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{"title"=>"Deficient of a clock gene, brain and muscle arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation", "type"=>"journal", "authors"=>[{"first_name"=>"Shigeki", "last_name"=>"Shimba", "scopus_author_id"=>"6603840146"}, {"first_name"=>"Tomohiro", "last_name"=>"Ogawa", "scopus_author_id"=>"53464149000"}, {"first_name"=>"Shunsuke", "last_name"=>"Hitosugi", "scopus_author_id"=>"53463481000"}, {"first_name"=>"Yuya", "last_name"=>"Ichihashi", "scopus_author_id"=>"53463877300"}, {"first_name"=>"Yuki", "last_name"=>"Nakadaira", "scopus_author_id"=>"53464071400"}, {"first_name"=>"Munehiro", "last_name"=>"Kobayashi", "scopus_author_id"=>"53463802800"}, {"first_name"=>"Masakatsu", "last_name"=>"Tezuka", "scopus_author_id"=>"7004554418"}, {"first_name"=>"Yasuhiro", "last_name"=>"Kosuge", "scopus_author_id"=>"7005364548"}, {"first_name"=>"Kumiko", "last_name"=>"Ishige", "scopus_author_id"=>"7004329809"}, {"first_name"=>"Yoshihisa", "last_name"=>"Ito", "scopus_author_id"=>"56567042000"}, {"first_name"=>"Kazuo", "last_name"=>"Komiyama", "scopus_author_id"=>"35407858100"}, {"first_name"=>"Yuko", "last_name"=>"Okamatsu-Ogura", "scopus_author_id"=>"13405174100"}, {"first_name"=>"Kazuhiro", "last_name"=>"Kimura", "scopus_author_id"=>"7404820658"}, {"first_name"=>"Masayuki", "last_name"=>"Saito", "scopus_author_id"=>"7404972966"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"arxiv"=>"138", "issn"=>"19326203", "pmid"=>"21966465", "pui"=>"362610320", "scopus"=>"2-s2.0-80053054824", "doi"=>"10.1371/journal.pone.0025231", "isbn"=>"10.1371/journal.pone.0025231", "sgr"=>"80053054824"}, "id"=>"d91a2616-7934-3a97-a21f-b14f8e7233be", "abstract"=>"A link between circadian rhythm and metabolism has long been discussed. Circadian rhythm is controlled by positive and negative transcriptional and translational feedback loops composed of several clock genes. Among clock genes, the brain and muscle Arnt-like protein-1 (BMAL1) and circadian locomotor output cycles kaput (CLOCK) play important roles in the regulation of the positive rhythmic transcription. In addition to control of circadian rhythm, we have previously shown that BMAL1 regulates adipogenesis. In metabolic syndrome patients, the function of BMAL1 is dysregulated in visceral adipose tissue. In addition, analysis of SNPs has revealed that BMAL1 is associated with susceptibility to hypertension and type II diabetes. Furthermore, the significant roles of BMAL1 in pancreatic β cells proliferation and maturation were recently reported. These results suggest that BMAL1 regulates energy homeostasis. Therefore, in this study, we examined whether loss of BMAL1 function is capable of inducing metabolic syndrome. Deficient of the Bmal1 gene in mice resulted in elevation of the respiratory quotient value, indicating that BMAL1 is involved in the utilization of fat as an energy source. Indeed, lack of Bmal1 reduced the capacity of fat storage in adipose tissue, resulting in an increase in the levels of circulating fatty acids, including triglycerides, free fatty acids, and cholesterol. Elevation of the circulating fatty acids level induced the formation of ectopic fat in the liver and skeletal muscle in Bmal1 -/- mice. Interestingly, ectopic fat formation was not observed in tissue-specific (liver or skeletal muscle) Bmal1 -/- mice even under high fat diet feeding condition. Therefore, we were led to conclude that BMAL1 is a crucial factor in the regulation of energy homeostasis, and disorders of the functions of BMAL1 lead to the development of metabolic syndrome.", "link"=>"http://www.mendeley.com/research/deficient-clock-gene-brain-muscle-arntlike-protein1-bmal1-induces-dyslipidemia-ectopic-fat-formation", "reader_count"=>86, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>5, "Researcher"=>17, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>2, "Other"=>6, "Student > Master"=>13, "Student > Bachelor"=>9, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>5, "Researcher"=>17, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>2, "Other"=>6, "Student > Master"=>13, "Student > Bachelor"=>9, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>12, "Nursing and Health Professions"=>2, "Agricultural and Biological Sciences"=>49, "Medicine and Dentistry"=>15, "Neuroscience"=>2, "Arts and Humanities"=>1, "Veterinary Science and Veterinary Medicine"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>15}, "Neuroscience"=>{"Neuroscience"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>49}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>12}, "Unspecified"=>{"Unspecified"=>2}, "Environmental Science"=>{"Environmental Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Austria"=>1, "Netherlands"=>2, "United States"=>1, "Japan"=>3, "United Kingdom"=>1, "Germany"=>1}, "group_count"=>1}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/371793", "https://ndownloader.figshare.com/files/371846", "https://ndownloader.figshare.com/files/371891", "https://ndownloader.figshare.com/files/371926", "https://ndownloader.figshare.com/files/371968", "https://ndownloader.figshare.com/files/372007", "https://ndownloader.figshare.com/files/372044", "https://ndownloader.figshare.com/files/372077", "https://ndownloader.figshare.com/files/372107", "https://ndownloader.figshare.com/files/372143", "https://ndownloader.figshare.com/files/372214"], "description"=>"<div><p>A link between circadian rhythm and metabolism has long been discussed. Circadian rhythm is controlled by positive and negative transcriptional and translational feedback loops composed of several clock genes. Among clock genes, the brain and muscle Arnt-like protein-1 (BMAL1) and circadian locomotor output cycles kaput (CLOCK) play important roles in the regulation of the positive rhythmic transcription. In addition to control of circadian rhythm, we have previously shown that BMAL1 regulates adipogenesis. In metabolic syndrome patients, the function of BMAL1 is dysregulated in visceral adipose tissue. In addition, analysis of SNPs has revealed that BMAL1 is associated with susceptibility to hypertension and type II diabetes. Furthermore, the significant roles of BMAL1 in pancreatic β cells proliferation and maturation were recently reported. These results suggest that BMAL1 regulates energy homeostasis. Therefore, in this study, we examined whether loss of BMAL1 function is capable of inducing metabolic syndrome. Deficient of the <em>Bmal1</em> gene in mice resulted in elevation of the respiratory quotient value, indicating that BMAL1 is involved in the utilization of fat as an energy source. Indeed, lack of Bmal1 reduced the capacity of fat storage in adipose tissue, resulting in an increase in the levels of circulating fatty acids, including triglycerides, free fatty acids, and cholesterol. Elevation of the circulating fatty acids level induced the formation of ectopic fat in the liver and skeletal muscle in <em>Bmal1</em> -/- mice. Interestingly, ectopic fat formation was not observed in tissue-specific (liver or skeletal muscle) <em>Bmal1</em> -/- mice even under high fat diet feeding condition. Therefore, we were led to conclude that BMAL1 is a crucial factor in the regulation of energy homeostasis, and disorders of the functions of BMAL1 lead to the development of metabolic syndrome.</p> </div>", "links"=>[], "tags"=>["deficient", "arnt-like", "protein-1", "induces", "dyslipidemia", "ectopic"], "article_id"=>133440, "categories"=>["Biotechnology", "Biochemistry", "Physiology", "Genetics"], "users"=>["Shigeki Shimba", "Tomohiro Ogawa", "Shunsuke Hitosugi", "Yuya Ichihashi", "Yuki Nakadaira", "Munehiro Kobayashi", "Masakatsu Tezuka", "Yasuhiro Kosuge", "Kumiko Ishige", "Yoshihisa Ito", "Kazuo Komiyama", "Yuko Okamatsu-Ogura", "Kazuhiro Kimura", "Masayuki Saito"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025231.s001", "https://dx.doi.org/10.1371/journal.pone.0025231.s002", "https://dx.doi.org/10.1371/journal.pone.0025231.s003", "https://dx.doi.org/10.1371/journal.pone.0025231.s004", "https://dx.doi.org/10.1371/journal.pone.0025231.s005", "https://dx.doi.org/10.1371/journal.pone.0025231.s006", "https://dx.doi.org/10.1371/journal.pone.0025231.s007", "https://dx.doi.org/10.1371/journal.pone.0025231.s008", "https://dx.doi.org/10.1371/journal.pone.0025231.s009", "https://dx.doi.org/10.1371/journal.pone.0025231.s010", "https://dx.doi.org/10.1371/journal.pone.0025231.s011"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Deficient_of_a_Clock_Gene_Brain_and_Muscle_Arnt_Like_Protein_1_BMAL1_Induces_Dyslipidemia_and_Ectopic_Fat_Formation/133440", "title"=>"Deficient of a Clock Gene, Brain and Muscle Arnt-Like Protein-1 (BMAL1), Induces Dyslipidemia and Ectopic Fat Formation", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-09-22 00:57:20"}
• {"files"=>["https://ndownloader.figshare.com/files/732465"], "description"=>"<p>(A) The respiratory quotient (RQ) of male mice housed under the light/dark condition (LD) or constant darkness condition (DD) was determined by indirect calorimeter. The daily average of RQ corrected by body weight was calculated. Data represent the means ± SEM (n = 6 for each genotype). Asterisks indicate significant differences (<i>P</i><0.05).</p>", "links"=>[], "tags"=>["respiration"], "article_id"=>402801, "categories"=>["Biotechnology", "Biochemistry", "Physiology", "Genetics"], "users"=>["Shigeki Shimba", "Tomohiro Ogawa", "Shunsuke Hitosugi", "Yuya Ichihashi", "Yuki Nakadaira", "Munehiro Kobayashi", "Masakatsu Tezuka", "Yasuhiro Kosuge", "Kumiko Ishige", "Yoshihisa Ito", "Kazuo Komiyama", "Yuko Okamatsu-Ogura", "Kazuhiro Kimura", "Masayuki Saito"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025231.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Abnormal_respiration_activity_in_Bmal1_mice_/402801", "title"=>"Abnormal respiration activity in <i>Bmal1</i> -/- mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-22 00:46:41"}
• {"files"=>["https://ndownloader.figshare.com/files/732550"], "description"=>"<p>(A) Male control mice and <i>Bmal1</i> -/- mice were subjected to a high-fat diet (HFD) challenge at 6 weeks of age. The body weights of the mice fed either a regular diet (RD) or HFD were determined. Data represent the means ± SEM (n = 8 for each genotype). Asterisks indicate significant differences (<i>P</i><0.05). (B) The daily average of the calorie intake of male mice at 11 weeks of age (5 weeks with a HFD) was determined. Data represent the means ± SEM (n = 8 for each genotype and treatment).</p>", "links"=>[], "tags"=>["high-fat", "feeding"], "article_id"=>402891, "categories"=>["Biotechnology", "Biochemistry", "Physiology", "Genetics"], "users"=>["Shigeki Shimba", "Tomohiro Ogawa", "Shunsuke Hitosugi", "Yuya Ichihashi", "Yuki Nakadaira", "Munehiro Kobayashi", "Masakatsu Tezuka", "Yasuhiro Kosuge", "Kumiko Ishige", "Yoshihisa Ito", "Kazuo Komiyama", "Yuko Okamatsu-Ogura", "Kazuhiro Kimura", "Masayuki Saito"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025231.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_a_high_fat_diet_feeding_on_the_body_weight_/402891", "title"=>"Effects of a high-fat diet feeding on the body weight.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-22 00:48:11"}
• {"files"=>["https://ndownloader.figshare.com/files/732648"], "description"=>"<p>Adipose tissue was excised at zeitgeber time (ZT) 10. (A) Representative morphology of adipose tissue in control mice and <i>Bmal1</i> -/- mice fed a HFD for 5 weeks. (B) Representative HE staining of epididymal white adipose tissue isolated from male control mice and <i>Bmal1</i> -/- mice fed a HFD for 5 weeks. Scale bars indicate 100 µm. (C) Average cross-sectional area of individual adipocytes in control mice and <i>Bmal1</i> -/- mice fed a HFD. Data represent the means ± SEM (n = 5 for each genotype). Asterisks indicate significant differences (<i>P</i><0.05).</p>", "links"=>[], "tags"=>["high-fat", "feeding", "histology", "adipocytes"], "article_id"=>402981, "categories"=>["Biotechnology", "Biochemistry", "Physiology", "Genetics"], "users"=>["Shigeki Shimba", "Tomohiro Ogawa", "Shunsuke Hitosugi", "Yuya Ichihashi", "Yuki Nakadaira", "Munehiro Kobayashi", "Masakatsu Tezuka", "Yasuhiro Kosuge", "Kumiko Ishige", "Yoshihisa Ito", "Kazuo Komiyama", "Yuko Okamatsu-Ogura", "Kazuhiro Kimura", "Masayuki Saito"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025231.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_a_high_fat_diet_feeding_on_histology_of_adipocytes_in_Bmal1_mice_/402981", "title"=>"Effects of a high-fat diet feeding on histology of adipocytes in <i>Bmal1</i> -/- mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-22 00:49:41"}
• {"files"=>["https://ndownloader.figshare.com/files/732746"], "description"=>"<p>Gene expressions in adipose tissues in control mice and <i>Bmal1 -/-</i> mice at ZT10 and 22 were determined by RT-qPCR. Relative mRNA levels were normalized to the 36B4 level. Data represents the means ± SEM (n = 5 for each genotype and point). Asterisks indicate significant differences (<i>P</i><0.05).</p>", "links"=>[], "tags"=>["expressions", "adipose"], "article_id"=>403085, "categories"=>["Biotechnology", "Biochemistry", "Physiology", "Genetics"], "users"=>["Shigeki Shimba", "Tomohiro Ogawa", "Shunsuke Hitosugi", "Yuya Ichihashi", "Yuki Nakadaira", "Munehiro Kobayashi", "Masakatsu Tezuka", "Yasuhiro Kosuge", "Kumiko Ishige", "Yoshihisa Ito", "Kazuo Komiyama", "Yuko Okamatsu-Ogura", "Kazuhiro Kimura", "Masayuki Saito"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025231.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_gene_expressions_in_adipose_tissues_/403085", "title"=>"Comparison of gene expressions in adipose tissues.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-22 00:51:25"}
• {"files"=>["https://ndownloader.figshare.com/files/732846"], "description"=>"<p>Serum samples were prepared from male mice fed a regular diet (RD) or a high-fat diet (HFD) for 5 weeks. All samples were collected at ZT 10. (A) Triglycerides (TG). (B) Non-esterified fatty acids (NEFA). (C) Total cholesterol. Data represent the means ± SEM (n = 8 for each genotype and treatment). Asterisks indicate significant differences (<i>P</i><0.05). (D) The LDL cholesterol/HDL cholesterol ratio was calculated based on the data shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0025231#pone-0025231-t001\" target=\"_blank\">Table 1</a>. Data represent the means ± SEM (n = 8 for each genotype and treatment). Asterisks indicate significant differences (<i>P</i><0.05).</p>", "links"=>[], "tags"=>["circulating", "fatty", "acids"], "article_id"=>403186, "categories"=>["Biotechnology", "Biochemistry", "Physiology", "Genetics"], "users"=>["Shigeki Shimba", "Tomohiro Ogawa", "Shunsuke Hitosugi", "Yuya Ichihashi", "Yuki Nakadaira", "Munehiro Kobayashi", "Masakatsu Tezuka", "Yasuhiro Kosuge", "Kumiko Ishige", "Yoshihisa Ito", "Kazuo Komiyama", "Yuko Okamatsu-Ogura", "Kazuhiro Kimura", "Masayuki Saito"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025231.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Alteration_of_circulating_fatty_acids_level_in_Bmal1_mice_/403186", "title"=>"Alteration of circulating fatty acids level in <i>Bmal1</i> -/- mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-22 00:53:06"}
• {"files"=>["https://ndownloader.figshare.com/files/732988"], "description"=>"<p>All tissue samples were excised at ZT10. (A) Representative morphology of the livers from control mice and <i>Bmal1</i> -/- mice fed a HFD for 5 weeks. (B) Representative oil red O staining of liver tissue samples isolated from male control mice and <i>Bmal1</i> -/- mice fed either a RD or HFD for 5 weeks. (C and D) Triglyceride (TG) contents in the liver (C) and skeletal muscle (D) from male control mice and <i>Bmal1</i> -/- mice fed a RD or HFD for 5 weeks. Data represent the means ± SEM (n = 8 for each genotype and treatment). Asterisks indicate significant differences (<i>P</i><0.05).</p>", "links"=>[], "tags"=>["accumulation", "skeletal"], "article_id"=>403325, "categories"=>["Biotechnology", "Biochemistry", "Physiology", "Genetics"], "users"=>["Shigeki Shimba", "Tomohiro Ogawa", "Shunsuke Hitosugi", "Yuya Ichihashi", "Yuki Nakadaira", "Munehiro Kobayashi", "Masakatsu Tezuka", "Yasuhiro Kosuge", "Kumiko Ishige", "Yoshihisa Ito", "Kazuo Komiyama", "Yuko Okamatsu-Ogura", "Kazuhiro Kimura", "Masayuki Saito"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025231.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ectopic_fat_accumulation_in_liver_and_skeletal_muscle_in_Bmal1_mice_/403325", "title"=>"Ectopic fat accumulation in liver and skeletal muscle in <i>Bmal1</i> -/- mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-22 00:55:25"}
• {"files"=>["https://ndownloader.figshare.com/files/733088"], "description"=>"<p>(A) Tissue samples were excised form male control mice and L-<i>Bmal1</i> -/- mice at ZT10. The total RNA was extracted from these tissues and the expression of Lpl mRNA was determined by RT-qPCR. Relative mRNA levels were normalized to the 36B4 level. Data represent the mean ± SEM (n = 5 for each genotype). Asterisks indicate significant differences (<i>P</i><0.05). Data represent the means ± SEM (n = 5 for each genotype and point). (B) The liver was excised male control mice at the indicated times. The open bar indicates the lights-on phase, and the dark bar indicates lights-off. The total RNA was extracted, and the expression of Bmal1 and Lpl mRNA was determined as described in (A). Data represent the means ± SEM (n = 5 for each point). (C) The liver was excised from the control mice housed in constant darkness for 10 days. The expression of Lpl mRNA was determined as described in (A). Data represent the means ± SEM (n = 5 for each point). (D) The liver was excised male control mice and L-<i>Bmal1</i> -/- mice at the indicated times. The open bar indicates the lights-on phase, and the dark bar indicates lights-off. The total RNA was extracted, and the expression of Lpl mRNA was determined as described in (A). Data represent the means ± SEM (n = 5 for each genotype and point). Asterisks indicate significant differences (<i>P</i><0.05).</p>", "links"=>[], "tags"=>["lpl", "deletion"], "article_id"=>403427, "categories"=>["Biotechnology", "Biochemistry", "Physiology", "Genetics"], "users"=>["Shigeki Shimba", "Tomohiro Ogawa", "Shunsuke Hitosugi", "Yuya Ichihashi", "Yuki Nakadaira", "Munehiro Kobayashi", "Masakatsu Tezuka", "Yasuhiro Kosuge", "Kumiko Ishige", "Yoshihisa Ito", "Kazuo Komiyama", "Yuko Okamatsu-Ogura", "Kazuhiro Kimura", "Masayuki Saito"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025231.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Induction_of_Lpl_gene_expression_in_the_liver_by_the_deletion_of_Bmal1_gene_/403427", "title"=>"Induction of Lpl gene expression in the liver by the deletion of <i>Bmal1</i> gene.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-22 00:57:07"}
• {"files"=>["https://ndownloader.figshare.com/files/733205"], "description"=>"<p>A schematic diagram of Bmal1 deficiency-induced abnormal lipid metabolism.</p>", "links"=>[], "tags"=>["schematic", "diagram", "bmal1", "deficiency-induced", "abnormal", "lipid"], "article_id"=>403536, "categories"=>["Biotechnology", "Biochemistry", "Physiology", "Genetics"], "users"=>["Shigeki Shimba", "Tomohiro Ogawa", "Shunsuke Hitosugi", "Yuya Ichihashi", "Yuki Nakadaira", "Munehiro Kobayashi", "Masakatsu Tezuka", "Yasuhiro Kosuge", "Kumiko Ishige", "Yoshihisa Ito", "Kazuo Komiyama", "Yuko Okamatsu-Ogura", "Kazuhiro Kimura", "Masayuki Saito"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025231.g008"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_schematic_diagram_of_Bmal1_deficiency_induced_abnormal_lipid_metabolism_/403536", "title"=>"A schematic diagram of Bmal1 deficiency-induced abnormal lipid metabolism.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-22 00:58:56"}
• {"files"=>["https://ndownloader.figshare.com/files/733294"], "description"=>"<p>Blood samples were collected at ZT 10. Plasma samples were prepared from male control mice and <i>Bmal1 -/-</i> mice fed either a regular diet (RD) or a high fat diet (HFD) for 5 weeks. Plasma lipoproteins were separated and analyzed by an on-line dual enzymatic method for simultaneous quantification of cholesterol and triglycerides by HPLC. Data represent the means ± SEM (n = 5 for each genotype). Asterisks indicate significant differences (<i>P</i><0.05).</p>", "links"=>[], "tags"=>["triglycerides"], "article_id"=>403628, "categories"=>["Biotechnology", "Biochemistry", "Physiology", "Genetics"], "users"=>["Shigeki Shimba", "Tomohiro Ogawa", "Shunsuke Hitosugi", "Yuya Ichihashi", "Yuki Nakadaira", "Munehiro Kobayashi", "Masakatsu Tezuka", "Yasuhiro Kosuge", "Kumiko Ishige", "Yoshihisa Ito", "Kazuo Komiyama", "Yuko Okamatsu-Ogura", "Kazuhiro Kimura", "Masayuki Saito"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025231.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Content_of_cholesterol_and_triglycerides_in_lipoproteins_/403628", "title"=>"Content of cholesterol and triglycerides in lipoproteins.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-09-22 01:00:28"}
• {"files"=>["https://ndownloader.figshare.com/files/733335"], "description"=>"<p>Gene expressions in control mice and <i>Bmal1 -/-</i> mice were determined by RT-qPCR. Relative mRNA levels were normalized to the 36B4 level. Each value represented the mean fold-changes (± SEM) of <i>Bmal1 -/-</i> mice in comparison to control mice (n = 5 for each genotype and point). Asterisks indicate significant differences (<i>P</i><0.05).</p>", "links"=>[], "tags"=>["expressions"], "article_id"=>403676, "categories"=>["Biotechnology", "Biochemistry", "Physiology", "Genetics"], "users"=>["Shigeki Shimba", "Tomohiro Ogawa", "Shunsuke Hitosugi", "Yuya Ichihashi", "Yuki Nakadaira", "Munehiro Kobayashi", "Masakatsu Tezuka", "Yasuhiro Kosuge", "Kumiko Ishige", "Yoshihisa Ito", "Kazuo Komiyama", "Yuko Okamatsu-Ogura", "Kazuhiro Kimura", "Masayuki Saito"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025231.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gene_expressions_in_Bmal1_mice_/403676", "title"=>"Gene expressions in <i>Bmal1</i> -/- mice.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-09-22 01:01:16"}
• {"files"=>["https://ndownloader.figshare.com/files/733382"], "description"=>"<p>Molar ratio was calculated from the data shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0025231#pone-0025231-t001\" target=\"_blank\">Table 1</a>. Molecular weights of 882.43 and 386.65 were used for triglycerides and cholesterol, respectively.</p>", "links"=>[], "tags"=>["genetics and genomics", "physiology", "biotechnology", "Biochemistry"], "article_id"=>403719, "categories"=>["Biotechnology", "Biochemistry", "Physiology", "Genetics"], "users"=>["Shigeki Shimba", "Tomohiro Ogawa", "Shunsuke Hitosugi", "Yuya Ichihashi", "Yuki Nakadaira", "Munehiro Kobayashi", "Masakatsu Tezuka", "Yasuhiro Kosuge", "Kumiko Ishige", "Yoshihisa Ito", "Kazuo Komiyama", "Yuko Okamatsu-Ogura", "Kazuhiro Kimura", "Masayuki Saito"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025231.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Molar_ratio_of_triglycerides_cholesterol_/403719", "title"=>"Molar ratio of triglycerides/cholesterol.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-09-22 01:01:59"}

PMC Usage Stats | Further Information

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F1000Prime