[], "tags"=>["t3", "cells", "differentiating", "mature", "compartment"], "article_id"=>531041, "categories"=>["Medicine", "Immunology"], "users"=>["Gitit Shahaf", "Michael P. Cancro", "Ramit Mehr"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009497.g004", "stats"=>{"downloads"=>6, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_number_of_T3_B_cells_differentiating_from_the_mature_compartment_per_time_step_/531041", "title"=>"The number of T3 B cells differentiating from the mature compartment per time step.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 02:26:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/860740"], "description"=>"<p>* This is the current accepted phenotype for immature B cells. Because we used historic data for these analyses, we felt it appropriate to indicate in the text the criteria used in the actual labeling studies, that is, B220+HSA+IgM<sup>hi</sup>IgD<sup>lo</sup>. It should be noted that this is unlikely to influence our conclusions, since the pro B subsets are not an immediate progenitor pool to any subsets that might enter the T3 pool, regardless of which model is used.</p>", "links"=>[], "tags"=>["bcr-expression"], "article_id"=>531202, "categories"=>["Medicine", "Immunology"], "users"=>["Gitit Shahaf", "Michael P. Cancro", "Ramit Mehr"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009497.t001", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Post_BCR_expression_developmental_subsets_/531202", "title"=>"Post BCR-expression developmental subsets.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 02:27:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/860768"], "description"=>"a<p>Rates are per 6 hours.</p>b<p>Models that obey our parameter choice criteria and fit the experimental data.</p>", "links"=>[], "tags"=>["ranges"], "article_id"=>531236, "categories"=>["Medicine", "Immunology"], "users"=>["Gitit Shahaf", "Michael P. Cancro", "Ramit Mehr"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009497.t002", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Parameter_ranges_that_result_from_the_simulation_/531236", "title"=>"Parameter ranges that result from the simulation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 02:27:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/860479"], "description"=>"<p>These numbers were obtained by a simulation with the parameters set that gave the best fit to the data. Parameter values are given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009497#pone-0009497-t002\" target=\"_blank\">Table 2</a>. The steady-state numbers are: T1/2: 1.17×10<sup>6</sup> cells, T3: 1.43×10<sup>6</sup> cells, and Mature FO: 2.51×10<sup>6</sup> cells.</p>", "links"=>[], "tags"=>["numbers", "simulation", "spleen"], "article_id"=>530937, "categories"=>["Medicine", "Immunology"], "users"=>["Gitit Shahaf", "Michael P. Cancro", "Ramit Mehr"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009497.g002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cell_numbers_versus_time_in_a_simulation_of_the_spleen_population_model_/530937", "title"=>"Cell numbers versus time in a simulation of the spleen population model.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 02:25:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/860640"], "description"=>"<p>In this model, mature B cells do not have a death rate, that is μ<sub>m</sub> = 0. The differentiation from B<sub>m</sub> to T<sub>3</sub> occurs a rate of δ<sub>m3</sub> = 0.003, thus the T<sub>3</sub> compartment accounts for all the mature B cell turnover. The other parameter values are given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009497#pone-0009497-t002\" target=\"_blank\">Table 2</a>.</p>", "links"=>[], "tags"=>["mature"], "article_id"=>531100, "categories"=>["Medicine", "Immunology"], "users"=>["Gitit Shahaf", "Michael P. Cancro", "Ramit Mehr"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009497.g005", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_model_without_mature_B_cell_death_/531100", "title"=>"The model without mature B cell death.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 02:26:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/860405"], "description"=>"<p>The main figure shows the one found as the best model in our previous study <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009497#pone.0009497-Allman3\" target=\"_blank\">[28]</a>. The new hypothesis differs from our previous model only in the direction of flow between T3 and mature B cells, as shown in the inset. Cell subsets and parameters represented in our model are shown (see “<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009497#s2\" target=\"_blank\">Methods</a>” for details).</p>", "links"=>[], "tags"=>["models", "populations"], "article_id"=>530863, "categories"=>["Medicine", "Immunology"], "users"=>["Gitit Shahaf", "Michael P. Cancro", "Ramit Mehr"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009497.g001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_alternative_models_of_developing_B_cell_populations_in_the_spleen_/530863", "title"=>"The alternative models of developing B cell populations in the spleen.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 02:25:19"}

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