CiteULike | Further Information

• {"link"=>{"url"=>"http://www.citeulike.org/user/ongenetics/article/10297334"}, "post_time"=>"2012-02-12 04:20:58", "tag"=>["circular_rna", "rna", "splicing", "splicing_fidelity"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pone.0030733"}, {"type"=>"Pubmed Central", "url"=>"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270023/"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/22319583"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=22319583"}], "username"=>"ongenetics", "article_id"=>"10297334"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/kentsis/article/10297334"}, "post_time"=>"2012-11-04 15:10:48", "tag"=>"genetics", "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pone.0030733"}, {"type"=>"Pubmed Central", "url"=>"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270023/"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/22319583"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=22319583"}], "username"=>"kentsis", "article_id"=>"10297334"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/fenghezi/article/10297334"}, "post_time"=>"2013-04-01 18:14:43", "tag"=>["rna", "rna-seq", "technology"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pone.0030733"}, {"type"=>"Pubmed Central", "url"=>"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270023/"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/22319583"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=22319583"}], "username"=>"fenghezi", "article_id"=>"10297334"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/dakelley/article/10297334"}, "post_time"=>"2013-03-07 20:43:11", "tag"=>"circular_rna", "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pone.0030733"}, {"type"=>"Pubmed Central", "url"=>"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270023/"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/22319583"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=22319583"}], "username"=>"dakelley", "article_id"=>"10297334"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/astoddard/article/10297334"}, "post_time"=>"2012-02-02 15:07:30", "tag"=>["rna", "rna-seq", "transcriptomics"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pone.0030733"}, {"type"=>"Pubmed Central", "url"=>"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270023/"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/22319583"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=22319583"}], "username"=>"astoddard", "article_id"=>"10297334"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/Andrew_Berry_70/article/10297334"}, "post_time"=>"2013-06-26 10:21:31", "tag"=>"no-tag", "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pone.0030733"}, {"type"=>"Pubmed Central", "url"=>"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270023/"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/22319583"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=22319583"}], "username"=>"Andrew_Berry_70", "article_id"=>"10297334"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/joeharper/article/10297334"}, "post_time"=>"2013-03-05 09:30:17", "tag"=>["circular", "rna"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pone.0030733"}, {"type"=>"Pubmed Central", "url"=>"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270023/"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/22319583"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=22319583"}], "username"=>"joeharper", "article_id"=>"10297334"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/cantalapiedra/article/10297334"}, "post_time"=>"2014-05-23 23:40:11", "tag"=>["circrna", "gene_regulation", "mirna", "rnaseq", "transcriptomics"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pone.0030733"}, {"type"=>"Pubmed Central", "url"=>"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270023/"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/22319583"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=22319583"}], "username"=>"cantalapiedra", "article_id"=>"10297334"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/antonkratz/article/10297334"}, "post_time"=>"2012-02-03 05:58:47", "tag"=>"circular_rna", "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pone.0030733"}, {"type"=>"Pubmed Central", "url"=>"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270023/"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/22319583"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=22319583"}], "username"=>"antonkratz", "article_id"=>"10297334"}

Mendeley | Further Information

{"title"=>"Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types", "type"=>"journal", "authors"=>[{"first_name"=>"Julia", "last_name"=>"Salzman", "scopus_author_id"=>"7004770708"}, {"first_name"=>"Charles", "last_name"=>"Gawad", "scopus_author_id"=>"8843775900"}, {"first_name"=>"Peter Lincoln", "last_name"=>"Wang", "scopus_author_id"=>"38062696600"}, {"first_name"=>"Norman", "last_name"=>"Lacayo", "scopus_author_id"=>"6507333888"}, {"first_name"=>"Patrick O.", "last_name"=>"Brown", "scopus_author_id"=>"35414776900"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"364181123", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0030733", "scopus"=>"2-s2.0-84863045982", "pmid"=>"22319583", "sgr"=>"84863045982"}, "id"=>"ed69635e-c46d-3753-a154-1328f588505b", "abstract"=>"Most human pre-mRNAs are spliced into linear molecules that retain the exon order defined by the genomic sequence. By deep sequencing of RNA from a variety of normal and malignant human cells, we found RNA transcripts from many human genes in which the exons were arranged in a non-canonical order. Statistical estimates and biochemical assays provided strong evidence that a substantial fraction of the spliced transcripts from hundreds of genes are circular RNAs. Our results suggest that a non-canonical mode of RNA splicing, resulting in a circular RNA isoform, is a general feature of the gene expression program in human cells.", "link"=>"http://www.mendeley.com/research/circular-rnas-predominant-transcript-isoform-hundreds-human-genes-diverse-cell-types", "reader_count"=>646, "reader_count_by_academic_status"=>{"Unspecified"=>12, "Professor > Associate Professor"=>36, "Student > Doctoral Student"=>28, "Researcher"=>168, "Student > Ph. D. Student"=>184, "Student > Postgraduate"=>30, "Other"=>21, "Student > Master"=>75, "Student > Bachelor"=>75, "Lecturer"=>2, "Professor"=>15}, "reader_count_by_user_role"=>{"Unspecified"=>12, "Professor > Associate Professor"=>36, "Student > Doctoral Student"=>28, "Researcher"=>168, "Student > Ph. D. Student"=>184, "Student > Postgraduate"=>30, "Other"=>21, "Student > Master"=>75, "Student > Bachelor"=>75, "Lecturer"=>2, "Professor"=>15}, "reader_count_by_subject_area"=>{"Unspecified"=>17, "Agricultural and Biological Sciences"=>392, "Philosophy"=>1, "Arts and Humanities"=>1, "Business, Management and Accounting"=>1, "Chemistry"=>8, "Computer Science"=>13, "Engineering"=>9, "Biochemistry, Genetics and Molecular Biology"=>145, "Mathematics"=>1, "Medicine and Dentistry"=>43, "Neuroscience"=>8, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>4, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>43}, "Social Sciences"=>{"Social Sciences"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>17}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>9}, "Chemistry"=>{"Chemistry"=>8}, "Neuroscience"=>{"Neuroscience"=>8}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>392}, "Computer Science"=>{"Computer Science"=>13}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>145}, "Philosophy"=>{"Philosophy"=>1}}, "reader_count_by_country"=>{"Argentina"=>1, "United States"=>27, "Uruguay"=>1, "Japan"=>6, "United Kingdom"=>6, "Portugal"=>1, "Spain"=>1, "Canada"=>2, "Sweden"=>1, "Czech Republic"=>1, "Norway"=>1, "China"=>4, "Luxembourg"=>2, "Brazil"=>5, "Denmark"=>2, "Italy"=>3, "South Africa"=>1, "Israel"=>1, "France"=>2, "Germany"=>5}, "group_count"=>27}

ORCID

CrossRef

• http://doi.org/10.1016/j.prp.2020.152861
• http://doi.org/10.1016/j.omtn.2019.08.016
• http://doi.org/10.1186/s12885-020-06794-5
• http://doi.org/10.1093/nar/gkv386
• http://doi.org/10.26508/lsa.201900398
• http://doi.org/10.1158/2159-8290.CD-13-0202
• http://doi.org/10.1177/1010428317694546
• http://doi.org/10.1016/j.tins.2020.07.007
• http://doi.org/10.1038/srep12453
• http://doi.org/10.1007/s40484-016-0085-y
• http://doi.org/10.1186/s12920-019-0616-2
• http://doi.org/10.1093/database/baz063
• http://doi.org/10.1016/j.mito.2019.11.002
• http://doi.org/10.1186/s12943-017-0630-y
• http://doi.org/10.1155/2020/6798590
• http://doi.org/10.1128/JVI.01952-18
• http://doi.org/10.1016/j.mcp.2020.101539
• http://doi.org/10.1038/s41421-018-0050-1
• http://doi.org/10.1016/j.gene.2020.145035
• http://doi.org/10.1371/journal.pone.0148407
• http://doi.org/10.1111/febs.14191
• http://doi.org/10.3390/ijms19051310
• http://doi.org/10.1155/2019/8690592
• http://doi.org/10.1051/medsci/2019267
• http://doi.org/10.1097/GOX.0000000000002265
• http://doi.org/10.1096/fj.201900965R
• http://doi.org/10.4103/1673-5374.268969
• http://doi.org/10.3389/fpsyt.2020.00392
• http://doi.org/10.1111/cea.13445
• http://doi.org/10.1093/bib/bby006
• http://doi.org/10.3390/ijms18030597
• http://doi.org/10.2217/epi-2019-0029
• http://doi.org/10.1016/j.biochi.2019.06.011
• http://doi.org/10.1016/j.ygeno.2020.03.024
• http://doi.org/10.1016/j.canlet.2017.08.015
• http://doi.org/10.1016/j.ijbiomac.2018.09.076
• http://doi.org/10.1038/cr.2017.136
• http://doi.org/10.1371/journal.ppat.1008346
• http://doi.org/10.3892/mmr.2017.7779
• http://doi.org/10.2147/CMAR.S258230
• http://doi.org/10.18632/oncotarget.16881
• http://doi.org/10.1007/s11033-019-04937-x
• http://doi.org/10.1038/nrm3611
• http://doi.org/10.1016/j.tcb.2019.12.004
• http://doi.org/10.1038/srep22572
• http://doi.org/10.15252/embj.2018100836
• http://doi.org/10.1002/jcp.29009
• http://doi.org/10.1093/bioinformatics/btz705
• http://doi.org/10.3390/genes9030118
• http://doi.org/10.1016/j.ymben.2019.01.002
• http://doi.org/10.1073/pnas.1811728115
• http://doi.org/10.1038/s41569-019-0185-2
• http://doi.org/10.1016/j.ygeno.2018.04.015
• http://doi.org/10.1038/s41580-020-0243-y
• http://doi.org/10.1016/j.celrep.2014.12.019
• http://doi.org/10.1093/bib/bbaa322
• http://doi.org/10.1016/j.ygeno.2019.01.013
• http://doi.org/10.18632/oncotarget.19930
• http://doi.org/10.1080/15476286.2017.1367886
• http://doi.org/10.1093/bfgp/elw001
• http://doi.org/10.18632/oncotarget.20441
• http://doi.org/10.1128/MCB.00473-19
• http://doi.org/10.1080/15384101.2018.1480210
• http://doi.org/10.1177/0394632016686985
• http://doi.org/10.3892/ol.2017.7348
• http://doi.org/10.1038/s41419-019-1744-5
• http://doi.org/10.1373/clinchem.2019.305854
• http://doi.org/10.7717/peerj.6267
• http://doi.org/10.1016/j.envpol.2019.01.014
• http://doi.org/10.3892/ol.2018.9125
• http://doi.org/10.3390/ijms21010258
• http://doi.org/10.1186/s13059-014-0571-3
• http://doi.org/10.3389/fendo.2018.00405
• http://doi.org/10.1186/s12864-018-5054-6
• http://doi.org/10.1038/nrm.2015.32
• http://doi.org/10.1093/nar/gkw075
• http://doi.org/10.1093/nar/gkv1367
• http://doi.org/10.1093/bioinformatics/btx129
• http://doi.org/10.18632/aging.103472
• http://doi.org/10.1038/srep34985
• http://doi.org/10.2217/epi-2020-0214
• http://doi.org/10.3390/ijms19030682
• http://doi.org/10.1038/ncomms12060
• http://doi.org/10.1038/s41388-019-0926-z
• http://doi.org/10.3748/wjg.v21.i41.11709
• http://doi.org/10.1186/s12864-018-4926-0
• http://doi.org/10.1002/wrna.1583
• http://doi.org/10.1096/fj.201903157R
• http://doi.org/10.1097/YCO.0000000000000582
• http://doi.org/10.7554/eLife.07540
• http://doi.org/10.1186/s13059-016-0991-3
• http://doi.org/10.1016/j.bbrc.2018.02.157
• http://doi.org/10.1093/nar/gkaa181
• http://doi.org/10.1038/nature11956
• http://doi.org/10.3389/fcimb.2018.00255
• http://doi.org/10.1002/cam4.3057
• http://doi.org/10.1016/j.coi.2020.10.010
• http://doi.org/10.5713/ajas.17.0563
• http://doi.org/10.1093/nar/gkz199
• http://doi.org/10.1186/s12943-019-1113-0
• http://doi.org/10.1016/j.ibmb.2017.09.003
• http://doi.org/10.3390/mps3020042
• http://doi.org/10.2174/1566523219666191107113046
• http://doi.org/10.3389/fmed.2019.00192
• http://doi.org/10.1186/s13059-016-1002-4
• http://doi.org/10.3390/v12091024
• http://doi.org/10.1111/jpy.13033
• http://doi.org/10.3390/ncrna6040045
• http://doi.org/10.3390/ncrna5010017
• http://doi.org/10.4161/rna.24972
• http://doi.org/10.3390/cancers12030697
• http://doi.org/10.1002/wrna.1478
• http://doi.org/10.18632/oncotarget.13656
• http://doi.org/10.1186/s12935-020-01208-9
• http://doi.org/10.1038/s41556-019-0311-8
• http://doi.org/10.1073/pnas.1605517113
• http://doi.org/10.1093/database/bax089
• http://doi.org/10.3389/fonc.2020.579940
• http://doi.org/10.1038/ncomms11215
• http://doi.org/10.1038/s41593-019-0501-5
• http://doi.org/10.1371/journal.pgen.1003777
• http://doi.org/10.1016/j.ncrna.2018.02.001
• http://doi.org/10.1016/j.omtn.2019.11.023
• http://doi.org/10.1124/dmd.116.073254
• http://doi.org/10.3389/fcell.2020.00230
• http://doi.org/10.1177/1533033819898728
• http://doi.org/10.1186/s12943-019-1121-0
• http://doi.org/10.7554/eLife.58478
• http://doi.org/10.1186/s12864-020-07000-3
• http://doi.org/10.18632/oncotarget.18350
• http://doi.org/10.1101/cshperspect.a032680
• http://doi.org/10.1038/s41598-017-14264-5
• http://doi.org/10.1016/j.mvr.2020.103983
• http://doi.org/10.1186/s12943-020-01231-4
• http://doi.org/10.1080/15476286.2020.1812910
• http://doi.org/10.1016/j.molcel.2014.08.019
• http://doi.org/10.1186/s12943-019-1125-9
• http://doi.org/10.1101/gr.238121.118
• http://doi.org/10.1371/journal.pone.0091264
• http://doi.org/10.2217/bmm-2019-0567
• http://doi.org/10.1007/s11427-020-1631-9
• http://doi.org/10.1002/2211-5463.12709
• http://doi.org/10.1186/s12859-019-2865-7
• http://doi.org/10.1093/dnares/dsx039
• http://doi.org/10.1038/s41419-018-1048-1
• http://doi.org/10.1101/sqb.2019.84.039495
• http://doi.org/10.1002/1873-3468.13423
• http://doi.org/10.1016/j.pharmthera.2020.107715
• http://doi.org/10.1186/s12885-018-4689-7
• http://doi.org/10.1038/s41525-017-0038-z
• http://doi.org/10.3390/v10050260
• http://doi.org/10.1038/srep08057
• http://doi.org/10.1016/j.molcel.2017.05.022
• http://doi.org/10.1186/s12859-018-2589-0
• http://doi.org/10.7124/bc.000A23
• http://doi.org/10.1038/scibx.2013.229
• http://doi.org/10.1007/s00018-017-2688-5
• http://doi.org/10.1016/j.lfs.2019.116571
• http://doi.org/10.15252/embr.201540078
• http://doi.org/10.1186/s12943-020-01149-x
• http://doi.org/10.2131/jts.43.281
• http://doi.org/10.2147/OTT.S274932
• http://doi.org/10.3389/fcell.2020.00273
• http://doi.org/10.18632/oncotarget.15719
• http://doi.org/10.1016/j.bbrc.2018.04.190
• http://doi.org/10.1093/bioinformatics/btaa232
• http://doi.org/10.1016/j.canlet.2018.04.006
• http://doi.org/10.1080/10409238.2018.1508411
• http://doi.org/10.1093/bfgp/elu034
• http://doi.org/10.1038/s41598-017-05432-8
• http://doi.org/10.1111/jcmm.14436
• http://doi.org/10.1111/jnc.15198
• http://doi.org/10.12677/WJCR.2017.74015
• http://doi.org/10.1038/s41419-018-0699-2
• http://doi.org/10.1016/j.neuroscience.2019.12.018
• http://doi.org/10.1016/j.molcel.2020.06.011
• http://doi.org/10.3389/fgene.2020.00503
• http://doi.org/10.3389/fgene.2014.00164
• http://doi.org/10.3389/fnmol.2016.00025
• http://doi.org/10.1186/s12864-018-4660-7
• http://doi.org/10.1016/j.molcel.2019.07.016
• http://doi.org/10.1073/pnas.1218353110
• http://doi.org/10.1016/j.omtn.2019.10.019
• http://doi.org/10.1186/s12943-019-1094-z
• http://doi.org/10.1371/journal.pone.0090859
• http://doi.org/10.3389/fonc.2018.00332
• http://doi.org/10.1093/nar/gkaa823
• http://doi.org/10.1016/j.molcel.2013.08.017
• http://doi.org/10.1186/s12943-020-01180-y
• http://doi.org/10.1146/annurev-biodatasci-072018-021255
• http://doi.org/10.3390/ijms21020456
• http://doi.org/10.1038/srep37982
• http://doi.org/10.1016/j.diabet.2015.03.006
• http://doi.org/10.15252/embj.201797945
• http://doi.org/10.1016/j.compbiolchem.2018.08.002
• http://doi.org/10.1002/jcb.27614
• http://doi.org/10.1186/s12870-019-1944-2
• http://doi.org/10.1038/s41388-018-0369-y
• http://doi.org/10.1002/wrna.1294
• http://doi.org/10.1261/rna.056838.116
• http://doi.org/10.3390/ijms140918319
• http://doi.org/10.3390/ijms20040919
• http://doi.org/10.1016/j.hbpd.2019.09.009
• http://doi.org/10.1080/15476286.2016.1220473
• http://doi.org/10.3390/ijms21228682
• http://doi.org/10.3892/ijmm.2017.3189
• http://doi.org/10.1016/j.bbagrm.2019.194417
• http://doi.org/10.1016/j.biopha.2019.108932
• http://doi.org/10.1002/1878-0261.12468
• http://doi.org/10.3389/fgene.2020.596308
• http://doi.org/10.1016/j.pharmthera.2018.01.010
• http://doi.org/10.1186/s12864-018-4670-5
• http://doi.org/10.1186/s13046-020-01799-1
• http://doi.org/10.1186/s12957-020-01832-9
• http://doi.org/10.1007/s11427-015-4855-y
• http://doi.org/10.1038/bjc.2016.451
• http://doi.org/10.1093/nar/gkv1013
• http://doi.org/10.3390/ijms20081938
• http://doi.org/10.1038/s41419-020-2293-7
• http://doi.org/10.1371/journal.pone.0187581
• http://doi.org/10.1186/s12958-020-00653-5
• http://doi.org/10.1186/s13046-020-01779-5
• http://doi.org/10.1590/S1807-55092013005000020
• http://doi.org/10.1152/physrev.00041.2015
• http://doi.org/10.1080/15476286.2016.1227904
• http://doi.org/10.1182/blood-2012-05-429811
• http://doi.org/10.1186/s12943-020-01286-3
• http://doi.org/10.1111/1471-0528.13897
• http://doi.org/10.3389/fnmol.2016.00074
• http://doi.org/10.1016/j.canlet.2017.11.034
• http://doi.org/10.1186/s12935-020-01523-1
• http://doi.org/10.1124/dmd.119.089102
• http://doi.org/10.3389/fgene.2020.00530
• http://doi.org/10.1155/2020/7165893
• http://doi.org/10.1002/jcb.27047
• http://doi.org/10.1038/s41598-019-57404-9
• http://doi.org/10.1002/jcp.29473
• http://doi.org/10.1155/2020/4143802
• http://doi.org/10.1161/CIRCRESAHA.117.304156
• http://doi.org/10.1515/cclm-2018-0231
• http://doi.org/10.1080/15384101.2020.1834301
• http://doi.org/10.3389/fnmol.2017.00412
• http://doi.org/10.1111/rda.13816
• http://doi.org/10.1016/j.semcancer.2020.11.009
• http://doi.org/10.1016/j.tig.2017.12.016
• http://doi.org/10.26508/lsa.201900354
• http://doi.org/10.1016/j.celrep.2020.01.083
• http://doi.org/10.1093/nar/gkaa1085
• http://doi.org/10.1080/15476286.2016.1207036
• http://doi.org/10.2217/epi-2019-0295
• http://doi.org/10.1155/2017/6218353
• http://doi.org/10.18632/aging.103264
• http://doi.org/10.3389/fgene.2018.00034
• http://doi.org/10.3389/fmolb.2020.00091
• http://doi.org/10.3390/cancers12051091
• http://doi.org/10.12688/f1000research.25060.1
• http://doi.org/10.1080/15476286.2020.1853977
• http://doi.org/10.1111/jcmm.15572
• http://doi.org/10.1016/j.omtn.2019.10.015
• http://doi.org/10.1016/j.critrevonc.2019.102854
• http://doi.org/10.1134/S1068162017020133
• http://doi.org/10.1038/mt.2013.101
• http://doi.org/10.1038/s41388-019-0699-4
• http://doi.org/10.1016/j.aca.2019.12.027
• http://doi.org/10.1007/s12031-015-0694-3
• http://doi.org/10.1016/j.cell.2014.09.001
• http://doi.org/10.1016/j.yexcr.2016.01.017
• http://doi.org/10.1042/BSR20180542
• http://doi.org/10.1002/jcb.26884
• http://doi.org/10.13070/mm.en.2.203
• http://doi.org/10.3892/ol.2017.7265
• http://doi.org/10.3389/fgene.2019.01409
• http://doi.org/10.1016/j.tig.2019.08.004
• http://doi.org/10.1126/sciadv.abb7426
• http://doi.org/10.1016/j.tjog.2019.09.007
• http://doi.org/10.1016/j.jmb.2015.05.019
• http://doi.org/10.3390/cells7110199
• http://doi.org/10.5802/crbiol.1
• http://doi.org/10.1093/noajnl/vdz023
• http://doi.org/10.1038/srep38820
• http://doi.org/10.1038/onc.2017.361
• http://doi.org/10.4236/abb.2015.66043
• http://doi.org/10.1186/s13046-019-1071-9
• http://doi.org/10.1186/s12859-016-0881-4
• http://doi.org/10.1016/j.biopsych.2016.02.021
• http://doi.org/10.1080/15384047.2018.1480889
• http://doi.org/10.1038/s41576-019-0158-7
• http://doi.org/10.18632/oncotarget.15288
• http://doi.org/10.1042/BST20170469
• http://doi.org/10.1002/jcp.29370
• http://doi.org/10.1016/j.cca.2018.01.026
• http://doi.org/10.1002/wfs2.1407
• http://doi.org/10.1080/10409238.2016.1276882
• http://doi.org/10.1002/jcp.28156
• http://doi.org/10.1007/s11010-020-03900-w
• http://doi.org/10.1038/s41598-020-65920-2
• http://doi.org/10.3390/ijms21228591
• http://doi.org/10.1007/s13277-015-3093-z
• http://doi.org/10.1042/BSR20181641
• http://doi.org/10.1016/j.jtbi.2019.01.031
• http://doi.org/10.1002/2211-5463.12981
• http://doi.org/10.1089/gtmb.2019.29050.gde
• http://doi.org/10.1186/s12864-019-6154-7
• http://doi.org/10.1007/s13238-015-0202-0
• http://doi.org/10.18632/oncotarget.21183
• http://doi.org/10.1039/C6MB00568C
• http://doi.org/10.1111/cas.14511
• http://doi.org/10.1016/j.bbrc.2018.02.036
• http://doi.org/10.1038/s41388-019-0933-0
• http://doi.org/10.3390/ncrna5010013
• http://doi.org/10.1016/j.canlet.2016.03.022
• http://doi.org/10.1016/j.isci.2020.101345
• http://doi.org/10.3390/ijms21186975
• http://doi.org/10.1186/s13048-020-00709-5
• http://doi.org/10.3390/ijms20184385
• http://doi.org/10.3390/ijms20030627
• http://doi.org/10.1016/j.ncrna.2018.02.002
• http://doi.org/10.3389/fmolb.2020.577938
• http://doi.org/10.3389/fnmol.2018.00304
• http://doi.org/10.1093/bib/bbz080
• http://doi.org/10.1186/s12935-020-01302-y
• http://doi.org/10.1016/j.ygeno.2016.07.004
• http://doi.org/10.1186/s12929-019-0523-z
• http://doi.org/10.3390/ijms20163988
• http://doi.org/10.3390/ijms21175972
• http://doi.org/10.1080/15476286.2018.1486659
• http://doi.org/10.1186/s13059-019-1685-4
• http://doi.org/10.1016/j.neulet.2020.135050
• http://doi.org/10.4161/epi.26405
• http://doi.org/10.1016/j.bbagrm.2015.07.007
• http://doi.org/10.1093/cvr/cvz227
• http://doi.org/10.1007/s00414-017-1690-7
• http://doi.org/10.1038/onc.2013.570
• http://doi.org/10.1101/gad.314856.118
• http://doi.org/10.1002/jcla.22726
• http://doi.org/10.1038/s41568-020-00306-0
• http://doi.org/10.2217/epi.16.3
• http://doi.org/10.1080/15476286.2015.1128065
• http://doi.org/10.1016/j.cca.2020.07.042
• http://doi.org/10.1016/j.cels.2018.05.007
• http://doi.org/10.3389/fgene.2019.00390
• http://doi.org/10.1016/S2095-3119(18)61976-8
• http://doi.org/10.1007/s13402-014-0180-x
• http://doi.org/10.1186/s11658-019-0178-5
• http://doi.org/10.1186/s13046-020-01555-5
• http://doi.org/10.1016/j.bbrc.2018.05.114
• http://doi.org/10.1093/pcp/pcz043
• http://doi.org/10.1016/j.bbagrm.2019.02.011
• http://doi.org/10.1016/j.omtn.2019.08.026
• http://doi.org/10.1016/j.bbagrm.2014.03.015
• http://doi.org/10.3390/ncrna4040038
• http://doi.org/10.1080/20013078.2018.1424473
• http://doi.org/10.1111/ppl.12600
• http://doi.org/10.1016/j.ymthe.2019.07.001
• http://doi.org/10.1016/j.gene.2020.144652
• http://doi.org/10.3892/mmr.2019.10637
• http://doi.org/10.1016/j.ebiom.2018.07.036
• http://doi.org/10.1016/j.prp.2019.152507
• http://doi.org/10.3390/cells9061544
• http://doi.org/10.7717/peerj.4500
• http://doi.org/10.1080/15476286.2015.1020271
• http://doi.org/10.1080/15476286.2015.1132069
• http://doi.org/10.1016/j.clinre.2019.07.005
• http://doi.org/10.3389/fimmu.2020.00545
• http://doi.org/10.1128/mBio.00071-19
• http://doi.org/10.1038/emboj.2013.53
• http://doi.org/10.1073/pnas.1405528111
• http://doi.org/10.1007/s12035-017-0533-3
• http://doi.org/10.1016/j.molcel.2018.06.034
• http://doi.org/10.1073/pnas.1418445112
• http://doi.org/10.3748/wjg.v25.i16.1964
• http://doi.org/10.1093/bib/bbw045
• http://doi.org/10.1042/BSR20170750
• http://doi.org/10.1016/j.semcdb.2020.08.003
• http://doi.org/10.1186/s13073-019-0614-1
• http://doi.org/10.1016/j.bbagrm.2019.04.005
• http://doi.org/10.1016/j.isci.2019.08.058
• http://doi.org/10.1186/s13046-020-01592-0
• http://doi.org/10.1007/s12035-016-0055-4
• http://doi.org/10.3389/fpls.2017.01678
• http://doi.org/10.1016/j.molmet.2018.01.010
• http://doi.org/10.1016/j.molcel.2012.07.033
• http://doi.org/10.1038/s42255-019-0078-z
• http://doi.org/10.3389/fgene.2019.00603
• http://doi.org/10.1155/2019/2624586
• http://doi.org/10.3389/fonc.2020.00663
• http://doi.org/10.1016/j.biopha.2018.12.116
• http://doi.org/10.1186/s12943-018-0934-6
• http://doi.org/10.1002/jcla.22333
• http://doi.org/10.1186/s12864-019-6020-7
• http://doi.org/10.1093/toxsci/kfaa173
• http://doi.org/10.7717/peerj.6831
• http://doi.org/10.1038/s41598-019-52932-w
• http://doi.org/10.1007/s12192-013-0456-5
• http://doi.org/10.1016/j.ekir.2018.05.012
• http://doi.org/10.3390/genes11040414
• http://doi.org/10.1016/j.gpb.2016.03.005
• http://doi.org/10.1016/j.biochi.2015.05.020
• http://doi.org/10.1038/onc.2015.318
• http://doi.org/10.18632/oncotarget.16709
• http://doi.org/10.3390/cells9081815
• http://doi.org/10.1016/j.tins.2016.06.006
• http://doi.org/10.1371/journal.pone.0159093
• http://doi.org/10.1186/s12864-018-4456-9
• http://doi.org/10.1186/s12920-020-00817-7
• http://doi.org/10.1038/cdd.2017.86
• http://doi.org/10.1080/19491034.2016.1179408
• http://doi.org/10.1186/s12943-019-1069-0
• http://doi.org/10.1016/j.diff.2020.03.001
• http://doi.org/10.1038/ncomms14741
• http://doi.org/10.1007/s00018-019-03345-5
• http://doi.org/10.3389/fgene.2019.00088
• http://doi.org/10.1016/j.fsigen.2020.102312
• http://doi.org/10.18632/aging.101254
• http://doi.org/10.1177/1533033819886867
• http://doi.org/10.1080/07352689.2020.1857602
• http://doi.org/10.3389/fncir.2017.00076
• http://doi.org/10.3390/cells8060616
• http://doi.org/10.3892/mmr.2015.4264
• http://doi.org/10.1016/j.omtn.2019.11.032
• http://doi.org/10.1097/CM9.0000000000000867
• http://doi.org/10.1080/17474124.2020.1715211
• http://doi.org/10.1016/j.gene.2019.03.030
• http://doi.org/10.1016/j.ygeno.2019.12.014
• http://doi.org/10.1177/1533033820945799
• http://doi.org/10.3390/cells9081806
• http://doi.org/10.2217/bmm-2020-0167
• http://doi.org/10.1016/j.celrep.2016.03.058
• http://doi.org/10.3892/mmr.2017.6871
• http://doi.org/10.1186/s12859-018-2298-8
• http://doi.org/10.3892/or.2017.5415
• http://doi.org/10.1111/jnc.14724
• http://doi.org/10.1016/j.ygeno.2020.09.035
• http://doi.org/10.1093/jnci/djx166
• http://doi.org/10.1007/s00109-017-1603-8
• http://doi.org/10.1371/journal.pone.0203850
• http://doi.org/10.1016/j.ymeth.2013.04.003
• http://doi.org/10.1038/s41598-019-48224-y
• http://doi.org/10.1002/jcp.29558
• http://doi.org/10.1016/j.bbrc.2018.04.215
• http://doi.org/10.1186/s12906-020-03009-z
• http://doi.org/10.1016/j.jmb.2015.02.018
• http://doi.org/10.1007/s12035-016-0213-8
• http://doi.org/10.1038/s41388-019-1138-2
• http://doi.org/10.1038/s41467-020-18355-2
• http://doi.org/10.3892/or.2015.3904
• http://doi.org/10.1371/journal.pcbi.1007568
• http://doi.org/10.1016/j.isci.2020.101842
• http://doi.org/10.1093/cvr/cvw250
• http://doi.org/10.1016/j.tibs.2015.03.001
• http://doi.org/10.1111/jcmm.13587
• http://doi.org/10.1007/s00109-017-1582-9
• http://doi.org/10.1042/BSR20190363
• http://doi.org/10.1093/nar/gkz718
• http://doi.org/10.1016/j.gpb.2016.12.005
• http://doi.org/10.1016/j.gendis.2017.12.002
• http://doi.org/10.1016/j.bbagrm.2019.05.002
• http://doi.org/10.1007/s12265-019-09912-2
• http://doi.org/10.1080/2159256X.2015.1045682
• http://doi.org/10.3389/fpls.2016.02024
• http://doi.org/10.3390/ijms16035682
• http://doi.org/10.1016/j.biopha.2018.12.052
• http://doi.org/10.1080/15476286.2016.1227905
• http://doi.org/10.1002/jcb.28610
• http://doi.org/10.1186/s41544-019-0046-5
• http://doi.org/10.1186/s13046-020-01556-4
• http://doi.org/10.2147/CMAR.S267927
• http://doi.org/10.18632/oncotarget.21766
• http://doi.org/10.3390/ijms20092150
• http://doi.org/10.1038/ni.3771
• http://doi.org/10.1139/cjpp-2018-0505
• http://doi.org/10.1016/j.pneurobio.2016.11.001
• http://doi.org/10.1093/jb/mvt113
• http://doi.org/10.1002/wrna.1528
• http://doi.org/10.2217/epi-2015-0019
• http://doi.org/10.1042/CS20190715
• http://doi.org/10.1080/15476286.2015.1122162
• http://doi.org/10.18632/aging.102405
• http://doi.org/10.2147/CMAR.S259393
• http://doi.org/10.15252/embj.201592655
• http://doi.org/10.1371/journal.pcbi.1005420
• http://doi.org/10.18632/oncotarget.21835
• http://doi.org/10.1016/j.gene.2017.10.016
• http://doi.org/10.1080/15476286.2019.1621621
• http://doi.org/10.1126/science.1238522
• http://doi.org/10.1016/j.cca.2017.01.025
• http://doi.org/10.1016/j.omtn.2017.04.004
• http://doi.org/10.1038/s10038-020-00826-5
• http://doi.org/10.1093/nar/gkz576
• http://doi.org/10.1007/s12031-018-1125-z
• http://doi.org/10.1111/febs.15639
• http://doi.org/10.3892/ol.2019.10168
• http://doi.org/10.1093/nar/gkw027
• http://doi.org/10.20900/mo.20190025
• http://doi.org/10.3389/fgene.2019.00407
• http://doi.org/10.1186/s13059-015-0690-5
• http://doi.org/10.1038/s41467-018-06862-2
• http://doi.org/10.1186/s12943-019-0986-2
• http://doi.org/10.4251/wjgo.v11.i10.909
• http://doi.org/10.1093/bioinformatics/btu257
• http://doi.org/10.3390/ijms21051754
• http://doi.org/10.1038/s41598-017-12550-w
• http://doi.org/10.3390/cancers11101473
• http://doi.org/10.1038/cr.2017.31
• http://doi.org/10.1016/j.tibtech.2019.07.008
• http://doi.org/10.2147/CMAR.S245525
• http://doi.org/10.1371/journal.pone.0164085
• http://doi.org/10.1002/jcp.28900
• http://doi.org/10.3389/fgene.2020.00095
• http://doi.org/10.1186/s12859-019-2966-3
• http://doi.org/10.1016/j.bbrc.2019.12.096
• http://doi.org/10.1016/j.cca.2019.10.026
• http://doi.org/10.1155/2017/5135781
• http://doi.org/10.1007/s12035-018-0903-5
• http://doi.org/10.3389/fmolb.2017.00038
• http://doi.org/10.1007/s00018-015-1934-y
• http://doi.org/10.1093/bib/bbz175
• http://doi.org/10.1016/j.gene.2020.144386
• http://doi.org/10.1093/bib/bbx070
• http://doi.org/10.1016/j.jplph.2020.153188
• http://doi.org/10.1042/BSR20190621
• http://doi.org/10.1246/bcsj.20200235
• http://doi.org/10.1093/nar/gkx453
• http://doi.org/10.1016/j.tig.2017.05.004
• http://doi.org/10.1161/JAHA.117.006642
• http://doi.org/10.1080/21541264.2015.1071301
• http://doi.org/10.1136/gutjnl-2014-307891
• http://doi.org/10.1038/nn.3975
• http://doi.org/10.18632/oncotarget.12186
• http://doi.org/10.1016/j.bbagrm.2015.06.003
• http://doi.org/10.1002/1873-3468.12500
• http://doi.org/10.3390/cells9081841
• http://doi.org/10.3892/ol.2015.3698
• http://doi.org/10.1038/s41598-017-05922-9
• http://doi.org/10.1089/wound.2019.0956
• http://doi.org/10.3389/fgene.2019.00940
• http://doi.org/10.3390/cells9030659
• http://doi.org/10.3390/cells9051240
• http://doi.org/10.1007/s12031-020-01698-2
• http://doi.org/10.1016/j.celrep.2014.10.062
• http://doi.org/10.1182/blood-2015-06-649434
• http://doi.org/10.1093/nar/gkaa704
• http://doi.org/10.1016/j.prp.2020.153075
• http://doi.org/10.3892/ijo.2018.4566
• http://doi.org/10.5306/wjco.v11.i8.563
• http://doi.org/10.1016/j.semcdb.2016.06.013
• http://doi.org/10.1186/s12911-020-1117-0
• http://doi.org/10.1016/j.canlet.2015.06.003
• http://doi.org/10.1186/s13048-018-0381-4
• http://doi.org/10.1371/journal.pone.0141214
• http://doi.org/10.1007/s12250-020-00275-6
• http://doi.org/10.3390/genes7120116
• http://doi.org/10.1158/0008-5472.CAN-18-0532
• http://doi.org/10.2217/bmm-2018-0447
• http://doi.org/10.1016/j.canlet.2017.11.022
• http://doi.org/10.3389/fimmu.2020.569524
• http://doi.org/10.1038/onc.2017.89
• http://doi.org/10.1007/s12551-018-0439-y
• http://doi.org/10.1002/cam4.3332
• http://doi.org/10.1126/science.aam8526
• http://doi.org/10.1038/s41598-018-37037-0
• http://doi.org/10.1186/s40659-019-0228-5
• http://doi.org/10.1111/gbb.12444
• http://doi.org/10.1093/bioinformatics/bty785
• http://doi.org/10.1080/15476286.2019.1669391
• http://doi.org/10.1093/bioinformatics/btz038
• http://doi.org/10.1002/JLB.2RU0619-213R
• http://doi.org/10.1186/s13054-020-03146-4
• http://doi.org/10.1155/2019/2756516
• http://doi.org/10.1097/MD.0000000000017488
• http://doi.org/10.1042/BSR20191961
• http://doi.org/10.1007/s13238-020-00799-3
• http://doi.org/10.1016/j.compbiolchem.2016.02.003
• http://doi.org/10.1186/s12864-015-1603-4
• http://doi.org/10.1242/dev.128074
• http://doi.org/10.1002/bies.201200140
• http://doi.org/10.1186/s12943-020-01224-3
• http://doi.org/10.1261/rna.071654.119
• http://doi.org/10.18632/oncotarget.18998
• http://doi.org/10.12677/ACM.2020.1011424
• http://doi.org/10.1016/j.yjmcc.2019.09.016
• http://doi.org/10.1016/j.ghir.2019.05.002
• http://doi.org/10.3390/ijms17010132
• http://doi.org/10.1002/cbf.3611
• http://doi.org/10.1186/s12943-018-0877-y
• http://doi.org/10.3390/jcm9030640
• http://doi.org/10.1007/s10620-018-5382-z
• http://doi.org/10.3390/ncrna5040054
• http://doi.org/10.1242/dev.175786
• http://doi.org/10.1152/physiolgenomics.00096.2018
• http://doi.org/10.1016/j.tig.2016.03.002
• http://doi.org/10.3389/fgene.2016.00100
• http://doi.org/10.1002/1878-0261.12412
• http://doi.org/10.1007/s00439-018-1955-3
• http://doi.org/10.1016/j.cell.2019.01.025
• http://doi.org/10.1016/j.bbcan.2018.06.002
• http://doi.org/10.1038/s41598-019-47189-2
• http://doi.org/10.1016/j.canlet.2020.04.006
• http://doi.org/10.1021/acs.jpcb.9b06831
• http://doi.org/10.1093/carcin/bgy061
• http://doi.org/10.1186/s12943-019-1002-6
• http://doi.org/10.1158/0008-5472.CAN-15-1989
• http://doi.org/10.3389/fpls.2020.00003
• http://doi.org/10.1038/s12276-018-0125-y
• http://doi.org/10.2217/epi-2018-0167
• http://doi.org/10.1016/j.tig.2015.02.002
• http://doi.org/10.1186/s40659-018-0194-3
• http://doi.org/10.1097/FJC.0000000000000841
• http://doi.org/10.1016/j.gene.2020.144625
• http://doi.org/10.1016/j.bbrc.2020.03.084
• http://doi.org/10.1016/j.ajhg.2017.11.002
• http://doi.org/10.1002/jcla.23409
• http://doi.org/10.1080/15384047.2019.1617563
• http://doi.org/10.1016/j.gdata.2015.07.017
• http://doi.org/10.1038/nrg.2016.46
• http://doi.org/10.1007/s12094-018-1839-y
• http://doi.org/10.1016/j.bbrc.2018.04.041
• http://doi.org/10.1039/C9MO00025A
• http://doi.org/10.4155/pbp.14.65
• http://doi.org/10.1002/jez.b.22542
• http://doi.org/10.1080/21691401.2019.1593999
• http://doi.org/10.1016/j.ibmb.2020.103430
• http://doi.org/10.3390/ijms19102897
• http://doi.org/10.1080/15476286.2016.1218588
• http://doi.org/10.3389/fphar.2019.00428
• http://doi.org/10.3390/genes8120353
• http://doi.org/10.3389/fmolb.2019.00146
• http://doi.org/10.1016/j.canlet.2017.07.002
• http://doi.org/10.17116/molgen202038031103
• http://doi.org/10.1016/j.talanta.2020.121021
• http://doi.org/10.1186/s13046-019-1487-2
• http://doi.org/10.3892/ijo.2017.4162
• http://doi.org/10.1038/494415a
• http://doi.org/10.1038/s41598-017-16344-y
• http://doi.org/10.1186/s12864-019-5462-2
• http://doi.org/10.1016/j.ebiom.2020.102848
• http://doi.org/10.1021/acs.jproteome.7b00707
• http://doi.org/10.1016/j.ajog.2015.07.046
• http://doi.org/10.1111/jcmm.14791
• http://doi.org/10.1038/s41598-018-35001-6
• http://doi.org/10.1016/j.canlet.2018.02.014
• http://doi.org/10.1002/jcp.29950
• http://doi.org/10.1016/j.bbagrm.2018.10.006
• http://doi.org/10.1146/annurev-genet-120417-031522
• http://doi.org/10.3390/v12111338
• http://doi.org/10.1177/1933719118759439
• http://doi.org/10.1038/s41386-019-0348-1
• http://doi.org/10.1016/j.bbrc.2016.07.032
• http://doi.org/10.1016/j.jfca.2018.12.004
• http://doi.org/10.3892/mmr.2019.10866
• http://doi.org/10.1016/j.suronc.2018.06.003
• http://doi.org/10.3389/fcell.2020.00850
• http://doi.org/10.2217/epi-2019-0124
• http://doi.org/10.1016/j.canlet.2019.05.036
• http://doi.org/10.1016/j.yexcr.2018.05.002
• http://doi.org/10.1101/gr.255463.119
• http://doi.org/10.18632/oncotarget.7266
• http://doi.org/10.1097/MD.0000000000003811
• http://doi.org/10.1507/endocrj.EJ18-0291
• http://doi.org/10.3892/ol.2018.8700
• http://doi.org/10.1016/j.molcel.2017.02.017
• http://doi.org/10.1155/2016/1579490
• http://doi.org/10.1038/srep38907
• http://doi.org/10.3389/fcvm.2018.00145
• http://doi.org/10.1186/s13148-018-0586-9
• http://doi.org/10.1080/15476286.2019.1649585
• http://doi.org/10.1016/j.bbrc.2019.12.116
• http://doi.org/10.1007/s13258-017-0576-x
• http://doi.org/10.7717/peerj.5503
• http://doi.org/10.1016/j.jbiotec.2016.09.011
• http://doi.org/10.1007/s12282-017-0793-9
• http://doi.org/10.1371/journal.pone.0204931
• http://doi.org/10.1016/j.celrep.2014.05.031
• http://doi.org/10.3390/cells8010015
• http://doi.org/10.1016/j.cca.2015.02.018
• http://doi.org/10.18632/oncotarget.16442
• http://doi.org/10.1038/ncomms12429
• http://doi.org/10.1373/clinchem.2014.230433
• http://doi.org/10.1016/j.tig.2016.02.001
• http://doi.org/10.3390/cells8090988
• http://doi.org/10.1002/wrna.1538
• http://doi.org/10.1111/exd.13502
• http://doi.org/10.1080/10495398.2020.1856125
• http://doi.org/10.1002/1873-3468.12440
• http://doi.org/10.1097/MD.0000000000007354
• http://doi.org/10.5483/BMBRep.2019.52.1.296
• http://doi.org/10.1186/s12943-018-0889-7
• http://doi.org/10.3390/genes11050489
• http://doi.org/10.1111/age.12781
• http://doi.org/10.1038/nbt.2890
• http://doi.org/10.1016/j.cell.2016.03.020
• http://doi.org/10.1080/15384101.2019.1617004
• http://doi.org/10.1002/1873-3468.12868
• http://doi.org/10.1016/j.gpb.2018.08.001
• http://doi.org/10.1016/j.omtn.2019.02.005
• http://doi.org/10.1186/s13059-014-0409-z
• http://doi.org/10.1038/nrg.2015.10
• http://doi.org/10.1038/nrn.2017.90
• http://doi.org/10.1016/j.yjmcc.2016.07.007
• http://doi.org/10.1080/10641963.2016.1273944
• http://doi.org/10.18632/oncotarget.23484
• http://doi.org/10.1038/nsmb.2580
• http://doi.org/10.1016/j.gene.2017.07.078
• http://doi.org/10.1016/j.biopha.2020.110385
• http://doi.org/10.18632/oncotarget.19154
• http://doi.org/10.3389/fphys.2019.00369
• http://doi.org/10.3389/fbioe.2015.00077
• http://doi.org/10.1093/jmcb/mjz080
• http://doi.org/10.3390/ani9100797
• http://doi.org/10.5483/BMBRep.2013.46.3.171
• http://doi.org/10.1371/journal.ppat.1007206
• http://doi.org/10.1016/j.gene.2020.145113
• http://doi.org/10.3389/fcell.2020.00050
• http://doi.org/10.1007/s11427-019-1605-0
• http://doi.org/10.1016/j.molp.2015.12.021
• http://doi.org/10.1016/j.ymeth.2018.10.022
• http://doi.org/10.1186/s13578-020-00394-3
• http://doi.org/10.1016/j.celrep.2017.08.027
• http://doi.org/10.1186/s12864-016-3476-6
• http://doi.org/10.1186/gb-2014-15-2-r34
• http://doi.org/10.1007/s11103-017-0684-7
• http://doi.org/10.1038/s41467-020-17435-7
• http://doi.org/10.3390/cells9010025
• http://doi.org/10.1016/j.canlet.2018.01.011
• http://doi.org/10.1016/j.semcancer.2018.12.002
• http://doi.org/10.1016/j.yexcr.2016.07.021
• http://doi.org/10.1073/pnas.1900391116
• http://doi.org/10.3389/fonc.2018.00179
• http://doi.org/10.1002/wrna.1307
• http://doi.org/10.18632/oncotarget.8917
• http://doi.org/10.1016/j.jpeds.2020.02.078
• http://doi.org/10.1093/nar/gkt317
• http://doi.org/10.1016/j.biocel.2013.10.009
• http://doi.org/10.1016/j.bbrc.2017.07.162
• http://doi.org/10.3389/fphys.2020.580465
• http://doi.org/10.4251/wjgo.v9.i2.62
• http://doi.org/10.1093/jmcb/mjz094
• http://doi.org/10.1097/CM9.0000000000000465
• http://doi.org/10.1016/j.gene.2017.12.020
• http://doi.org/10.1016/j.lfs.2019.01.055
• http://doi.org/10.3892/br.2018.1178
• http://doi.org/10.18632/oncotarget.21694
• http://doi.org/10.1007/s00425-018-2857-2
• http://doi.org/10.15252/embr.201643581
• http://doi.org/10.1038/s41380-020-0653-4
• http://doi.org/10.1093/cvr/cvaa020
• http://doi.org/10.1089/gtmb.2020.0034
• http://doi.org/10.2217/pme-2016-0090
• http://doi.org/10.1080/15384047.2018.1523848
• http://doi.org/10.1111/jcmm.15150
• http://doi.org/10.1016/j.biopha.2016.12.097
• http://doi.org/10.1186/s12931-018-0962-1
• http://doi.org/10.1016/j.bbrc.2018.10.200
• http://doi.org/10.1155/2016/2681925
• http://doi.org/10.1042/CS20180826
• http://doi.org/10.3390/cells9122555
• http://doi.org/10.1093/bioinformatics/btaa522
• http://doi.org/10.1002/cbic.201300415
• http://doi.org/10.1002/ajmg.c.31833
• http://doi.org/10.1124/mol.118.113977
• http://doi.org/10.1002/cbic.201900514
• http://doi.org/10.4048/jbc.2015.18.3.235
• http://doi.org/10.1093/dnares/dsx022
• http://doi.org/10.1002/jcp.29165
• http://doi.org/10.1080/15384047.2018.1507254
• http://doi.org/10.3390/cells9071574
• http://doi.org/10.1177/1010428317705850
• http://doi.org/10.1016/j.canlet.2017.03.027
• http://doi.org/10.1016/j.ncrna.2019.01.001
• http://doi.org/10.3892/ijo.2020.5049
• http://doi.org/10.1016/j.cellsig.2020.109696
• http://doi.org/10.1093/nar/gkaa187
• http://doi.org/10.1186/1471-2164-14-550
• http://doi.org/10.1016/j.bbrc.2016.01.183
• http://doi.org/10.1016/j.ncrna.2018.05.002
• http://doi.org/10.1007/s12282-020-01140-w
• http://doi.org/10.1038/s41419-019-2028-9
• http://doi.org/10.1038/srep31313
• http://doi.org/10.1016/j.omtn.2020.05.012
• http://doi.org/10.1007/s00535-020-01744-1
• http://doi.org/10.3389/fgene.2015.00175
• http://doi.org/10.1042/BSR20181900
• http://doi.org/10.1016/j.envres.2019.108825
• http://doi.org/10.1002/1878-0261.12830
• http://doi.org/10.1080/14728222.2017.1319938
• http://doi.org/10.3390/ijms19092475
• http://doi.org/10.3349/ymj.2018.59.3.349
• http://doi.org/10.1080/15476286.2016.1239009
• http://doi.org/10.3892/mmr.2018.8827
• http://doi.org/10.1038/s41598-018-26157-2
• http://doi.org/10.3390/genes10090642
• http://doi.org/10.1371/journal.pone.0200692
• http://doi.org/10.1002/cbic.202000003
• http://doi.org/10.3389/fmolb.2020.00109
• http://doi.org/10.1016/j.biochi.2015.05.005
• http://doi.org/10.1111/jcmm.16102
• http://doi.org/10.1128/MCB.00683-13
• http://doi.org/10.1007/s00239-019-09892-6
• http://doi.org/10.1038/nrg.2016.10
• http://doi.org/10.1016/j.jneuroim.2019.576971
• http://doi.org/10.3233/CBM-171109
• http://doi.org/10.1186/s13046-018-0870-8
• http://doi.org/10.1152/ajpheart.00418.2018
• http://doi.org/10.1093/nar/gky032
• http://doi.org/10.1177/1535370218813525
• http://doi.org/10.1007/s00432-016-2256-7
• http://doi.org/10.1186/s12935-020-01245-4
• http://doi.org/10.3389/fonc.2020.545460
• http://doi.org/10.1016/j.biochi.2019.06.015
• http://doi.org/10.1016/j.chemosphere.2018.02.140
• http://doi.org/10.1016/j.jtbi.2018.03.021
• http://doi.org/10.3390/ijms18091977
• http://doi.org/10.1038/s41598-019-50864-z
• http://doi.org/10.3390/genes11030301
• http://doi.org/10.1007/s12185-019-02766-z
• http://doi.org/10.3389/fonc.2020.00150
• http://doi.org/10.1038/s41598-019-45954-x
• http://doi.org/10.1038/nature11928
• http://doi.org/10.3390/genes11091111
• http://doi.org/10.1111/febs.15525
• http://doi.org/10.1186/s13073-020-00812-8
• http://doi.org/10.18632/oncotarget.13134
• http://doi.org/10.3892/ijo.2018.4371
• http://doi.org/10.1186/s12864-017-4335-9
• http://doi.org/10.1186/s12943-020-1135-7
• http://doi.org/10.1155/2019/4128315
• http://doi.org/10.1038/nature11993
• http://doi.org/10.3390/ijms140713307
• http://doi.org/10.1016/j.jdermsci.2016.05.012
• http://doi.org/10.3390/ijms21093292
• http://doi.org/10.1080/15476286.2018.1557498
• http://doi.org/10.1186/s12943-019-1003-5
• http://doi.org/10.3389/fgene.2014.00459
• http://doi.org/10.1080/15476286.2015.1076611
• http://doi.org/10.1161/JAHA.117.008261
• http://doi.org/10.1016/j.plantsci.2018.06.016
• http://doi.org/10.3389/fgene.2019.00649
• http://doi.org/10.1016/j.omtn.2019.08.024
• http://doi.org/10.1016/j.neulet.2019.02.032
• http://doi.org/10.1038/srep35576
• http://doi.org/10.1038/s41598-017-08806-0
• http://doi.org/10.1186/s12943-020-01184-8
• http://doi.org/10.1128/mBio.03059-20
• http://doi.org/10.3892/ijmm.2018.3795
• http://doi.org/10.1186/s12943-020-01187-5
• http://doi.org/10.1093/database/baz003
• http://doi.org/10.1093/nar/gkx863
• http://doi.org/10.13070/mm.en.3.203
• http://doi.org/10.1111/pbi.12336
• http://doi.org/10.1155/2019/7239206
• http://doi.org/10.1038/s41374-018-0108-6
• http://doi.org/10.1093/hmg/ddx243
• http://doi.org/10.1016/j.vph.2018.03.003
• http://doi.org/10.3390/ijms21186658
• http://doi.org/10.1007/s10048-016-0490-4
• http://doi.org/10.2142/biophys.57.005
• http://doi.org/10.3892/mmr.2020.11069
• http://doi.org/10.1186/s12859-018-2304-1
• http://doi.org/10.1016/j.molcel.2017.10.034
• http://doi.org/10.3390/diagnostics8030060
• http://doi.org/10.1016/j.omtn.2019.01.003
• http://doi.org/10.1186/s12943-018-0823-z
• http://doi.org/10.3389/fcell.2020.594992
• http://doi.org/10.1371/journal.pone.0202375
• http://doi.org/10.1093/nar/gkv940
• http://doi.org/10.2217/pme-2020-0103
• http://doi.org/10.1093/nar/gkv045
• http://doi.org/10.1371/journal.pgen.1007114
• http://doi.org/10.1016/j.semcdb.2017.11.012
• http://doi.org/10.1016/j.jsbmb.2019.105425
• http://doi.org/10.1016/j.tig.2020.10.008
• http://doi.org/10.1134/S0026893320050131
• http://doi.org/10.1016/j.omtn.2019.12.027
• http://doi.org/10.1093/nar/gku643
• http://doi.org/10.1186/s13048-019-0558-5
• http://doi.org/10.3389/fgene.2020.00999
• http://doi.org/10.3389/fgene.2015.00002
• http://doi.org/10.1093/nar/gkv1458
• http://doi.org/10.1186/s12935-019-0994-8
• http://doi.org/10.1093/bib/bbaa001
• http://doi.org/10.2147/OTT.S242482
• http://doi.org/10.1038/nrgastro.2017.169
• http://doi.org/10.1038/s41598-018-29360-3
• http://doi.org/10.1038/bcj.2016.81
• http://doi.org/10.1186/s12935-019-1011-y
• http://doi.org/10.1186/s12864-017-4029-3
• http://doi.org/10.1186/s12885-019-5967-8
• http://doi.org/10.1016/j.biocel.2018.04.016
• http://doi.org/10.1016/j.tibs.2020.08.006
• http://doi.org/10.1080/15476286.2019.1710054
• http://doi.org/10.1016/j.omtn.2018.09.025
• http://doi.org/10.3390/plants8090302
• http://doi.org/10.3390/ijms15069331
• http://doi.org/10.1016/j.omtn.2019.06.021
• http://doi.org/10.1016/j.gene.2018.02.030
• http://doi.org/10.1007/s11596-017-1822-9
• http://doi.org/10.1007/s11011-019-00497-y
• http://doi.org/10.1007/s00018-015-1990-3
• http://doi.org/10.1080/15476286.2019.1565284
• http://doi.org/10.1016/j.molcel.2015.03.027
• http://doi.org/10.1016/j.jtbi.2015.12.003
• http://doi.org/10.1016/j.bbagrm.2019.194410
• http://doi.org/10.3389/fcell.2020.00389
• http://doi.org/10.1038/s41598-018-25242-w
• http://doi.org/10.3390/ijms19113454
• http://doi.org/10.3389/fgene.2020.591806
• http://doi.org/10.1038/nrg.2016.114
• http://doi.org/10.3389/fphys.2018.01262
• http://doi.org/10.1242/dev.182725
• http://doi.org/10.1007/s40484-017-0112-7
• http://doi.org/10.1186/s40478-019-0674-x
• http://doi.org/10.1002/arch.21735
• http://doi.org/10.1021/acs.molpharmaceut.0c00618
• http://doi.org/10.3389/fpls.2019.00379
• http://doi.org/10.1002/1873-3468.13119
• http://doi.org/10.3892/ol.2019.10880
• http://doi.org/10.1016/j.gdata.2014.07.005
• http://doi.org/10.1002/jcb.29703
• http://doi.org/10.1177/1535370217708978
• http://doi.org/10.1016/j.cell.2015.02.014
• http://doi.org/10.3892/etm.2019.8288
• http://doi.org/10.3390/ijms21217864
• http://doi.org/10.1016/j.prp.2019.04.011
• http://doi.org/10.1038/s41401-018-0063-1
• http://doi.org/10.1038/s41598-018-21300-5
• http://doi.org/10.1093/bib/bby111
• http://doi.org/10.1097/CM9.0000000000000908
• http://doi.org/10.1161/CIRCRESAHA.116.309303
• http://doi.org/10.1016/j.exer.2018.05.026
• http://doi.org/10.1161/CIRCRESAHA.119.315856
• http://doi.org/10.1016/j.yjmcc.2018.08.012
• http://doi.org/10.1080/08830185.2019.1648454
• http://doi.org/10.1177/1533033820957026
• http://doi.org/10.1038/srep16435
• http://doi.org/10.3390/ijms20030735
• http://doi.org/10.1038/s41587-019-0090-6
• http://doi.org/10.1016/j.mad.2018.05.001
• http://doi.org/10.1111/jcmm.13789
• http://doi.org/10.3390/ijms20133148
• http://doi.org/10.1038/s41417-019-0130-x
• http://doi.org/10.3389/fcell.2020.569977
• http://doi.org/10.1038/s41467-019-11777-7
• http://doi.org/10.1016/j.omtn.2018.08.008
• http://doi.org/10.1080/15476286.2016.1271524
• http://doi.org/10.1089/neu.2018.6366
• http://doi.org/10.18632/aging.102091
• http://doi.org/10.1111/nph.13585
• http://doi.org/10.1016/j.bbagrm.2016.07.009
• http://doi.org/10.3389/fonc.2019.01549
• http://doi.org/10.3389/fimmu.2019.01186
• http://doi.org/10.2147/OTT.S253936
• http://doi.org/10.3892/ijmm.2018.3740
• http://doi.org/10.1038/s41598-018-31719-5
• http://doi.org/10.1007/s12031-018-1211-2
• http://doi.org/10.1161/CIRCRESAHA.115.306319
• http://doi.org/10.3390/cells9061473
• http://doi.org/10.3390/cancers12020320
• http://doi.org/10.1186/s12979-015-0042-z
• http://doi.org/10.1016/j.genrep.2017.08.001
• http://doi.org/10.1080/15476286.2018.1435248
• http://doi.org/10.1007/s12250-020-00255-w
• http://doi.org/10.1038/s41440-019-0294-7
• http://doi.org/10.1007/s11605-020-04834-w
• http://doi.org/10.1186/s12864-020-6599-8
• http://doi.org/10.1038/s41598-017-14807-w
• http://doi.org/10.1002/1873-3468.13253
• http://doi.org/10.1016/j.lfs.2020.118420
• http://doi.org/10.1016/j.trecan.2020.01.012
• http://doi.org/10.1038/srep40342
• http://doi.org/10.1155/2017/4723193
• http://doi.org/10.1016/j.lfs.2020.118511
• http://doi.org/10.1007/s00059-017-4660-4
• http://doi.org/10.1093/biomethods/bpaa010
• http://doi.org/10.1261/rna.064394.117
• http://doi.org/10.1097/HCO.0000000000000054
• http://doi.org/10.1080/15476286.2016.1255398
• http://doi.org/10.1016/j.margen.2016.12.004
• http://doi.org/10.1111/nph.14901
• http://doi.org/10.1016/j.gene.2017.12.064
• http://doi.org/10.3390/ijms21030792

DataCite

Europe PMC Citations | Further Information

Europe PMC Database Citations | Further Information

{"ARXPR"=>1, "OMIM"=>4}

PubMed Central | Further Information

• 3732940
• 4034220
• 4343165
• 3695527
• 4132752
• 4344496
• 4482092
• 4053862
• 4056463
• 4165365
• 4316645
• 4506483
• 3751903
• 4137096
• 4465157
• 3616293
• 3811677
• 4201285
• 3875859
• 4315302
• 4448684
• 3933615
• 4597608
• 3801300
• 3821980
• 4063205
• 4096963
• 4113058
• 4121655
• 4141855
• 4279448
• 4332885
• 3543092
• 4201819
• 4238349
• 4647462
• 3764148
• 4376664
• 3946582
• 3946716
• 4617279
• 3507147
• 4345829
• 4207428
• 3742188
• 3794782
• 4100097
• 4394499
• 4631972
• 3677299
• 3928172
• 3849169
• 4600687
• 4306919
• 4515639
• 4639774
• 4396047
• 3875874
• 3906566
• 4047558
• 4285795
• 4306305
• 4423433
• 4665929
• 4479058
• 4402329
• 4656206
• 4453482
• 4133869
• 4535946
• 4583707

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84863045982"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84863045982?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863045982&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84863045982&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84863045982", "dc:identifier"=>"SCOPUS_ID:84863045982", "eid"=>"2-s2.0-84863045982", "dc:title"=>"Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types", "dc:creator"=>"Salzman J.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"7", "prism:issueIdentifier"=>"2", "prism:pageRange"=>nil, "prism:coverDate"=>"2012-02-01", "prism:coverDisplayDate"=>"1 February 2012", "prism:doi"=>"10.1371/journal.pone.0030733", "citedby-count"=>"1134", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Stanford University School of Medicine", "affiliation-city"=>"Stanford", "affiliation-country"=>"United States"}], "pubmed-id"=>"22319583", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e30733", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}, {"$"=>"repositoryam"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}

Web of Science® | Further Information

Article Coverage

• {"referral"=>"http://www.bio360.net/news/show/3995.html", "language"=>"English", "title"=>"Nature：两项研究证实环状RNA影响基因表达 --分子--新闻 --生物360 --中文生命科学界资讯站", "type"=>"Blog", "publication"=>"", "published_on"=>"", "link_state"=>""}
• {"referral"=>"http://www.circbase.org/", "language"=>"", "title"=>"circBase", "type"=>"Discussion board", "publication"=>"", "published_on"=>"", "link_state"=>""}

Article Coverage Curated

Facebook

• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0030733", "share_count"=>1, "like_count"=>5, "comment_count"=>1, "click_count"=>0, "total_count"=>7}

Journal Comments | Further Information

• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/14b1d2e0-6254-4b4a-a2d6-e78d396b9007", "title"=>"Media Coverage of This Article", "body"=>"The following article represents some of the media coverage that has occurred for this paper:\n\nPublication: The Scientist \nTitle: “RNA Chases Its Tail | The Scientist”\nhttp://the-scientist.com/2012/02/02/rna-chases-its-tail\n\nPublication: Science Codex \nTitle: “Circular RNAs more common than previously thought | Science Codex”\nhttp://www.sciencecodex.com/read/circular_rnas_more_common_than_previously_thought-85312\n\nPublication: Eureka Alert \nTitle: “Circular RNAs more common than previously thought”\nhttp://www.eurekalert.org/pub_releases/2012-02/plos-crm013012.php\n\nIf you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article. ", "isRemoved"=>false, "created"=>"2012-02-03T23:47:24Z", "lastModified"=>"2012-02-03T23:47:24Z", "creator"=>{"userId"=>"80539"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"PLoS ONE Staff"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0030733", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2012-02-03T23:47:24Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/b87bdac2-96e3-41e5-8335-e744b3c5ca1f", "title"=>"Note on missing panel in Figure 4", "body"=>"The top left panel of Figure 4 was lost during the production process. It can be found at http://www.stanford.edu/~horence/original-figure4.eps. ", "isRemoved"=>false, "created"=>"2014-08-19T00:03:19Z", "lastModified"=>"2014-08-19T00:03:19Z", "creator"=>{"userId"=>"402815"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0030733", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2014-08-19T00:03:19Z", "replies"=>[]}

Nature

Reddit

Research Blogging | Further Information

ScienceSeeker | Further Information

Twitter

• {"id"=>"307133029388783618", "text"=>"Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types Salzman 2012 http://t.co/39t2fIAjpE", "created_at"=>"2013-02-28T14:19:55Z", "user"=>"Jen_Angela", "user_name"=>"Jennifer Angela", "user_profile_image"=>"http://a0.twimg.com/profile_images/1616591058/RTIpartyJen2_normal.jpg"}
• {"id"=>"307514824802312192", "text"=>"PLOS ONE: Circular #RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes... http://t.co/UObPmlCzLQ #rnomics_rna @MyEN", "created_at"=>"2013-03-01T15:37:02Z", "user"=>"rnomics", "user_name"=>"Fabrice Leclerc", "user_profile_image"=>"http://a0.twimg.com/profile_images/1607343775/Imagen19_2x_normal.png"}
• {"id"=>"308957572906500096", "text"=>"Reading the Salzman paper that initially detected many circular RNAs by RNA-seq analysis alone. Lovely. http://t.co/2RH0PaPG9c", "created_at"=>"2013-03-05T15:10:00Z", "user"=>"joe_pickrell", "user_name"=>"Joe Pickrell", "user_profile_image"=>"http://a0.twimg.com/profile_images/1397871733/cuba_normal.jpg"}
• {"id"=>"308958510350213121", "text"=>"I and presumably many others were doing similar analyses, never noticed this. Chance and the prepared mind indeed.. http://t.co/2RH0PaPG9c", "created_at"=>"2013-03-05T15:13:43Z", "user"=>"joe_pickrell", "user_name"=>"Joe Pickrell", "user_profile_image"=>"http://a0.twimg.com/profile_images/1397871733/cuba_normal.jpg"}
• {"id"=>"332071926581309440", "text"=>"Circular RNAs discovered by a comput'nal statistician, Julia Salzman, published @PLOSONE 2012. #Howcoolisthat #bog13 http://t.co/Z9JwfnQ3ZX", "created_at"=>"2013-05-08T09:58:11Z", "user"=>"KevinADavies", "user_name"=>"Kevin Davies", "user_profile_image"=>"http://a0.twimg.com/profile_images/2959353264/17b1dda6e3ed5f97f2fdaad5345c2514_normal.jpeg"}
• {"id"=>"332110378274287616", "text"=>"Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types http://t.co/kSwctIwSiV #bog13", "created_at"=>"2013-05-08T12:30:59Z", "user"=>"genetics_blog", "user_name"=>"Stephen Turner", "user_profile_image"=>"http://a0.twimg.com/profile_images/1356990961/pic2-square-cropped-350x350_normal.jpg"}
• {"id"=>"332125680890441729", "text"=>"@pauldennyuk @KevinADavies @PLOSONE yeah, seems the circular RNA got lost to be found again! http://t.co/XKKneB4sgJ http://t.co/nHQj2DlWEi", "created_at"=>"2013-05-08T13:31:47Z", "user"=>"bioinfosm", "user_name"=>"Sumit Middha", "user_profile_image"=>"http://a0.twimg.com/profile_images/1628963369/sm_normal.jpg"}

Wikipedia | Further Information

• {"title"=>"Circular RNA", "url"=>"http://en.wikipedia.org/wiki/Circular_RNA", "timestamp"=>"2019-03-15T15:28:37Z"}

Wordpress.com | Further Information

Counter

• {"month"=>"2", "year"=>"2012", "pdf_views"=>"737", "xml_views"=>"31", "html_views"=>"2595"}
• {"month"=>"3", "year"=>"2012", "pdf_views"=>"102", "xml_views"=>"12", "html_views"=>"373"}
• {"month"=>"4", "year"=>"2012", "pdf_views"=>"62", "xml_views"=>"18", "html_views"=>"316"}
• {"month"=>"5", "year"=>"2012", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"202"}
• {"month"=>"6", "year"=>"2012", "pdf_views"=>"43", "xml_views"=>"0", "html_views"=>"201"}
• {"month"=>"7", "year"=>"2012", "pdf_views"=>"48", "xml_views"=>"0", "html_views"=>"216"}
• {"month"=>"8", "year"=>"2012", "pdf_views"=>"36", "xml_views"=>"5", "html_views"=>"176"}
• {"month"=>"9", "year"=>"2012", "pdf_views"=>"38", "xml_views"=>"1", "html_views"=>"197"}
• {"month"=>"10", "year"=>"2012", "pdf_views"=>"58", "xml_views"=>"1", "html_views"=>"282"}
• {"month"=>"11", "year"=>"2012", "pdf_views"=>"48", "xml_views"=>"0", "html_views"=>"278"}
• {"month"=>"12", "year"=>"2012", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"254"}
• {"month"=>"1", "year"=>"2013", "pdf_views"=>"52", "xml_views"=>"2", "html_views"=>"378"}
• {"month"=>"2", "year"=>"2013", "pdf_views"=>"191", "xml_views"=>"2", "html_views"=>"855"}
• {"month"=>"3", "year"=>"2013", "pdf_views"=>"677", "xml_views"=>"3", "html_views"=>"2757"}
• {"month"=>"4", "year"=>"2013", "pdf_views"=>"356", "xml_views"=>"6", "html_views"=>"1699"}
• {"month"=>"5", "year"=>"2013", "pdf_views"=>"279", "xml_views"=>"5", "html_views"=>"1255"}
• {"month"=>"6", "year"=>"2013", "pdf_views"=>"191", "xml_views"=>"1", "html_views"=>"897"}
• {"month"=>"7", "year"=>"2013", "pdf_views"=>"147", "xml_views"=>"1", "html_views"=>"615"}
• {"month"=>"8", "year"=>"2013", "pdf_views"=>"126", "xml_views"=>"0", "html_views"=>"510"}
• {"month"=>"9", "year"=>"2013", "pdf_views"=>"131", "xml_views"=>"1", "html_views"=>"573"}
• {"month"=>"10", "year"=>"2013", "pdf_views"=>"161", "xml_views"=>"3", "html_views"=>"736"}
• {"month"=>"11", "year"=>"2013", "pdf_views"=>"150", "xml_views"=>"3", "html_views"=>"643"}
• {"month"=>"12", "year"=>"2013", "pdf_views"=>"98", "xml_views"=>"0", "html_views"=>"482"}
• {"month"=>"1", "year"=>"2014", "pdf_views"=>"104", "xml_views"=>"0", "html_views"=>"482"}
• {"month"=>"2", "year"=>"2014", "pdf_views"=>"112", "xml_views"=>"0", "html_views"=>"450"}
• {"month"=>"3", "year"=>"2014", "pdf_views"=>"115", "xml_views"=>"2", "html_views"=>"556"}
• {"month"=>"4", "year"=>"2014", "pdf_views"=>"88", "xml_views"=>"1", "html_views"=>"570"}
• {"month"=>"5", "year"=>"2014", "pdf_views"=>"109", "xml_views"=>"3", "html_views"=>"675"}
• {"month"=>"6", "year"=>"2014", "pdf_views"=>"81", "xml_views"=>"0", "html_views"=>"451"}
• {"month"=>"7", "year"=>"2014", "pdf_views"=>"72", "xml_views"=>"2", "html_views"=>"466"}
• {"month"=>"8", "year"=>"2014", "pdf_views"=>"73", "xml_views"=>"2", "html_views"=>"398"}
• {"month"=>"9", "year"=>"2014", "pdf_views"=>"134", "xml_views"=>"2", "html_views"=>"607"}
• {"month"=>"10", "year"=>"2014", "pdf_views"=>"138", "xml_views"=>"4", "html_views"=>"632"}
• {"month"=>"11", "year"=>"2014", "pdf_views"=>"105", "xml_views"=>"6", "html_views"=>"552"}
• {"month"=>"12", "year"=>"2014", "pdf_views"=>"96", "xml_views"=>"1", "html_views"=>"410"}
• {"month"=>"1", "year"=>"2015", "pdf_views"=>"78", "xml_views"=>"0", "html_views"=>"384"}
• {"month"=>"2", "year"=>"2015", "pdf_views"=>"63", "xml_views"=>"0", "html_views"=>"339"}
• {"month"=>"3", "year"=>"2015", "pdf_views"=>"91", "xml_views"=>"0", "html_views"=>"449"}
• {"month"=>"4", "year"=>"2015", "pdf_views"=>"99", "xml_views"=>"1", "html_views"=>"588"}
• {"month"=>"5", "year"=>"2015", "pdf_views"=>"95", "xml_views"=>"0", "html_views"=>"378"}
• {"month"=>"6", "year"=>"2015", "pdf_views"=>"80", "xml_views"=>"0", "html_views"=>"382"}
• {"month"=>"7", "year"=>"2015", "pdf_views"=>"99", "xml_views"=>"0", "html_views"=>"372"}
• {"month"=>"8", "year"=>"2015", "pdf_views"=>"113", "xml_views"=>"1", "html_views"=>"368"}
• {"month"=>"9", "year"=>"2015", "pdf_views"=>"138", "xml_views"=>"0", "html_views"=>"409"}
• {"month"=>"10", "year"=>"2015", "pdf_views"=>"116", "xml_views"=>"0", "html_views"=>"471"}
• {"month"=>"11", "year"=>"2015", "pdf_views"=>"79", "xml_views"=>"0", "html_views"=>"350"}
• {"month"=>"12", "year"=>"2015", "pdf_views"=>"83", "xml_views"=>"1", "html_views"=>"355"}
• {"month"=>"1", "year"=>"2016", "pdf_views"=>"84", "xml_views"=>"0", "html_views"=>"415"}
• {"month"=>"2", "year"=>"2016", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"210"}
• {"month"=>"3", "year"=>"2016", "pdf_views"=>"64", "xml_views"=>"0", "html_views"=>"259"}
• {"month"=>"4", "year"=>"2016", "pdf_views"=>"123", "xml_views"=>"0", "html_views"=>"354"}
• {"month"=>"5", "year"=>"2016", "pdf_views"=>"101", "xml_views"=>"0", "html_views"=>"314"}
• {"month"=>"6", "year"=>"2016", "pdf_views"=>"83", "xml_views"=>"0", "html_views"=>"256"}
• {"month"=>"7", "year"=>"2016", "pdf_views"=>"88", "xml_views"=>"0", "html_views"=>"235"}
• {"month"=>"8", "year"=>"2016", "pdf_views"=>"73", "xml_views"=>"0", "html_views"=>"208"}
• {"month"=>"9", "year"=>"2016", "pdf_views"=>"92", "xml_views"=>"0", "html_views"=>"251"}
• {"month"=>"10", "year"=>"2016", "pdf_views"=>"107", "xml_views"=>"0", "html_views"=>"328"}
• {"month"=>"11", "year"=>"2016", "pdf_views"=>"64", "xml_views"=>"0", "html_views"=>"408"}
• {"month"=>"12", "year"=>"2016", "pdf_views"=>"89", "xml_views"=>"0", "html_views"=>"302"}
• {"month"=>"1", "year"=>"2017", "pdf_views"=>"80", "xml_views"=>"1", "html_views"=>"383"}
• {"month"=>"2", "year"=>"2017", "pdf_views"=>"68", "xml_views"=>"1", "html_views"=>"322"}
• {"month"=>"3", "year"=>"2017", "pdf_views"=>"71", "xml_views"=>"2", "html_views"=>"384"}
• {"month"=>"4", "year"=>"2017", "pdf_views"=>"79", "xml_views"=>"0", "html_views"=>"469"}
• {"month"=>"5", "year"=>"2017", "pdf_views"=>"99", "xml_views"=>"0", "html_views"=>"456"}
• {"month"=>"6", "year"=>"2017", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"303"}
• {"month"=>"7", "year"=>"2017", "pdf_views"=>"71", "xml_views"=>"4", "html_views"=>"389"}
• {"month"=>"8", "year"=>"2017", "pdf_views"=>"63", "xml_views"=>"1", "html_views"=>"474"}
• {"month"=>"9", "year"=>"2017", "pdf_views"=>"69", "xml_views"=>"0", "html_views"=>"505"}
• {"month"=>"10", "year"=>"2017", "pdf_views"=>"59", "xml_views"=>"4", "html_views"=>"563"}
• {"month"=>"11", "year"=>"2017", "pdf_views"=>"62", "xml_views"=>"1", "html_views"=>"584"}
• {"month"=>"12", "year"=>"2017", "pdf_views"=>"68", "xml_views"=>"4", "html_views"=>"401"}
• {"month"=>"1", "year"=>"2018", "pdf_views"=>"109", "xml_views"=>"0", "html_views"=>"337"}
• {"month"=>"2", "year"=>"2018", "pdf_views"=>"83", "xml_views"=>"1", "html_views"=>"159"}
• {"month"=>"3", "year"=>"2018", "pdf_views"=>"118", "xml_views"=>"0", "html_views"=>"196"}
• {"month"=>"4", "year"=>"2018", "pdf_views"=>"129", "xml_views"=>"0", "html_views"=>"197"}
• {"month"=>"5", "year"=>"2018", "pdf_views"=>"88", "xml_views"=>"1", "html_views"=>"170"}
• {"month"=>"6", "year"=>"2018", "pdf_views"=>"62", "xml_views"=>"2", "html_views"=>"125"}
• {"month"=>"7", "year"=>"2018", "pdf_views"=>"61", "xml_views"=>"4", "html_views"=>"125"}
• {"month"=>"8", "year"=>"2018", "pdf_views"=>"48", "xml_views"=>"1", "html_views"=>"118"}
• {"month"=>"9", "year"=>"2018", "pdf_views"=>"52", "xml_views"=>"1", "html_views"=>"155"}
• {"month"=>"10", "year"=>"2018", "pdf_views"=>"91", "xml_views"=>"1", "html_views"=>"131"}
• {"month"=>"11", "year"=>"2018", "pdf_views"=>"63", "xml_views"=>"1", "html_views"=>"114"}
• {"month"=>"12", "year"=>"2018", "pdf_views"=>"71", "xml_views"=>"0", "html_views"=>"110"}
• {"month"=>"1", "year"=>"2019", "pdf_views"=>"85", "xml_views"=>"0", "html_views"=>"131"}
• {"month"=>"2", "year"=>"2019", "pdf_views"=>"93", "xml_views"=>"0", "html_views"=>"128"}
• {"month"=>"3", "year"=>"2019", "pdf_views"=>"120", "xml_views"=>"1", "html_views"=>"152"}
• {"month"=>"4", "year"=>"2019", "pdf_views"=>"78", "xml_views"=>"0", "html_views"=>"140"}
• {"month"=>"5", "year"=>"2019", "pdf_views"=>"115", "xml_views"=>"0", "html_views"=>"144"}
• {"month"=>"6", "year"=>"2019", "pdf_views"=>"58", "xml_views"=>"0", "html_views"=>"106"}
• {"month"=>"7", "year"=>"2019", "pdf_views"=>"93", "xml_views"=>"0", "html_views"=>"119"}
• {"month"=>"8", "year"=>"2019", "pdf_views"=>"91", "xml_views"=>"1", "html_views"=>"103"}
• {"month"=>"9", "year"=>"2019", "pdf_views"=>"75", "xml_views"=>"3", "html_views"=>"112"}
• {"month"=>"10", "year"=>"2019", "pdf_views"=>"102", "xml_views"=>"1", "html_views"=>"130"}
• {"month"=>"11", "year"=>"2019", "pdf_views"=>"87", "xml_views"=>"1", "html_views"=>"114"}
• {"month"=>"12", "year"=>"2019", "pdf_views"=>"59", "xml_views"=>"1", "html_views"=>"120"}
• {"month"=>"1", "year"=>"2020", "pdf_views"=>"78", "xml_views"=>"1", "html_views"=>"127"}
• {"month"=>"2", "year"=>"2020", "pdf_views"=>"86", "xml_views"=>"2", "html_views"=>"108"}
• {"month"=>"3", "year"=>"2020", "pdf_views"=>"180", "xml_views"=>"3", "html_views"=>"137"}
• {"month"=>"4", "year"=>"2020", "pdf_views"=>"191", "xml_views"=>"1", "html_views"=>"112"}
• {"month"=>"5", "year"=>"2020", "pdf_views"=>"226", "xml_views"=>"1", "html_views"=>"109"}
• {"month"=>"6", "year"=>"2020", "pdf_views"=>"177", "xml_views"=>"0", "html_views"=>"109"}
• {"month"=>"7", "year"=>"2020", "pdf_views"=>"205", "xml_views"=>"0", "html_views"=>"110"}
• {"month"=>"8", "year"=>"2020", "pdf_views"=>"84", "xml_views"=>"2", "html_views"=>"67"}
• {"month"=>"9", "year"=>"2020", "pdf_views"=>"74", "xml_views"=>"0", "html_views"=>"95"}
• {"month"=>"10", "year"=>"2020", "pdf_views"=>"136", "xml_views"=>"1", "html_views"=>"103"}
• {"month"=>"11", "year"=>"2020", "pdf_views"=>"110", "xml_views"=>"0", "html_views"=>"124"}
• {"month"=>"12", "year"=>"2020", "pdf_views"=>"97", "xml_views"=>"3", "html_views"=>"112"}
• {"month"=>"1", "year"=>"2021", "pdf_views"=>"76", "xml_views"=>"2", "html_views"=>"90"}

Figshare

• {"files"=>["https://ndownloader.figshare.com/files/686567"], "description"=>"<p>At left: a schematic diagram of the canonical splicing process splicing out the first intron of the a pre-mRNA of a 4 exon gene, and subsequent removal of introns 2 and 3. Canonical splicing of exon 1 to exon 2 occurs when the splicing machinery catalyzes the formation of the intron lariat and the attack of the free 3′ OH of exon 1 on the 3′ splice site upstream of exon 2. This produces a lariat containing intron 1 and a pre-mRNA with exons 1 and 2 spliced together. At right: a model for the production of circular transcripts. If there is a canonical transcriptional start, and if intron excision does not proceed sequentially in time from the 5′ to 3′ direction of the pre-mRNA, non-canonical pairing of 3′ and 5′ splice sites could be generated. Since the sequences of each 5′ splice site of the pre-mRNA contain the same splicing signals, it is possible that the 3′ splice site upstream of exon 2 is paired with the 5′ splice site downstream of exon 3 and splicing proceeds as if this 5′ splice site were paired with the 3′ splice site upstream of exon 4. In this case, exon 3 would be spliced upstream of exon 2, creating a pre-mRNA intermediate comprised of these two exons and intron 2. Canonical splicing would be predicted to excise this intron, leaving a circular RNA composed of exons 2 and 3. Non-canonical transcription start, as suggested in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030733#pone.0030733-Schindewolf1\" target=\"_blank\">[25]</a>, could produce an orphan 3′ splice site corresponding to the first transcribed exon. This splice site could be paired with a downstream 5′ splice site, generating a circular RNA. In both models, the excised intron would be linear and branched, and expected to be quickly degraded.</p>", "links"=>[], "tags"=>["circular"], "article_id"=>357055, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Julia Salzman", "Charles Gawad", "Peter Lincoln Wang", "Norman Lacayo", "Patrick O. Brown"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030733.g006", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Models_for_generation_of_circular_RNA_/357055", "title"=>"Models for generation of circular RNA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-02-01 01:57:35"}
• {"files"=>["https://ndownloader.figshare.com/files/350411", "https://ndownloader.figshare.com/files/350439", "https://ndownloader.figshare.com/files/350475", "https://ndownloader.figshare.com/files/350492", "https://ndownloader.figshare.com/files/350511", "https://ndownloader.figshare.com/files/350519", "https://ndownloader.figshare.com/files/350532", "https://ndownloader.figshare.com/files/350594", "https://ndownloader.figshare.com/files/350638", "https://ndownloader.figshare.com/files/350649", "https://ndownloader.figshare.com/files/350656", "https://ndownloader.figshare.com/files/350693", "https://ndownloader.figshare.com/files/350714"], "description"=>"<div><p>Most human pre-mRNAs are spliced into linear molecules that retain the exon order defined by the genomic sequence. By deep sequencing of RNA from a variety of normal and malignant human cells, we found RNA transcripts from many human genes in which the exons were arranged in a non-canonical order. Statistical estimates and biochemical assays provided strong evidence that a substantial fraction of the spliced transcripts from hundreds of genes are circular RNAs. Our results suggest that a non-canonical mode of RNA splicing, resulting in a circular RNA isoform, is a general feature of the gene expression program in human cells.</p> </div>", "links"=>[], "tags"=>["circular", "rnas", "are", "predominant", "transcript", "isoform", "hundreds", "genes", "types"], "article_id"=>129257, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Julia Salzman", "Charles Gawad", "Peter Lincoln Wang", "Norman Lacayo", "Patrick O. Brown"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0030733.s001", "https://dx.doi.org/10.1371/journal.pone.0030733.s002", "https://dx.doi.org/10.1371/journal.pone.0030733.s003", "https://dx.doi.org/10.1371/journal.pone.0030733.s004", "https://dx.doi.org/10.1371/journal.pone.0030733.s005", "https://dx.doi.org/10.1371/journal.pone.0030733.s006", "https://dx.doi.org/10.1371/journal.pone.0030733.s007", "https://dx.doi.org/10.1371/journal.pone.0030733.s008", "https://dx.doi.org/10.1371/journal.pone.0030733.s009", "https://dx.doi.org/10.1371/journal.pone.0030733.s010", "https://dx.doi.org/10.1371/journal.pone.0030733.s011", "https://dx.doi.org/10.1371/journal.pone.0030733.s012", "https://dx.doi.org/10.1371/journal.pone.0030733.s013"], "stats"=>{"downloads"=>11, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Circular_RNAs_Are_the_Predominant_Transcript_Isoform_from_Hundreds_of_Human_Genes_in_Diverse_Cell_Types/129257", "title"=>"Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-02-01 02:34:17"}
• {"files"=>["https://ndownloader.figshare.com/files/686111"], "description"=>"<p>The canonical linear reference transcript is depicted with exons as colored boxes with four exons 1, 2, 3, and 4. Two simple models of RNA structure that could explain scrambled transcripts are depicted at left and right. At left, model 1 depicts how a scrambled exon 3-exon 2 junction could arise from a tandem duplication of exons 3 and 2, positioning the first copy of exon 3 upstream of exon 2. At the RNA level, this event could arise from post-transcriptional exon rearrangement, or a genomic duplication of exons 2 and 3. Under the model of tandem duplication, when one side of a paired-end read maps to the junction between exon 3 and 2, the other may map to any of exons 1, 2, 3 or 4 with probabilities determined by the library's insert length distribution and the exon lengths. Our data supports paired-end mapping between a junction and exons 2 or 3, but not exons 1 and 4. We note that in principle, the scrambled exon 3 - exon 2 junction could arise from other splicing events and does not necessarily entail tandem duplication. At right, model 2 depicts how a scrambled exon 3 - exon 2 junction could arise from splicing of exons 2 and 3 into a circular RNA molecule, again positioning exon 3 upstream of exon 2. In this model, when one side of a paired-end read maps to the junction between exon 3 and 2, the other will map to exon 2 or exon 3.</p>", "links"=>[], "tags"=>["exon"], "article_id"=>356602, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Julia Salzman", "Charles Gawad", "Peter Lincoln Wang", "Norman Lacayo", "Patrick O. Brown"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030733.g001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Models_to_explain_exon_scrambling_/356602", "title"=>"Models to explain exon scrambling.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-02-01 01:50:02"}
• {"files"=>["https://ndownloader.figshare.com/files/686176"], "description"=>"<p>Analysis of paired-end RNA-Seq data from random primed libraries reveals evidence that scrambled exons are present at high stoichiometries compared to the canonical linear transcript transcribed from a large number of human genes. This phenomenon persists across cell types and is illustrated by the expression patterns of 3 leukocyte cell types: CD19 (B cells), CD34 (stem cells) and neutrophils. The fraction of each scrambled transcript as a fraction of total gene expression is computed. The bar plot depicts the number of circular isoforms with estimated abundance relative to all transcripts of the gene in the following ranges: between 0–25%, 25–50%, 50–75% and 75+%. Hundreds of isoforms in each cell type are estimated to represent more than half of all transcripts from each gene.</p>", "links"=>[], "tags"=>["levels", "scrambled"], "article_id"=>356662, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Julia Salzman", "Charles Gawad", "Peter Lincoln Wang", "Norman Lacayo", "Patrick O. Brown"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030733.g002", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_levels_of_scrambled_exons_/356662", "title"=>"Expression levels of scrambled exons.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-02-01 01:51:02"}
• {"files"=>["https://ndownloader.figshare.com/files/686237"], "description"=>"<p>Panel A: Total RNA from HeLa cells was digested with RNaseR at varying enzyme concentrations (0, 3, 10, and 100 units) after the RNA was depleted of ribosomal RNA. Primers capable of amplifying the canonical linear transcript and the predicted circular transcript (by outward facing primers within a single exon predicted in the scramble) were used in a RT-PCR experiment for each of the digestion conditions. Canonical transcripts were consistently degraded by RNaseR, only detectable by PCR at 0 units of RNaseR, whereas predicted circular transcripts consistently resisted the RNaseR challenge, providing strong evidence of circularity. FBXW4 and MAN1A2 respectively show 2 and 4 circular isoforms, both of which were predicted by the sequencing data. The predicted lengths of circular isoforms are respectively a 3-2 junction of CAMSAP1 (predicted to produce a 435 bp circle), a 4-2 and 5-2 junction of FBXW4 (predicted to produce 415 and 510 bp circles), a 4-2, 5-2 and 6-2 junction of MAN1A2 (predicted to produce 471, 553, and 648 bp circles), a 3-3 junction in REXO4 (predicted to produce a 338 bp circle), a 2-2 junction of RNF220 (predicted to produce a 742 bp circle) and a 3-2 junction of ZKSCAN1 (predicted to produce a 667 bp circle). Panel B: A northern blot on total and cytoplasmic lysate from HeLa cells shows hybridization of a 481 bp probe complementary to the MAN1A2 5-2 exon scramble. 3.7 and 6.2 ug of total and cytoplasmic RNA were loaded onto a 1% agarose gel and 10 pM of probe was hybridized for 24–48 hours. Detection was performed using the BrightStar BioDetect Kit (Ambion, Austin, TX). The specific band at 553 bp corresponds to the predicted size of a circular RNA containing exons 2,3,4 and 5 of MAN1A2.</p>", "links"=>[], "tags"=>["assay", "confirms", "scrambled", "exons", "circular"], "article_id"=>356723, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Julia Salzman", "Charles Gawad", "Peter Lincoln Wang", "Norman Lacayo", "Patrick O. Brown"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030733.g003", "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RNaseR_assay_confirms_scrambled_exons_arise_from_circular_RNA_/356723", "title"=>"RNaseR assay confirms scrambled exons arise from circular RNA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-02-01 01:52:03"}
• {"files"=>["https://ndownloader.figshare.com/files/686315"], "description"=>"<p>Single-end 76-bp RNA-Seq was performed on matched experiments on HeLa, and H9 Human embryonic stem cell lysates were polyA selected and polyA depleted (data from Yang et al <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030733#pone.0030733-Yang1\" target=\"_blank\">[22]</a>). The numbers of scrambled exons detected in each sample which appeared in our curated database of scrambled junctions from the leukocyte data are depicted as colored bars. Roughly equal numbers of sequencing reads were available from each of 4 samples. Left panels of bar plot: both H9 and HeLa cells show markedly more exon scrambles in polyA depleted fractions compared to polyA enriched fractions, consistent with scrambles arising from circular transcripts which lack polyA tails. Right panels of bar plot: conversely, in the much smaller subset of scrambled exon pairs where we have evidence of internal tandem duplication (i.e. evidence against circularity), we find the opposite enrichment: more exon scrambles in polyA enriched fractions compared to polyA depleted fractions, consistent with this small subset of scrambles arising from linear, polyA transcripts.</p>", "links"=>[], "tags"=>["exons", "enriched", "poly-a", "depleted"], "article_id"=>356804, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Julia Salzman", "Charles Gawad", "Peter Lincoln Wang", "Norman Lacayo", "Patrick O. Brown"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030733.g004", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Scrambled_exons_are_enriched_in_poly_A_depleted_samples_/356804", "title"=>"Scrambled exons are enriched in poly-A depleted samples.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-02-01 01:53:24"}
• {"files"=>["https://ndownloader.figshare.com/files/686503"], "description"=>"<p>HeLa whole cells lysates were fractioned into cytoplasmic and nuclear. The nuclear localized noncoding RNA XIST served as a control for fractionation:, and as expected, was enriched in the nuclear fraction. In addition, precursor ribosomal RNA bands were present in the nucleus but not the cytoplasm (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030733#pone.0030733.s004\" target=\"_blank\">Figure S4</a>). Using probes specific to each canonical and circular isoform (corresponding to those examples depicted in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030733#pone-0030733-g003\" target=\"_blank\">Figure 3</a>), we compared Ct values calculated from qPCR on cDNA from the cytoplasmic fraction to the Ct value from qPCR on cDNA from the nuclear fraction. Bar heights show this average Ct value difference across 2 biological replicates. Error bars represent 2.5 standard deviations computed from biological variation of the qPCR assay. These results show that most circular isoforms are more enriched in the cytoplasm compared to the canonical linear isoforms.</p>", "links"=>[], "tags"=>["shows", "scrambled", "exons", "enriched"], "article_id"=>356991, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Julia Salzman", "Charles Gawad", "Peter Lincoln Wang", "Norman Lacayo", "Patrick O. Brown"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030733.g005", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_qPCR_shows_scrambled_exons_are_enriched_in_the_cytoplasm_/356991", "title"=>"qPCR shows scrambled exons are enriched in the cytoplasm.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-02-01 01:56:31"}

PMC Usage Stats | Further Information

• {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"65", "year"=>"2012", "pdf"=>"49", "unique-ip"=>"85", "figure"=>"46", "scanned-summary"=>"0", "supp-data"=>"13"}
• {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"46", "unique-ip"=>"58", "pdf"=>"29", "year"=>"2012", "figure"=>"30", "scanned-summary"=>"0", "supp-data"=>"5"}
• {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"25", "year"=>"2012", "pdf"=>"15", "unique-ip"=>"26", "figure"=>"16", "scanned-summary"=>"0", "supp-data"=>"1"}
• {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"11", "unique-ip"=>"13", "pdf"=>"4", "year"=>"2012", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"2"}
• {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"20", "year"=>"2012", "pdf"=>"4", "unique-ip"=>"23", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"6"}
• {"unique-ip"=>"34", "full-text"=>"34", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"23", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
• {"unique-ip"=>"25", "full-text"=>"30", "pdf"=>"11", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
• {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"11", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
• {"unique-ip"=>"30", "full-text"=>"31", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"16", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
• {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
• {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
• {"unique-ip"=>"153", "full-text"=>"139", "pdf"=>"122", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"76", "supp-data"=>"37", "cited-by"=>"3", "year"=>"2013", "month"=>"3"}
• {"unique-ip"=>"41", "full-text"=>"35", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"21", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2013", "month"=>"2"}
• {"unique-ip"=>"85", "full-text"=>"90", "pdf"=>"55", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"51", "supp-data"=>"19", "cited-by"=>"2", "year"=>"2013", "month"=>"4"}
• {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
• {"unique-ip"=>"68", "full-text"=>"61", "pdf"=>"37", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"35", "supp-data"=>"27", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
• {"unique-ip"=>"52", "full-text"=>"57", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"34", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
• {"unique-ip"=>"46", "full-text"=>"47", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
• {"unique-ip"=>"37", "full-text"=>"31", "pdf"=>"20", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"29", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
• {"unique-ip"=>"45", "full-text"=>"44", "pdf"=>"23", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"23", "supp-data"=>"25", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
• {"unique-ip"=>"47", "full-text"=>"44", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"26", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
• {"unique-ip"=>"37", "full-text"=>"31", "pdf"=>"22", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"36", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
• {"unique-ip"=>"36", "full-text"=>"35", "pdf"=>"18", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"33", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
• {"unique-ip"=>"39", "full-text"=>"35", "pdf"=>"19", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
• {"unique-ip"=>"42", "full-text"=>"34", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
• {"unique-ip"=>"29", "full-text"=>"34", "pdf"=>"19", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
• {"unique-ip"=>"25", "full-text"=>"17", "pdf"=>"8", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
• {"unique-ip"=>"23", "full-text"=>"20", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
• {"unique-ip"=>"34", "full-text"=>"26", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
• {"unique-ip"=>"57", "full-text"=>"57", "pdf"=>"38", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"21", "supp-data"=>"11", "cited-by"=>"3", "year"=>"2015", "month"=>"4"}
• {"unique-ip"=>"70", "full-text"=>"75", "pdf"=>"41", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"29", "supp-data"=>"24", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
• {"unique-ip"=>"80", "full-text"=>"79", "pdf"=>"51", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"27", "supp-data"=>"16", "cited-by"=>"3", "year"=>"2015", "month"=>"6"}
• {"unique-ip"=>"60", "full-text"=>"65", "pdf"=>"34", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
• {"unique-ip"=>"43", "full-text"=>"42", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
• {"unique-ip"=>"35", "full-text"=>"29", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"2", "year"=>"2015", "month"=>"2"}
• {"unique-ip"=>"69", "full-text"=>"72", "pdf"=>"43", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
• {"unique-ip"=>"86", "full-text"=>"92", "pdf"=>"52", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"22", "supp-data"=>"19", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
• {"unique-ip"=>"72", "full-text"=>"71", "pdf"=>"40", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"28", "supp-data"=>"19", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
• {"unique-ip"=>"43", "full-text"=>"32", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"21", "supp-data"=>"14", "cited-by"=>"3", "year"=>"2014", "month"=>"7"}
• {"unique-ip"=>"32", "full-text"=>"27", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
• {"unique-ip"=>"62", "full-text"=>"36", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"25", "supp-data"=>"37", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
• {"unique-ip"=>"62", "full-text"=>"54", "pdf"=>"43", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
• {"unique-ip"=>"36", "full-text"=>"37", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
• {"unique-ip"=>"58", "full-text"=>"59", "pdf"=>"35", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
• {"unique-ip"=>"50", "full-text"=>"51", "pdf"=>"39", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
• {"unique-ip"=>"55", "full-text"=>"96", "pdf"=>"30", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"5", "cited-by"=>"1", "year"=>"2015", "month"=>"1"}
• {"unique-ip"=>"87", "full-text"=>"85", "pdf"=>"49", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"12", "cited-by"=>"17", "year"=>"2015", "month"=>"11"}
• {"unique-ip"=>"77", "full-text"=>"82", "pdf"=>"55", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"3", "cited-by"=>"7", "year"=>"2015", "month"=>"12"}
• {"unique-ip"=>"71", "full-text"=>"75", "pdf"=>"35", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"38", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
• {"unique-ip"=>"49", "full-text"=>"52", "pdf"=>"45", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2016", "month"=>"3"}
• {"unique-ip"=>"70", "full-text"=>"66", "pdf"=>"43", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"49", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
• {"unique-ip"=>"54", "full-text"=>"50", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
• {"unique-ip"=>"38", "full-text"=>"39", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
• {"unique-ip"=>"40", "full-text"=>"52", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
• {"unique-ip"=>"32", "full-text"=>"43", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
• {"unique-ip"=>"47", "full-text"=>"54", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
• {"unique-ip"=>"77", "full-text"=>"79", "pdf"=>"30", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"33", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2016", "month"=>"10"}
• {"unique-ip"=>"59", "full-text"=>"60", "pdf"=>"33", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"31", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
• {"unique-ip"=>"55", "full-text"=>"65", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"31", "supp-data"=>"18", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
• {"unique-ip"=>"71", "full-text"=>"58", "pdf"=>"31", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"21", "supp-data"=>"22", "cited-by"=>"2", "year"=>"2017", "month"=>"1"}
• {"unique-ip"=>"58", "full-text"=>"60", "pdf"=>"35", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
• {"unique-ip"=>"93", "full-text"=>"105", "pdf"=>"45", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
• {"unique-ip"=>"69", "full-text"=>"85", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"27", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
• {"unique-ip"=>"81", "full-text"=>"93", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"15", "cited-by"=>"1", "year"=>"2017", "month"=>"5"}
• {"unique-ip"=>"57", "full-text"=>"71", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
• {"unique-ip"=>"77", "full-text"=>"92", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"21", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
• {"unique-ip"=>"70", "full-text"=>"81", "pdf"=>"47", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
• {"unique-ip"=>"113", "full-text"=>"96", "pdf"=>"48", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"40", "supp-data"=>"337", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
• {"unique-ip"=>"88", "full-text"=>"107", "pdf"=>"48", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"40", "supp-data"=>"1", "cited-by"=>"5", "year"=>"2017", "month"=>"10"}
• {"unique-ip"=>"67", "full-text"=>"73", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"25", "supp-data"=>"1", "cited-by"=>"6", "year"=>"2017", "month"=>"11"}
• {"unique-ip"=>"78", "full-text"=>"92", "pdf"=>"42", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
• {"unique-ip"=>"76", "full-text"=>"76", "pdf"=>"40", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
• {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
• {"unique-ip"=>"87", "full-text"=>"94", "pdf"=>"46", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"23", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
• {"unique-ip"=>"76", "full-text"=>"91", "pdf"=>"33", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"16", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
• {"unique-ip"=>"81", "full-text"=>"84", "pdf"=>"32", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
• {"unique-ip"=>"78", "full-text"=>"89", "pdf"=>"30", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
• {"unique-ip"=>"84", "full-text"=>"81", "pdf"=>"31", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"4", "cited-by"=>"2", "year"=>"2018", "month"=>"5"}
• {"unique-ip"=>"88", "full-text"=>"94", "pdf"=>"55", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"6"}
• {"unique-ip"=>"75", "full-text"=>"74", "pdf"=>"22", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"58", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
• {"unique-ip"=>"62", "full-text"=>"55", "pdf"=>"31", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2018", "month"=>"8"}
• {"unique-ip"=>"75", "full-text"=>"84", "pdf"=>"21", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
• {"unique-ip"=>"85", "full-text"=>"92", "pdf"=>"26", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
• {"unique-ip"=>"86", "full-text"=>"97", "pdf"=>"30", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
• {"unique-ip"=>"63", "full-text"=>"68", "pdf"=>"20", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
• {"unique-ip"=>"87", "full-text"=>"90", "pdf"=>"32", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
• {"unique-ip"=>"74", "full-text"=>"83", "pdf"=>"28", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
• {"unique-ip"=>"110", "full-text"=>"132", "pdf"=>"32", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
• {"unique-ip"=>"67", "full-text"=>"74", "pdf"=>"16", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
• {"unique-ip"=>"80", "full-text"=>"100", "pdf"=>"27", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
• {"unique-ip"=>"137", "full-text"=>"214", "pdf"=>"22", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"31", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
• {"unique-ip"=>"72", "full-text"=>"86", "pdf"=>"24", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
• {"unique-ip"=>"112", "full-text"=>"126", "pdf"=>"52", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2020", "month"=>"2"}
• {"unique-ip"=>"130", "full-text"=>"129", "pdf"=>"56", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
• {"unique-ip"=>"101", "full-text"=>"111", "pdf"=>"32", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"25", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2020", "month"=>"4"}
• {"unique-ip"=>"106", "full-text"=>"132", "pdf"=>"38", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"16", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
• {"unique-ip"=>"86", "full-text"=>"92", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
• {"unique-ip"=>"67", "full-text"=>"70", "pdf"=>"19", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
• {"unique-ip"=>"45", "full-text"=>"43", "pdf"=>"16", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
• {"unique-ip"=>"60", "full-text"=>"62", "pdf"=>"16", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
• {"unique-ip"=>"63", "full-text"=>"62", "pdf"=>"24", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2020", "month"=>"10"}
• {"unique-ip"=>"74", "full-text"=>"76", "pdf"=>"19", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"4", "year"=>"2020", "month"=>"11"}
• {"unique-ip"=>"63", "full-text"=>"70", "pdf"=>"27", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[322, 550, 671, 773, 864, 955, 1048, 1135, 1223, 1308, 1387, 1465, 1534, 1602, 1673, 1744, 1813, 1885, 1955, 2026, 2093, 2160, 2228, 2290, 2349]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[316, 541, 663, 766, 856, 950, 1041, 1128, 1218, 1302, 1382, 1456, 1526, 1593, 1657, 1729, 1796, 1862, 1930, 1999, 2065, 2132, 2202, 2261, 2319]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[319, 556, 679, 785, 881, 970, 1062, 1149, 1236, 1323, 1402, 1474, 1545, 1617, 1681, 1754, 1822, 1892, 1963, 2031, 2099, 2165, 2233, 2299, 2359]}, {"subject_area"=>"/Biology and life sciences/Computational biology", "average_usage"=>[375, 629, 760, 889, 1000, 1110, 1203, 1298, 1399, 1492, 1603, 1699, 1774, 1855, 1918, 1998, 2062, 2152, 2227, 2312, 2378, 2461, 2528, 2600, 2664]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[312, 547, 668, 769, 861, 953, 1046, 1135, 1224, 1307, 1388, 1464, 1536, 1606, 1676, 1744, 1812, 1882, 1954, 2020, 2089, 2155, 2218, 2282, 2344]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[307, 545, 668, 765, 855, 943, 1029, 1113, 1202, 1285, 1361, 1439, 1506, 1571, 1636, 1706, 1772, 1837, 1901, 1969, 2031, 2096, 2160, 2228, 2287]}]}

F1000Prime | Further Information

• {"year"=>2014, "month"=>5, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2014-05-26T08:33:48Z"}
• {"year"=>2014, "month"=>6, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2014-06-30T08:33:42Z"}
• {"year"=>2014, "month"=>7, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2014-07-28T08:33:49Z"}
• {"year"=>2014, "month"=>8, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2014-08-25T08:33:50Z"}
• {"year"=>2014, "month"=>9, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2014-09-29T08:33:51Z"}
• {"year"=>2014, "month"=>10, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2014-10-27T08:33:42Z"}
• {"year"=>2014, "month"=>11, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2014-11-24T09:32:27Z"}
• {"year"=>2014, "month"=>12, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2014-12-29T09:42:11Z"}
• {"year"=>2015, "month"=>1, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2015-01-26T09:40:47Z"}
• {"year"=>2015, "month"=>2, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2015-02-23T09:40:48Z"}
• {"year"=>2015, "month"=>3, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2015-03-23T08:41:00Z"}
• {"year"=>2015, "month"=>4, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2015-04-27T08:40:53Z"}
• {"year"=>2015, "month"=>5, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2015-05-25T08:40:49Z"}
• {"year"=>2015, "month"=>6, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2015-06-29T08:40:51Z"}
• {"year"=>2015, "month"=>7, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2015-07-27T08:40:42Z"}
• {"year"=>2015, "month"=>8, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2015-08-31T08:40:53Z"}
• {"year"=>2015, "month"=>9, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2015-09-28T08:40:46Z"}
• {"year"=>2015, "month"=>10, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2015-10-26T08:40:56Z"}
• {"year"=>2015, "month"=>11, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2015-11-30T09:40:57Z"}
• {"year"=>2015, "month"=>12, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2015-12-28T09:40:59Z"}
• {"year"=>2016, "month"=>1, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2016-01-25T09:41:01Z"}
• {"year"=>2016, "month"=>2, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2016-02-29T09:40:40Z"}
• {"year"=>2016, "month"=>3, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2016-03-28T08:40:39Z"}
• {"year"=>2016, "month"=>4, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2016-04-25T08:40:44Z"}
• {"year"=>2016, "month"=>5, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2016-05-16T08:40:44Z"}
• {"year"=>2016, "month"=>6, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2016-06-27T08:40:42Z"}
• {"year"=>2016, "month"=>7, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2016-07-25T08:40:43Z"}
• {"year"=>2016, "month"=>8, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2016-08-29T08:40:36Z"}
• {"year"=>2016, "month"=>9, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2016-09-26T08:40:42Z"}
• {"year"=>2016, "month"=>10, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2016-10-31T08:40:40Z"}
• {"year"=>2016, "month"=>11, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2016-11-28T09:40:42Z"}
• {"year"=>2016, "month"=>12, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2016-12-26T09:40:51Z"}
• {"year"=>2017, "month"=>1, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2017-01-30T09:40:44Z"}
• {"year"=>2017, "month"=>2, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2017-02-27T09:40:46Z"}
• {"year"=>2017, "month"=>3, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2017-03-27T08:40:34Z"}
• {"year"=>2017, "month"=>4, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2017-04-24T08:40:31Z"}
• {"year"=>2017, "month"=>5, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2017-05-29T08:40:50Z"}
• {"year"=>2017, "month"=>6, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"http://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2017-06-26T08:40:56Z"}
• {"year"=>2017, "month"=>7, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2017-07-31T08:40:49Z"}
• {"year"=>2017, "month"=>8, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2017-08-28T08:40:53Z"}
• {"year"=>2017, "month"=>9, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2017-09-25T08:40:35Z"}
• {"year"=>2017, "month"=>10, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2017-10-30T08:40:52Z"}
• {"year"=>2017, "month"=>11, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2017-11-27T09:40:59Z"}
• {"year"=>2017, "month"=>12, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2017-12-25T09:40:47Z"}
• {"year"=>2018, "month"=>1, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2018-01-29T09:40:33Z"}
• {"year"=>2018, "month"=>2, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2018-02-26T09:40:36Z"}
• {"year"=>2018, "month"=>3, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2018-03-26T08:40:38Z"}
• {"year"=>2018, "month"=>4, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2018-04-30T08:40:34Z"}
• {"year"=>2018, "month"=>5, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2018-05-28T08:40:36Z"}
• {"year"=>2018, "month"=>6, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2018-06-25T08:40:36Z"}
• {"year"=>2018, "month"=>7, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2018-07-30T08:40:42Z"}
• {"year"=>2018, "month"=>8, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2018-08-27T08:40:47Z"}
• {"year"=>2018, "month"=>9, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2018-09-24T08:40:40Z"}
• {"year"=>2018, "month"=>10, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2018-10-29T08:40:47Z"}
• {"year"=>2018, "month"=>11, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2018-11-26T09:40:38Z"}
• {"year"=>2018, "month"=>12, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2018-12-31T09:40:54Z"}
• {"year"=>2019, "month"=>1, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2019-01-28T09:40:39Z"}
• {"year"=>2019, "month"=>2, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2019-02-25T09:40:42Z"}
• {"year"=>2019, "month"=>3, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2019-03-25T08:40:37Z"}
• {"year"=>2019, "month"=>4, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2019-04-29T08:40:41Z"}
• {"year"=>2019, "month"=>5, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2019-05-27T08:40:50Z"}
• {"year"=>2019, "month"=>6, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2019-06-24T08:40:43Z"}
• {"year"=>2019, "month"=>7, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2019-07-29T08:40:51Z"}
• {"year"=>2019, "month"=>8, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2019-08-26T08:40:49Z"}
• {"year"=>2019, "month"=>9, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2019-09-30T08:40:49Z"}
• {"year"=>2019, "month"=>10, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2019-10-28T08:40:46Z"}
• {"year"=>2019, "month"=>11, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2019-11-25T09:40:51Z"}
• {"year"=>2019, "month"=>12, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2019-12-30T09:41:01Z"}
• {"year"=>2020, "month"=>1, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2020-01-27T09:40:44Z"}
• {"year"=>2020, "month"=>2, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2020-02-24T09:40:49Z"}
• {"year"=>2020, "month"=>3, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2020-03-30T08:40:51Z"}
• {"year"=>2020, "month"=>4, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2020-04-27T08:40:46Z"}
• {"year"=>2020, "month"=>5, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2020-05-25T08:40:47Z"}
• {"year"=>2020, "month"=>6, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2020-06-29T08:40:49Z"}
• {"year"=>2020, "month"=>7, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2020-07-27T08:40:47Z"}
• {"year"=>2020, "month"=>8, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2020-08-31T08:40:48Z"}
• {"year"=>2020, "month"=>9, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2020-09-28T08:40:50Z"}
• {"year"=>2020, "month"=>10, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2020-10-26T08:40:47Z"}
• {"year"=>2020, "month"=>11, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2020-11-30T09:40:51Z"}
• {"year"=>2020, "month"=>12, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2020-12-28T09:40:50Z"}
• {"year"=>2021, "month"=>1, "doi"=>"10.1371/journal.pone.0030733", "f1000_id"=>"13763957", "url"=>"https://f1000.com/prime/13763957", "score"=>3, "classifications"=>["controversial", "new_finding", "technical_advance"], "updated_at"=>"2021-01-18T09:40:57Z"}