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{"title"=>"Evaluation of a novel non-penetrating electrode for use in DNA vaccination", "type"=>"journal", "authors"=>[{"first_name"=>"Amy", "last_name"=>"Donate", "scopus_author_id"=>"36476174500"}, {"first_name"=>"Domenico", "last_name"=>"Coppola", "scopus_author_id"=>"7005933277"}, {"first_name"=>"Yolmari", "last_name"=>"Cruz", "scopus_author_id"=>"6701604818"}, {"first_name"=>"Richard", "last_name"=>"Heller", "scopus_author_id"=>"16071668100"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"21559474", "sgr"=>"79955745986", "doi"=>"10.1371/journal.pone.0019181", "scopus"=>"2-s2.0-79955745986", "pui"=>"361724294", "isbn"=>"1932-6203", "issn"=>"19326203"}, "id"=>"8167cddc-bae4-352f-9ca6-cd4620163508", "abstract"=>"Current progress in the development of vaccines has decreased the incidence of fatal and non-fatal infections and increased longevity. However, new technologies need to be developed to combat an emerging generation of infectious diseases. DNA vaccination has been demonstrated to have great potential for use with a wide variety of diseases. Alone, this technology does not generate a significant immune response for vaccination, but combined with delivery by electroporation (EP), can enhance plasmid expression and immunity. Most EP systems, while effective, can be invasive and painful making them less desirable for use in vaccination. Our lab recently developed a non-invasive electrode known as the multi-electrode array (MEA), which lies flat on the surface of the skin without penetrating the tissue. In this study we evaluated the MEA for its use in DNA vaccination using Hepatitis B virus as the infectious model. We utilized the guinea pig model because their skin is similar in thickness and morphology to humans. The plasmid encoding Hepatitis B surface antigen (HBsAg) was delivered intradermally with the MEA to guinea pig skin. The results show increased protein expression resulting from plasmid delivery using the MEA as compared to injection alone. Within 48 hours of treatment, there was an influx of cellular infiltrate in experimental groups. Humoral responses were also increased significantly in both duration and intensity as compared to injection only groups. While this electrode requires further study, our results suggest that the MEA has potential for use in electrically mediated intradermal DNA vaccination", "link"=>"http://www.mendeley.com/research/evaluation-novel-nonpenetrating-electrode-dna-vaccination", "reader_count"=>13, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Other"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>1, "Materials Science"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>3, "Physics and Astronomy"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

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• http://doi.org/10.1016/j.bioelechem.2018.03.005
• http://doi.org/10.1016/j.bioelechem.2013.04.004
• http://doi.org/10.1016/j.virol.2012.07.014
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• http://doi.org/10.1038/mtna.2016.65
• http://doi.org/10.1088/1748-6041/11/3/035002
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• http://doi.org/10.1016/j.jconrel.2013.09.030
• http://doi.org/10.4161/hv.21624

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• {"files"=>["https://ndownloader.figshare.com/files/778290"], "description"=>"<p>Guinea pigs were treated as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019181#s2\" target=\"_blank\">Methods</a> 2.1 with pHBsAg. Serum was collected at multiple time points and an ELISA performed. Geometric mean titers are expressed. Positive was determined by two standard deviations greater than the Day 0 OD. IO and EP n = 6 for each experiment with 3 independent experiments conducted (total n = 18). Statistics were determined by two-sided student t-test with bonferroni correction to p<0.05.</p>", "links"=>[], "tags"=>["anti-hbs", "serum"], "article_id"=>448660, "categories"=>["Physics", "Biotechnology", "Genetics"], "users"=>["Amy Donate", "Domenico Coppola", "Yolmari Cruz", "Richard Heller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019181.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Evaluation_of_anti_HBs_serum_titer_/448660", "title"=>"Evaluation of anti-HBs serum titer.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 18:42:29"}
• {"files"=>["https://ndownloader.figshare.com/files/777965"], "description"=>"<p>The MEA has 16 electrodes placed 2 mm apart and is arranged in 4 rows. Pulses are administered in a sequence that utilizes 4 electrodes at a time, forming 2×2 mm squares (9 total squares). Pulses are applied in pairs, in two directions, perpendicular to each other (18 pulses) for 4 rounds of pulsing (72 total pulses). This image is reprinted from The Journal of Controlled Release doi:10.1016/j.jconrel.2011.01.014 Siqi Guo, Amy Donate, Guarav Basu, Cathryn Lundberg, Loree Heller, Richard Heller “Electro-gene transfer to the skin using a non-invasive multi-electrode array” with permission from Elsevier.</p>", "links"=>[], "tags"=>["multi-electrode"], "article_id"=>448337, "categories"=>["Physics", "Biotechnology", "Genetics"], "users"=>["Amy Donate", "Domenico Coppola", "Yolmari Cruz", "Richard Heller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019181.g001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Non_invasive_Multi_Electrode_Array_/448337", "title"=>"Non-invasive Multi-Electrode Array.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 18:40:48"}
• {"files"=>["https://ndownloader.figshare.com/files/778068"], "description"=>"<p>Guinea pigs were treated as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019181#s2\" target=\"_blank\">Methods</a> 2.1 with pHBsAg. Expression of plasmid was evaluated at 48 hrs post treatment by IHC (A-IO; B I+EP). Inflammation was measured 96 hrs post treatment and assessed by H&E (C-No treatment; D- IO, E–I+EP) at 100× magnification and 200× magnification (F- I+EP).</p>", "links"=>[], "tags"=>["inflammation"], "article_id"=>448442, "categories"=>["Physics", "Biotechnology", "Genetics"], "users"=>["Amy Donate", "Domenico Coppola", "Yolmari Cruz", "Richard Heller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019181.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plasmid_expression_and_inflammation_in_the_skin_/448442", "title"=>"Plasmid expression and inflammation in the skin.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 18:41:22"}

PMC Usage Stats | Further Information

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Relative Metric

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F1000Prime