Adverse Drug Reactions in Children—A Systematic Review
Publication Date
March 05, 2012
Journal
PLOS ONE
Authors
Rebecca Mary Diane Smyth, Elizabeth Gargon, Jamie Kirkham, Lynne Cresswell, et al
Volume
7
Issue
3
Pages
e24061
DOI
https://dx.plos.org/10.1371/journal.pone.0024061
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0024061
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/22403604
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293884
Europe PMC
http://europepmc.org/abstract/MED/22403604
Web of Science
000303017700001
Scopus
84857772838
Mendeley
http://www.mendeley.com/research/adverse-drug-reactions-childrena-systematic-review
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Mendeley | Further Information

{"title"=>"Adverse drug reactions in children-A systematic review", "type"=>"generic", "authors"=>[{"first_name"=>"Rebecca Mary Diane", "last_name"=>"Smyth", "scopus_author_id"=>"23475511800"}, {"first_name"=>"Elizabeth", "last_name"=>"Gargon", "scopus_author_id"=>"35745919700"}, {"first_name"=>"Jamie", "last_name"=>"Kirkham", "scopus_author_id"=>"7006455894"}, {"first_name"=>"Lynne", "last_name"=>"Cresswell", "scopus_author_id"=>"35784065500"}, {"first_name"=>"Su", "last_name"=>"Golder", "scopus_author_id"=>"35748331400"}, {"first_name"=>"Rosalind", "last_name"=>"Smyth", "scopus_author_id"=>"7102358057"}, {"first_name"=>"Paula", "last_name"=>"Williamson", "scopus_author_id"=>"55559027000"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"364370712", "sgr"=>"84857772838", "issn"=>"19326203", "pmid"=>"22403604", "scopus"=>"2-s2.0-84857772838", "doi"=>"10.1371/journal.pone.0024061", "isbn"=>"1932-6203"}, "id"=>"9a6df5db-8632-3f03-ae53-b09098e31557", "abstract"=>"BACKGROUND: Adverse drug reactions in children are an important public health problem. We have undertaken a systematic review of observational studies in children in three settings: causing admission to hospital, occurring during hospital stay and occurring in the community. We were particularly interested in understanding how ADRs might be better detected, assessed and avoided.\\n\\nMETHODS AND FINDINGS: We searched nineteen electronic databases using a comprehensive search strategy. In total, 102 studies were included. The primary outcome was any clinical event described as an adverse drug reaction to one or more drugs. Additional information relating to the ADR was collected: associated drug classification; clinical presentation; associated risk factors; methods used for assessing causality, severity, and avoidability. Seventy one percent (72/102) of studies assessed causality, and thirty four percent (34/102) performed a severity assessment. Only nineteen studies (19%) assessed avoidability. Incidence rates for ADRs causing hospital admission ranged from 0.4% to 10.3% of all children (pooled estimate of 2.9% (2.6%, 3.1%)) and from 0.6% to 16.8% of all children exposed to a drug during hospital stay. Anti-infectives and anti-epileptics were the most frequently reported therapeutic class associated with ADRs in children admitted to hospital (17 studies; 12 studies respectively) and children in hospital (24 studies; 14 studies respectively), while anti-infectives and non-steroidal anti-inflammatory drugs (NSAIDs) were frequently reported as associated with ADRs in outpatient children (13 studies; 6 studies respectively). Fourteen studies reported rates ranging from 7%-98% of ADRs being either definitely/possibly avoidable.\\n\\nCONCLUSIONS: There is extensive literature which investigates ADRs in children. Although these studies provide estimates of incidence in different settings and some indication of the therapeutic classes most frequently associated with ADRs, further work is needed to address how such ADRs may be prevented.", "link"=>"http://www.mendeley.com/research/adverse-drug-reactions-childrena-systematic-review", "reader_count"=>112, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>5, "Librarian"=>1, "Researcher"=>11, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>18, "Other"=>12, "Student > Master"=>25, "Student > Bachelor"=>11, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>5, "Librarian"=>1, "Researcher"=>11, "Student > Doctoral Student"=>4, "Student > Ph. D. 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CrossRef

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/672204"], "description"=>"<p>Univariate meta-regression results for causing admission and in hospital incidence rates.</p>", "links"=>[], "tags"=>["meta-regression", "causing", "incidence"], "article_id"=>342688, "categories"=>["Biotechnology", "Medicine"], "users"=>["Rebecca Mary Diane Smyth", "Elizabeth Gargon", "Jamie Kirkham", "Lynne Cresswell", "Su Golder", "Rosalind Smyth", "Paula Williamson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0024061.t006", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Univariate_meta_regression_results_for_causing_admission_and_in_hospital_incidence_rates_/342688", "title"=>"Univariate meta-regression results for causing admission and in hospital incidence rates.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-03-05 00:44:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/343711", "https://ndownloader.figshare.com/files/343756"], "description"=>"<div><h3>Background</h3><p>Adverse drug reactions in children are an important public health problem. We have undertaken a systematic review of observational studies in children in three settings: causing admission to hospital, occurring during hospital stay and occurring in the community. We were particularly interested in understanding how ADRs might be better detected, assessed and avoided.</p> <h3>Methods and Findings</h3><p>We searched nineteen electronic databases using a comprehensive search strategy. In total, 102 studies were included. The primary outcome was any clinical event described as an adverse drug reaction to one or more drugs. Additional information relating to the ADR was collected: associated drug classification; clinical presentation; associated risk factors; methods used for assessing causality, severity, and avoidability. Seventy one percent (72/102) of studies assessed causality, and thirty four percent (34/102) performed a severity assessment. Only nineteen studies (19%) assessed avoidability. Incidence rates for ADRs causing hospital admission ranged from 0.4% to 10.3% of all children (pooled estimate of 2.9% (2.6%, 3.1%)) and from 0.6% to 16.8% of all children exposed to a drug during hospital stay. Anti-infectives and anti-epileptics were the most frequently reported therapeutic class associated with ADRs in children admitted to hospital (17 studies; 12 studies respectively) and children in hospital (24 studies; 14 studies respectively), while anti-infectives and non-steroidal anti-inflammatory drugs (NSAIDs) were frequently reported as associated with ADRs in outpatient children (13 studies; 6 studies respectively). Fourteen studies reported rates ranging from 7%–98% of ADRs being either definitely/possibly avoidable.</p> <h3>Conclusions</h3><p>There is extensive literature which investigates ADRs in children. Although these studies provide estimates of incidence in different settings and some indication of the therapeutic classes most frequently associated with ADRs, further work is needed to address how such ADRs may be prevented.</p> </div>", "links"=>[], "tags"=>["adverse", "reactions", "systematic"], "article_id"=>127937, "categories"=>["Biotechnology", "Medicine"], "users"=>["Rebecca Mary Diane Smyth", "Elizabeth Gargon", "Jamie Kirkham", "Lynne Cresswell", "Su Golder", "Rosalind Smyth", "Paula Williamson"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0024061.s001", "https://dx.doi.org/10.1371/journal.pone.0024061.s002"], "stats"=>{"downloads"=>6, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Adverse_Drug_Reactions_in_Children_A_Systematic_Review/127937", "title"=>"Adverse Drug Reactions in Children—A Systematic Review", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-03-05 02:12:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/671915"], "description"=>"<p>What proportion of outpatient children experience ADRs?</p>", "links"=>[], "tags"=>["outpatient", "children"], "article_id"=>342404, "categories"=>["Biotechnology", "Medicine"], "users"=>["Rebecca Mary Diane Smyth", "Elizabeth Gargon", "Jamie Kirkham", "Lynne Cresswell", "Su Golder", "Rosalind Smyth", "Paula Williamson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0024061.g003", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_What_proportion_of_outpatient_children_experience_ADRs_/342404", "title"=>"What proportion of outpatient children experience ADRs?", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-05 00:40:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/672284"], "description"=>"<p>Study characteristics.</p>", "links"=>[], "tags"=>["public health and epidemiology", "pediatrics and child health"], "article_id"=>342769, "categories"=>["Biotechnology", "Medicine"], "users"=>["Rebecca Mary Diane Smyth", "Elizabeth Gargon", "Jamie Kirkham", "Lynne Cresswell", "Su Golder", "Rosalind Smyth", "Paula Williamson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0024061.t004", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_characteristics_/342769", "title"=>"Study characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-03-05 00:46:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/671795"], "description"=>"<p>What proportion of children in hospital experience an ADR during their admission?</p>", "links"=>[], "tags"=>["children", "adr"], "article_id"=>342281, "categories"=>["Biotechnology", "Medicine"], "users"=>["Rebecca Mary Diane Smyth", "Elizabeth Gargon", "Jamie Kirkham", "Lynne Cresswell", "Su Golder", "Rosalind Smyth", "Paula Williamson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0024061.g002", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_What_proportion_of_children_in_hospital_experience_an_ADR_during_their_admission_/342281", "title"=>"What proportion of children in hospital experience an ADR during their admission?", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-05 00:38:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/672246"], "description"=>"<p>Note 1 patient in the Zahraoui (2010) study died (gastrointestinal bleeding and severe thrombocytopenia after prolonged anti-convulsant treatment.</p><p>Mitchell (1988) – 5 deaths (fever, vomiting, arrhythmia and cardiopulmonary arrest attributed to theophylline and erythromycin; cardiac arrest and hypernatremia attributed to halothane and nitrous oxide pneumonia attributed to chemotherapy-induced immunosuppression; cardiotoxicity attributed to doxorubicin; candida sepsis and meningitis attributed to chemotherapy-induced immunosuppression).</p><p>Yosselson-Superstine (1982) – 1 death (no detail provided).</p>", "links"=>[], "tags"=>["public health and epidemiology", "pediatrics and child health"], "article_id"=>342734, "categories"=>["Biotechnology", "Medicine"], "users"=>["Rebecca Mary Diane Smyth", "Elizabeth Gargon", "Jamie Kirkham", "Lynne Cresswell", "Su Golder", "Rosalind Smyth", "Paula Williamson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0024061.t005", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Drug_class_and_clinical_presentation_of_ADRs_/342734", "title"=>"Drug class and clinical presentation of ADRs.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-03-05 00:45:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/672121"], "description"=>"<p>The terms within each concept were ORed, and then all 5 concepts were combined using the AND Boolean operator. This search strategy was translated as appropriate for the other databases.</p>", "links"=>[], "tags"=>["public health and epidemiology", "pediatrics and child health"], "article_id"=>342609, "categories"=>["Biotechnology", "Medicine"], "users"=>["Rebecca Mary Diane Smyth", "Elizabeth Gargon", "Jamie Kirkham", "Lynne Cresswell", "Su Golder", "Rosalind Smyth", "Paula Williamson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0024061.t002", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MEDLINE_search_strategy_/342609", "title"=>"MEDLINE search strategy.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-03-05 00:43:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/671650"], "description"=>"<p>What proportion of all paediatric hospital admissions are ADR related?</p>", "links"=>[], "tags"=>["paediatric", "admissions", "adr"], "article_id"=>342130, "categories"=>["Biotechnology", "Medicine"], "users"=>["Rebecca Mary Diane Smyth", "Elizabeth Gargon", "Jamie Kirkham", "Lynne Cresswell", "Su Golder", "Rosalind Smyth", "Paula Williamson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0024061.g001", "stats"=>{"downloads"=>4, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_What_proportion_of_all_paediatric_hospital_admissions_are_ADR_related_/342130", "title"=>"What proportion of all paediatric hospital admissions are ADR related?", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-05 00:35:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/672091"], "description"=>"<p>Assessment of methodological quality.</p>", "links"=>[], "tags"=>["methodological"], "article_id"=>342581, "categories"=>["Biotechnology", "Medicine"], "users"=>["Rebecca Mary Diane Smyth", "Elizabeth Gargon", "Jamie Kirkham", "Lynne Cresswell", "Su Golder", "Rosalind Smyth", "Paula Williamson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0024061.t003", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Assessment_of_methodological_quality_/342581", "title"=>"Assessment of methodological quality.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-03-05 00:43:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/672160"], "description"=>"<p>Databases searched.</p>", "links"=>[], "tags"=>["public health and epidemiology", "pediatrics and child health"], "article_id"=>342648, "categories"=>["Biotechnology", "Medicine"], "users"=>["Rebecca Mary Diane Smyth", "Elizabeth Gargon", "Jamie Kirkham", "Lynne Cresswell", "Su Golder", "Rosalind Smyth", "Paula Williamson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0024061.t001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Databases_searched_/342648", "title"=>"Databases searched.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-03-05 00:44:08"}

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Relative Metric

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