Multicenter Phase 2 Trial of Sirolimus for Tuberous Sclerosis: Kidney Angiomyolipomas and Other Tumors Regress and VEGF- D Levels Decrease
- Publication Date
- September 06, 2011
- Journal
- PLOS ONE
- Authors
- Sandra L. Dabora, David Neal Franz, Stephen Ashwal, Arthur Sagalowsky, et al
- Volume
- 6
- Issue
- 9
- Pages
- e23379
- DOI
- https://dx.plos.org/10.1371/journal.pone.0023379
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0023379
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/21915260
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167813
- Europe PMC
- http://europepmc.org/abstract/MED/21915260
- Web of Science
- 000294689200005
- Scopus
- 80052472675
- Mendeley
- http://www.mendeley.com/research/multicenter-phase-2-trial-sirolimus-tuberous-sclerosis-kidney-angiomyolipomas-other-tumors-regress-v
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Mendeley | Further Information
{"title"=>"Multicenter phase 2 trial of sirolimus for tuberous sclerosis: Kidney angiomyolipomas and other tumors regress and VEGF- D levels decrease", "type"=>"journal", "authors"=>[{"first_name"=>"Sandra L.", "last_name"=>"Dabora", "scopus_author_id"=>"6603037507"}, {"first_name"=>"David Neal", "last_name"=>"Franz", "scopus_author_id"=>"7005114108"}, {"first_name"=>"Stephen", "last_name"=>"Ashwal", "scopus_author_id"=>"7005184300"}, {"first_name"=>"Arthur", "last_name"=>"Sagalowsky", "scopus_author_id"=>"7005622967"}, {"first_name"=>"Francis J.", "last_name"=>"DiMario", "scopus_author_id"=>"7007181456"}, {"first_name"=>"Daniel", "last_name"=>"Miles", "scopus_author_id"=>"7201525269"}, {"first_name"=>"Drew", "last_name"=>"Cutler", "scopus_author_id"=>"57198032270"}, {"first_name"=>"Darcy", "last_name"=>"Krueger", "scopus_author_id"=>"36660783000"}, {"first_name"=>"Raul N.", "last_name"=>"Uppot", "scopus_author_id"=>"6603025315"}, {"first_name"=>"Rahmin", "last_name"=>"Rabenou", "scopus_author_id"=>"6506893757"}, {"first_name"=>"Susana", "last_name"=>"Camposano", "scopus_author_id"=>"36814733900"}, {"first_name"=>"Jan", "last_name"=>"Paolini", "scopus_author_id"=>"54992732900"}, {"first_name"=>"Fiona", "last_name"=>"Fennessy", "scopus_author_id"=>"6602870987"}, {"first_name"=>"Nancy", "last_name"=>"Lee", "scopus_author_id"=>"35205567700"}, {"first_name"=>"Chelsey", "last_name"=>"Woodrum", "scopus_author_id"=>"35207610600"}, {"first_name"=>"Judith", "last_name"=>"Manola", "scopus_author_id"=>"35419589700"}, {"first_name"=>"Judy", "last_name"=>"Garber", "scopus_author_id"=>"56882437700"}, {"first_name"=>"Elizabeth A.", "last_name"=>"Thiele", "scopus_author_id"=>"7006357003"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"362504732", "doi"=>"10.1371/journal.pone.0023379", "sgr"=>"80052472675", "scopus"=>"2-s2.0-80052472675", "isbn"=>"1932-6203", "pmid"=>"21915260"}, "id"=>"01253169-d063-35e5-8b3c-3ec6d094fd3b", "abstract"=>"BACKGROUND: Tuberous sclerosis (TSC) related tumors are characterized by constitutively activated mTOR signaling due to mutations in TSC1 or TSC2.\\n\\nMETHODS: We completed a phase 2 multicenter trial to evaluate the efficacy and tolerability of the mTOR inhibitor, sirolimus, for the treatment of kidney angiomyolipomas.\\n\\nRESULTS: 36 adults with TSC or TSC/LAM were enrolled and started on daily sirolimus. The overall response rate was 44.4% (95% confidence intervals [CI] 28 to 61); 16/36 had a partial response. The remainder had stable disease (47.2%, 17/36), or were unevaluable (8.3%, 3/36). The mean decrease in kidney tumor size (sum of the longest diameters [sum LD]) was 29.9% (95% CI, 22 to 37; n = 28 at week 52). Drug related grade 1-2 toxicities that occurred with a frequency of >20% included: stomatitis, hypertriglyceridemia, hypercholesterolemia, bone marrow suppression (anemia, mild neutropenia, leucopenia), proteinuria, and joint pain. There were three drug related grade 3 events: lymphopenia, headache, weight gain. Kidney angiomyolipomas regrew when sirolimus was discontinued but responses tended to persist if treatment was continued after week 52. We observed regression of brain tumors (SEGAs) in 7/11 cases (26% mean decrease in diameter), regression of liver angiomyolipomas in 4/5 cases (32.1% mean decrease in longest diameter), subjective improvement in facial angiofibromas in 57%, and stable lung function in women with TSC/LAM (n = 15). A correlative biomarker study showed that serum VEGF-D levels are elevated at baseline, decrease with sirolimus treatment, and correlate with kidney angiomyolipoma size (Spearman correlation coefficient 0.54, p = 0.001, at baseline).\\n\\nCONCLUSIONS: Sirolimus treatment for 52 weeks induced regression of kidney angiomyolipomas, SEGAs, and liver angiomyolipomas. Serum VEGF-D may be a useful biomarker for monitoring kidney angiomyolipoma size. Future studies are needed to determine benefits and risks of longer duration treatment in adults and children with TSC.\\n\\nTRIAL REGISTRATION: Clinicaltrials.gov NCT00126672.", "link"=>"http://www.mendeley.com/research/multicenter-phase-2-trial-sirolimus-tuberous-sclerosis-kidney-angiomyolipomas-other-tumors-regress-v", "reader_count"=>56, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>9, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Other"=>8, "Student > Master"=>8, "Student > Bachelor"=>7, "Lecturer > Senior Lecturer"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>9, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Other"=>8, "Student > Master"=>8, "Student > Bachelor"=>7, "Lecturer > Senior Lecturer"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>8, "Nursing and Health Professions"=>2, "Mathematics"=>1, "Medicine and Dentistry"=>29, "Agricultural and Biological Sciences"=>6, "Neuroscience"=>2, "Chemistry"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>29}, "Neuroscience"=>{"Neuroscience"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>5}}, "reader_count_by_country"=>{"Netherlands"=>2, "United States"=>1, "China"=>1, "United Kingdom"=>1}, "group_count"=>2}CrossRef
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- {"month"=>"3", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"60"}
- {"month"=>"4", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"58"}
- {"month"=>"5", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"77"}
- {"month"=>"6", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"64"}
- {"month"=>"7", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"47"}
- {"month"=>"8", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"62"}
- {"month"=>"9", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"201"}
- {"month"=>"10", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"481"}
- {"month"=>"11", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"422"}
- {"month"=>"12", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"359"}
- {"month"=>"1", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"422"}
- {"month"=>"2", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"578"}
- {"month"=>"3", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"532"}
- {"month"=>"4", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"318"}
- {"month"=>"5", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"86"}
- {"month"=>"6", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"67"}
- {"month"=>"7", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"55"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"41"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"58"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"3", "html_views"=>"46"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"61"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"49"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"52"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"23"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"28"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"29"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"18"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"5", "html_views"=>"18"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"23"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"19"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"24"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"22"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"22"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"20"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"15"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"14"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"16"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"14"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"9"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"18"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"15"}
- {"month"=>"1", "year"=>"2020", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"2", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"7"}
- {"month"=>"3", "year"=>"2020", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"8"}
- {"month"=>"4", "year"=>"2020", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"9"}
- {"month"=>"5", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"7"}
- {"month"=>"6", "year"=>"2020", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"10"}
- {"month"=>"7", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"5"}
- {"month"=>"8", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"5"}
- {"month"=>"9", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"10", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"3", "html_views"=>"27"}
- {"month"=>"11", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"20"}
- {"month"=>"12", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"9"}
- {"month"=>"1", "year"=>"2021", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"2", "year"=>"2021", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"9"}
PMC Usage Stats | Further Information
- {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"69", "unique-ip"=>"59", "pdf"=>"49", "year"=>"2011", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"97", "year"=>"2011", "pdf"=>"79", "unique-ip"=>"89", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"5"}
- {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"84", "unique-ip"=>"73", "pdf"=>"61", "year"=>"2011", "figure"=>"18", "scanned-summary"=>"0", "supp-data"=>"9"}
- {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"61", "year"=>"2011", "pdf"=>"41", "unique-ip"=>"59", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"53", "unique-ip"=>"44", "pdf"=>"16", "year"=>"2012", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"61", "year"=>"2012", "pdf"=>"44", "unique-ip"=>"62", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"91", "unique-ip"=>"82", "pdf"=>"30", "year"=>"2012", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"1"}
- {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"49", "year"=>"2012", "pdf"=>"28", "unique-ip"=>"47", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"2"}
- {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"58", "unique-ip"=>"57", "pdf"=>"32", "year"=>"2012", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"3"}
- {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"45", "year"=>"2012", "pdf"=>"30", "unique-ip"=>"46", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"8"}
- {"unique-ip"=>"41", "full-text"=>"43", "pdf"=>"25", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
- {"unique-ip"=>"29", "full-text"=>"33", "pdf"=>"24", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
- {"unique-ip"=>"39", "full-text"=>"38", "pdf"=>"34", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
- {"unique-ip"=>"45", "full-text"=>"42", "pdf"=>"31", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
- {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
- {"unique-ip"=>"44", "full-text"=>"48", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
- {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
- {"unique-ip"=>"39", "full-text"=>"39", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2013", "month"=>"2"}
- {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
- {"unique-ip"=>"50", "full-text"=>"45", "pdf"=>"29", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
- {"unique-ip"=>"32", "full-text"=>"34", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"50", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
- {"unique-ip"=>"29", "full-text"=>"29", "pdf"=>"36", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
- {"unique-ip"=>"20", "full-text"=>"16", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"25", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
- {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
- {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"25", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
- {"unique-ip"=>"33", "full-text"=>"32", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
- {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
- {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
- {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
- {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
- {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
- {"unique-ip"=>"13", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
- {"unique-ip"=>"17", "full-text"=>"29", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
- {"unique-ip"=>"20", "full-text"=>"24", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
- {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
- {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
- {"unique-ip"=>"23", "full-text"=>"32", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
- {"unique-ip"=>"22", "full-text"=>"24", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
- {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
- {"unique-ip"=>"23", "full-text"=>"26", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
- {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
- {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
- {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
- {"unique-ip"=>"23", "full-text"=>"52", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
- {"unique-ip"=>"17", "full-text"=>"13", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
- {"unique-ip"=>"27", "full-text"=>"22", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
- {"unique-ip"=>"39", "full-text"=>"34", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
- {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
- {"unique-ip"=>"26", "full-text"=>"35", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"11"}
- {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
- {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
- {"unique-ip"=>"24", "full-text"=>"22", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
- {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
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