Plant-Made Trastuzumab (Herceptin) Inhibits HER2/Neu+ Cell Proliferation and Retards Tumor Growth
- Publication Date
- March 03, 2011
- Journal
- PLOS ONE
- Authors
- Tatiana V. Komarova, Vyacheslav S. Kosorukov, Olga Y. Frolova, Igor V. Petrunia, et al
- Volume
- 6
- Issue
- 3
- Pages
- e17541
- DOI
- https://dx.plos.org/10.1371/journal.pone.0017541
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0017541
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/21390232
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048398
- Europe PMC
- http://europepmc.org/abstract/MED/21390232
- Web of Science
- 000287965200021
- Scopus
- 79952299823
- Mendeley
- http://www.mendeley.com/research/plantmade-trastuzumab-herceptin-inhibits-her2neu-cell-proliferation-retards-tumor-growth
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Mendeley | Further Information
{"title"=>"Plant-made trastuzumab (Herceptin) inhibits HER2/Neu+ cell proliferation and retards tumor growth", "type"=>"journal", "authors"=>[{"first_name"=>"Tatiana V.", "last_name"=>"Komarova", "scopus_author_id"=>"7005623058"}, {"first_name"=>"Vyacheslav S.", "last_name"=>"Kosorukov", "scopus_author_id"=>"6505962801"}, {"first_name"=>"Olga Y.", "last_name"=>"Frolova", "scopus_author_id"=>"7006584649"}, {"first_name"=>"Igor V.", "last_name"=>"Petrunia", "scopus_author_id"=>"24491077100"}, {"first_name"=>"Ksenia A.", "last_name"=>"Skrypnik", "scopus_author_id"=>"37010028500"}, {"first_name"=>"Yuri Y.", "last_name"=>"Gleba", "scopus_author_id"=>"7003670117"}, {"first_name"=>"Yuri L.", "last_name"=>"Dorokhov", "scopus_author_id"=>"6603938889"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-79952299823", "sgr"=>"79952299823", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0017541", "pmid"=>"21390232", "isbn"=>"1932-6203", "pui"=>"361382340"}, "id"=>"f0146bed-856c-34d9-9d74-c50f922b6aa9", "abstract"=>"BACKGROUND: Plant biotechnology provides a valuable contribution to global health, in part because it can decrease the cost of pharmaceutical products. Breast cancer can now be successfully treated by a humanized monoclonal antibody (mAb), trastuzumab (Herceptin). A course of treatment, however, is expensive and requires repeated administrations of the mAb. Here we used an Agrobacterium-mediated transient expression system to produce trastuzumab in plant cells.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: We describe the cloning and expression of gene constructs in Nicotiana benthamiana plants using intron-optimized Tobacco mosaic virus- and Potato virus X-based vectors encoding, respectively, the heavy and light chains of trastuzumab. Full-size antibodies extracted and purified from plant tissues were tested for functionality and specificity by (i) binding to HER2/neu on the surface of a human mammary gland adenocarcinoma cell line, SK-BR-3, in fluorescence-activated cell sorting assay and (ii) testing the in vitro and in vivo inhibition of HER-2-expressing cancer cell proliferation. We show that plant-made trastuzumab (PMT) bound to the Her2/neu oncoprotein of SK-BR-3 cells and efficiently inhibited SK-BR-3 cell proliferation. Furthermore, mouse intraperitoneal PMT administration retarded the growth of xenografted tumors derived from human ovarian cancer SKOV3 Her2+ cells.\\n\\nCONCLUSIONS/SIGNIFICANCE: We conclude that PMT is active in suppression of cell proliferation and tumor growth.", "link"=>"http://www.mendeley.com/research/plantmade-trastuzumab-herceptin-inhibits-her2neu-cell-proliferation-retards-tumor-growth", "reader_count"=>58, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Librarian"=>2, "Student > Doctoral Student"=>1, "Researcher"=>20, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>4, "Student > Master"=>5, "Other"=>2, "Student > Bachelor"=>9, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Librarian"=>2, "Student > Doctoral Student"=>1, "Researcher"=>20, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>4, "Student > Master"=>5, "Other"=>2, "Student > Bachelor"=>9, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>8, "Materials Science"=>1, "Agricultural and Biological Sciences"=>35, "Medicine and Dentistry"=>4, "Design"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>3, "Social Sciences"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Engineering"=>{"Engineering"=>2}, "Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Chemistry"=>{"Chemistry"=>3}, "Social Sciences"=>{"Social Sciences"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>35}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Canada"=>1}, "group_count"=>5}CrossRef
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Scopus | Further Information
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Relative Metric
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