A Mighty Small Heart: The Cardiac Proteome of Adult Drosophila melanogaster
Publication Date
April 25, 2011
Journal
PLOS ONE
Authors
Anthony Cammarato, Christian H. Ahrens, Nakissa N. Alayari, Ermir Qeli, et al
Volume
6
Issue
4
Pages
e18497
DOI
https://dx.plos.org/10.1371/journal.pone.0018497
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0018497
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/21541028
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081823
Europe PMC
http://europepmc.org/abstract/MED/21541028
Web of Science
000290016800012
Scopus
79955553504
Mendeley
http://www.mendeley.com/research/mighty-small-heart-cardiac-proteome-adult-drosophila-melanogaster-1
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Mendeley | Further Information

{"title"=>"A mighty small heart: The cardiac proteome of adult Drosophila melanogaster", "type"=>"journal", "authors"=>[{"first_name"=>"Anthony", "last_name"=>"Cammarato", "scopus_author_id"=>"13008040700"}, {"first_name"=>"Christian H.", "last_name"=>"Ahrens", "scopus_author_id"=>"16301095500"}, {"first_name"=>"Nakissa N.", "last_name"=>"Alayari", "scopus_author_id"=>"35422080900"}, {"first_name"=>"Ermir", "last_name"=>"Qeli", "scopus_author_id"=>"57199332702"}, {"first_name"=>"Jasma", "last_name"=>"Rucker", "scopus_author_id"=>"23028925600"}, {"first_name"=>"Mary C.", "last_name"=>"Reedy", "scopus_author_id"=>"7004405861"}, {"first_name"=>"Christian M.", "last_name"=>"Zmasek", "scopus_author_id"=>"7801374086"}, {"first_name"=>"Marjan", "last_name"=>"Gucek", "scopus_author_id"=>"6603624874"}, {"first_name"=>"Robert N.", "last_name"=>"Cole", "scopus_author_id"=>"22633360100"}, {"first_name"=>"Jennifer E.", "last_name"=>"van Eyk", "scopus_author_id"=>"7004835259"}, {"first_name"=>"Rolf", "last_name"=>"Bodmer", "scopus_author_id"=>"7004270274"}, {"first_name"=>"Brian", "last_name"=>"O'Rourke", "scopus_author_id"=>"7006763781"}, {"first_name"=>"Sanford I.", "last_name"=>"Bernstein", "scopus_author_id"=>"7201589050"}, {"first_name"=>"D. Brian", "last_name"=>"Foster", "scopus_author_id"=>"15047760400"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"79955553504", "doi"=>"10.1371/journal.pone.0018497", "pui"=>"361692597", "pmid"=>"21541028", "scopus"=>"2-s2.0-79955553504", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)"}, "id"=>"4ef8937d-f9e1-3905-9aa0-3a2e8330648d", "abstract"=>"Drosophila melanogaster is emerging as a powerful model system for the study of cardiac disease. Establishing peptide and protein maps of the Drosophila heart is central to implementation of protein network studies that will allow us to assess the hallmarks of Drosophila heart pathogenesis and gauge the degree of conservation with human disease mechanisms on a systems level. Using a gel-LC-MS/MS approach, we identified 1228 protein clusters from 145 dissected adult fly hearts. Contractile, cytostructural and mitochondrial proteins were most abundant consistent with electron micrographs of the Drosophila cardiac tube. Functional/Ontological enrichment analysis further showed that proteins involved in glycolysis, Ca(2+)-binding, redox, and G-protein signaling, among other processes, are also over-represented. Comparison with a mouse heart proteome revealed conservation at the level of molecular function, biological processes and cellular components. The subsisting peptidome encompassed 5169 distinct heart-associated peptides, of which 1293 (25%) had not been identified in a recent Drosophila peptide compendium. PeptideClassifier analysis was further used to map peptides to specific gene-models. 1872 peptides provide valuable information about protein isoform groups whereas a further 3112 uniquely identify specific protein isoforms and may be used as a heart-associated peptide resource for quantitative proteomic approaches based on multiple-reaction monitoring. In summary, identification of excitation-contraction protein landmarks, orthologues of proteins associated with cardiovascular defects, and conservation of protein ontologies, provides testimony to the heart-like character of the Drosophila cardiac tube and to the utility of proteomics as a complement to the power of genetics in this growing model of human heart disease.", "link"=>"http://www.mendeley.com/research/mighty-small-heart-cardiac-proteome-adult-drosophila-melanogaster-1", "reader_count"=>73, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Researcher"=>20, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>27, "Student > Postgraduate"=>1, "Student > Master"=>5, "Student > Bachelor"=>4, "Professor"=>8}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Researcher"=>20, "Student > Doctoral Student"=>2, "Student > Ph. D. 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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/4435423"], "description"=>"<p>Panel A. TRITC-Phalloidin labeled wild-type <i>Drosophila</i> heart\n tube and associated structures (10× magnification).\n CC = conical chamber; AM = alary\n muscle; v = internal valve;\n Os = ostia in flow tract. Inset: luminal surface of\n TRITC-Phalloidin-labeled myosin-GFP-expressing heart (20×\n magnification). Ostia inflow tracts and the striated alternating myosin and\n actin myofilament bands are clearly resolved. Panel B. Electron micrograph\n of a longitudinal section through the conical chamber reveals the\n contractile myofibrils and mitochondria (M)(3,800×). Densely stained\n Z-bands (Z) demarcate individual sarcomeres and bisect the I-bands.\n Centrally-located A-bands are also apparent. Panel C. Cross-section through\n cardiac myofibrils of the conical chamber (10,500×). Individual thick\n filaments are surrounded by 9–11 thin filaments. Regions of\n sarcoplasmic reticulum (SR) can also be resolved. Panel D. 10%\n Coomassie-stained polyacrylamide gel from 30 <i>Drosophila</i>\n heart tubes. Sarcomeric myosin heavy chain (MHC) and actin are highlighted\n for reference.</p>", "links"=>[], "tags"=>["mouse heart proteome", "protein maps", "1872 peptides", "heart disease", "1228 protein clusters", "proteomic approaches", "electron micrographs", "PeptideClassifier analysis", "subsisting peptidome", "map peptides", "protein isoform groups", "disease mechanisms", "Adult Drosophila melanogaster Drosophila melanogaster", "Drosophila peptide compendium", "Drosophila heart pathogenesis", "protein isoforms", "mitochondrial proteins", "protein ontologies", "systems level", "Drosophila heart", "protein network studies", "model system", "Cardiac Proteome"], "article_id"=>451088, "categories"=>["Biochemistry", "Cell Biology", "Genetics", "Molecular Biology", "Physiology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Cancer"], "users"=>["Anthony Cammarato", "Christian H. Ahrens", "Nakissa N. Alayari", "Ermir Qeli", "Jasma Rucker", "Mary C. Reedy", "Christian M. Zmasek", "Marjan Gucek", "Robert N. Cole", "Jennifer E. Van Eyk", "Rolf Bodmer", "Brian O'Rourke", "Sanford I. Bernstein", "D. Brian Foster"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018497.g001"], "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Cardiac_Tube_of_Drosophila_melanogaster_/451088", "title"=>"The Cardiac Tube <i>of Drosophila melanogaster</i>.", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-25 14:29:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/4435501"], "description"=>"<p><i>Drosophila</i> Cardiac Peptidome.</p>", "links"=>[], "tags"=>["mouse heart proteome", "protein maps", "1872 peptides", "heart disease", "1228 protein clusters", "proteomic approaches", "electron micrographs", "PeptideClassifier analysis", "subsisting peptidome", "map peptides", "protein isoform groups", "disease mechanisms", "Adult Drosophila melanogaster Drosophila melanogaster", "Drosophila peptide compendium", "Drosophila heart pathogenesis", "protein isoforms", "mitochondrial proteins", "protein ontologies", "systems level", "Drosophila heart", "protein network studies", "model system", "Cardiac Proteome"], "article_id"=>451848, "categories"=>["Biochemistry", "Cell Biology", "Genetics", "Molecular Biology", "Physiology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Cancer"], "users"=>["Anthony Cammarato", "Christian H. Ahrens", "Nakissa N. Alayari", "Ermir Qeli", "Jasma Rucker", "Mary C. Reedy", "Christian M. Zmasek", "Marjan Gucek", "Robert N. Cole", "Jennifer E. Van Eyk", "Rolf Bodmer", "Brian O'Rourke", "Sanford I. Bernstein", "D. Brian Foster"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018497.t001"], "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Drosophila_Cardiac_Peptidome_/451848", "title"=>"<i>Drosophila</i> Cardiac Peptidome.", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-25 14:29:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/4435450"], "description"=>"<p>Panel A. The cardiac tube proteome was compared with the extensive\n <i>Drosophila</i> proteome of Brunner <i>et\n al</i>\n <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018497#pone.0018497-Brunner1\" target=\"_blank\">[24]</a>. To minimize complications arising from\n the use of different databases (Refseq vs. BDGP3.2), comparison at\n the level of peptides is preferred. 1293 peptides, or approximately\n 25% of those identified in this study, were uniquely detected\n in our heart dataset and ultimately mapped to 237 protein clusters\n that were novel to the cardiac tube dataset. Panel B. The cardiac\n tube proteome was cross-referenced with the developing heart\n transcriptome of Zeitouni <i>et al</i>\n <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018497#pone.0018497-Zeitouni1\" target=\"_blank\">[25]</a>. Protein and transcript datasets were\n mapped onto CG gene models to facilitate comparison (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018497#pone.0018497.s015\" target=\"_blank\">Methods S1</a>).</p>", "links"=>[], "tags"=>["mouse heart proteome", "protein maps", "1872 peptides", "heart disease", "1228 protein clusters", "proteomic approaches", "electron micrographs", "PeptideClassifier analysis", "subsisting peptidome", "map peptides", "protein isoform groups", "disease mechanisms", "Adult Drosophila melanogaster Drosophila melanogaster", "Drosophila peptide compendium", "Drosophila heart pathogenesis", "protein isoforms", "mitochondrial proteins", "protein ontologies", "systems level", "Drosophila heart", "protein network studies", "model system", "Cardiac Proteome"], "article_id"=>451236, "categories"=>["Biochemistry", "Cell Biology", "Genetics", "Molecular Biology", "Physiology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Cancer"], "users"=>["Anthony Cammarato", "Christian H. Ahrens", "Nakissa N. Alayari", "Ermir Qeli", "Jasma Rucker", "Mary C. Reedy", "Christian M. Zmasek", "Marjan Gucek", "Robert N. Cole", "Jennifer E. Van Eyk", "Rolf Bodmer", "Brian O'Rourke", "Sanford I. Bernstein", "D. Brian Foster"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018497.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Specificity_of_the_Drosophila_Cardiac_____Proteome_/451236", "title"=>"Specificity of the <i>Drosophila</i> Cardiac\n Proteome.", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-25 14:29:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/4435489"], "description"=>"<p>Functional descriptions of protein domains (as defined by the Pfam\n database <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018497#pone.0018497-Finn1\" target=\"_blank\">[42]</a>) of the <i>Drosophila</i>\n cardiac proteome (left) and the mouse heart proteome (right) were\n subjected to Gene-ontology term enrichment analysis using\n Ontologizer 2.0 software <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018497#pone.0018497-Bauer1\" target=\"_blank\">[22]</a> with the\n Topology-Elim algorithm <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018497#pone.0018497-Alexa1\" target=\"_blank\">[43]</a> and Bonferroni\n correction. The table is laid out according to the three branches of\n ontology: Molecular Function, Biological Process or Cellular\n Component. Annotation terms within each section are listed in\n descending order of enrichment (lowest p-values at the top). Within\n each branch of ontology <i>Drosophila</i> terms are color\n coded from red (lowest p-value) to blue (highest p-values). These\n colors were mapped onto related ontological terms found in the mouse\n to highlight commonalities (colors) and differences (grey).</p>", "links"=>[], "tags"=>["mouse heart proteome", "protein maps", "1872 peptides", "heart disease", "1228 protein clusters", "proteomic approaches", "electron micrographs", "PeptideClassifier analysis", "subsisting peptidome", "map peptides", "protein isoform groups", "disease mechanisms", "Adult Drosophila melanogaster Drosophila melanogaster", "Drosophila peptide compendium", "Drosophila heart pathogenesis", "protein isoforms", "mitochondrial proteins", "protein ontologies", "systems level", "Drosophila heart", "protein network studies", "model system", "Cardiac Proteome"], "article_id"=>451686, "categories"=>["Biochemistry", "Cell Biology", "Genetics", "Molecular Biology", "Physiology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Cancer"], "users"=>["Anthony Cammarato", "Christian H. Ahrens", "Nakissa N. Alayari", "Ermir Qeli", "Jasma Rucker", "Mary C. Reedy", "Christian M. Zmasek", "Marjan Gucek", "Robert N. Cole", "Jennifer E. Van Eyk", "Rolf Bodmer", "Brian O'Rourke", "Sanford I. Bernstein", "D. Brian Foster"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018497.g004"], "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_the_Drosophila_and_Mouse_Heart_____Proteomes_/451686", "title"=>"Comparison of the <i>Drosophila</i> and Mouse Heart\n Proteomes.", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-25 14:29:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/4435471"], "description"=>"<p>Panel A <i>By abundance</i>: Using the number of assigned\n spectra as a measure of relative protein abundance, the top 245 proteins\n (20%) were annotated manually with information from NCBI and\n Flybase. Total assigned spectra within a group are expressed as a\n percentage of the total number of spectra assigned to the top 245\n proteins. The chart provides a measure of the relative abundance of\n proteins that comprise each group. Panel B. <i>By clustering &\n enrichment of gene-ontology terms</i>: 928 proteins for which\n functional annotation was available among the 1228 proteins were\n subjected to functional clustering and enrichment analysis using the\n Functional Classification tool at the DAVID knowledgebase. Approximately\n 600 proteins were grouped into 47 functional classes based on the\n similarity of their gene-annotations. The annotation clusters are ranked\n by their <i>enrichment score</i> (−log(p-value)). The\n number of proteins per cluster is indicated in parentheses. A score of\n >2 (<b>—</b>) denotes high probability that a class is\n enriched.</p>", "links"=>[], "tags"=>["mouse heart proteome", "protein maps", "1872 peptides", "heart disease", "1228 protein clusters", "proteomic approaches", "electron micrographs", "PeptideClassifier analysis", "subsisting peptidome", "map peptides", "protein isoform groups", "disease mechanisms", "Adult Drosophila melanogaster Drosophila melanogaster", "Drosophila peptide compendium", "Drosophila heart pathogenesis", "protein isoforms", "mitochondrial proteins", "protein ontologies", "systems level", "Drosophila heart", "protein network studies", "model system", "Cardiac Proteome"], "article_id"=>451496, "categories"=>["Biochemistry", "Cell Biology", "Genetics", "Molecular Biology", "Physiology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Cancer"], "users"=>["Anthony Cammarato", "Christian H. Ahrens", "Nakissa N. Alayari", "Ermir Qeli", "Jasma Rucker", "Mary C. Reedy", "Christian M. Zmasek", "Marjan Gucek", "Robert N. Cole", "Jennifer E. Van Eyk", "Rolf Bodmer", "Brian O'Rourke", "Sanford I. Bernstein", "D. Brian Foster"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018497.g003"], "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Annotation_and_Classification_of_the_Drosophila____Cardiac_Proteome_/451496", "title"=>"Annotation and Classification of the <i>Drosophila</i>\n Cardiac Proteome.", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-25 14:29:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/4435084", "https://ndownloader.figshare.com/files/4435342", "https://ndownloader.figshare.com/files/4435336", "https://ndownloader.figshare.com/files/4435318", "https://ndownloader.figshare.com/files/4435291", "https://ndownloader.figshare.com/files/4435240", "https://ndownloader.figshare.com/files/4435225", "https://ndownloader.figshare.com/files/4435201", "https://ndownloader.figshare.com/files/4435189", "https://ndownloader.figshare.com/files/4435183", "https://ndownloader.figshare.com/files/4435162", "https://ndownloader.figshare.com/files/4435144", "https://ndownloader.figshare.com/files/4435126", "https://ndownloader.figshare.com/files/4435102", "https://ndownloader.figshare.com/files/4435357"], "description"=>"<div><p><i>Drosophila melanogaster</i> is emerging as a powerful model system\n for the study of cardiac disease. Establishing peptide and protein maps of the\n <i>Drosophila</i> heart is central to implementation of protein\n network studies that will allow us to assess the hallmarks of\n <i>Drosophila</i> heart pathogenesis and gauge the degree of\n conservation with human disease mechanisms on a systems level. Using a\n gel-LC-MS/MS approach, we identified 1228 protein clusters from 145 dissected\n adult fly hearts. Contractile, cytostructural and mitochondrial proteins were\n most abundant consistent with electron micrographs of the\n <i>Drosophila</i> cardiac tube. Functional/Ontological enrichment\n analysis further showed that proteins involved in glycolysis,\n Ca<sup>2+</sup>-binding, redox, and G-protein signaling, among other\n processes, are also over-represented. Comparison with a mouse heart proteome\n revealed conservation at the level of molecular function, biological processes\n and cellular components. The subsisting peptidome encompassed 5169 distinct\n heart-associated peptides, of which 1293 (25%) had not been identified in\n a recent <i>Drosophila</i> peptide compendium. PeptideClassifier\n analysis was further used to map peptides to specific gene-models. 1872 peptides\n provide valuable information about protein isoform groups whereas a further 3112\n uniquely identify specific protein isoforms and may be used as a\n heart-associated peptide resource for quantitative proteomic approaches based on\n multiple-reaction monitoring. In summary, identification of\n excitation-contraction protein landmarks, orthologues of proteins associated\n with cardiovascular defects, and conservation of protein ontologies, provides\n testimony to the heart-like character of the <i>Drosophila</i> cardiac\n tube and to the utility of proteomics as a complement to the power of genetics\n in this growing model of human heart disease.</p></div>", "links"=>[], "tags"=>["mouse heart proteome", "protein maps", "1872 peptides", "heart disease", "1228 protein clusters", "proteomic approaches", "electron micrographs", "PeptideClassifier analysis", "subsisting peptidome", "map peptides", "protein isoform groups", "disease mechanisms", "Adult Drosophila melanogaster Drosophila melanogaster", "Drosophila peptide compendium", "Drosophila heart pathogenesis", "protein isoforms", "mitochondrial proteins", "protein ontologies", "systems level", "Drosophila heart", "protein network studies", "model system", "Cardiac Proteome"], "article_id"=>1083640, "categories"=>["Biochemistry", "Cell Biology", "Genetics", "Molecular Biology", "Physiology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Cancer"], "users"=>["Anthony Cammarato", "Christian H. Ahrens", "Nakissa N. Alayari", "Ermir Qeli", "Jasma Rucker", "Mary C. Reedy", "Christian M. Zmasek", "Marjan Gucek", "Robert N. Cole", "Jennifer E. Van Eyk", "Rolf Bodmer", "Brian O'Rourke", "Sanford I. Bernstein", "D. Brian Foster"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018497.s001", "https://dx.doi.org/10.1371/journal.pone.0018497.s014", "https://dx.doi.org/10.1371/journal.pone.0018497.s013", "https://dx.doi.org/10.1371/journal.pone.0018497.s012", "https://dx.doi.org/10.1371/journal.pone.0018497.s011", "https://dx.doi.org/10.1371/journal.pone.0018497.s010", "https://dx.doi.org/10.1371/journal.pone.0018497.s009", "https://dx.doi.org/10.1371/journal.pone.0018497.s008", "https://dx.doi.org/10.1371/journal.pone.0018497.s007", "https://dx.doi.org/10.1371/journal.pone.0018497.s006", "https://dx.doi.org/10.1371/journal.pone.0018497.s005", "https://dx.doi.org/10.1371/journal.pone.0018497.s004", "https://dx.doi.org/10.1371/journal.pone.0018497.s003", "https://dx.doi.org/10.1371/journal.pone.0018497.s002", "https://dx.doi.org/10.1371/journal.pone.0018497.s015"], "stats"=>{"downloads"=>6, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_Mighty_Small_Heart_The_Cardiac_Proteome_of_Adult____Drosophila_melanogaster_/1083640", "title"=>"A Mighty Small Heart: The Cardiac Proteome of Adult\n <i>Drosophila melanogaster</i>", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-25 14:29:00"}

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