CiteULike

Mendeley | Further Information

{"title"=>"BAFF promotes Th17 cells and aggravates experimental autoimmune encephalomyelitis", "type"=>"journal", "authors"=>[{"first_name"=>"Xiaohui", "last_name"=>"Zhou", "scopus_author_id"=>"56332617600"}, {"first_name"=>"Zanxian", "last_name"=>"Xia", "scopus_author_id"=>"56714586800"}, {"first_name"=>"Qin", "last_name"=>"Lan", "scopus_author_id"=>"49561357900"}, {"first_name"=>"Julie", "last_name"=>"Wang", "scopus_author_id"=>"36083699300"}, {"first_name"=>"Wenru", "last_name"=>"Su", "scopus_author_id"=>"37035267600"}, {"first_name"=>"Yuan Ping", "last_name"=>"Han", "scopus_author_id"=>"7404096288"}, {"first_name"=>"Huimin", "last_name"=>"Fan", "scopus_author_id"=>"14037153100"}, {"first_name"=>"Zhongmin", "last_name"=>"Liu", "scopus_author_id"=>"35318039400"}, {"first_name"=>"William", "last_name"=>"Stohl", "scopus_author_id"=>"7005917493"}, {"first_name"=>"Song Guo", "last_name"=>"Zheng", "scopus_author_id"=>"7403146499"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pmid"=>"21897850", "scopus"=>"2-s2.0-80052293917", "doi"=>"10.1371/journal.pone.0023629", "pui"=>"362461749", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"80052293917"}, "id"=>"1c31f5df-6490-3f99-a48c-0656af7b8e73", "abstract"=>"BACKGROUND: BAFF, in addition to promoting B cell survival and differentiation, may affect T cells. The objective of this study was to determine the effect of BAFF on Th17 cell generation and its ramifications for the Th17 cell-driven disease, EAE.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: Th17 cells were increased in BAFF-Tg B6 (B6.BTg) mice and decreased in B6.Baff(-/-) mice. Th17 cells in B6.Baff(-/-) mice bearing a BAFF Tg (B6.Baff(-/-).BTg mice) were identical to those in B6.BTg mice, indicating that membrane BAFF is dispensable for Th17 cell generation as long as soluble BAFF is plentiful. In T + non-T cell criss-cross co-cultures, Th17 cell generation was greatest in cultures containing B6.BTg T cells and lowest in cultures containing B6.Baff(-/-) T cells, regardless of the source of non-T cells. In cultures containing only T cells, Th17 cell generation followed an identical pattern. CD4(+) cell expression of CD126 (IL-6R α chain) was increased in B6.BTg mice and decreased in B6.Baff(-/-) mice, and activation of STAT3 following stimulation with IL-6 + TGF-β was also greatest in B6.BTg cells and lowest in B6.Baff(-/-) cells. EAE was clinically and pathologically most severe in B6.BTg mice and least severe in B6.Baff(-/-) mice and correlated with MOG(35-55) peptide-induced Th17 cell responses.\\n\\nCONCLUSIONS/SIGNIFICANCE: Collectively, these findings document a contribution of BAFF to pathogenic Th17 cell responses and suggest that BAFF antagonism may be efficacious in Th17 cell-driven diseases.", "link"=>"http://www.mendeley.com/research/baff-promotes-th17-cells-aggravates-experimental-autoimmune-encephalomyelitis", "reader_count"=>26, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>1, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>1, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>9, "Psychology"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>0}

ORCID

CrossRef

• http://doi.org/10.1016/j.autrev.2012.02.019
• http://doi.org/10.1517/14728222.2014.888415
• http://doi.org/10.4049/jimmunol.1300749
• http://doi.org/10.1016/j.imlet.2014.11.013
• http://doi.org/10.1016/j.cytogfr.2013.12.011
• http://doi.org/10.1016/j.cell.2018.11.035
• http://doi.org/10.4049/jimmunol.1302865
• http://doi.org/10.1016/j.livres.2017.06.001
• http://doi.org/10.4049/jimmunol.1600281
• http://doi.org/10.1016/j.drudis.2014.03.023
• http://doi.org/10.1177/0961203319829818
• http://doi.org/10.1186/ar4277
• http://doi.org/10.1111/eci.13032
• http://doi.org/10.3109/00207454.2016.1163550
• http://doi.org/10.1093/jmcb/mjt026
• http://doi.org/10.1007/s10620-016-4317-9
• http://doi.org/10.1007/s00403-018-1823-y
• http://doi.org/10.17116/jnevro20191192224
• http://doi.org/10.3390/ijms160818683
• http://doi.org/10.3389/fimmu.2017.00294
• http://doi.org/10.1007/s11926-012-0254-6
• http://doi.org/10.1016/j.neuint.2019.104468
• http://doi.org/10.1038/nbt.2076
• http://doi.org/10.1016/j.jaut.2014.08.003
• http://doi.org/10.1007/s10571-014-0133-y
• http://doi.org/10.1212/NXI.0000000000000240
• http://doi.org/10.1182/blood-2011-05-354019
• http://doi.org/10.1007/s00403-016-1617-z
• http://doi.org/10.1038/nrd3930
• http://doi.org/10.1002/eji.201646630

DataCite

Europe PMC Citations | Further Information

Europe PMC Database Citations | Further Information

{"UNIPROT"=>6}

PubMed Central | Further Information

• 3979031
• 4545922
• 3264947
• 3374593
• 3625401
• 4055514
• 4278953
• 4581266
• 3927769
• 4357613
• 4507150
• 4637387

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/80052293917"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/80052293917?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80052293917&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=80052293917&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/80052293917", "dc:identifier"=>"SCOPUS_ID:80052293917", "eid"=>"2-s2.0-80052293917", "dc:title"=>"BAFF promotes Th17 cells and aggravates experimental autoimmune encephalomyelitis", "dc:creator"=>"Zhou X.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"6", "prism:issueIdentifier"=>"8", "prism:pageRange"=>nil, "prism:coverDate"=>"2011-08-29", "prism:coverDisplayDate"=>"29 August 2011", "prism:doi"=>"10.1371/journal.pone.0023629", "citedby-count"=>"45", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Tongji University", "affiliation-city"=>"Shanghai", "affiliation-country"=>"China"}, {"@_fa"=>"true", "affilname"=>"Keck School of Medicine of USC", "affiliation-city"=>"Los Angeles", "affiliation-country"=>"United States"}], "pubmed-id"=>"21897850", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e23629", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Web of Science® | Further Information

Article Coverage

Article Coverage Curated

Facebook

• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0023629", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments

Nature

Reddit

Research Blogging

ScienceSeeker | Further Information

Twitter

Wikipedia

Wordpress.com | Further Information

Counter

• {"month"=>"8", "year"=>"2011", "pdf_views"=>"17", "xml_views"=>"4", "html_views"=>"131"}
• {"month"=>"9", "year"=>"2011", "pdf_views"=>"74", "xml_views"=>"2", "html_views"=>"246"}
• {"month"=>"10", "year"=>"2011", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"64"}
• {"month"=>"11", "year"=>"2011", "pdf_views"=>"23", "xml_views"=>"4", "html_views"=>"51"}
• {"month"=>"12", "year"=>"2011", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"41"}
• {"month"=>"1", "year"=>"2012", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"53"}
• {"month"=>"2", "year"=>"2012", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"39"}
• {"month"=>"3", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"24"}
• {"month"=>"4", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"15"}
• {"month"=>"5", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"33"}
• {"month"=>"6", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"26"}
• {"month"=>"7", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"35"}
• {"month"=>"8", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"5", "html_views"=>"23"}
• {"month"=>"9", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"23"}
• {"month"=>"10", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"24"}
• {"month"=>"11", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"25"}
• {"month"=>"12", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"24"}
• {"month"=>"1", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"41"}
• {"month"=>"2", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"38"}
• {"month"=>"3", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
• {"month"=>"4", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
• {"month"=>"5", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"33"}
• {"month"=>"6", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"22"}
• {"month"=>"7", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"25"}
• {"month"=>"8", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
• {"month"=>"9", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"29"}
• {"month"=>"10", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"49"}
• {"month"=>"11", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"45"}
• {"month"=>"12", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"64"}
• {"month"=>"1", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"122"}
• {"month"=>"2", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"28"}
• {"month"=>"3", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"45"}
• {"month"=>"4", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"3", "html_views"=>"43"}
• {"month"=>"5", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"31"}
• {"month"=>"6", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"30"}
• {"month"=>"7", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"32"}
• {"month"=>"8", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"27"}
• {"month"=>"9", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"13"}
• {"month"=>"10", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"15"}
• {"month"=>"11", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"14"}
• {"month"=>"12", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"3", "html_views"=>"20"}
• {"month"=>"1", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
• {"month"=>"2", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"7"}
• {"month"=>"3", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"17"}
• {"month"=>"4", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"22"}
• {"month"=>"5", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"21"}
• {"month"=>"6", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"24"}
• {"month"=>"7", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"18"}
• {"month"=>"8", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"34"}
• {"month"=>"9", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"39"}
• {"month"=>"10", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"63"}
• {"month"=>"11", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"44"}
• {"month"=>"12", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"51"}
• {"month"=>"1", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"54"}
• {"month"=>"2", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"18"}
• {"month"=>"3", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"41"}
• {"month"=>"4", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"16"}
• {"month"=>"5", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"16"}
• {"month"=>"6", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"18"}
• {"month"=>"7", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"11"}
• {"month"=>"8", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"30"}
• {"month"=>"9", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"30"}
• {"month"=>"10", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"18"}
• {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"20"}
• {"month"=>"12", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
• {"month"=>"1", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"23"}
• {"month"=>"2", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"29"}
• {"month"=>"3", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
• {"month"=>"4", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"26"}
• {"month"=>"5", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"20"}
• {"month"=>"6", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"18"}
• {"month"=>"7", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"17"}
• {"month"=>"8", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"13"}
• {"month"=>"9", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"13"}
• {"month"=>"10", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"27"}
• {"month"=>"11", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"35"}
• {"month"=>"12", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"12"}
• {"month"=>"1", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"18"}
• {"month"=>"2", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"7"}
• {"month"=>"3", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"3"}
• {"month"=>"4", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"11"}
• {"month"=>"5", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"3"}
• {"month"=>"6", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"5"}
• {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"4", "html_views"=>"3"}
• {"month"=>"8", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"5"}
• {"month"=>"9", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"9"}
• {"month"=>"10", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"1"}
• {"month"=>"11", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"8"}
• {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"5"}
• {"month"=>"1", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
• {"month"=>"2", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"4"}
• {"month"=>"3", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"15"}
• {"month"=>"4", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"12"}
• {"month"=>"5", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"8"}
• {"month"=>"6", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
• {"month"=>"7", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"7"}
• {"month"=>"8", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"8"}
• {"month"=>"9", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"6"}
• {"month"=>"10", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"11"}
• {"month"=>"11", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"3"}
• {"month"=>"12", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"3"}

Figshare

• {"files"=>["https://ndownloader.figshare.com/files/741538"], "description"=>"<p>Panel A: LN cells were double-stained for CD4 and CD126 from the indicated mice. The dot plots reflect representative mice, with the values outside the parentheses indicating the percentages of CD126⁺ cells within the CD4⁺ population and the values inside the parentheses indicating the mean fluorescence intensity of the CD126⁺ cell population. Panel B: Results (mean ± SEM) are presented for the 3 mice in each cohort. Panels C–D: Naive CD4⁺ cells from the indicated mice were stimulated with IL-6 (10 ng/ml) + TGF-β (2 ng/ml) for the indicated periods of time (minutes) and were subjected to Western blot analysis for total Stat3, phosphorylated Stat3 (p-Stat3), and GADPH (panels C–D) and phosphorylated Smad3 (p-Smad3) and GADPH (panels E–F). The levels of p-Stat3 and p-Smad3 were normalized to GAPDH, with the ratios of p-Stat3 or p-Smad3 to GADPH at 30 minutes being arbitrarily assigned a value of 1. The results shown in panels C and E are representative of the 7 independent experiments, and the results shown in panels D and F are the mean ± SEM of these 7 experiments. *, p≤0.05; **, p≤0.01; ***, p≤0.001 in comparison to WT values.</p>", "links"=>[], "tags"=>["cd126", "il-6-triggered", "signaling", "cells", "b6"], "article_id"=>411893, "categories"=>["Ecology", "Immunology"], "users"=>["Xiaohui Zhou", "Zanxian Xia", "Qin Lan", "Julie Wang", "Wenru Su", "Yuan-Ping Han", "Huimin Fan", "Zhongmin Liu", "William Stohl", "Song Guo Zheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0023629.g004", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differential_CD126_expression_and_IL_6_triggered_signaling_in_CD4_cells_from_B6_WT_B6_Baff_8722_8722_and_B6_BTg_mice_/411893", "title"=>"Differential CD126 expression and IL-6-triggered signaling in CD4⁺ cells from B6 WT, B6.<i>Baff^−/−</i>, and B6.BTg mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 15:19:10"}
• {"files"=>["https://ndownloader.figshare.com/files/741232"], "description"=>"<p>T cells from spleen, blood, or LN of the indicated mice were cultured for 5 hr with PMA + ionomycin. Brefeldin A was added for the final 4 hr of culture to block secretion of cytokines and permit their accumulation intracellularly. Harvested cells were stained for surface CD4 and intracellular IL-17 (panel A), intracellular RORγt (panel B), or surface CCR-6 (panel C). *, p≤0.05; **, p≤0.01; ***, p≤0.001 in comparison to WT values.</p>", "links"=>[], "tags"=>["th17", "cells"], "article_id"=>411598, "categories"=>["Ecology", "Immunology"], "users"=>["Xiaohui Zhou", "Zanxian Xia", "Qin Lan", "Julie Wang", "Wenru Su", "Yuan-Ping Han", "Huimin Fan", "Zhongmin Liu", "William Stohl", "Song Guo Zheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0023629.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Promotion_of_Th17_cells_by_BAFF_/411598", "title"=>"Promotion of Th17 cells by BAFF.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 15:17:35"}
• {"files"=>["https://ndownloader.figshare.com/files/741020"], "description"=>"<p>Panel A: Spleen (top) or LN (bottom) cells from representative B6 WT (WT), B6.<i>Baff^−/−</i> (KO), and B6.BTg (Tg) mice were stained for surface CD3 and surface CD19 expression. The values adjacent to the boxes in each tracing indicate the percentages of CD3⁺ or CD19⁺ cells in that sample. Panel B: Results (mean ± SEM) are presented for total spleen CD3⁺, CD4⁺, CD8⁺, and CD19⁺ cells for the 6 mice in each cohort. Panel C: Results (mean ± SEM) are presented for LN CD4⁺CD69⁺, CD4⁺CD44^hi, and CD4⁺CD62L^lo cells for the 6 mice in each cohort. *, p≤0.05; **, p≤0.01; ***, p≤0.001 in comparison to WT values.</p>", "links"=>[], "tags"=>["cells", "mice"], "article_id"=>411387, "categories"=>["Ecology", "Immunology"], "users"=>["Xiaohui Zhou", "Zanxian Xia", "Qin Lan", "Julie Wang", "Wenru Su", "Yuan-Ping Han", "Huimin Fan", "Zhongmin Liu", "William Stohl", "Song Guo Zheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0023629.g001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Decrease_in_both_B_cells_and_T_cells_in_B6_Baff_8722_8722_mice_and_increase_in_both_B_cells_and_T_cells_in_B6_BTg_mice_/411387", "title"=>"Decrease in both B cells and T cells in B6.<i>Baff^−/−</i> mice and increase in both B cells and T cells in B6.BTg mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 15:16:26"}
• {"files"=>["https://ndownloader.figshare.com/files/741372"], "description"=>"<p>Panel A: Spleen naive CD4⁺ cells from the indicated mice (n = 4 in each cohort) were cultured for 3 days with anti-CD3 + anti-CD28 mAb (1 µg/ml each) in the presence of irradiated syngeneic non-T cells, IL-6 (10 ng/ml), TGF-β (2 ng/ml), and anti-IL-4 + anti-IFNγ antibodies (10 µg/ml each) and in the presence or absence of exogenous BAFF (100 ng/ml). Harvested cells were stained for surface CD4 and intracellular IL-17. Significantly (p≤0.01) greater percentages of CD4⁺IL-17⁺ cells were generated in B6 WT cultures with added BAFF vs no added BAFF; in B6.<i>Baff^−/−</i> cultures with added BAFF vs no added BAFF; and in B6.BTg cultures with no added BAFF vs WT cultures with no added BAFF. Significantly (p≤0.01) reduced percentages of CD4⁺IL-17⁺ cells were generated in B6.<i>Baff^−/−</i> cultures with added BAFF vs B6 WT cultures with no added BAFF. Panel B: Spleen naive CD4⁺ cells from the indicated mice were co-cultured for 3 days with irradiated non-T cells from the indicated mice for 3 days as in panel A without exogenous BAFF. Harvested cells were stained for surface CD4 and intracellular IL-17. Panel C: Spleen naive CD4⁺ cells from the indicated mice (n = 2 in each cohort) were cultured for 3 days as in panel A, except that no irradiated non-T cells were added to the cultures, and plate-bound anti-CD3 mAb (2 µg/ml) was used in place of soluble anti-CD3 mAb. *, p≤0.05; **, p≤0.01; ***, p≤0.001 in comparison to WT values.</p>", "links"=>[], "tags"=>["baff", "cells", "th17"], "article_id"=>411738, "categories"=>["Ecology", "Immunology"], "users"=>["Xiaohui Zhou", "Zanxian Xia", "Qin Lan", "Julie Wang", "Wenru Su", "Yuan-Ping Han", "Huimin Fan", "Zhongmin Liu", "William Stohl", "Song Guo Zheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0023629.g003", "stats"=>{"downloads"=>1, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Direct_effect_of_BAFF_on_T_cells_in_generation_of_Th17_cells_/411738", "title"=>"Direct effect of BAFF on T cells in generation of Th17 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 15:18:18"}
• {"files"=>["https://ndownloader.figshare.com/files/741678"], "description"=>"<p>Panel A: The indicated mice were immunized with MOG_35–55 in CFA and evaluated for clinical EAE. Results (mean ± SEM) are the aggregate of 3 independent experiments (each containing ≥3 mice per cohort). *, p<0.05; **, p<0.01; ***, p<0.001 in comparison to WT mice at the indicated time points. Panel B: T cells from the draining LN of the indicated mice were stimulated with PMA + ionomycin in the presence of brefeldin A as in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023629#pone-0023629-g002\" target=\"_blank\">Figure 2</a> and stained for surface CD4 or CD8 and intracellular IL-17 or IFNγ. The values in the upper left quadrants in each tracing indicate the percentages of IL-17⁺ cells (within the CD4⁺ population) in that sample, and the values in the lower right quadrants indicate the percentages of IFNγ⁺ cells (within the CD4⁺ population). Results from a representative mouse from each cohort are shown. Panel C: Results are presented for CD4⁺IL-17⁺ cells for the 3 mice in each cohort. Panel D: Draining LN cells from the MOG_35–55 peptide-immunized mice either were (+) or were not (−) cultured with MOG_35–55 peptide for 3 days. Percentages of CD4⁺IL-17⁺ cells were determined. Results are presented for the 6 mice in each cohort (left) or a representative mouse from each cohort (right). ***, p<0.001. Panel E: Supernatants from the cultures in panel D were assayed for IL-17A. Results are presented as mean ± SEM. Panel F: The indicated mice were sacrificed on day 25 post-immunization, and sections of their brains and spinal cords were stained with H&E and immunostained for IL-17. Results are representative of the 6 mice in each cohort. Original magnification is 400×.</p>", "links"=>[], "tags"=>["severity", "eae", "mice", "th17"], "article_id"=>412037, "categories"=>["Ecology", "Immunology"], "users"=>["Xiaohui Zhou", "Zanxian Xia", "Qin Lan", "Julie Wang", "Wenru Su", "Yuan-Ping Han", "Huimin Fan", "Zhongmin Liu", "William Stohl", "Song Guo Zheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0023629.g005", "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differential_severity_of_EAE_in_B6_Baff_8722_8722_and_B6_BTg_mice_and_its_association_with_a_Th17_profile_/412037", "title"=>"Differential severity of EAE in B6.<i>Baff^−/−</i> and B6.BTg mice and its association with a Th17 profile.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 15:19:55"}

PMC Usage Stats | Further Information

• {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"72", "unique-ip"=>"68", "pdf"=>"45", "year"=>"2011", "figure"=>"29", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"62", "year"=>"2011", "pdf"=>"41", "unique-ip"=>"62", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"35", "unique-ip"=>"39", "pdf"=>"32", "year"=>"2011", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "year"=>"2011", "pdf"=>"25", "unique-ip"=>"28", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"29", "unique-ip"=>"32", "pdf"=>"22", "year"=>"2012", "figure"=>"17", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"19", "year"=>"2012", "pdf"=>"13", "unique-ip"=>"21", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"21", "unique-ip"=>"22", "pdf"=>"10", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"13", "year"=>"2012", "pdf"=>"8", "unique-ip"=>"15", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"19", "unique-ip"=>"22", "pdf"=>"18", "year"=>"2012", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"14", "year"=>"2012", "pdf"=>"11", "unique-ip"=>"13", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
• {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"30", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
• {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
• {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
• {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
• {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
• {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
• {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
• {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
• {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
• {"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
• {"unique-ip"=>"10", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
• {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
• {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
• {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
• {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
• {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
• {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
• {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
• {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
• {"unique-ip"=>"8", "full-text"=>"3", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
• {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
• {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
• {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"21", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"4"}
• {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
• {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
• {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
• {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
• {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
• {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
• {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
• {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
• {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
• {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
• {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
• {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
• {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
• {"unique-ip"=>"13", "full-text"=>"9", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
• {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
• {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
• {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
• {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2016", "month"=>"1"}
• {"unique-ip"=>"14", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"3"}
• {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
• {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
• {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
• {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
• {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
• {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
• {"unique-ip"=>"8", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
• {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
• {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
• {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
• {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
• {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
• {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
• {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
• {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
• {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
• {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
• {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
• {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
• {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
• {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
• {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
• {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
• {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
• {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
• {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
• {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
• {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
• {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
• {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
• {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
• {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
• {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
• {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
• {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
• {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[301, 558, 690, 806, 916, 1018, 1112, 1197, 1275, 1349, 1421, 1495, 1561, 1631, 1697, 1762, 1835, 1895, 1954, 2020, 2078, 2142, 2197, 2258, 2313, 2376, 2437, 2494, 2557, 2618, 2682, 2744, 2818, 2880, 2940, 3000, 3056]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[301, 573, 717, 840, 956, 1063, 1159, 1248, 1327, 1406, 1478, 1557, 1626, 1700, 1772, 1843, 1910, 1980, 2052, 2124, 2192, 2263, 2328, 2391, 2443, 2496, 2564, 2629, 2698, 2771, 2834, 2897, 2959, 3021, 3077, 3144, 3193]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[303, 577, 713, 831, 950, 1048, 1144, 1230, 1307, 1381, 1454, 1521, 1590, 1655, 1713, 1778, 1848, 1913, 1972, 2033, 2098, 2154, 2215, 2263, 2322, 2388, 2436, 2500, 2571, 2623, 2689, 2754, 2806, 2864, 2930, 2984, 3038]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[296, 551, 687, 800, 903, 1001, 1095, 1184, 1259, 1327, 1406, 1473, 1535, 1600, 1669, 1736, 1794, 1857, 1922, 1983, 2046, 2109, 2169, 2223, 2278, 2344, 2402, 2457, 2517, 2574, 2621, 2688, 2756, 2811, 2872, 2936, 2985]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[296, 554, 686, 802, 910, 1014, 1104, 1195, 1277, 1349, 1419, 1483, 1551, 1620, 1690, 1757, 1820, 1888, 1957, 2017, 2081, 2140, 2202, 2259]}]}

F1000Prime