Adolescent Binge Drinking Leads to Changes in Alcohol Drinking, Anxiety, and Amygdalar Corticotropin Releasing Factor Cells in Adulthood in Male Rats
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{"title"=>"Adolescent binge drinking leads to changes in alcohol drinking, anxiety, and amygdalar corticotropin releasing factor cells in adulthood in male rats", "type"=>"journal", "authors"=>[{"first_name"=>"Nicholas W.", "last_name"=>"Gilpin", "scopus_author_id"=>"6507590188"}, {"first_name"=>"Chrisanthi A.", "last_name"=>"Karanikas", "scopus_author_id"=>"54962507100"}, {"first_name"=>"Heather N.", "last_name"=>"Richardson", "scopus_author_id"=>"7102123608"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84856728533", "sgr"=>"84856728533", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0031466", "pmid"=>"22347484", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"364218439"}, "id"=>"d259cfb5-6e87-3976-b192-4afe826a0ca0", "abstract"=>"Heavy episodic drinking early in adolescence is associated with increased risk of addiction and other stress-related disorders later in life. This suggests that adolescent alcohol abuse is an early marker of innate vulnerability and/or binge exposure impacts the developing brain to increase vulnerability to these disorders in adulthood. Animal models are ideal for clarifying the relationship between adolescent and adult alcohol abuse, but we show that methods of involuntary alcohol exposure are not effective. We describe an operant model that uses multiple bouts of intermittent access to sweetened alcohol to elicit voluntary binge alcohol drinking early in adolescence (~postnatal days 28-42) in genetically heterogeneous male Wistar rats. We next examined the effects of adolescent binge drinking on alcohol drinking and anxiety-like behavior in dependent and non-dependent adult rats, and counted corticotropin-releasing factor (CRF) cell in the lateral portion of the central amygdala (CeA), a region that contributes to regulation of anxiety- and alcohol-related behaviors. Adolescent binge drinking did not alter alcohol drinking under baseline drinking conditions in adulthood. However, alcohol-dependent and non-dependent adult rats with a history of adolescent alcohol binge drinking did exhibit increased alcohol drinking when access to alcohol was intermittent. Adult rats that binged alcohol during adolescence exhibited increased exploration on the open arms of the elevated plus maze (possibly indicating either decreased anxiety or increased impulsivity), an effect that was reversed by a history of alcohol dependence during adulthood. Finally, CRF cell counts were reduced in the lateral CeA of rats with adolescent alcohol binge history, suggesting semi-permanent changes in the limbic stress peptide system with this treatment. These data suggest that voluntary binge drinking during early adolescence produces long-lasting neural and behavioral effects with implications for anxiety and alcohol use disorders.", "link"=>"http://www.mendeley.com/research/adolescent-binge-drinking-leads-changes-alcohol-drinking-anxiety-amygdalar-corticotropin-releasing-f", "reader_count"=>79, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>11, "Researcher"=>12, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>2, "Student > Master"=>8, "Student > Bachelor"=>17, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>11, "Researcher"=>12, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>2, "Student > Master"=>8, "Student > Bachelor"=>17, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Engineering"=>1, "Agricultural and Biological Sciences"=>24, "Medicine and Dentistry"=>11, "Neuroscience"=>12, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>20, "Social Sciences"=>2, "Decision Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Neuroscience"=>{"Neuroscience"=>12}, "Social Sciences"=>{"Social Sciences"=>2}, "Decision Sciences"=>{"Decision Sciences"=>1}, "Psychology"=>{"Psychology"=>20}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>24}, "Unspecified"=>{"Unspecified"=>7}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Argentina"=>2, "United States"=>4, "Ireland"=>1, "United Kingdom"=>2, "Italy"=>1, "Portugal"=>1}, "group_count"=>7}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/685014"], "description"=>"<p>(a) Illustration of the binge self-administration apparatus. (b) The pattern of alcohol intake (g/kg) from representative high (<i>n</i> = 8; 76.8±3.5 g/kg total intake; 27.1±2.1 total number of binges), medium (<i>n</i> = 6; 63.6±3.3 g/kg total intake; 22.5±2.7 total number of binges), and low (<i>n</i> = 6; 35.3±2.8 g/kg total intake; 35.3±2.8 total number of binges) binging rats over the two week treatment period (14 overnight sessions×6 bouts = 84 sessions total). (c) A scatter plot showing the relationship between g/kg intake and resultant blood alcohol levels in a single bout on the last binge day in a subset of rats. A linear fit trend line is used to estimate the average g/kg intake that results in ≥0.08 g% blood alcohol levels (i.e., ∼1.25 g/kg would be classified as “binge drinking”). As shown in (b) and (c) not all animals binge within a single session and instead vary regarding the bout(s) in which they binge within each overnight session and the total number of binges over the two-week treatment period. (d) By the time animals reach postnatal day (PN) 42 the cumulative intake approaches 50–60 g/kg. Data are expressed as mean ± SEM (c: n = 8 binge rats; d: n = 20 binge rats).</p>", "links"=>[], "tags"=>["binge", "self-administration", "wistar"], "article_id"=>355506, "categories"=>["Biochemistry", "Mental Health", "Medicine", "Biotechnology", "Neuroscience", "Chemistry"], "users"=>["Nicholas W. Gilpin", "Chrisanthi A. Karanikas", "Heather N. Richardson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031466.g002", "stats"=>{"downloads"=>8, "page_views"=>34, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Operant_model_of_binge_alcohol_self_administration_in_adolescent_male_Wistar_rats_/355506", "title"=>"Operant model of binge alcohol self-administration in adolescent male Wistar rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:15:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/685417"], "description"=>"<p>A history of adolescent binge alcohol drinking produced a decrease in anxiety-like behavior (increased percent of time spent in the open arms) that was reversed by alcohol dependence. Data are expressed as mean ± SEM (n = 7–10/group). *p<0.05 main effect of adolescent alcohol binge drinking; <sup>a,b</sup>p<0.02, with different letters indicating individual group differences (i.e., Binge NonDep is different from BingeDep and Control NonDep).</p>", "links"=>[], "tags"=>["binge", "adolescence", "decreases", "anxiety-like", "elevated", "maze", "non-dependent", "wistar"], "article_id"=>355899, "categories"=>["Biochemistry", "Mental Health", "Medicine", "Biotechnology", "Neuroscience", "Chemistry"], "users"=>["Nicholas W. Gilpin", "Chrisanthi A. Karanikas", "Heather N. Richardson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031466.g006", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Voluntary_binge_drinking_early_in_adolescence_decreases_anxiety_like_behavior_on_the_elevated_plus_maze_in_non_dependent_male_Wistar_rats_/355899", "title"=>"Voluntary binge drinking early in adolescence decreases anxiety-like behavior on the elevated plus maze in non-dependent male Wistar rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:17:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/685198"], "description"=>"<p>(a) Responses for sweetened water (3% glucose/0.125% saccharin, 1 day), (b) sweetened 10% w/v alcohol intake (g/kg) with (3 days, left graph) and without (2 days, right graph) glucose, and (c) unsweetened 10% w/v alcohol intake (g/kg, 14 days). Daily operant self-administration tests lasted 30-min in adult rats with an adolescent history of voluntary binge alcohol (red) or control (yellow) drinking alcohol during early adolescence. Data are expressed as mean ± SEM (n = 15–20/group). *p<0.05 relative to rats without a history of adolescent binge alcohol drinking.</p>", "links"=>[], "tags"=>["binge", "adolescence", "baseline", "wistar"], "article_id"=>355685, "categories"=>["Biochemistry", "Mental Health", "Medicine", "Biotechnology", "Neuroscience", "Chemistry"], "users"=>["Nicholas W. Gilpin", "Chrisanthi A. Karanikas", "Heather N. Richardson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031466.g004", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Voluntary_binge_drinking_early_in_adolescence_does_not_affect_baseline_drinking_in_adult_male_Wistar_rats_/355685", "title"=>"Voluntary binge drinking early in adolescence does not affect baseline drinking in adult male Wistar rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:16:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/685592"], "description"=>"<p>Photomicrograph of CRF immunoreactive (CRF-ir) cells and fibers in the lateral portion of the CeA (−2.56 mm posterior to Bregma) in a Control NonDep male rat (a) and high magnification photomicrographs of CRF neurons with dark (b) and light (c) immunolabeling (magnification indicated by bars within the photomicrographs). (d) Shows CRF-ir cell counts (expressed as cells/section) in lateral CeA at various anterior-posterior distances from Bregma in abstinent adult male rats with (Binge) or without (Control) a previous history of binge self-administration in early adolescence and with (Dep) or without (NonDep) chronic intermittent vapor exposure in adulthood. Binge alcohol exposure reduced CRF-ir cell counts in lateral CeA in a manner that was not affected by subsequent chronic intermittent alcohol exposure. Data are expressed as mean ± SEM (n = 4–9/group). *p<0.05 main effect of adolescent alcohol binge drinking. <i>Abbreviations:</i> BLA, basolateral amygdala; lCeA, lateral division of the central amygdala, mCeA, medial division of the central amygdala; opt, optic tract.</p>", "links"=>[], "tags"=>["binge", "adolescence", "crf-ir", "cells", "lateral", "amygdala", "abstinence", "vapors", "non-dependent", "wistar"], "article_id"=>356070, "categories"=>["Biochemistry", "Mental Health", "Medicine", "Biotechnology", "Neuroscience", "Chemistry"], "users"=>["Nicholas W. Gilpin", "Chrisanthi A. Karanikas", "Heather N. Richardson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031466.g007", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Voluntary_binge_drinking_early_in_adolescence_reduces_the_number_of_CRF_ir_cells_in_the_lateral_division_of_the_central_amygdala_lCeA_one_month_into_abstinence_from_vapors_in_adult_dependent_and_non_dependent_male_Wistar_rats_/356070", "title"=>"Voluntary binge drinking early in adolescence reduces the number of CRF-ir cells in the lateral division of the central amygdala (lCeA) one month into abstinence from vapors in adult dependent and non-dependent male Wistar rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:18:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/685120"], "description"=>"<p>Voluntary binge alcohol self-administration took place during early adolescence (postnatal days 28–42) and dependence induction (chronic exposure to intermittent alcohol vapors) took place after baseline drinking testing in adulthood. In adulthood, drinking behavior was measured in 30-min operant self-administration tests before and during dependence induction by intermittent vapors. Anxiety-like behavior was measured in the elevated plus maze in abstinence (approximately one month after removal from intermittent alcohol vapors). Brains were collected for CRF immunoreactivity one week after testing for anxiety-like behavior.</p>", "links"=>[], "tags"=>["timeline", "binge", "experiments", "wistar"], "article_id"=>355607, "categories"=>["Biochemistry", "Mental Health", "Medicine", "Biotechnology", "Neuroscience", "Chemistry"], "users"=>["Nicholas W. Gilpin", "Chrisanthi A. Karanikas", "Heather N. Richardson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031466.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Illustration_of_the_timeline_of_treatment_behavioral_measures_and_brain_collection_for_the_voluntary_binge_drinking_experiments_in_male_Wistar_rats_/355607", "title"=>"Illustration of the timeline of treatment, behavioral measures, and brain collection for the voluntary binge drinking experiments in male Wistar rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:15:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/685314"], "description"=>"<p>Chronic intermittent alcohol vapor produced significant elevations in alcohol self-administration by Dependent rats (black) during 30-min operant tests relative to Non-dependent rats. Animals with a history of adolescent binge alcohol drinking (right panel of line graph) also drank more than non-binge controls during adulthood. Data are expressed as mean ± SEM (n = 6–10/group). Dependent and non-dependent groups did not differ in adolescent consumption levels (p = 0.34). *p<0.05 main effect of adolescent alcohol binge drinking. #p<0.05 main effects of adult alcohol dependence.</p>", "links"=>[], "tags"=>["binge", "adolescence", "augments", "relapse-like", "non-dependent", "wistar"], "article_id"=>355799, "categories"=>["Biochemistry", "Mental Health", "Medicine", "Biotechnology", "Neuroscience", "Chemistry"], "users"=>["Nicholas W. Gilpin", "Chrisanthi A. Karanikas", "Heather N. Richardson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031466.g005", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Voluntary_binge_drinking_early_in_adolescence_augments_relapse_like_drinking_in_adult_non_dependent_and_dependent_male_Wistar_rats_/355799", "title"=>"Voluntary binge drinking early in adolescence augments relapse-like drinking in adult non-dependent and dependent male Wistar rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:16:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/684928"], "description"=>"<p>Adult drinking data from male Wistar rats previously exposed to involuntary alcohol (“alcohol injected, 2 g/kg <i>ip</i>) or voluntary alcohol drinking (four 30-min bouts of home cage drinking of sweetened 5% w/v alcohol) early in adolescence (postnatal days 27, 30, 33, 36, 39). Control animals either received saline injections or voluntary sweetened water drinking on the same adolescent treatment days. Previous exposure to involuntary binge-like alcohol during adolescence via <i>ip</i> injections (but not control injections or voluntary alcohol drinking) significantly reduced drinking of sweetened water (a), 5% w/v alcohol sweetened with 3% glucose/0.125% saccharin (left graph, b) but not when the glucose was removed (right graph, b), and 5% w/v unsweetened alcohol (c) in adulthood. Data are expressed as mean ± SEM (n = 8/group). *p<0.05 relative to all control groups.</p>", "links"=>[], "tags"=>["adolescence", "baseline"], "article_id"=>355415, "categories"=>["Biochemistry", "Mental Health", "Medicine", "Biotechnology", "Neuroscience", "Chemistry"], "users"=>["Nicholas W. Gilpin", "Chrisanthi A. Karanikas", "Heather N. Richardson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031466.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Involuntary_alcohol_exposure_during_adolescence_reduces_baseline_drinking_in_adulthood_/355415", "title"=>"Involuntary alcohol exposure during adolescence reduces baseline drinking in adulthood.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:14:52"}

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Relative Metric

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