MAGE-C2/CT10 Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer
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{"title"=>"MAGE-C2/CT10 protein expression is an independent predictor of recurrence in prostate cancer", "type"=>"journal", "authors"=>[{"first_name"=>"Lotta", "last_name"=>"von Boehmer", "scopus_author_id"=>"16070657100"}, {"first_name"=>"Lukas", "last_name"=>"Keller", "scopus_author_id"=>"44761228800"}, {"first_name"=>"Ashkan", "last_name"=>"Mortezavi", "scopus_author_id"=>"26423984600"}, {"first_name"=>"Maurizio", "last_name"=>"Provenzano", "scopus_author_id"=>"36850944300"}, {"first_name"=>"Giovanni", "last_name"=>"Sais", "scopus_author_id"=>"15122636300"}, {"first_name"=>"Thomas", "last_name"=>"Hermanns", "scopus_author_id"=>"57197412406"}, {"first_name"=>"Tullio", "last_name"=>"Sulser", "scopus_author_id"=>"7006010406"}, {"first_name"=>"Achim A.", "last_name"=>"Jungbluth", "scopus_author_id"=>"7004817509"}, {"first_name"=>"Lloyd J.", "last_name"=>"Old", "scopus_author_id"=>"7101617884"}, {"first_name"=>"Glen", "last_name"=>"Kristiansen", "scopus_author_id"=>"24169060100"}, {"first_name"=>"Maries", "last_name"=>"van den Broek", "scopus_author_id"=>"7005936491"}, {"first_name"=>"Holger", "last_name"=>"Moch", "scopus_author_id"=>"8076762000"}, {"first_name"=>"Alexander", "last_name"=>"Knuth", "scopus_author_id"=>"7004920514"}, {"first_name"=>"Peter J.", "last_name"=>"Wild", "scopus_author_id"=>"7102744064"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"21754986", "scopus"=>"2-s2.0-79959943107", "sgr"=>"79959943107", "doi"=>"10.1371/journal.pone.0021366", "pui"=>"362084926", "issn"=>"19326203"}, "id"=>"cc8209e2-728b-3f4d-b89a-41f1b1106a39", "abstract"=>"The cancer-testis (CT) family of antigens is expressed in a variety of malignant neoplasms. In most cases, no CT antigen is found in normal tissues, except in testis, making them ideal targets for cancer immunotherapy. A comprehensive analysis of CT antigen expression has not yet been reported in prostate cancer. MAGE-C2/CT-10 is a novel CT antigen. The objective of this study was to analyze extent and prognostic significance of MAGE-C2/CT10 protein expression in prostate cancer. 348 prostate carcinomas from consecutive radical prostatectomies, 29 castration-refractory prostate cancer, 46 metastases, and 45 benign hyperplasias were immunohistochemically analyzed for MAGE-C2/CT10 expression using tissue microarrays. Nuclear MAGE-C2/CT10 expression was identified in only 3.3% primary prostate carcinomas. MAGE-C2/CT10 protein expression was significantly more frequent in metastatic (16.3% positivity) and castration-resistant prostate cancer (17% positivity; p<0.001). Nuclear MAGE-C2/CT10 expression was identified as predictor of biochemical recurrence after radical prostatectomy (p = 0.015), which was independent of preoperative PSA, Gleason score, tumor stage, and surgical margin status in multivariate analysis (p<0.05). MAGE-C2/CT10 expression in prostate cancer correlates with the degree of malignancy and indicates a higher risk for biochemical recurrence after radical prostatectomy. Further, the results suggest MAGE-C2/CT10 as a potential target for adjuvant and palliative immunotherapy in patients with prostate cancer.", "link"=>"http://www.mendeley.com/research/magec2ct10-protein-expression-independent-predictor-recurrence-prostate-cancer", "reader_count"=>6, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Mexico"=>1}, "group_count"=>0}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/759558"], "description"=>"<p>*P-values<0.05 are marked in bold.</p><p>HR = Hazard ratio.</p>", "links"=>[], "tags"=>["cox", "regression"], "article_id"=>429921, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Lotta von Boehmer", "Lukas Keller", "Ashkan Mortezavi", "Maurizio Provenzano", "Giovanni Sais", "Thomas Hermanns", "Tullio Sulser", "Achim A. Jungbluth", "Lloyd J. Old", "Glen Kristiansen", "Maries van den Broek", "Holger Moch", "Alexander Knuth", "Peter J. Wild"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0021366.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Univariate_Cox_regression_analysis_/429921", "title"=>"Univariate Cox regression analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-07-06 02:45:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/759665"], "description"=>"a<p>Fisher's exact test, two-sided; bold face representing p<0.05.</p>b<p>Pearson Chi-Square, Asymp. Sig., two sided.</p><p>p = p-value.</p>", "links"=>[], "tags"=>["characteristics", "ct10", "immunoreactivity", "prostatectomy"], "article_id"=>430024, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Lotta von Boehmer", "Lukas Keller", "Ashkan Mortezavi", "Maurizio Provenzano", "Giovanni Sais", "Thomas Hermanns", "Tullio Sulser", "Achim A. Jungbluth", "Lloyd J. Old", "Glen Kristiansen", "Maries van den Broek", "Holger Moch", "Alexander Knuth", "Peter J. Wild"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0021366.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinicopathological_characteristics_in_relation_to_CT10_immunoreactivity_in_radical_prostatectomy_tumor_specimens_/430024", "title"=>"Clinicopathological characteristics in relation to CT10 immunoreactivity in radical prostatectomy tumor specimens.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-07-06 00:00:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/759485"], "description"=>"<p>Kaplan–Meyer curves regarding disease-free survival of patients with no MAGE-C2/CT10 expression (blue line) <i>vs.</i> patients with positive MAGE-C2/CT10 expression (green line) in invasive prostate carcinomas receiving radical prostatectomy.</p>", "links"=>[], "tags"=>["curves", "disease-free", "patients", "invasive", "prostate", "carcinomas", "receiving"], "article_id"=>429834, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Lotta von Boehmer", "Lukas Keller", "Ashkan Mortezavi", "Maurizio Provenzano", "Giovanni Sais", "Thomas Hermanns", "Tullio Sulser", "Achim A. Jungbluth", "Lloyd J. Old", "Glen Kristiansen", "Maries van den Broek", "Holger Moch", "Alexander Knuth", "Peter J. Wild"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0021366.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kaplan_Meyer_curves_regarding_disease_free_survival_of_patients_with_no_MAGE_C2_CT10_expression_blue_line_vs_patients_with_positive_MAGE_C2_CT10_expression_green_line_in_invasive_prostate_carcinomas_receiving_radical_prostatectomy_/429834", "title"=>"Kaplan–Meyer curves regarding disease-free survival of patients with no MAGE-C2/CT10 expression (blue line) <i>vs.</i> patients with positive MAGE-C2/CT10 expression (green line) in invasive prostate carcinomas receiving radical prostatectomy.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-06 02:43:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/759229"], "description"=>"<p>A: Radical prostatectomy specimen (Gleason 4+3), B: Bone metastasis of prostate cancer, C: Bone metastasis of prostate cancer, D: Radical prostatectomy specimen (Gleason 4+3), E: Castration-resistant prostate cancer (Gleason 5+5), F: Palliative transurethral resection of prostate cancer (Gleason 4+5), G: Bone metastasis of prostate cancer, H: Palliative transurethral resection of prostate cancer (Gleason 5+4), I: Castration-resistant prostate cancer (Gleason 5+4). Original magnification: 200×; Magnification bar: 20 µM.</p>", "links"=>[], "tags"=>["immunohistochemical", "patterns", "ny-eso-1"], "article_id"=>429583, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Lotta von Boehmer", "Lukas Keller", "Ashkan Mortezavi", "Maurizio Provenzano", "Giovanni Sais", "Thomas Hermanns", "Tullio Sulser", "Achim A. Jungbluth", "Lloyd J. Old", "Glen Kristiansen", "Maries van den Broek", "Holger Moch", "Alexander Knuth", "Peter J. Wild"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0021366.g002", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_immunohistochemical_expression_patterns_from_1_8211_10_11_8211_50_and_51_8211_100_of_MAGE_C2_CT10_A_B_and_C_MAGE_C1_CT7_D_E_and_F_and_NY_ESO_1_G_H_and_I_/429583", "title"=>"Representative immunohistochemical expression patterns from 1–10%, 11–50% and 51–100% of MAGE-C2/CT10 (A, B and C), MAGE-C1/CT7 (D, E and F) and NY-ESO-1 (G, H and I).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-06 02:39:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/759333"], "description"=>"<p>BPH: benign prostatic hyperplasia; ADCA: organ-confined adenocarcinoma of the prostate; MTS: prostate cancer metastasis; CRPC: castration-resistant prostate cancer.</p>", "links"=>[], "tags"=>["immunoreactivity", "prostate", "prostatic", "hyperplasia", "organ-confined", "cancer", "metastatic", "castration", "resistant"], "article_id"=>429681, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Lotta von Boehmer", "Lukas Keller", "Ashkan Mortezavi", "Maurizio Provenzano", "Giovanni Sais", "Thomas Hermanns", "Tullio Sulser", "Achim A. Jungbluth", "Lloyd J. Old", "Glen Kristiansen", "Maries van den Broek", "Holger Moch", "Alexander Knuth", "Peter J. Wild"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0021366.g003", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cumulative_bar_chart_representing_nuclear_immunoreactivity_for_MAGE_C2_CT10_in_different_prostate_tissue_types_showing_increased_expression_from_prostatic_hyperplasia_to_organ_confined_prostate_cancer_to_metastatic_and_castration_resistant_disease_p_lt_0/429681", "title"=>"Cumulative bar chart representing nuclear immunoreactivity for MAGE-C2/CT10 in different prostate tissue types, showing increased expression from prostatic hyperplasia to organ-confined prostate cancer to metastatic and castration resistant disease (p<0.001).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-06 02:41:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/381618", "https://ndownloader.figshare.com/files/381646", "https://ndownloader.figshare.com/files/381669"], "description"=>"<div><p>The cancer-testis (CT) family of antigens is expressed in a variety of malignant neoplasms. In most cases, no CT antigen is found in normal tissues, except in testis, making them ideal targets for cancer immunotherapy. A comprehensive analysis of CT antigen expression has not yet been reported in prostate cancer. MAGE-C2/CT-10 is a novel CT antigen. The objective of this study was to analyze extent and prognostic significance of MAGE-C2/CT10 protein expression in prostate cancer. 348 prostate carcinomas from consecutive radical prostatectomies, 29 castration-refractory prostate cancer, 46 metastases, and 45 benign hyperplasias were immunohistochemically analyzed for MAGE-C2/CT10 expression using tissue microarrays. Nuclear MAGE-C2/CT10 expression was identified in only 3.3% primary prostate carcinomas. MAGE-C2/CT10 protein expression was significantly more frequent in metastatic (16.3% positivity) and castration-resistant prostate cancer (17% positivity; p<0.001). Nuclear MAGE-C2/CT10 expression was identified as predictor of biochemical recurrence after radical prostatectomy (p = 0.015), which was independent of preoperative PSA, Gleason score, tumor stage, and surgical margin status in multivariate analysis (p<0.05). MAGE-C2/CT10 expression in prostate cancer correlates with the degree of malignancy and indicates a higher risk for biochemical recurrence after radical prostatectomy. Further, the results suggest MAGE-C2/CT10 as a potential target for adjuvant and palliative immunotherapy in patients with prostate cancer.</p> </div>", "links"=>[], "tags"=>["predictor", "recurrence", "prostate", "cancer"], "article_id"=>135382, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Lotta von Boehmer", "Lukas Keller", "Ashkan Mortezavi", "Maurizio Provenzano", "Giovanni Sais", "Thomas Hermanns", "Tullio Sulser", "Achim A. Jungbluth", "Lloyd J. Old", "Glen Kristiansen", "Maries van den Broek", "Holger Moch", "Alexander Knuth", "Peter J. Wild"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0021366.s001", "https://dx.doi.org/10.1371/journal.pone.0021366.s002", "https://dx.doi.org/10.1371/journal.pone.0021366.s003"], "stats"=>{"downloads"=>4, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/MAGE_C2_CT10_Protein_Expression_Is_an_Independent_Predictor_of_Recurrence_in_Prostate_Cancer/135382", "title"=>"MAGE-C2/CT10 Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-07-06 01:29:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/759141"], "description"=>"<p>MAGE-C2/CT10 expression could be observed in 11 of 341 (3.2%) prostatectomy specimens. The occurrence of MAGE-C2/CT10 expression should double the risk of PSA recurrence during follow up, resulting in a hazard ratio of approximately 2.0. Accordingly, the available sample size of 341 analyzable patients would be sufficient to detect a difference concerning PSA recurrence with a significance of p<0.05 and a power of approximately 86%. For higher hazard ratios (2.4, 2.8, 3.2) a statistical power of approximately 99% was calculated.</p>", "links"=>[], "tags"=>["immunology", "urology", "oncology", "pathology"], "article_id"=>429495, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Lotta von Boehmer", "Lukas Keller", "Ashkan Mortezavi", "Maurizio Provenzano", "Giovanni Sais", "Thomas Hermanns", "Tullio Sulser", "Achim A. Jungbluth", "Lloyd J. Old", "Glen Kristiansen", "Maries van den Broek", "Holger Moch", "Alexander Knuth", "Peter J. Wild"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0021366.g001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Estimation_of_statistical_power_versus_total_sample_size_N_for_different_hazard_ratios_/429495", "title"=>"Estimation of statistical power <i>versus</i> total sample size N for different hazard ratios.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-06 02:38:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/759617"], "description"=>"<p>*p-values<0.05 are marked in bold.</p><p>HR = Hazard ratio.</p>", "links"=>[], "tags"=>["cox", "regression"], "article_id"=>429976, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Lotta von Boehmer", "Lukas Keller", "Ashkan Mortezavi", "Maurizio Provenzano", "Giovanni Sais", "Thomas Hermanns", "Tullio Sulser", "Achim A. Jungbluth", "Lloyd J. Old", "Glen Kristiansen", "Maries van den Broek", "Holger Moch", "Alexander Knuth", "Peter J. Wild"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0021366.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multivariate_Cox_regression_analysis_/429976", "title"=>"Multivariate Cox regression analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-07-06 02:46:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/759393"], "description"=>"<p>Significant coexpression of MAGE-C2/CT10 with NY-ESO-1 and MAGE-C1/CT7 on the tissue microarray.</p>", "links"=>[], "tags"=>["coexpression", "ny-eso-1"], "article_id"=>429753, "categories"=>["Cancer", "Cell Biology", "Immunology"], "users"=>["Lotta von Boehmer", "Lukas Keller", "Ashkan Mortezavi", "Maurizio Provenzano", "Giovanni Sais", "Thomas Hermanns", "Tullio Sulser", "Achim A. Jungbluth", "Lloyd J. Old", "Glen Kristiansen", "Maries van den Broek", "Holger Moch", "Alexander Knuth", "Peter J. Wild"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0021366.g004", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Significant_coexpression_of_MAGE_C2_CT10_with_NY_ESO_1_and_MAGE_C1_CT7_on_the_tissue_microarray_/429753", "title"=>"Significant coexpression of MAGE-C2/CT10 with NY-ESO-1 and MAGE-C1/CT7 on the tissue microarray.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-06 02:42:33"}

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