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{"title"=>"Developing a highly stable PLGA-mPEG nanoparticle loaded with cisplatin for chemotherapy of ovarian cancer", "type"=>"journal", "authors"=>[{"first_name"=>"Lihua", "last_name"=>"Cheng", "scopus_author_id"=>"57189627030"}, {"first_name"=>"Chengmeng", "last_name"=>"Jin", "scopus_author_id"=>"53463671700"}, {"first_name"=>"Wen", "last_name"=>"Lv", "scopus_author_id"=>"23995396400"}, {"first_name"=>"Qiuping", "last_name"=>"Ding", "scopus_author_id"=>"53463433900"}, {"first_name"=>"Xu", "last_name"=>"Han", "scopus_author_id"=>"55267755700"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-80053155384", "pmid"=>"21966528", "sgr"=>"80053155384", "doi"=>"10.1371/journal.pone.0025433", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203", "pui"=>"362627622"}, "id"=>"cf6669ef-fad1-3de6-bdef-11e3c9202410", "abstract"=>"BACKGROUND: Cisplatin is a potent anticancer drug, but its clinical application has been limited due to its undesirable physicochemical characteristics and severe side effects. Better drug formulations for cisplatin are highly desired.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: Herein, we have developed a nanoparticle formulation for cisplatin with high encapsulation efficiency and reduced toxicity by using cisplatin-crosslinked carboxymethyl cellulose (CMC) core nanoparticles made from poly(lactide-co-glycolide)-monomethoxy-poly(polyethylene glycol) copolymers (PLGA-mPEG). The nanoparticles have an average diameter of approximately 80 nm measured by transmission electron microscope (TEM). The encapsulation efficiency of cisplatin in the nanoparticles is up to 72%. Meanwhile, we have also observed a controlled release of cisplatin in a sustained manner and dose-dependent treatment efficacy of cisplatin-loaded nanoparticles against IGROV1-CP cells. Moreover, the median lethal dose (LD(50)) of the cisplatin-loaded nanoparticles was more than 100 mg/kg by intravenous administration, which was much higher than that of free cisplatin.\\n\\nCONCLUSION: This developed cisplatin-loaded nanoparticle is a promising formulation for the delivery of cisplatin, which will be an effective therapeutic regimen of ovarian cancer without severe side effects and cumulative toxicity.", "link"=>"http://www.mendeley.com/research/developing-highly-stable-plgampeg-nanoparticle-loaded-cisplatin-chemotherapy-ovarian-cancer", "reader_count"=>41, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>15, "Student > Master"=>7, "Other"=>1, "Student > Bachelor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>15, "Student > Master"=>7, "Other"=>1, "Student > Bachelor"=>5}, "reader_count_by_subject_area"=>{"Engineering"=>6, "Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>3, "Materials Science"=>3, "Agricultural and Biological Sciences"=>13, "Medicine and Dentistry"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Chemistry"=>8}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>6}, "Materials Science"=>{"Materials Science"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Chemistry"=>{"Chemistry"=>8}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "reader_count_by_country"=>{"United States"=>1, "Denmark"=>1, "Israel"=>1}, "group_count"=>1}

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• http://doi.org/10.1016/j.biopha.2013.02.004
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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/731833"], "description"=>"<p>(A) Relative cell viability of IGROV1-CP cells exposed to blank nanoparticles for 72 hours with various doses. (B) Cell growth inhibition after exposure to free cisplatin (gray histogram) and cisplatin-loaded nanoparticles (black histogram) for 72 hours. The data represented as Mean ± SD.</p>", "links"=>[], "tags"=>["viability", "igrov1-cp", "cells"], "article_id"=>402189, "categories"=>["Cancer", "Biotechnology"], "users"=>["Lihua Cheng", "Chengmeng Jin", "Wen Lv", "Qiuping Ding", "Xu Han"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025433.g005", "stats"=>{"downloads"=>3, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relative_cell_viability_of_IGROV1_CP_cells_with_different_treatments_/402189", "title"=>"Relative cell viability of IGROV1-CP cells with different treatments.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:26:36"}
• {"files"=>["https://ndownloader.figshare.com/files/732306"], "description"=>"<p>Each group included ten mice; LD₅₀ represented as median lethal dose.</p>", "links"=>[], "tags"=>["cisplatin"], "article_id"=>402663, "categories"=>["Cancer", "Biotechnology"], "users"=>["Lihua Cheng", "Chengmeng Jin", "Wen Lv", "Qiuping Ding", "Xu Han"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025433.t003", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_LD_50_of_cisplatin_and_NPs_cp_/402663", "title"=>"LD₅₀ of cisplatin and NPs-cp.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 14:29:04"}
• {"files"=>["https://ndownloader.figshare.com/files/732094"], "description"=>"<p>(A) Microscopic evaluation of tumor apoptosis by TUNEL staining. Athymic mice bearing IGROV1-CP xenografts were treated with saline (control), blank nanoparticles (blank NPs), cisplatin and cisplatin loaded nanoparticles (NPs-cp) at five doses. (B) The average apoptotic cell counts were calculated on the basis of TUNEL staining. Athymic mice bearing IGROV1-CP xenografts were treated as described in (A).</p>", "links"=>[], "tags"=>["examined", "tunel"], "article_id"=>402447, "categories"=>["Cancer", "Biotechnology"], "users"=>["Lihua Cheng", "Chengmeng Jin", "Wen Lv", "Qiuping Ding", "Xu Han"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025433.g007", "stats"=>{"downloads"=>9, "page_views"=>463, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Apoptosis_in_tumor_examined_by_TUNEL_staining_/402447", "title"=>"Apoptosis in tumor examined by TUNEL staining.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:28:01"}
• {"files"=>["https://ndownloader.figshare.com/files/732194"], "description"=>"<p>(A) Effect of free cisplatin (3 mg/kg) and cisplatin-loaded nanoparticles (NPs-cp, 3 mg/kg on the basis of cisplatin) on tumor growth in athymic mice bearing with IGROV1-CP cell xenografts. The mice were administered with prepared formulations at 4-day intervals in the total treatment period of 21 days. Saline solution was used as the control group, and the effect of blank nanoparticles (blank NPs) was also confirmed. The data were presented as Mean ± SD (n = 8 at the beginning of the experiment). (B) Survival rate of tumor-bearing athymic mice treated with cisplatin (3 mg/kg), NPs-cp (3 mg/kg on the basis of cisplatin), blank NPs and saline (control). (C) Body weight change as the treatment time of IGROV1-CP tumor-bearing mice. Bars indicated standard deviations.</p>", "links"=>[], "tags"=>["cisplatin-loaded", "nanoparticles", "athymic"], "article_id"=>402544, "categories"=>["Cancer", "Biotechnology"], "users"=>["Lihua Cheng", "Chengmeng Jin", "Wen Lv", "Qiuping Ding", "Xu Han"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025433.g008", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_cisplatin_loaded_nanoparticles_on_athymic_mice_/402544", "title"=>"Effect of cisplatin-loaded nanoparticles on athymic mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:28:32"}
• {"files"=>["https://ndownloader.figshare.com/files/731482"], "description"=>"<p>The peaks at 1.65 and 5.10 ppm belonged to the protons from methine (-CH) and methyl (-CH₃) groups of PLGA segments, the peaks of methene protons (-CH₂-) in the PEG segments located at 3.65 ppm, and the peaks of methene protons (-COCH₂O-) located at 4.78 ppm represented conjugated segments of PLGA and mPEG.</p>", "links"=>[], "tags"=>["nmr", "plga-mpeg"], "article_id"=>401838, "categories"=>["Cancer", "Biotechnology"], "users"=>["Lihua Cheng", "Chengmeng Jin", "Wen Lv", "Qiuping Ding", "Xu Han"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025433.g001", "stats"=>{"downloads"=>5, "page_views"=>327, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_1_H_NMR_spectrum_of_PLGA_mPEG_copolymer_/401838", "title"=>"¹H NMR spectrum of PLGA-mPEG copolymer.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:24:43"}
• {"files"=>["https://ndownloader.figshare.com/files/732329"], "description"=>"<p>NPs are nanoparticles; NPs-cp is cisplatin-encapsulated nanoparticles.</p>", "links"=>[], "tags"=>["zeta", "nps", "nps-cp"], "article_id"=>402684, "categories"=>["Cancer", "Biotechnology"], "users"=>["Lihua Cheng", "Chengmeng Jin", "Wen Lv", "Qiuping Ding", "Xu Han"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025433.t002", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Particle_size_and_zeta_potential_of_blank_NPs_and_NPs_cp_n_8202_8202_3_/402684", "title"=>"Particle size and zeta potential of blank NPs and NPs-cp (n = 3).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 14:29:14"}
• {"files"=>["https://ndownloader.figshare.com/files/731941"], "description"=>"<p>Nude athymic mice bearing IGROV1-CP xenografts were treated with saline (control), blank nanoparticles (blank NPs), cisplatin and cisplatin loaded nanoparticles (NPs-cp) at five doses every 4 days. The organs including heart, lung, spleen, liver and kidney from the mice treated with saline were shown in the first row. The organs from the mice treated with blank nanoparticles were shown in the second row. The organs from the mice treated with free cisplatin were shown in the third row. The organs from the mice treated with cisplatin-loaded nanoparticles were shown in the fourth row.</p>", "links"=>[], "tags"=>["organs"], "article_id"=>402297, "categories"=>["Cancer", "Biotechnology"], "users"=>["Lihua Cheng", "Chengmeng Jin", "Wen Lv", "Qiuping Ding", "Xu Han"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025433.g006", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Microscopic_examination_of_organs_with_HE_staining_/402297", "title"=>"Microscopic examination of organs with HE staining.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:27:11"}
• {"files"=>["https://ndownloader.figshare.com/files/731584"], "description"=>"<p>The peak represented the average molecular weight of synthesized copolymers was calculated to be 37062.</p>", "links"=>[], "tags"=>["plga-mpeg", "copolymer", "molecular"], "article_id"=>401938, "categories"=>["Cancer", "Biotechnology"], "users"=>["Lihua Cheng", "Chengmeng Jin", "Wen Lv", "Qiuping Ding", "Xu Han"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025433.g002", "stats"=>{"downloads"=>1, "page_views"=>123, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_measurement_of_PLGA_mPEG_copolymer_molecular_weight_by_GPC_/401938", "title"=>"The measurement of PLGA-mPEG copolymer molecular weight by GPC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:25:17"}
• {"files"=>["https://ndownloader.figshare.com/files/731776"], "description"=>"<p>Cisplatin released from nanoparticles as a function of incubation time in 100 mmol/L sodium chloride solution at 37°C.</p>", "links"=>[], "tags"=>["profiles", "cisplatin-loaded"], "article_id"=>402134, "categories"=>["Cancer", "Biotechnology"], "users"=>["Lihua Cheng", "Chengmeng Jin", "Wen Lv", "Qiuping Ding", "Xu Han"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025433.g004", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Release_profiles_of_cisplatin_loaded_nanoparticles_/402134", "title"=>"Release profiles of cisplatin-loaded nanoparticles.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:26:18"}
• {"files"=>["https://ndownloader.figshare.com/files/732272"], "description"=>"<p>The entrapment efficiency was calculated as the amount of cisplatin recovered from nanoparticles relative to the initial amount of cisplatin used for preparation. The loading efficiency of cisplatin was the amount of cisplatin recovered from nanoparticles relative to the amount of CMC and PLGA-mPEG.</p>", "links"=>[], "tags"=>["loading", "nps-cp"], "article_id"=>402625, "categories"=>["Cancer", "Biotechnology"], "users"=>["Lihua Cheng", "Chengmeng Jin", "Wen Lv", "Qiuping Ding", "Xu Han"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025433.t001", "stats"=>{"downloads"=>2, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Entrapment_efficiency_and_drug_loading_of_NPs_cp_n_8202_8202_3_/402625", "title"=>"Entrapment efficiency and drug loading of NPs-cp (n = 3).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 14:28:54"}
• {"files"=>["https://ndownloader.figshare.com/files/731712"], "description"=>"<p>(A) blank nanoparticles; (B) cisplatin-loaded nanoparticles. Samples were stained with 1% phosphotungstic acid (50000×).</p>", "links"=>[], "tags"=>["electron", "microscopic"], "article_id"=>402066, "categories"=>["Cancer", "Biotechnology"], "users"=>["Lihua Cheng", "Chengmeng Jin", "Wen Lv", "Qiuping Ding", "Xu Han"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025433.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Transmission_electron_microscopic_examination_of_nanoparticles_/402066", "title"=>"Transmission electron microscopic examination of nanoparticles.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:25:58"}

PMC Usage Stats | Further Information

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Relative Metric

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