Detachment of Breast Tumor Cells Induces Rapid Secretion of Exosomes Which Subsequently Mediate Cellular Adhesion and Spreading
- Publication Date
- September 06, 2011
- Journal
- PLOS ONE
- Authors
- Rainelli B. Koumangoye, Amos M. Sakwe, J. Shawn Goodwin, Tina Patel, et al
- Volume
- 6
- Issue
- 9
- Pages
- e24234
- DOI
- https://dx.plos.org/10.1371/journal.pone.0024234
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0024234
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/21915303
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167827
- Europe PMC
- http://europepmc.org/abstract/MED/21915303
- Web of Science
- 000294689200029
- Scopus
- 80052446161
- Mendeley
- http://www.mendeley.com/research/detachment-breast-tumor-cells-induces-rapid-secretion-exosomes-subsequently-mediate-cellular-adhesio
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Mendeley | Further Information
{"title"=>"Detachment of breast tumor cells induces rapid secretion of exosomes which subsequently mediate cellular adhesion and spreading", "type"=>"journal", "authors"=>[{"first_name"=>"Rainelli B.", "last_name"=>"Koumangoye", "scopus_author_id"=>"36617180000"}, {"first_name"=>"Amos M.", "last_name"=>"Sakwe", "scopus_author_id"=>"6603131076"}, {"first_name"=>"J. Shawn", "last_name"=>"Goodwin", "scopus_author_id"=>"7201951448"}, {"first_name"=>"Tina", "last_name"=>"Patel", "scopus_author_id"=>"51663855100"}, {"first_name"=>"Josiah", "last_name"=>"Ochieng", "scopus_author_id"=>"7003905679"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-80052446161", "sgr"=>"80052446161", "pui"=>"362504708", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"21915303", "doi"=>"10.1371/journal.pone.0024234"}, "id"=>"24e5aae9-3795-33b2-9602-6fa8bc42aa41", "abstract"=>"Exosomes are nano-vesicles secreted by a wide range of mammalian cell types. These vesicles are abundant in serum and other extracellular fluids and contain a large repertoire of proteins, mRNA and microRNA. Exosomes have been implicated in cell to cell communication, the transfer of infectious agents, and neurodegenerative diseases as well as tumor progression. However, the precise mechanisms by which they are internalized and/or secreted remain poorly understood. In order to follow their release and uptake in breast tumor cells in real time, cell-derived exosomes were tagged with green fluorescent protein (GFP)-CD63 while human serum exosomes were rhodamine isothiocynate-labeled. We show that detachment of adherent cells from various substrata induces a rapid and substantial secretion of exosomes, which then concentrate on the cell surfaces and mediate adhesion to various extracellular matrix proteins. We also demonstrate that disruption of lipid rafts with methyl-beta-cyclodextrin (MbetaCD) inhibits the internalization of exosomes and that annexins are essential for the exosomal uptake mechanisms. Taken together, these data suggest that cellular detachment is accompanied by significant release of exosomes while cellular adhesion and spreading are enhanced by rapid uptake and disposition of exosomes on the cell surface.", "link"=>"http://www.mendeley.com/research/detachment-breast-tumor-cells-induces-rapid-secretion-exosomes-subsequently-mediate-cellular-adhesio", "reader_count"=>143, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>9, "Researcher"=>34, "Student > Doctoral Student"=>9, "Student > Ph. D. Student"=>38, "Student > Postgraduate"=>4, "Other"=>4, "Student > Master"=>16, "Student > Bachelor"=>17, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>9, "Researcher"=>34, "Student > Doctoral Student"=>9, "Student > Ph. D. Student"=>38, "Student > Postgraduate"=>4, "Other"=>4, "Student > Master"=>16, "Student > Bachelor"=>17, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Agricultural and Biological Sciences"=>73, "Arts and Humanities"=>1, "Philosophy"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Chemical Engineering"=>1, "Chemistry"=>8, "Engineering"=>5, "Biochemistry, Genetics and Molecular Biology"=>21, "Materials Science"=>1, "Medicine and Dentistry"=>19, "Neuroscience"=>2, "Sports and Recreations"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>19}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Unspecified"=>{"Unspecified"=>7}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Chemical Engineering"=>{"Chemical Engineering"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>5}, "Chemistry"=>{"Chemistry"=>8}, "Neuroscience"=>{"Neuroscience"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>73}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>21}, "Philosophy"=>{"Philosophy"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Sweden"=>1, "Hungary"=>1, "Belgium"=>1, "United States"=>1, "China"=>1, "United Kingdom"=>1, "Chile"=>1, "France"=>1, "Spain"=>1}, "group_count"=>8}CrossRef
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Scopus | Further Information
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Wikipedia | Further Information
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- {"month"=>"6", "year"=>"2018", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"42"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"5", "html_views"=>"28"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"24"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"26"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"38"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"39"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"14"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"35"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"23"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"29"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"33"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"26"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"25"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"23"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"16"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"7", "html_views"=>"31"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"58", "html_views"=>"33"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"19", "html_views"=>"22"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"8", "html_views"=>"5"}
PMC Usage Stats | Further Information
- {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"94", "unique-ip"=>"90", "pdf"=>"86", "year"=>"2011", "figure"=>"28", "scanned-summary"=>"0", "supp-data"=>"10"}
- {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"129", "year"=>"2011", "pdf"=>"136", "unique-ip"=>"122", "figure"=>"50", "scanned-summary"=>"0", "supp-data"=>"9"}
- {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"104", "unique-ip"=>"96", "pdf"=>"83", "year"=>"2011", "figure"=>"45", "scanned-summary"=>"0", "supp-data"=>"23"}
- {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"65", "year"=>"2011", "pdf"=>"57", "unique-ip"=>"60", "figure"=>"31", "scanned-summary"=>"0", "supp-data"=>"1"}
- {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"56", "unique-ip"=>"54", "pdf"=>"41", "year"=>"2012", "figure"=>"19", "scanned-summary"=>"0", "supp-data"=>"3"}
- {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"64", "year"=>"2012", "pdf"=>"36", "unique-ip"=>"52", "figure"=>"34", "scanned-summary"=>"0", "supp-data"=>"6"}
- {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"62", "unique-ip"=>"58", "pdf"=>"33", "year"=>"2012", "figure"=>"21", "scanned-summary"=>"0", "supp-data"=>"2"}
- {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"42", "year"=>"2012", "pdf"=>"27", "unique-ip"=>"39", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"2"}
- {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"42", "unique-ip"=>"39", "pdf"=>"18", "year"=>"2012", "figure"=>"34", "scanned-summary"=>"0", "supp-data"=>"4"}
- {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"36", "year"=>"2012", "pdf"=>"26", "unique-ip"=>"33", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"unique-ip"=>"36", "full-text"=>"41", "pdf"=>"15", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
- {"unique-ip"=>"38", "full-text"=>"37", "pdf"=>"46", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
- {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
- {"unique-ip"=>"35", "full-text"=>"37", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"26", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
- {"unique-ip"=>"21", "full-text"=>"19", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
- {"unique-ip"=>"41", "full-text"=>"46", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
- {"unique-ip"=>"34", "full-text"=>"29", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"25", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
- {"unique-ip"=>"23", "full-text"=>"29", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2013", "month"=>"2"}
- {"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
- {"unique-ip"=>"44", "full-text"=>"50", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
- {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
- {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"13", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
- {"unique-ip"=>"25", "full-text"=>"28", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
- {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2013", "month"=>"8"}
- {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
- {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
- {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
- {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
- {"unique-ip"=>"25", "full-text"=>"20", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"1"}
- {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"12", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
- {"unique-ip"=>"28", "full-text"=>"21", "pdf"=>"13", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
- {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
- {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"12", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
- {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"24", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
- {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
- {"unique-ip"=>"29", "full-text"=>"33", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
- {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"6"}
- {"unique-ip"=>"36", "full-text"=>"34", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
- {"unique-ip"=>"27", "full-text"=>"30", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
- {"unique-ip"=>"27", "full-text"=>"29", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
- {"unique-ip"=>"21", "full-text"=>"13", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
- {"unique-ip"=>"35", "full-text"=>"38", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
- {"unique-ip"=>"26", "full-text"=>"25", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
- {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
- {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"8"}
- {"unique-ip"=>"17", "full-text"=>"11", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"9"}
- {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
- {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
- {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"19", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
- {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
- {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
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- {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"32", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
- {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
- {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
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- {"unique-ip"=>"25", "full-text"=>"21", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
- {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
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- {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
- {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
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- {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"1"}
- {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
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Relative Metric
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