ALM

Investigation of Indazole Unbinding Pathways in CYP2E1 by Molecular Dynamics Simulations

Publication Date: March 19, 2012
Journal: PLOS ONE
Authors: Zhonghua Shen, Feixiong Cheng, You Xu, Jing Fu, et al
Volume: 7
Issue: 3
Pages: e33500
DOI: https://dx.plos.org/10.1371/journal.pone.0033500
Publisher URL: http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0033500
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/22442693
PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307744
Europe PMC: http://europepmc.org/abstract/MED/22442693
Web of Science: 000303836500034
Scopus: 84863348961
Mendeley: http://www.mendeley.com/research/investigation-indazole-unbinding-pathways-cyp2e1-molecular-dynamics-simulations

Loading …

Events

Loading …

CiteULike17 May 18:08 UTC

CiteULike

Mendeley 2230 Apr 15:14 UTC

Mendeley | Further Information

{"title"=>"Investigation of indazole unbinding pathways in CYP2E1 by molecular dynamics simulations", "type"=>"journal", "authors"=>[{"first_name"=>"Zhonghua", "last_name"=>"Shen", "scopus_author_id"=>"55109152300"}, {"first_name"=>"Feixiong", "last_name"=>"Cheng", "scopus_author_id"=>"36514277000"}, {"first_name"=>"You", "last_name"=>"Xu", "scopus_author_id"=>"36547205600"}, {"first_name"=>"Jing", "last_name"=>"Fu", "scopus_author_id"=>"57199932774"}, {"first_name"=>"Wen", "last_name"=>"Xiao", "scopus_author_id"=>"55703622100"}, {"first_name"=>"Jie", "last_name"=>"Shen", "scopus_author_id"=>"57199270521"}, {"first_name"=>"Guixia", "last_name"=>"Liu", "scopus_author_id"=>"55706595300"}, {"first_name"=>"Weihua", "last_name"=>"Li", "scopus_author_id"=>"7501794094"}, {"first_name"=>"Yun", "last_name"=>"Tang", "scopus_author_id"=>"35312761700"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84863348961", "doi"=>"10.1371/journal.pone.0033500", "pui"=>"364464860", "scopus"=>"2-s2.0-84863348961", "issn"=>"19326203", "pmid"=>"22442693"}, "id"=>"c94eb63b-075a-33dd-a618-77626587df97", "abstract"=>"Human microsomal cytochrome P450 2E1 (CYP2E1) can oxidize not only low molecular weight xenobiotic compounds such as ethanol, but also many endogenous fatty acids. The crystal structure of CYP2E1 in complex with indazole reveals that the active site is deeply buried into the protein center. Thus, the unbinding pathways and associated unbinding mechanisms remain elusive. In this study, random acceleration molecular dynamics simulations combined with steered molecular dynamics and potential of mean force calculations were performed to identify the possible unbinding pathways in CYP2E1. The results show that channel 2c and 2a are most likely the unbinding channels of CYP2E1. The former channel is located between helices G and I and the B-C loop, and the latter resides between the region formed by the F-G loop, the B-C loop and the β1 sheet. Phe298 and Phe478 act as the gate keeper during indazole unbinding along channel 2c and 2a, respectively. Previous site-directed mutagenesis experiments also supported these findings.", "link"=>"http://www.mendeley.com/research/investigation-indazole-unbinding-pathways-cyp2e1-molecular-dynamics-simulations", "reader_count"=>21, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>9, "Student > Master"=>5, "Student > Bachelor"=>3, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>9, "Student > Master"=>5, "Student > Bachelor"=>3, "Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>1, "Arts and Humanities"=>1, "Physics and Astronomy"=>1, "Chemistry"=>8, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Chemistry"=>{"Chemistry"=>8}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Czech Republic"=>1, "Germany"=>2}, "group_count"=>1}

ORCID 205 Apr 04:31 UTC

Europe PMC Database Citations | Further Information

{"UNIPROT"=>9}

PubMed Central14 Apr 09:41 UTC

PubMed Central

Scopus 3818 Mar 00:10 UTC

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84863348961"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84863348961?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863348961&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84863348961&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84863348961", "dc:identifier"=>"SCOPUS_ID:84863348961", "eid"=>"2-s2.0-84863348961", "dc:title"=>"Investigation of indazole unbinding pathways in CYP2E1 by molecular dynamics simulations", "dc:creator"=>"Shen Z.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"7", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2012-03-19", "prism:coverDisplayDate"=>"19 March 2012", "prism:doi"=>"10.1371/journal.pone.0033500", "citedby-count"=>"38", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"East China University of Science and Technology", "affiliation-city"=>"Shanghai", "affiliation-country"=>"China"}], "pubmed-id"=>"22442693", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e33500", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}

Web of Science®17 Mar 06:32 UTC

Web of Science® | Further Information

Article Coverage18 May 19:15 UTC

Article Coverage

Article Coverage Curated09 Apr 20:45 UTC

Article Coverage Curated

Facebook31 Jul 22:11 UTC

Facebook

{"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0033500", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments23 Oct 01:18 UTC

Journal Comments

Nature09 Jun 05:37 UTC

Nature

Reddit29 Dec 12:06 UTC

Research Blogging06 May 10:33 UTC

Research Blogging

ScienceSeeker06 Aug 16:31 UTC

ScienceSeeker | Further Information

Twitter05 Apr 14:07 UTC

Twitter

Wikipedia19 Mar 21:50 UTC

Wikipedia

Wordpress.com15 Oct 13:29 UTC

Wordpress.com | Further Information

Counter 363910 Apr 00:04 UTC

Counter

{"month"=>"3", "year"=>"2012", "pdf_views"=>"57", "xml_views"=>"13", "html_views"=>"259"}
{"month"=>"4", "year"=>"2012", "pdf_views"=>"38", "xml_views"=>"18", "html_views"=>"80"}
{"month"=>"5", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"61"}
{"month"=>"6", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"51"}
{"month"=>"7", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"25"}
{"month"=>"8", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"4", "html_views"=>"20"}
{"month"=>"9", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"30"}
{"month"=>"10", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"38"}
{"month"=>"11", "year"=>"2012", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"47"}
{"month"=>"12", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"43"}
{"month"=>"1", "year"=>"2013", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"68"}
{"month"=>"2", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"41"}
{"month"=>"3", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"48"}
{"month"=>"4", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"26"}
{"month"=>"5", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"20"}
{"month"=>"6", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"45"}
{"month"=>"7", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"26"}
{"month"=>"8", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"15"}
{"month"=>"9", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"35"}
{"month"=>"10", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"52"}
{"month"=>"11", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"36"}
{"month"=>"12", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"67"}
{"month"=>"1", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"28"}
{"month"=>"2", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"38"}
{"month"=>"3", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"61"}
{"month"=>"4", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"46"}
{"month"=>"5", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"49"}
{"month"=>"6", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"43"}
{"month"=>"7", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"49"}
{"month"=>"8", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"33"}
{"month"=>"9", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"36"}
{"month"=>"10", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"101"}
{"month"=>"11", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"51"}
{"month"=>"12", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"38"}
{"month"=>"1", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"32"}
{"month"=>"2", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"8"}
{"month"=>"3", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"27"}
{"month"=>"4", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"19"}
{"month"=>"5", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"17"}
{"month"=>"6", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
{"month"=>"7", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
{"month"=>"8", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"22"}
{"month"=>"9", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"27"}
{"month"=>"10", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"21"}
{"month"=>"11", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
{"month"=>"12", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
{"month"=>"1", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"25"}
{"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"23"}
{"month"=>"3", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"32"}
{"month"=>"4", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"14"}
{"month"=>"5", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"10"}
{"month"=>"6", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"12"}
{"month"=>"7", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"18"}
{"month"=>"8", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"13"}
{"month"=>"9", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"28"}
{"month"=>"10", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"15"}
{"month"=>"11", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"26"}
{"month"=>"12", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"3", "html_views"=>"30"}
{"month"=>"1", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"21"}
{"month"=>"2", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"26"}
{"month"=>"3", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"22"}
{"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"34"}
{"month"=>"5", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"15"}
{"month"=>"6", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"23"}
{"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"14"}
{"month"=>"8", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"23"}
{"month"=>"9", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"20"}
{"month"=>"10", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"24"}
{"month"=>"11", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"57"}
{"month"=>"12", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"15"}
{"month"=>"1", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"13"}
{"month"=>"2", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"11"}
{"month"=>"3", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"11"}
{"month"=>"4", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"10"}
{"month"=>"5", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"7"}
{"month"=>"6", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"10"}
{"month"=>"7", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"3", "html_views"=>"2"}
{"month"=>"8", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"3"}
{"month"=>"9", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"9"}
{"month"=>"10", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"8"}
{"month"=>"11", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"13"}
{"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"7"}
{"month"=>"1", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"7"}
{"month"=>"2", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"10"}
{"month"=>"3", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"5"}
{"month"=>"4", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"4"}
{"month"=>"5", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"1"}
{"month"=>"6", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"3"}
{"month"=>"7", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"6"}
{"month"=>"8", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"2"}
{"month"=>"9", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"4"}
{"month"=>"10", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"18"}
{"month"=>"11", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"12"}
{"month"=>"12", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"24"}
{"month"=>"1", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"22"}
{"month"=>"2", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"17"}
{"month"=>"3", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"0"}
{"month"=>"4", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"5"}
{"month"=>"5", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"0"}
{"month"=>"6", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"4"}
{"month"=>"7", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"4"}
{"month"=>"8", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"0"}
{"month"=>"9", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"1"}
{"month"=>"10", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"6"}
{"month"=>"11", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"4"}
{"month"=>"12", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"3", "html_views"=>"5"}
{"month"=>"1", "year"=>"2021", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"6"}
{"month"=>"2", "year"=>"2021", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"0"}
{"month"=>"3", "year"=>"2021", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"9"}

Figshare06 Jan 19:24 UTC

Figshare

{"files"=>["https://ndownloader.figshare.com/files/342207", "https://ndownloader.figshare.com/files/342256", "https://ndownloader.figshare.com/files/342296", "https://ndownloader.figshare.com/files/342350"], "description"=>"<div>Human microsomal cytochrome P450 2E1 (CYP2E1) can oxidize not only low molecular weight xenobiotic compounds such as ethanol, but also many endogenous fatty acids. The crystal structure of CYP2E1 in complex with indazole reveals that the active site is deeply buried into the protein center. Thus, the unbinding pathways and associated unbinding mechanisms remain elusive. In this study, random acceleration molecular dynamics simulations combined with steered molecular dynamics and potential of mean force calculations were performed to identify the possible unbinding pathways in CYP2E1. The results show that channel 2c and 2a are most likely the unbinding channels of CYP2E1. The former channel is located between helices G and I and the B-C loop, and the latter resides between the region formed by the F-G loop, the B-C loop and the β1 sheet. Phe298 and Phe478 act as the gate keeper during indazole unbinding along channel 2c and 2a, respectively. Previous site-directed mutagenesis experiments also supported these findings. </div>", "links"=>[], "tags"=>["indazole", "unbinding", "pathways", "cyp2e1", "molecular", "simulations"], "article_id"=>127648, "categories"=>["Biological Sciences", "Biochemistry", "Chemistry", "Pharmacology"], "users"=>["Zhonghua Shen", "Feixiong Cheng", "You Xu", "Jing Fu", "Wen Xiao", "Jie Shen", "Guixia Liu", "Weihua Li", "Yun Tang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0033500.s001", "https://dx.doi.org/10.1371/journal.pone.0033500.s002", "https://dx.doi.org/10.1371/journal.pone.0033500.s003", "https://dx.doi.org/10.1371/journal.pone.0033500.s004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Investigation_of_Indazole_Unbinding_Pathways_in_CYP2E1_by_Molecular_Dynamics_Simulations/127648", "title"=>"Investigation of Indazole Unbinding Pathways in CYP2E1 by Molecular Dynamics Simulations", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-03-19 02:07:28"}
{"files"=>["https://ndownloader.figshare.com/files/665250"], "description"=>"The major helices are labeled. Heme is shown as black spheres; indazole is shown as magenta sticks. All figures were generated with Pymol.", "links"=>[], "tags"=>["cyp2e1", "complexed"], "article_id"=>335730, "categories"=>["Biological Sciences", "Biochemistry", "Chemistry", "Pharmacology"], "users"=>["Zhonghua Shen", "Feixiong Cheng", "You Xu", "Jing Fu", "Wen Xiao", "Jie Shen", "Guixia Liu", "Weihua Li", "Yun Tang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0033500.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_crystal_structure_of_CYP2E1_complexed_with_indazole_/335730", "title"=>"The crystal structure of CYP2E1 complexed with indazole.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-19 01:35:30"}
{"files"=>["https://ndownloader.figshare.com/files/665375"], "description"=>"Channel 2c is shown in cyan and channel 2a is shown in magenta. The major secondary elements of CYP2E1 are labeled.", "links"=>[], "tags"=>["unbinding", "routes", "cyp2e1", "illustrated", "mole"], "article_id"=>335857, "categories"=>["Biological Sciences", "Biochemistry", "Chemistry", "Pharmacology"], "users"=>["Zhonghua Shen", "Feixiong Cheng", "You Xu", "Jing Fu", "Wen Xiao", "Jie Shen", "Guixia Liu", "Weihua Li", "Yun Tang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0033500.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Indazole_unbinding_routes_from_CYP2E1_illustrated_by_using_the_MOLE_program_/335857", "title"=>"Indazole unbinding routes from CYP2E1 illustrated by using the MOLE program.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-19 01:37:37"}
{"files"=>["https://ndownloader.figshare.com/files/665509"], "description"=>"Three different lines represent data from three representative SMD simulations.", "links"=>[], "tags"=>["profiles", "2c", "2a"], "article_id"=>335989, "categories"=>["Biological Sciences", "Biochemistry", "Chemistry", "Pharmacology"], "users"=>["Zhonghua Shen", "Feixiong Cheng", "You Xu", "Jing Fu", "Wen Xiao", "Jie Shen", "Guixia Liu", "Weihua Li", "Yun Tang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0033500.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Force_profiles_along_channel_2c_A_and_2a_B_/335989", "title"=>"Force profiles along channel 2c (A) and 2a (B).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-19 01:39:49"}
{"files"=>["https://ndownloader.figshare.com/files/665700"], "description"=>"Indazole is shown as green sticks. Heme is shown as a red stick. Phe106, Phe116 and Phe207 are shown as blue sticks.", "links"=>[], "tags"=>["positions", "indazole", "smd", "simulation", "2c", "200", "500", "800"], "article_id"=>336164, "categories"=>["Biological Sciences", "Biochemistry", "Chemistry", "Pharmacology"], "users"=>["Zhonghua Shen", "Feixiong Cheng", "You Xu", "Jing Fu", "Wen Xiao", "Jie Shen", "Guixia Liu", "Weihua Li", "Yun Tang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0033500.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Snapshots_of_the_relative_positions_of_indazole_and_the_protein_throughout_the_SMD_simulation_along_channel_2c_A_200_ps_B_500_ps_and_C_800_ps_/336164", "title"=>"Snapshots of the relative positions of indazole and the protein throughout the SMD simulation along channel 2c (A, 200 ps; B, 500 ps; and C, 800 ps).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-19 01:42:44"}
{"files"=>["https://ndownloader.figshare.com/files/665805"], "description"=>"Three different lines represent data from three representative SMD simulations.", "links"=>[], "tags"=>["benzene", "f298", "shown", "smd"], "article_id"=>336282, "categories"=>["Biological Sciences", "Biochemistry", "Chemistry", "Pharmacology"], "users"=>["Zhonghua Shen", "Feixiong Cheng", "You Xu", "Jing Fu", "Wen Xiao", "Jie Shen", "Guixia Liu", "Weihua Li", "Yun Tang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0033500.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Variation_of_the_benzene_ring_of_F298_is_shown_as_a_function_of_time_during_SMD_simulation_/336282", "title"=>"Variation of the benzene ring of F298 is shown as a function of time during SMD simulation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-19 01:44:42"}
{"files"=>["https://ndownloader.figshare.com/files/666020"], "description"=>"Indazole is shown as green sticks. The heme is shown as a red stick. Phe207 and Phe478 are shown as blue sticks.", "links"=>[], "tags"=>["positions", "indazole", "simulation", "2a", "490", "980"], "article_id"=>336496, "categories"=>["Biological Sciences", "Biochemistry", "Chemistry", "Pharmacology"], "users"=>["Zhonghua Shen", "Feixiong Cheng", "You Xu", "Jing Fu", "Wen Xiao", "Jie Shen", "Guixia Liu", "Weihua Li", "Yun Tang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0033500.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Snapshots_of_the_relative_positions_of_indazole_and_the_protein_throughout_the_simulation_along_channel_2a_A_490_ps_B_980_ps_/336496", "title"=>"Snapshots of the relative positions of indazole and the protein throughout the simulation along channel 2a (A, 490 ps; B, 980 ps).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-19 01:48:16"}
{"files"=>["https://ndownloader.figshare.com/files/666124"], "description"=>"The error bar indicates the standard deviation of PMF by the bootstrap approach.", "links"=>[], "tags"=>["profiles", "2a", "2c"], "article_id"=>336607, "categories"=>["Biological Sciences", "Biochemistry", "Chemistry", "Pharmacology"], "users"=>["Zhonghua Shen", "Feixiong Cheng", "You Xu", "Jing Fu", "Wen Xiao", "Jie Shen", "Guixia Liu", "Weihua Li", "Yun Tang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0033500.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PMF_profiles_along_channel_2a_magenta_and_channel_2c_green_/336607", "title"=>"PMF profiles along channel 2a (magenta) and channel 2c (green).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-19 01:50:07"}
{"files"=>["https://ndownloader.figshare.com/files/666247"], "description"=>"Statistical summary of RAMD simulations of CYP2E1.", "links"=>[], "tags"=>["ramd", "simulations"], "article_id"=>336731, "categories"=>["Biological Sciences", "Biochemistry", "Chemistry", "Pharmacology"], "users"=>["Zhonghua Shen", "Feixiong Cheng", "You Xu", "Jing Fu", "Wen Xiao", "Jie Shen", "Guixia Liu", "Weihua Li", "Yun Tang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0033500.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Statistical_summary_of_RAMD_simulations_of_CYP2E1_/336731", "title"=>"Statistical summary of RAMD simulations of CYP2E1.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-03-19 01:52:11"}

PMC Usage Stats 67117 Mar 15:10 UTC

PMC Usage Stats | Further Information

{"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"1", "unique-ip"=>"4", "pdf"=>"1", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
{"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"25", "year"=>"2012", "pdf"=>"19", "unique-ip"=>"25", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
{"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "unique-ip"=>"10", "pdf"=>"7", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"1"}
{"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2012", "pdf"=>"1", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
{"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
{"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
{"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
{"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
{"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
{"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
{"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
{"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
{"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
{"unique-ip"=>"13", "full-text"=>"8", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
{"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
{"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
{"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
{"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
{"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
{"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
{"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
{"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
{"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
{"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
{"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
{"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
{"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
{"unique-ip"=>"11", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
{"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
{"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
{"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
{"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
{"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
{"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
{"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
{"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
{"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
{"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
{"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
{"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
{"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
{"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
{"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2014", "month"=>"11"}
{"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
{"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
{"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
{"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
{"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
{"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
{"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
{"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
{"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
{"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
{"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
{"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
{"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
{"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
{"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
{"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
{"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
{"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
{"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
{"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
{"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
{"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
{"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
{"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
{"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
{"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
{"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
{"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
{"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
{"unique-ip"=>"25", "full-text"=>"11", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
{"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
{"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
{"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
{"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
{"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
{"unique-ip"=>"9", "full-text"=>"4", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
{"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
{"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
{"unique-ip"=>"31", "full-text"=>"16", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
{"unique-ip"=>"29", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2019", "month"=>"2"}
{"unique-ip"=>"15", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
{"unique-ip"=>"49", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"34", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
{"unique-ip"=>"44", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"28", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
{"unique-ip"=>"11", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
{"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
{"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
{"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
{"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
{"unique-ip"=>"5", "full-text"=>"1", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
{"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
{"unique-ip"=>"2", "full-text"=>"0", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
{"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
{"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
{"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
{"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
{"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
{"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
{"unique-ip"=>"3", "full-text"=>"0", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
{"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2021", "month"=>"1"}

Relative Metric 13794726 Apr 18:39 UTC

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[322, 550, 671, 773, 864, 955, 1048, 1135, 1223, 1308, 1387, 1465, 1534, 1602, 1673, 1744, 1813, 1885, 1955, 2026, 2093, 2160, 2228, 2290, 2349]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[304, 506, 616, 712, 799, 879, 968, 1052, 1134, 1212, 1284, 1357, 1427, 1494, 1557, 1621, 1689, 1756, 1823, 1883, 1944, 1997, 2056, 2118, 2171]}, {"subject_area"=>"/Physical sciences/Chemistry", "average_usage"=>[302, 508, 622, 720, 804, 888, 973, 1054, 1141, 1219, 1299, 1370, 1442, 1511, 1574, 1644, 1711, 1782, 1846, 1911, 1971, 2030, 2097, 2155, 2217]}, {"subject_area"=>"/Physical sciences/Physics", "average_usage"=>[298, 476, 578, 665, 743, 821, 891, 962, 1036, 1108, 1174, 1240, 1312, 1371, 1430, 1494, 1551, 1609, 1673, 1736, 1795, 1857, 1913, 1976, 2035]}]}

F1000Prime07 Apr 11:14 UTC

F1000Prime

Loading …

There are currently no alerts

Mendeley | Further Information

ORCID | Further Information

Europe PMC Citations | Further Information

Europe PMC Database Citations | Further Information

Scopus | Further Information

Web of Science® | Further Information

ScienceSeeker | Further Information

Wordpress.com | Further Information

PMC Usage Stats | Further Information