A Combined Transcriptomics and Lipidomics Analysis of Subcutaneous, Epididymal and Mesenteric Adipose Tissue Reveals Marked Functional Differences
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{"title"=>"A combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences", "type"=>"journal", "authors"=>[{"first_name"=>"Robert", "last_name"=>"Caesar", "scopus_author_id"=>"24764667900"}, {"first_name"=>"Monia", "last_name"=>"Manieri", "scopus_author_id"=>"7801547633"}, {"first_name"=>"Thomas", "last_name"=>"Kelder", "scopus_author_id"=>"24450676300"}, {"first_name"=>"Mark", "last_name"=>"Boekschoten", "scopus_author_id"=>"7801531201"}, {"first_name"=>"Chris", "last_name"=>"Evelo", "scopus_author_id"=>"7003950754"}, {"first_name"=>"Michael", "last_name"=>"Müller", "scopus_author_id"=>"7404689194"}, {"first_name"=>"Teake", "last_name"=>"Kooistra", "scopus_author_id"=>"55122622600"}, {"first_name"=>"Saverio", "last_name"=>"Cinti", "scopus_author_id"=>"7004604501"}, {"first_name"=>"Robert", "last_name"=>"Kleemann", "scopus_author_id"=>"19640368100"}, {"first_name"=>"Christian A.", "last_name"=>"Drevon", "scopus_author_id"=>"55389973300"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"20634946", "doi"=>"10.1371/journal.pone.0011525", "sgr"=>"77955375161", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "scopus"=>"2-s2.0-77955375161", "issn"=>"19326203", "pui"=>"359318749"}, "id"=>"e22bcc22-b266-303b-992f-632f993c06a6", "abstract"=>"Depot-dependent differences in adipose tissue physiology may reflect specialized functions and local interactions between adipocytes and surrounding tissues. We combined time-resolved microarray analyses of mesenteric- (MWAT), subcutaneous- (SWAT) and epididymal adipose tissue (EWAT) during high-fat feeding of male transgenic ApoE3Leiden mice with histology, targeted lipidomics and biochemical analyses of metabolic pathways to identify differentially regulated processes and site-specific functions. EWAT was found to exhibit physiological zonation. De novo lipogenesis in fat proximal to epididymis was stably low, whereas de novo lipogenesis distal to epididymis and at other locations was down-regulated in response to high-fat diet. The contents of linoleic acid and α-linolenic acid in EWAT were increased compared to other depots. Expression of the androgen receptor (Ar) was higher in EWAT than in MWAT and SWAT. We suggest that Ar may mediate depot-dependent differences in de novo lipogenesis rate and propose that accumulation of linoleic acid and α-linolenic acid in EWAT is favored by testosterone-mediated inhibition of de novo lipogenesis and may promote further elongation and desaturation of these polyunsaturated fatty acids during spermatogenesis.", "link"=>"http://www.mendeley.com/research/combined-transcriptomics-lipidomics-analysis-subcutaneous-epididymal-mesenteric-adipose-tissue-revea", "reader_count"=>80, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>4, "Librarian"=>1, "Researcher"=>24, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>9, "Student > Master"=>7, "Other"=>2, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>5}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>4, "Librarian"=>1, "Researcher"=>24, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>9, "Student > Master"=>7, "Other"=>2, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>4, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>8, "Agricultural and Biological Sciences"=>39, "Medicine and Dentistry"=>11, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Sports and Recreations"=>1, "Veterinary Science and Veterinary Medicine"=>3, "Chemistry"=>3, "Social Sciences"=>1, "Computer Science"=>4, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Social Sciences"=>{"Social Sciences"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Engineering"=>{"Engineering"=>4}, "Chemistry"=>{"Chemistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>39}, "Computer Science"=>{"Computer Science"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>3}}, "reader_count_by_country"=>{"Netherlands"=>4, "Sweden"=>1, "United States"=>1, "Ireland"=>1, "Brazil"=>2, "Denmark"=>1, "United Kingdom"=>2, "Spain"=>1}, "group_count"=>8}

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  • {"files"=>["https://ndownloader.figshare.com/files/840795"], "description"=>"<p>Adipose tissue at the distal end of the depot, limited by the upper dashed line, is denoted distal adipose tissue. Adipose tissue associated with the head and the tail of epididymis, indicated by the lower dashed line, is denoted proximal adipose tissue.</p>", "links"=>[], "tags"=>["proximal", "distal", "epididymal", "adipose"], "article_id"=>511233, "categories"=>["Computational Biology", "Medicine", "Physiology"], "users"=>["Robert Caesar", "Monia Manieri", "Thomas Kelder", "Mark Boekschoten", "Chris Evelo", "Michael Müller", "Teake Kooistra", "Saverio Cinti", "Robert Kleemann", "Christian A. Drevon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011525.g001", "stats"=>{"downloads"=>6, "page_views"=>132, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Location_of_the_proximal_and_distal_section_of_the_epididymal_adipose_tissue_EWAT_/511233", "title"=>"Location of the proximal and distal section of the epididymal adipose tissue (EWAT).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-07-12 00:20:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/841617"], "description"=>"<p><i>A)</i> Gene expression levels of the androgen receptor (Ar) in proximal and distal epididymal (EWAT) adipose tissue, in mesenteric (MWAT), and in subcutaneous (SWAT) adipose tissue determined by RT-PCR. <i>B)</i> Expression of the gene encoding the androgen receptor (Ar) determined by RT-PCR plotted against rate of lipogenesis measured by incorporation of [<sup>14</sup>C]glucose in TAG in adipose tissue explants. <i>C)</i> Expression of carbohydrate responsive element binding protein (ChREBP), ATP citrate lyase (Acly) and fatty acid synthase (Fasn) on 12 weeks of high-fat diet determined by microarray analysis. The expression level at baseline was set to 1 for all genes. (A) Ar expression differed between depots (p<0.05, Kruskall-Wallis analysis, 3 degrees of freedom), *Difference between proximal EWAT and other adipose tissues determined by Mann-Whitney analysis (p<0.05 adjusted to 0.017 by Bonferroni correction). MWAT-EWAT proximal U(5) = 0, p = 0.009; SWAT-EWAT proximal U(5) = 1, 0.02; EWAT proximal-EWAT distal U(5) = 3, p = 0.05 (B) the relation between lipogenesis and Ar expression was determined by Pearson correlation coefficient with one-sided significance calculated by Cronbach's Alpha, (C) *p<0.05 (one way ANOVA with Tukey post hoc analysis, 4 degrees of freedom. Error bars indicate standard deviation. SWAT: ChREBP F(4,21) = 10, p = 0.0001; Acly F(4,21) = 30.0, p = 2.0×10<sup>−8</sup>; Fasn F(4,21) = 8.8, p = 0.0002; MWAT: ChREBP F(4,18) = 8.6, p = 0.0004; Acly F(4,18) = 29.9, p = 9.9×10<sup>−8</sup>; Fasn F(4,18) = 5.3, p = 0.0.005; EWAT: ChREBP F(4,20) = 2.8, p = 0.055; Acly F(4,20) = 1.4, p = 0.25; Fasn F(4,20) = 0.82, p = 0.53.</p>", "links"=>[], "tags"=>["lipogenesis", "putative"], "article_id"=>512069, "categories"=>["Computational Biology", "Medicine", "Physiology"], "users"=>["Robert Caesar", "Monia Manieri", "Thomas Kelder", "Mark Boekschoten", "Chris Evelo", "Michael Müller", "Teake Kooistra", "Saverio Cinti", "Robert Kleemann", "Christian A. Drevon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011525.g007", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Rate_of_lipogenesis_and_expression_of_putative_regulatory_factors_/512069", "title"=>"Rate of lipogenesis and expression of putative regulatory factors.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-07-12 00:34:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/841377"], "description"=>"<p><i>A) De novo</i> lipogenesis determined by incorporation of [<sup>14</sup>C] from radiolabeled glucose in triacylglycerols in explants from the proximal and distal zone of epididymal (EWAT), subcutaneous (SWAT) and mesenteric (MWAT) adipose tissue. <i>B)</i> Expression of genes encoding fatty acid synthase (Fasn) and ATP citrate lyase (Acly) determined by RT-PCR. <i>De novo</i> lipogenesis and Fasn expression but not Acly expression differed between depots (p<0.05, Kruskall-Wallis analysis, 3 degrees of freedom). *Difference between proximal EWAT and other adipose tissues determined by Mann-Whitney analysis (p<0.05 adjusted to 0.017 by Bonferroni correction). Experiments were performed with 4–5 animals. Error bars indicate standard deviation. <i>de novo</i> lipogenesis: MWAT-EWAT proximal U(4,5) = 0, p = 0.014; SWAT-EWAT proximal U(5) = 5, p = 0.12; EWAT proximal-EWAT distal U(5) = 0, p = 0.009; Fasn: MWAT-EWAT proximal U(4) = 2, p = 0.08; SWAT-EWAT proximal U(4) = 0, 0.02; EWAT proximal-EWAT distal U(4) = 0, p = 0.02; Acly: MWAT-EWAT proximal U(4) = 2, p = 0.08; SWAT-EWAT proximal U(4) = 2, 0.08; EWAT proximal-EWAT distal U(4,3) = 5, p = 0.72.</p>", "links"=>[], "tags"=>["genes", "lipogenesis", "proximal", "epididymal", "adipose", "tissues", "compared", "chow"], "article_id"=>511819, "categories"=>["Computational Biology", "Medicine", "Physiology"], "users"=>["Robert Caesar", "Monia Manieri", "Thomas Kelder", "Mark Boekschoten", "Chris Evelo", "Michael Müller", "Teake Kooistra", "Saverio Cinti", "Robert Kleemann", "Christian A. Drevon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011525.g005", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Lipogenesis_and_expression_of_genes_involved_in_lipogenesis_in_proximal_epididymal_adipose_tissues_compared_to_other_adipose_tissues_during_chow_feeding_/511819", "title"=>"Lipogenesis and expression of genes involved in lipogenesis in proximal epididymal adipose tissues compared to other adipose tissues during chow feeding.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-07-12 00:30:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/841506"], "description"=>"<p>Cell-associated incorporation of [<sup>14</sup>C]radiolabeled docosahexaenoic acid (DHA) and oleic acid (OA) in cellular triacylglycerols in the proximal and distal zone of epididymal (EWAT), subcutaneous (SWAT) and mesenteric (MWAT) adipose tissues. Adipose tissue explants from animals on chow diet were incubated in medium containing fatty acids bound to BSA, lipids were extracted and triacylglycerols were isolated by thin layer chromatography. The experiments were performed with 4–5 animals. DHA uptake but not OA uptake differed between depots (p<0.05, Kruskall-Wallis analysis, 3 degrees of freedom). *Difference determined by Mann-Whitney analysis (p<0.05 adjusted to 0.017 by Bonferroni correction). Error bars indicate standard deviation. DHA uptake: MWAT-EWAT proximal U(4,5) = 0, p = 0.014; SWAT-EWAT proximal U(5) = 3, 0.05; EWAT proximal-EWAT distal U(5,4) = 5, p = 0.22; OA uptake: MWAT-EWAT proximal U(4,5) = 3, p = 0.08; SWAT-EWAT proximal U(4,5) = 9, 0.80; EWAT proximal-EWAT distal U(5) = 9, p = 0.46.</p>", "links"=>[], "tags"=>["triacylglycerol", "fatty", "acids", "adipose"], "article_id"=>511955, "categories"=>["Computational Biology", "Medicine", "Physiology"], "users"=>["Robert Caesar", "Monia Manieri", "Thomas Kelder", "Mark Boekschoten", "Chris Evelo", "Michael Müller", "Teake Kooistra", "Saverio Cinti", "Robert Kleemann", "Christian A. Drevon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011525.g006", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Accumulation_of_triacylglycerol_fatty_acids_in_adipose_tissue_explants_/511955", "title"=>"Accumulation of triacylglycerol fatty acids in adipose tissue explants.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-07-12 00:32:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/841080"], "description"=>"<p>Expression of acetyl-CoA synthetase short-chain family member 2 (Acss2), pyruvate dehydrogenase α1 (Pdha1), pyruvate dehydrogenase β (Pdhb) dihydrolipoamide S-acetyltransferase (Dlat), ATP citrate lyase (Acly), fatty acid synthase (Fasn), long chain elongation enzymes Elovl5 and Elovl6 and stearoyl-CoA desaturase 1 and 2 (Scd1/2) in subcutaneous (SWAT), mesenteric (MWAT) and epididymal (EWAT) adipose tissue. The y-axis scale is the same for all three depots. Gene expression is given as relative expression. N at time-point 0, 1, 6, 9 and 12 weeks were 4, 5, 7, 3, 6 for epididymal adipose tissue (EWAT); 5, 6, 4, 6, 5 for subcutaneous adipose tissue (SWAT); and 3, 5, 4, 5, 7 for mesenteric adipose tissue (MWAT), respectively. Error bars indicate standard deviation. Statistically significant changes in expression over time are indicated by *(p<0.05 (one way ANOVA)). SWAT: Acss2 F(4,21) = 10.1, p = 9.8×10<sup>−5</sup>; Pdha1 F(4,21) = 17.9, p = 1.5×10<sup>−6</sup>; Pdhb F(4,21) = 15.3, p = 5.3×10<sup>−6</sup>; Dlat F(4,21) = 8.8, p = 0.0002; Acly F(4,21) = 30.0, p = 2.0×10<sup>−8</sup>; Fasn F(4,21) = 8.8, p = 0.0002; Elovl5 F(4,21) = 2.9, p = 0.04; Elovl6 F(4,21) = 27.5, p = 4.4×10<sup>−8</sup>; Scd1 F(4,21) = 0.9, p = 0.47; Scd2 F(4,21) = 2.2, p = 0.10; MWAT: Acss2 F(4,18) = 4.3, p = 0.013; Pdha1 F(4,18) = 9.9, p = 0.0002; Pdhb F(4,18) = 7.2, p = 0.001; Dlat F(4,18) = 4.6, p = 0.009; Acly F(4,18) = 29.9, p = 9.9×10<sup>−8</sup>; Fasn F(4,18) = 5.3, p = 0.0.005; Elovl5 F(4,18) = 9.7, p = 0.0002; Elovl6 F(4,18) = 14.4, p = 1.9×10<sup>−5</sup>; Scd1 F(4,18) = 2.0, p = 0.14; Scd2 F(4,18) = 0.42, p = 0.79; EWAT: Acss2 F(4,20) = 1.1, p = 0.37; Pdha1 F(4,20) = 1.9, p = 0.19; Pdhb F(4,20) = 2.3, p = 0.09; Dlat F(4,20) = 2.0, p = 0.12; Acly F(4,20) = 1.4, p = 0.25; Fasn F(4,20) = 0.82, p = 0.53; Elovl5 F(4,20) = 1.7, p = 0.28; Elovl6 F(4,20) = 1.2, p = 0.32; Scd1 F(4,20) = 5.1, p = 0.005; Scd2 F(4,20) = 3.4, p = 0.027.</p>", "links"=>[], "tags"=>["genes", "encoding", "enzymes", "fatty", "synthesis", "basal", "conditions", "high-fat"], "article_id"=>511518, "categories"=>["Computational Biology", "Medicine", "Physiology"], "users"=>["Robert Caesar", "Monia Manieri", "Thomas Kelder", "Mark Boekschoten", "Chris Evelo", "Michael Müller", "Teake Kooistra", "Saverio Cinti", "Robert Kleemann", "Christian A. Drevon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011525.g003", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_genes_encoding_enzymes_in_fatty_acid_synthesis_and_processing_during_basal_conditions_chow_and_high_fat_feeding_/511518", "title"=>"Expression of genes encoding enzymes in fatty acid synthesis and processing during basal conditions (chow) and high-fat feeding.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-07-12 00:25:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/418853", "https://ndownloader.figshare.com/files/418959", "https://ndownloader.figshare.com/files/419011", "https://ndownloader.figshare.com/files/419068"], "description"=>"<div><p>Depot-dependent differences in adipose tissue physiology may reflect specialized functions and local interactions between adipocytes and surrounding tissues. We combined time-resolved microarray analyses of mesenteric- (MWAT), subcutaneous- (SWAT) and epididymal adipose tissue (EWAT) during high-fat feeding of male transgenic ApoE3Leiden mice with histology, targeted lipidomics and biochemical analyses of metabolic pathways to identify differentially regulated processes and site-specific functions. EWAT was found to exhibit physiological zonation. <em>De novo</em> lipogenesis in fat proximal to epididymis was stably low, whereas <em>de novo</em> lipogenesis distal to epididymis and at other locations was down-regulated in response to high-fat diet. The contents of linoleic acid and α-linolenic acid in EWAT were increased compared to other depots. Expression of the androgen receptor (Ar) was higher in EWAT than in MWAT and SWAT. We suggest that Ar may mediate depot-dependent differences in <em>de novo</em> lipogenesis rate and propose that accumulation of linoleic acid and α-linolenic acid in EWAT is favored by testosterone-mediated inhibition of <em>de novo</em> lipogenesis and may promote further elongation and desaturation of these polyunsaturated fatty acids during spermatogenesis.</p></div>", "links"=>[], "tags"=>["transcriptomics", "lipidomics", "epididymal", "mesenteric", "adipose", "reveals", "marked", "differences"], "article_id"=>142710, "categories"=>["Biological Sciences", "Medicine", "Physiology"], "users"=>["Robert Caesar", "Monia Manieri", "Thomas Kelder", "Mark Boekschoten", "Chris Evelo", "Michael Müller", "Teake Kooistra", "Saverio Cinti", "Robert Kleemann", "Christian A. Drevon"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0011525.s001", "https://dx.doi.org/10.1371/journal.pone.0011525.s002", "https://dx.doi.org/10.1371/journal.pone.0011525.s003", "https://dx.doi.org/10.1371/journal.pone.0011525.s004"], "stats"=>{"downloads"=>20, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_Combined_Transcriptomics_and_Lipidomics_Analysis_of_Subcutaneous_Epididymal_and_Mesenteric_Adipose_Tissue_Reveals_Marked_Functional_Differences/142710", "title"=>"A Combined Transcriptomics and Lipidomics Analysis of Subcutaneous, Epididymal and Mesenteric Adipose Tissue Reveals Marked Functional Differences", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-07-12 00:45:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/842059"], "description"=>"<p>Enrichment of genes regulated during high-fat diet within Gene Ontology (GO) categories were analyzed for mesenteric (MWAT), subcutaneous (SWAT) and epididymal (EWAT) adipose tissue. To identify processes with major differences in enrichment of regulated genes between depots, the results were filtered for GO categories significantly enriched (p<0.005) in one or two depots but less enriched (p>0.1) in the other depot(s). Gene regulation in response to high-fat diet was determined by ANOVA (p-value <0.05, 4 degrees of freedom, N at time-point 0, 1, 6, 9 and 12 weeks were 4, 5, 7, 3, 6 for EWAT; 5, 6, 4, 6, 5 for SWAT; and 3, 5, 4, 5, 7 for MWAT, respectively). GO category enrichment analysis was performed in Metacore.</p>", "links"=>[], "tags"=>["regulated", "genes", "categories", "adipose"], "article_id"=>512504, "categories"=>["Computational Biology", "Medicine", "Physiology"], "users"=>["Robert Caesar", "Monia Manieri", "Thomas Kelder", "Mark Boekschoten", "Chris Evelo", "Michael Müller", "Teake Kooistra", "Saverio Cinti", "Robert Kleemann", "Christian A. Drevon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011525.t001", "stats"=>{"downloads"=>7, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Enrichment_of_regulated_genes_within_functional_categories_in_adipose_depots_/512504", "title"=>"Enrichment of regulated genes within functional categories in adipose depots.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-07-12 00:41:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/841797"], "description"=>"<p>Proportions of saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), linoleic acid (18∶2 ω-6) and α-linolenic acid (18∶3 ω-3) in proximal epididymal and distal epididymal (EWAT) adipose tissue, in mesenteric (MWAT), and in subcutaneous (SWAT) adipose tissue on chow feeding. SFA, linoleic acid and α-linolenic acid but not MUFA differed between depots (p<0.05, Kruskall-Wallis analysis, 3 degrees of freedom). *Difference between proximal EWAT and other adipose tissues determined by Mann-Whitney analysis (p<0.05 adjusted to 0.017 by Bonferroni correction). Error bars indicate standard deviation. SFA: MWAT-EWAT proximal U(5) = 0, p = 0.009; SWAT-EWAT proximal U(5) = 1, 0.02; EWAT proximal-EWAT distal U(5) = 12, p = 0.9; MUFA: MWAT-EWAT proximal U(5) = 7, p = 0.25; SWAT-EWAT proximal U(5) = 9, 0.46; EWAT proximal-EWAT distal U(5) = 11, p = 0.75; linoleic acid: MWAT-EWAT proximal U(5) = 0, p = 0.009; SWAT-EWAT proximal U(5) = 0, 0.009; EWAT proximal-EWAT distal U(5) = 10, p = 0.6; α-linolenic acid: MWAT-EWAT proximal U(5) = 0, p = 0.009; SWAT-EWAT proximal U(5) = 2, 0.03; EWAT proximal-EWAT distal U(5) = 7, p = 0.25.</p>", "links"=>[], "tags"=>["profiles", "adipose"], "article_id"=>512251, "categories"=>["Computational Biology", "Medicine", "Physiology"], "users"=>["Robert Caesar", "Monia Manieri", "Thomas Kelder", "Mark Boekschoten", "Chris Evelo", "Michael Müller", "Teake Kooistra", "Saverio Cinti", "Robert Kleemann", "Christian A. Drevon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011525.g008", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fatty_acid_profiles_of_adipose_tissues_/512251", "title"=>"Fatty acid profiles of adipose tissues.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-07-12 00:37:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/841938"], "description"=>"<p>Androgen suppression of adipose tissue <i>de novo</i> lipogenesis is regulated by androgen receptor (Ar). Ar is highly expressed in proximal epididymal adipose tissue (EWATp). Low rate of <i>de novo</i> lipogenesis causes high content of dietary fatty acids and on chow diet the essential fatty acids linoleic acid and α-linolenic acid accumulate. Delta-6 and delta-5 desaturase (D6D and D5D) in epididymis convert linoleic acid and α-linolenic acid into polyunsaturated fatty acids (PUFA) with 20 and 22 carbon atoms required for spermatogenesis. When animals are fed high-fat diet (HFD) rich in saturated fatty acids adipose tissue is depleted of PUFA, potentially resulting in impaired sperm quality and decreased fertility.</p>", "links"=>[], "tags"=>["site-specific", "androgen", "lipogenesis", "promoting", "enrichment", "fatty", "acids", "proximal", "epididymal", "adipose"], "article_id"=>512381, "categories"=>["Computational Biology", "Medicine", "Physiology"], "users"=>["Robert Caesar", "Monia Manieri", "Thomas Kelder", "Mark Boekschoten", "Chris Evelo", "Michael Müller", "Teake Kooistra", "Saverio Cinti", "Robert Kleemann", "Christian A. Drevon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011525.g009", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Model_for_site_specific_androgen_control_of_lipogenesis_promoting_enrichment_of_essential_fatty_acids_in_the_proximal_epididymal_adipose_tissue_/512381", "title"=>"Model for site-specific androgen control of lipogenesis promoting enrichment of essential fatty acids in the proximal epididymal adipose tissue.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-07-12 00:39:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/841232"], "description"=>"<p>Proportions of total fatty acids in epididymal adipose tissue at 0 and 12 weeks on high-fat diet: <i>A)</i> Saturated fatty acids (SFA) monounsaturated fatty acids (MUFA), linoleic acid (18∶2 ω-6) and α-linolenic acid (18∶3 ω-3). <i>B)</i> Low abundance omega-6 (ω-6) and omega-3 (ω-3) fatty acids. Error bars indicate standard deviation. *p<0.05 (Mann–Whitney analysis). SFA U(8) = 23, p = 0.34; MUFA U(8) = 14, p = 0.06; 18∶2 ω-6 U(8) = 0, p = 0.0007; 18∶3 ω-3 U(8) = 0, p = 0.0007; 18∶3 ω-6 U(8) = 0, p = 0.0007; 20∶3 ω-6 U(8) = 0, p = 0.0007; 20∶4 ω-6 U(8) = 0, p = 0.0007; 22∶4 ω-6 U(8) = 0, p = 0.0007; 22∶5 ω-6 U(8) = 3, p = 0.0023; 18∶4 ω-3 U(8) = 0, p = 0.0007; 20∶3 ω-3 U(8) = 0, p = 0.0007; 20∶4 ω-3 U(8) = 0, p = 0.0007; 22∶5 ω-3 U(8) = 0, p = 0.0007; 22∶6 ω-3 U(8) = 0, p = 0.0007.</p>", "links"=>[], "tags"=>["analyses", "epididymal", "adipose", "basal", "conditions", "high-fat"], "article_id"=>511678, "categories"=>["Computational Biology", "Medicine", "Physiology"], "users"=>["Robert Caesar", "Monia Manieri", "Thomas Kelder", "Mark Boekschoten", "Chris Evelo", "Michael Müller", "Teake Kooistra", "Saverio Cinti", "Robert Kleemann", "Christian A. Drevon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011525.g004", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Lipidomics_analyses_of_epididymal_adipose_tissue_during_basal_conditions_chow_and_high_fat_feeding_/511678", "title"=>"Lipidomics analyses of epididymal adipose tissue during basal conditions (chow) and high-fat feeding.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-07-12 00:27:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/840904"], "description"=>"<p><i>A)</i> Adipocyte cell area in epididymal (EWAT), subcutaneous (SWAT) and mesenteric (MWAT) adipose tissue on high-fat diet (HFD). The areas of adipocytes were determined histologically. The values are based upon 200 measurements from each animal. <i>B)</i> Mass of the adipose depots on HFD. 14–15 animals were used for depot weight determination and 6–7 animals for adipocyte size determination. Cell size and depot mass differed over time in all three depots (p<0.05, Kruskall-Wallis analysis, 4 degrees of freedom). *Difference in cell size or depot mass between consecutive time points determined by Mann-Whitney analysis (p<0.05 adjusted to 0.0125 by Bonferroni correction). Error bars indicate standard deviation. Cell size - EWAT: time-point 0–1 weeks U(7) = 6, p = 0.02; 1–6 weeks U(7) = 24, p = 0.94; 6–9 weeks U(7,6) = 16, p = 0.47; 9–12 weeks U(6,7) = 11, p = 0.15; SWAT: time-point 0–1 weeks U(7) = 7, p = 0.02; 1–6 weeks U(7) = 16, p = 0.27; 6–9 weeks U(7,6) = 17, p = 0.56; 9–12 weeks U(6,7) = 9, p = 0.09; MWAT: time-point 0–1 weeks U(7) = 6, p = 0.02; 1–6 weeks U(7,6) = 11, p = 0.15; 6–9 weeks U(6,6) = 10, p = 0.2; 9–12 weeks U(6,7) = 3, p = 0.01; Depot mass - EWAT: time-point 0–1 weeks U(15) = 41, p = 0.003; 1–6 weeks U(15) = 92, p = 0.39; 6–9 weeks U(15,14) = 86.5, p = 0.42; 9–12 weeks U(14,15) = 51, p = 0.02; SWAT: time-point 0–1 weeks U(15) = 26, p = 0.0003; 1–6 weeks U(15) = 108, p = 0.85; 6–9 weeks U(15,14) = 92, p = 0.57; 9–12 weeks U(14,15) = 31, p = 0.001; MWAT: time-point 0–1 weeks U(15) = 29, p = 0.0005; 1–6 weeks U(15,14) = 83, p = 0.33; 6–9 weeks U(14,14) = 60, p = 0.08; 9–12 weeks U(14,15) = 71, p = 0.13.</p>", "links"=>[], "tags"=>["adipocyte", "adipose", "depot", "high-fat"], "article_id"=>511349, "categories"=>["Computational Biology", "Medicine", "Physiology"], "users"=>["Robert Caesar", "Monia Manieri", "Thomas Kelder", "Mark Boekschoten", "Chris Evelo", "Michael Müller", "Teake Kooistra", "Saverio Cinti", "Robert Kleemann", "Christian A. Drevon"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011525.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Change_of_adipocyte_cell_size_and_adipose_depot_mass_during_high_fat_feeding_/511349", "title"=>"Change of adipocyte cell size and adipose depot mass during high-fat feeding.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-07-12 00:22:29"}

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