Depression in Patients with Mastocytosis: Prevalence, Features and Effects of Masitinib Therapy
Publication Date
October 21, 2011
Journal
PLOS ONE
Authors
Daniela Silva Moura, Serge Sultan, Sophie Georgin Lavialle, Nathalie Pillet, et al
Volume
6
Issue
10
Pages
e26375
DOI
https://dx.plos.org/10.1371/journal.pone.0026375
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0026375
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/22031830
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198767
Europe PMC
http://europepmc.org/abstract/MED/22031830
Web of Science
000296513200019
Scopus
80054848122
Mendeley
http://www.mendeley.com/research/depression-patients-mastocytosis-prevalence-features-effects-masitinib-therapy
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Mendeley | Further Information

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CrossRef

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/366468"], "description"=>"<div><p>Depression in patients with mastocytosis is often reported but its prevalence and characteristics are not precisely described. In addition, the impact of therapies targeting mast cells proliferation, differentiation and degranulation on psychic symptoms of depression have never been investigated. Our objective was to determine the prevalence and to describe features of depression in a large cohort of mastocytosis patients (n = 288) and to investigate the therapeutic impact of the protein kinase inhibitor masitinib in depression symptoms. The description of depression was based on the analysis of a database with Hamilton scores using Principal Component Analysis (PCA). Efficacy of masitinib therapy was evaluated using non parametric Wilcoxon test for paired data within a three months period (n = 35). Our results show that patients with indolent mastocytosis present an elevated prevalence of depression (64%). Depression was moderate in 56% but severe in 8% of cases. Core symptoms (such as psychic anxiety, depressed mood, work and interests) characterized depression in mastocytosis patients. Masitinib therapy was associated with significant improvement (67% of the cases) of overall depression, with 75% of recovery cases. Global Quality of Life slightly improved after masitinib therapy and did not predicted depression improvement. In conclusion, depression is very frequent in mastocytosis patients and masitinib therapy is associated with the reduction its psychic experiences. We conclude that depression in mastocytosis may originate from processes related to mast cells activation. Masitinib could therefore be a useful treatment for mastocytosis patients with depression and anxiety symptoms.</p> </div>", "links"=>[], "tags"=>["patients", "features", "effects", "masitinib"], "article_id"=>132415, "categories"=>["Hematology", "Marine Biology", "Mental Health", "Immunology", "Physiology", "Neuroscience", "Cell Biology"], "users"=>["Daniela Silva Moura", "Serge Sultan", "Sophie Georgin-Lavialle", "Nathalie Pillet", "François Montestruc", "Paul Gineste", "Stéphane Barete", "Gandhi Damaj", "Alain Moussy", "Olivier Lortholary", "Olivier Hermine"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0026375"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Depression_in_Patients_with_Mastocytosis_Prevalence_Features_and_Effects_of_Masitinib_Therapy/132415", "title"=>"Depression in Patients with Mastocytosis: Prevalence, Features and Effects of Masitinib Therapy", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-21 00:40:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/720749"], "description"=>"<p>Chi square test was performed to compare groups item by item. Severe depression was characterized by a huge prevalence of impairment in work and activities (97%), depressed mood (95%), somatic anxiety (83%), guilt (61%) and genital symptoms (56%). Mild-moderate depression was characterized by a higher prevalence of late insomnia (22%), agitation (37%), psychic anxiety (44%) and hypochondriasis (34%).</p>", "links"=>[], "tags"=>["ham-d17", "non", "mild-moderate", "patients"], "article_id"=>391094, "categories"=>["Hematology", "Marine Biology", "Mental Health", "Immunology", "Physiology", "Neuroscience", "Cell Biology"], "users"=>["Daniela Silva Moura", "Serge Sultan", "Sophie Georgin-Lavialle", "Nathalie Pillet", "François Montestruc", "Paul Gineste", "Stéphane Barete", "Gandhi Damaj", "Alain Moussy", "Olivier Lortholary", "Olivier Hermine"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0026375.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Symptoms_of_depression_from_the_Ham_D17_in_non_depressed_mild_moderate_and_severe_depressed_patients_with_mastocytosis_/391094", "title"=>"Symptoms of depression from the Ham-D17 in non depressed, mild-moderate and severe depressed patients with mastocytosis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-21 00:18:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/720821"], "description"=>"<p>A. Mean total score in depression reduced significantly at the end of the trial (p = .0001); pre-mean Ham-D17 = 11.23 (S.D. = 6.8); post-mean Ham-D17 = 6.97 (S.D. = 6.9). B. Mean score in sleep disturbances dimension reduced significantly at the end of the trial (p = .0112); pre-mean Ham-D17 = 1.57 (S.D. = 1.5); post-mean Ham-D17 = 1.00 (S.D. = 1.3). C. Mean score in anxious depression dimension reduced significantly at the end of the trial (p = .0004); pre-mean Ham-D17 = 5.83 (S.D. = 4.0); post-mean Ham-D17 = 3.77 (S.D. = 3.9). + Exclusion of this patient from the analysis did not change the results. * (p≤0.05); ** (p≤0.0005); *** (p≤0.0001).</p>", "links"=>[], "tags"=>["masitinib"], "article_id"=>391170, "categories"=>["Hematology", "Marine Biology", "Mental Health", "Immunology", "Physiology", "Neuroscience", "Cell Biology"], "users"=>["Daniela Silva Moura", "Serge Sultan", "Sophie Georgin-Lavialle", "Nathalie Pillet", "François Montestruc", "Paul Gineste", "Stéphane Barete", "Gandhi Damaj", "Alain Moussy", "Olivier Lortholary", "Olivier Hermine"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0026375.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Depression_improvement_following_masitinib_therapy_/391170", "title"=>"Depression improvement following masitinib therapy.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-21 00:19:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/720919"], "description"=>"<p>Two components solution explaining 54% of the overall variance and moderately correlated (r = .46) after exclusion of items with correlation loadings under .40. “Anxious-depression” dimension included the following items: depressed mood, guilt, work and activities and anxiety (psychic and somatic). “Sleep disturbances” dimension included the items middle and late insomnia. The Keiser-Meyer-Olkin measure of sampling adequacy revealed a score of 0.85 confirming the adequacy of the data for factor analysis.</p>", "links"=>[], "tags"=>["loadings", "promax"], "article_id"=>391267, "categories"=>["Hematology", "Marine Biology", "Mental Health", "Immunology", "Physiology", "Neuroscience", "Cell Biology"], "users"=>["Daniela Silva Moura", "Serge Sultan", "Sophie Georgin-Lavialle", "Nathalie Pillet", "François Montestruc", "Paul Gineste", "Stéphane Barete", "Gandhi Damaj", "Alain Moussy", "Olivier Lortholary", "Olivier Hermine"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0026375.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Factor_loadings_after_promax_rotation_/391267", "title"=>"Factor loadings after promax rotation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-21 00:21:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/720971"], "description"=>"<p>S.D: standard deviation; Ham-D17: Hamilton depression scale-17 items.</p>", "links"=>[], "tags"=>["Nephrology", "immunology", "Mental health", "physiology", "cell biology", "hematology", "neuroscience"], "article_id"=>391311, "categories"=>["Hematology", "Marine Biology", "Mental Health", "Immunology", "Physiology", "Neuroscience", "Cell Biology"], "users"=>["Daniela Silva Moura", "Serge Sultan", "Sophie Georgin-Lavialle", "Nathalie Pillet", "François Montestruc", "Paul Gineste", "Stéphane Barete", "Gandhi Damaj", "Alain Moussy", "Olivier Lortholary", "Olivier Hermine"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0026375.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sample_description_/391311", "title"=>"Sample description.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-21 00:21:51"}

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Relative Metric

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