Single Cell Profiling of Circulating Tumor Cells: Transcriptional Heterogeneity and Diversity from Breast Cancer Cell Lines
- Publication Date
- May 07, 2012
- Journal
- PLOS ONE
- Authors
- Ashley A. Powell, Amir Ali H. Talasaz, Haiyu Zhang, Marc A. Coram, et al
- Volume
- 7
- Issue
- 5
- Pages
- e33788
- DOI
- https://dx.plos.org/10.1371/journal.pone.0033788
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0033788
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/22586443
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346739
- Europe PMC
- http://europepmc.org/abstract/MED/22586443
- Web of Science
- 000305335000005
- Scopus
- 84860601923
- Mendeley
- http://www.mendeley.com/research/single-cell-profiling-circulating-tumor-cells-transcriptional-heterogeneity-diversity-breast-cancer-1
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CiteULike | Further Information
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Mendeley | Further Information
{"title"=>"Single cell profiling of Circulating tumor cells: Transcriptional heterogeneity and diversity from breast cancer cell lines", "type"=>"journal", "authors"=>[{"first_name"=>"Ashley A.", "last_name"=>"Powell", "scopus_author_id"=>"7202501725"}, {"first_name"=>"Amir Ali H.", "last_name"=>"Talasaz", "scopus_author_id"=>"16176403700"}, {"first_name"=>"Haiyu", "last_name"=>"Zhang", "scopus_author_id"=>"8859827000"}, {"first_name"=>"Marc A.", "last_name"=>"Coram", "scopus_author_id"=>"14065755100"}, {"first_name"=>"Anupama", "last_name"=>"Reddy", "scopus_author_id"=>"24559491100"}, {"first_name"=>"Glenn", "last_name"=>"Deng", "scopus_author_id"=>"7101932147"}, {"first_name"=>"Melinda L.", "last_name"=>"Telli", "scopus_author_id"=>"16064818700"}, {"first_name"=>"Ranjana H.", "last_name"=>"Advani", "scopus_author_id"=>"7003342788"}, {"first_name"=>"Robert W.", "last_name"=>"Carlson", "scopus_author_id"=>"35274579200"}, {"first_name"=>"Joseph A.", "last_name"=>"Mollick", "scopus_author_id"=>"6603027680"}, {"first_name"=>"Shruti", "last_name"=>"Sheth", "scopus_author_id"=>"55209076200"}, {"first_name"=>"Allison W.", "last_name"=>"Kurian", "scopus_author_id"=>"56730290700"}, {"first_name"=>"James M.", "last_name"=>"Ford", "scopus_author_id"=>"7402915714"}, {"first_name"=>"Frank E.", "last_name"=>"Stockdale", "scopus_author_id"=>"7005205252"}, {"first_name"=>"Stephen R.", "last_name"=>"Quake", "scopus_author_id"=>"7004146463"}, {"first_name"=>"R. Fabian", "last_name"=>"Pease", "scopus_author_id"=>"57197500248"}, {"first_name"=>"Michael N.", "last_name"=>"Mindrinos", "scopus_author_id"=>"6603048545"}, {"first_name"=>"Gyan", "last_name"=>"Bhanot", "scopus_author_id"=>"7004654825"}, {"first_name"=>"Shanaz H.", "last_name"=>"Dairkee", "scopus_author_id"=>"57189963791"}, {"first_name"=>"Ronald W.", "last_name"=>"Davis", "scopus_author_id"=>"36012646500"}, {"first_name"=>"Stefanie S.", "last_name"=>"Jeffrey", "scopus_author_id"=>"23569502400"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84860601923", "sgr"=>"84860601923", "pui"=>"364751107", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"22586443", "doi"=>"10.1371/journal.pone.0033788"}, "id"=>"01957967-3870-38ee-94a9-810f5f58a382", "abstract"=>"BACKGROUND: To improve cancer therapy, it is critical to target metastasizing cells. Circulating tumor cells (CTCs) are rare cells found in the blood of patients with solid tumors and may play a key role in cancer dissemination. Uncovering CTC phenotypes offers a potential avenue to inform treatment. However, CTC transcriptional profiling is limited by leukocyte contamination; an approach to surmount this problem is single cell analysis. Here we demonstrate feasibility of performing high dimensional single CTC profiling, providing early insight into CTC heterogeneity and allowing comparisons to breast cancer cell lines widely used for drug discovery. METHODOLOGY/PRINCIPAL FINDINGS: We purified CTCs using the MagSweeper, an immunomagnetic enrichment device that isolates live tumor cells from unfractionated blood. CTCs that met stringent criteria for further analysis were obtained from 70% (14/20) of primary and 70% (21/30) of metastatic breast cancer patients; none were captured from patients with non-epithelial cancer (n = 20) or healthy subjects (n = 25). Microfluidic-based single cell transcriptional profiling of 87 cancer-associated and reference genes showed heterogeneity among individual CTCs, separating them into two major subgroups, based on 31 highly expressed genes. In contrast, single cells from seven breast cancer cell lines were tightly clustered together by sample ID and ER status. CTC profiles were distinct from those of cancer cell lines, questioning the suitability of such lines for drug discovery efforts for late stage cancer therapy. CONCLUSIONS/SIGNIFICANCE: For the first time, we directly measured high dimensional gene expression in individual CTCs without the common practice of pooling such cells. Elevated transcript levels of genes associated with metastasis NPTN, S100A4, S100A9, and with epithelial mesenchymal transition: VIM, TGFss1, ZEB2, FOXC1, CXCR4, were striking compared to cell lines. Our findings demonstrate that profiling CTCs on a cell-by-cell basis is possible and may facilitate the application of 'liquid biopsies' to better model drug discovery.", "link"=>"http://www.mendeley.com/research/single-cell-profiling-circulating-tumor-cells-transcriptional-heterogeneity-diversity-breast-cancer-1", "reader_count"=>424, "reader_count_by_academic_status"=>{"Unspecified"=>8, "Professor > Associate Professor"=>25, "Librarian"=>1, "Researcher"=>109, "Student > Doctoral Student"=>21, "Student > Ph. D. Student"=>126, "Student > Postgraduate"=>14, "Student > Master"=>40, "Other"=>19, "Student > Bachelor"=>33, "Lecturer"=>11, "Lecturer > Senior Lecturer"=>6, "Professor"=>11}, "reader_count_by_user_role"=>{"Unspecified"=>8, "Professor > Associate Professor"=>25, "Librarian"=>1, "Researcher"=>109, "Student > Doctoral Student"=>21, "Student > Ph. D. Student"=>126, "Student > Postgraduate"=>14, "Student > Master"=>40, "Other"=>19, "Student > Bachelor"=>33, "Lecturer"=>11, "Lecturer > Senior Lecturer"=>6, "Professor"=>11}, "reader_count_by_subject_area"=>{"Unspecified"=>15, "Agricultural and Biological Sciences"=>178, "Veterinary Science and Veterinary Medicine"=>1, "Chemical Engineering"=>3, "Chemistry"=>26, "Computer Science"=>8, "Engineering"=>53, "Biochemistry, Genetics and Molecular Biology"=>54, "Nursing and Health Professions"=>1, "Materials Science"=>1, "Mathematics"=>5, "Medicine and Dentistry"=>63, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Physics and Astronomy"=>8, "Psychology"=>1, "Social Sciences"=>2, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>63}, "Social Sciences"=>{"Social Sciences"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>8}, "Psychology"=>{"Psychology"=>1}, "Mathematics"=>{"Mathematics"=>5}, "Unspecified"=>{"Unspecified"=>15}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Chemical Engineering"=>{"Chemical Engineering"=>3}, "Engineering"=>{"Engineering"=>53}, "Chemistry"=>{"Chemistry"=>26}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>178}, "Computer Science"=>{"Computer Science"=>8}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>54}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United States"=>13, "Japan"=>2, "United Kingdom"=>5, "Switzerland"=>2, "Portugal"=>1, "Spain"=>3, "Saudi Arabia"=>1, "Austria"=>1, "Netherlands"=>1, "Sweden"=>1, "South Korea"=>1, "Belgium"=>1, "Iran"=>1, "China"=>1, "Italy"=>1, "South Africa"=>2, "Mexico"=>1, "Israel"=>1, "France"=>2, "Nigeria"=>1, "Germany"=>2}, "group_count"=>25}CrossRef
- http://doi.org/10.1007/s10544-013-9781-9
- http://doi.org/10.3389/fonc.2016.00234
- http://doi.org/10.1158/1541-7786.MCR-17-0070
- http://doi.org/10.1007/s10585-019-09977-y
- http://doi.org/10.1371/journal.pone.0050253
- http://doi.org/10.1016/j.semcdb.2016.08.025
- http://doi.org/10.1016/j.addr.2013.09.016
- http://doi.org/10.3748/wjg.v22.i32.7175
- http://doi.org/10.1586/14737159.2016.1116942
- http://doi.org/10.1016/j.molonc.2016.01.011
- http://doi.org/10.1186/1471-2407-14-456
- http://doi.org/10.1016/j.molonc.2016.01.007
- http://doi.org/10.3390/ijms17122142
- http://doi.org/10.1158/0008-5472.CAN-12-4140
- http://doi.org/10.1634/theoncologist.2013-0135
- http://doi.org/10.1016/j.pharmthera.2013.10.004
- http://doi.org/10.3390/cells8070641
- http://doi.org/10.1016/j.mce.2015.09.035
- http://doi.org/10.1245/s10434-018-6540-4
- http://doi.org/10.1038/srep36917
- http://doi.org/10.1016/S0007-4551(16)30144-8
- http://doi.org/10.1242/jcs.183129
- http://doi.org/10.1002/jcp.24369
- http://doi.org/10.1039/c6ib00202A
- http://doi.org/10.1101/sqb.2016.81.031120
- http://doi.org/10.1186/bcr3395
- http://doi.org/10.1021/acs.langmuir.8b00676
- http://doi.org/10.18632/oncotarget.12242
- http://doi.org/10.1021/ac500896k
- http://doi.org/10.1016/j.biotechadv.2015.06.006
- http://doi.org/10.1016/j.jim.2013.03.002
- http://doi.org/10.1039/C3LC50617G
- http://doi.org/10.1038/srep18437
- http://doi.org/10.1186/gm474
- http://doi.org/10.1039/c3lc90136j
- http://doi.org/10.1089/rej.2018.2154
- http://doi.org/10.1186/s13059-014-0452-9
- http://doi.org/10.1073/pnas.1608461113
- http://doi.org/10.1002/mc.22645
- http://doi.org/10.13070/mm.en.8.2673
- http://doi.org/10.1038/s41556-020-0532-x
- http://doi.org/10.1586/14737159.2013.811896
- http://doi.org/10.1016/j.mne.2019.01.002
- http://doi.org/10.1093/annonc/mdu239
- http://doi.org/10.1039/C9LC00575G
- http://doi.org/10.1021/acs.analchem.7b01782
- http://doi.org/10.1038/nrclinonc.2013.253
- http://doi.org/10.1002/ijc.30006
- http://doi.org/10.1002/ijc.29399
- http://doi.org/10.1038/nbt.2576
- http://doi.org/10.1039/C7LC00703E
- http://doi.org/10.1039/C3LC50582K
- http://doi.org/10.1002/ange.201505100
- http://doi.org/10.1039/C5LC01024A
- http://doi.org/10.1186/s12885-016-2330-1
- http://doi.org/10.1373/clinchem.2014.229476
- http://doi.org/10.1039/c3lc51136g
- http://doi.org/10.1002/ange.201208452
- http://doi.org/10.1039/C3LC50644D
- http://doi.org/10.3390/cancers11070903
- http://doi.org/10.1002/anie.201208452
- http://doi.org/10.1039/C5LC00226E
- http://doi.org/10.1371/journal.pone.0123683
- http://doi.org/10.1586/epr.12.61
- http://doi.org/10.1016/j.critrevonc.2013.05.002
- http://doi.org/10.1093/annonc/mdu480
- http://doi.org/10.18632/oncotarget.19289
- http://doi.org/10.1373/clinchem.2015.249706
- http://doi.org/10.1093/annonc/mdu018
- http://doi.org/10.18632/oncotarget.13214
- http://doi.org/10.18632/oncotarget.18277
- http://doi.org/10.1186/s13058-019-1182-4
- http://doi.org/10.1016/j.bbcan.2016.11.005
- http://doi.org/10.1371/journal.pone.0144535
- http://doi.org/10.3390/cancers6042369
- http://doi.org/10.1007/s00262-012-1387-1
- http://doi.org/10.1002/smll.201202867
- http://doi.org/10.3390/cancers12103001
- http://doi.org/10.1039/C5AN00382B
- http://doi.org/10.1186/s40169-017-0145-6
- http://doi.org/10.1007/s00404-017-4562-y
- http://doi.org/10.1007/s10586-018-2183-2
- http://doi.org/10.1073/pnas.1819408116
- http://doi.org/10.1097/PPO.0000000000000315
- http://doi.org/10.1007/s10544-015-9956-7
- http://doi.org/10.4236/ijcm.2014.516129
- http://doi.org/10.1371/journal.pone.0191520
- http://doi.org/10.3390/genes6041053
- http://doi.org/10.1016/j.it.2016.12.001
- http://doi.org/10.2116/analsci.18P568
- http://doi.org/10.1186/bcr3622
- http://doi.org/10.1002/ijc.28134
- http://doi.org/10.1177/1087057116637837
- http://doi.org/10.1007/s10549-016-4026-2
- http://doi.org/10.1158/1541-7786.MCR-13-0096
- http://doi.org/10.1007/s12195-017-0497-4
- http://doi.org/10.3389/fmed.2017.00227
- http://doi.org/10.2217/lmt-2017-0019
- http://doi.org/10.3390/cancers12061556
- http://doi.org/10.1007/s10555-014-9502-8
- http://doi.org/10.3390/ijms21051696
- http://doi.org/10.1007/s11864-013-0253-5
- http://doi.org/10.1002/smll.201802865
- http://doi.org/10.1088/1748-6041/10/2/025010
- http://doi.org/10.1007/s10555-012-9414-4
- http://doi.org/10.1186/s12935-019-1067-8
- http://doi.org/10.1038/nrclinonc.2014.82
- http://doi.org/10.1016/j.critrevonc.2018.12.004
- http://doi.org/10.1111/joim.12240
- http://doi.org/10.1158/1078-0432.CCR-14-1190
- http://doi.org/10.1038/nrd.2015.16
- http://doi.org/10.1073/pnas.1304186110
- http://doi.org/10.1021/acscombsci.7b00146
- http://doi.org/10.1186/s13058-016-0706-4
- http://doi.org/10.18186/journal-of-thermal-engineering.330181
- http://doi.org/10.1371/journal.pone.0055044
- http://doi.org/10.3109/09553002.2014.906766
- http://doi.org/10.1186/s12916-017-0840-6
- http://doi.org/10.1039/C9TB02457C
- http://doi.org/10.3390/cancers12123525
- http://doi.org/10.1158/2159-8290.CD-13-1014
- http://doi.org/10.1186/s13048-017-0369-5
- http://doi.org/10.3389/fonc.2020.00569
- http://doi.org/10.1038/bjc.2013.92
- http://doi.org/10.1016/j.molonc.2016.01.001
- http://doi.org/10.1158/0008-5472.CAN-13-1739
- http://doi.org/10.1186/1479-5876-12-143
- http://doi.org/10.1021/jacs.8b09397
- http://doi.org/10.1080/14737140.2019.1699065
- http://doi.org/10.1007/s12609-014-0177-5
- http://doi.org/10.1186/s13045-019-0833-3
- http://doi.org/10.1016/j.critrevonc.2015.10.010
- http://doi.org/10.1038/nrclinonc.2017.14
- http://doi.org/10.3390/cancers6010595
- http://doi.org/10.1038/onc.2017.48
- http://doi.org/10.1063/1.5049149
- http://doi.org/10.1039/c3lc00052d
- http://doi.org/10.1038/onc.2015.192
- http://doi.org/10.1371/journal.pone.0130418
- http://doi.org/10.1021/acs.analchem.5b02241
- http://doi.org/10.1038/srep17533
- http://doi.org/10.18632/oncotarget.18679
- http://doi.org/10.1038/aja.2013.106
- http://doi.org/10.1021/acs.analchem.6b01475
- http://doi.org/10.3390/s121115947
- http://doi.org/10.1007/s10555-017-9682-0
- http://doi.org/10.1038/nrclinonc.2013.4
- http://doi.org/10.1136/jclinpath-2014-202499
- http://doi.org/10.1101/cshperspect.a029587
- http://doi.org/10.1158/1078-0432.CCR-17-3078
- http://doi.org/10.1093/bioinformatics/bts714
- http://doi.org/10.1016/j.molonc.2016.04.002
- http://doi.org/10.1016/j.biocel.2017.08.003
- http://doi.org/10.1080/14737159.2019.1664290
- http://doi.org/10.1038/srep22076
- http://doi.org/10.1038/nbt.2295
- http://doi.org/10.1021/acs.analchem.8b04975
- http://doi.org/10.1371/journal.pone.0088821
- http://doi.org/10.18632/oncotarget.9528
- http://doi.org/10.1177/2472630317738698
- http://doi.org/10.1186/s13045-019-0735-4
- http://doi.org/10.1007/s13277-015-3196-6
- http://doi.org/10.1158/1078-0432.CCR-13-0838
- http://doi.org/10.1016/j.ajpath.2013.06.012
- http://doi.org/10.3390/cancers11020143
- http://doi.org/10.1007/s00216-013-6930-1
- http://doi.org/10.1016/j.bbcan.2017.12.005
- http://doi.org/10.3390/cancers12051135
- http://doi.org/10.1158/1078-0432.CCR-17-2312
- http://doi.org/10.1021/acs.analchem.6b01284
- http://doi.org/10.1373/clinchem.2012.191551
- http://doi.org/10.1021/acs.langmuir.6b03903
- http://doi.org/10.1039/C7AN01979C
- http://doi.org/10.1172/jci.insight.99791
- http://doi.org/10.1158/1078-0432.CCR-14-0894
- http://doi.org/10.1021/acs.analchem.9b01181
- http://doi.org/10.13070/mm.en.7.2271
- http://doi.org/10.1038/s41698-019-0095-0
- http://doi.org/10.1002/smll.201400719
- http://doi.org/10.1007/s00432-020-03428-y
- http://doi.org/10.1039/C5LC00304K
- http://doi.org/10.1111/basr.12134
- http://doi.org/10.1039/c3lc00009e
- http://doi.org/10.1136/gutjnl-2016-311447
- http://doi.org/10.1038/nrclinonc.2013.80
- http://doi.org/10.1007/s10585-016-9796-8
- http://doi.org/10.1021/ac303628j
- http://doi.org/10.1007/s11033-018-4359-5
- http://doi.org/10.1007/s10269-014-2414-y
- http://doi.org/10.3389/fonc.2015.00042
- http://doi.org/10.1021/am500394j
- http://doi.org/10.1158/0008-5472.CAN-12-3970
- http://doi.org/10.3390/s140304856
- http://doi.org/10.3390/cancers12102760
- http://doi.org/10.1371/journal.pone.0049144
- http://doi.org/10.1016/j.biotechadv.2013.08.016
- http://doi.org/10.1002/cac2.12078
- http://doi.org/10.1111/joim.12084
- http://doi.org/10.1016/j.molonc.2013.07.007
- http://doi.org/10.1007/s00432-014-1752-x
- http://doi.org/10.1016/j.tcb.2016.08.003
- http://doi.org/10.1016/j.jmoldx.2015.02.001
- http://doi.org/10.1097/PPO.0000000000000308
- http://doi.org/10.1002/1878-0261.12533
- http://doi.org/10.1002/path.4270
- http://doi.org/10.1016/j.tibtech.2018.02.007
- http://doi.org/10.5772/61822
- http://doi.org/10.1021/mp300577s
- http://doi.org/10.1021/acs.analchem.9b03690
- http://doi.org/10.1002/pros.22625
- http://doi.org/10.1146/annurev-chembioeng-060713-035958
- http://doi.org/10.18632/oncotarget.1683
- http://doi.org/10.1002/adbi.201800278
- http://doi.org/10.1634/theoncologist.2015-0207
- http://doi.org/10.18632/oncotarget.26510
- http://doi.org/10.1158/2159-8290.CD-14-0471
- http://doi.org/10.1038/nrc3820
- http://doi.org/10.2217/fon.12.119
- http://doi.org/10.1053/j.gastro.2016.05.052
- http://doi.org/10.1002/smtd.201800544
- http://doi.org/10.18632/oncotarget.13350
- http://doi.org/10.1039/C9LC00550A
- http://doi.org/10.1007/s11670-012-0279-4
- http://doi.org/10.1186/s12967-014-0312-0
- http://doi.org/10.1002/smll.201503188
- http://doi.org/10.1016/j.ab.2014.03.001
- http://doi.org/10.1089/cmb.2017.0049
- http://doi.org/10.1371/journal.pone.0147400
- http://doi.org/10.1093/mutage/gew037
- http://doi.org/10.1016/j.molcel.2015.05.005
- http://doi.org/10.18632/oncotarget.17893
- http://doi.org/10.1002/anie.201505100
- http://doi.org/10.1593/tlo.12310
- http://doi.org/10.1002/adfm.201504176
- http://doi.org/10.3109/10408363.2014.896316
- http://doi.org/10.1186/s12885-017-3305-6
- http://doi.org/10.1007/s10059-013-0304-6
- http://doi.org/10.1016/j.ymeth.2013.09.006
- http://doi.org/10.1016/j.biotechadv.2018.03.007
- http://doi.org/10.1002/adma.201404677
- http://doi.org/10.1039/c2lc41201b
- http://doi.org/10.3390/mi8060172
- http://doi.org/10.1007/s11064-014-1431-y
- http://doi.org/10.1038/s41598-018-23217-5
- http://doi.org/10.1111/joim.12047
- http://doi.org/10.1155/2016/9369240
- http://doi.org/10.1586/14737159.2014.868308
- http://doi.org/10.1007/s11426-020-9734-7
- http://doi.org/10.1039/C6SC04671A
- http://doi.org/10.1016/j.aca.2018.07.060
- http://doi.org/10.3389/fcell.2016.00116
- http://doi.org/10.1186/s13058-019-1166-4
- http://doi.org/10.1103/PhysRevE.92.042149
- http://doi.org/10.1021/ac5029038
- http://doi.org/10.1016/j.prp.2016.01.008
- http://doi.org/10.3390/mi8010028
- http://doi.org/10.1007/s10555-013-9438-4
- http://doi.org/10.1002/bies.201800244
- http://doi.org/10.1186/s12967-016-0876-y
- http://doi.org/10.1038/s41598-019-53899-4
- http://doi.org/10.2217/nnm.15.99
- http://doi.org/10.1039/C6MB00388E
- http://doi.org/10.3390/ijms160816763
- http://doi.org/10.1007/s10895-012-1136-z
- http://doi.org/10.1016/S1470-2045(14)70091-9
- http://doi.org/10.1039/C3LC51107C
- http://doi.org/10.1007/s10120-014-0426-3
- http://doi.org/10.1039/C4LC00041B
- http://doi.org/10.1038/s41467-018-04701-y
- http://doi.org/10.2217/bmm-2016-0192
- http://doi.org/10.1016/j.molonc.2014.12.011
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- http://doi.org/10.1373/clinchem.2014.230144
- http://doi.org/10.1002/smll.201503639
- http://doi.org/10.15746/sms.19.001
- http://doi.org/10.2217/fon-2016-0427
- http://doi.org/10.3390/s16091489
- http://doi.org/10.18632/oncotarget.12370
- http://doi.org/10.1186/s12864-018-4527-y
- http://doi.org/10.1007/s10544-016-0041-7
- http://doi.org/10.1039/C7CS00016B
- http://doi.org/10.1039/C3LC50689D
- http://doi.org/10.1007/s10549-014-3215-0
- http://doi.org/10.3390/diagnostics8020030
- http://doi.org/10.1038/srep08745
- http://doi.org/10.3390/mi11050531
- http://doi.org/10.18632/oncotarget.8015
- http://doi.org/10.3892/ijo.2020.5075
- http://doi.org/10.1186/s13059-016-1077-y
- http://doi.org/10.1039/c3ib40264a
- http://doi.org/10.1586/14789450.2013.858021
- http://doi.org/10.1093/molbev/msy115
- http://doi.org/10.1007/s10555-014-9503-7
- http://doi.org/10.1002/smll.201403658
- http://doi.org/10.1517/17460441.2014.941351
- http://doi.org/10.1007/s12094-015-1460-2
- http://doi.org/10.1177/2211068213495394
- http://doi.org/10.1126/science.abb0736
- http://doi.org/10.1158/0008-5472.CAN-14-0420
- http://doi.org/10.1016/j.coisb.2017.11.008
- http://doi.org/10.1007/s12154-012-0085-y
- http://doi.org/10.1093/bfgp/elt021
- http://doi.org/10.1371/journal.pone.0086717
- http://doi.org/10.1158/1078-0432.CCR-14-0149
- http://doi.org/10.1039/C5LC00445D
- http://doi.org/10.1186/s13059-018-1593-z
- http://doi.org/10.1186/gm477
- http://doi.org/10.1038/s41467-017-01705-y
- http://doi.org/10.1038/bjc.2013.265
- http://doi.org/10.1002/jhbp.125
- http://doi.org/10.3390/cancers11081115
- http://doi.org/10.1016/j.canlet.2013.04.021
- http://doi.org/10.1038/srep16047
PubMed Central | Further Information
- 3612640
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- 4281948
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Scopus | Further Information
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Journal Comments | Further Information
- {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/2901486b-a1da-4d86-bcbe-77b455c31ba4", "title"=>"Maybe this will finally kill some old ideas.", "body"=>"It is amazing to me that this idea is taking so long to accept. People seem desperate to hang onto the idea that all cancer cells are alike, even though that assertion was falsified decades ago. We have spent billions of dollars trying to cure primary tumors that surgeons remove and have spent very little trying to kill the cells that actually kill patients. Perhaps this paper will finally kill the idea that we can learn much of interest from the primary tumor. All the \"targeted therapy\" designed to target the primary tumor is doomed to failure. This is a beautiful and elegant paper.", "isRemoved"=>false, "created"=>"2012-05-08T20:15:07Z", "lastModified"=>"2012-05-08T20:15:07Z", "creator"=>{"userId"=>"265521"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0033788", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2012-05-08T20:15:07Z", "replies"=>[]}
- {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/30ffc32d-a039-4f49-97ce-d1fd5212762a", "title"=>"Media Coverage of This Article", "body"=>"The following article represents some of the media coverage that has occurred for this paper:\n\nPublication: Genetic Engineering and Biotechnology News \nTitle: “GEN | News Highlights:Transcriptional Diversity Found in Circulating Tumor Cells from Individual Breast Cancer Patients”\nhttp://www.genengnews.com/gen-news-highlights/transcriptional-diversity-found-in-circulating-tumor-cells-from-individual-breast-cancer-patients/81246738\n\nPublication: Health Canal \nTitle: “Health News - Not all tumor cells are equal: Study reveals genetic diversity in cells shed by tumors”\nhttp://www.healthcanal.com/cancers/29176-Not-all-tumor-cells-are-equal-Study-reveals-genetic-diversity-cells-shed-tumors.html\n\nPublication: Health Day News \nTitle: “Cancer Cells in Bloodstream Show Great Diversity: Study”\nhttp://consumer.healthday.com/Article.asp?AID=664463\n\nPublication: Stanford University School of Medicine \nTitle: “Not all tumor cells are equal: Study reveals genetic diversity in cells shed by tumors - Office of Communications & Public Affairs - Stanford University School of Medicine”\nhttp://med.stanford.edu/ism/2012/may/jeffrey.html\n\nPublication: Stanford University School of Medicine Scope \nTitle: “Study finds huge genetic diversity in cancer cells - Scope - medical blog - Stanford University School of Medicine”\nhttp://scopeblog.stanford.edu/2012/05/study-finds-huge-genetic-diversity-in-cancer-cells\n\nIf you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article. ", "isRemoved"=>false, "created"=>"2012-05-11T21:40:21Z", "lastModified"=>"2012-05-11T21:40:21Z", "creator"=>{"userId"=>"80539"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"PLoS ONE Staff"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0033788", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>1, "mostRecentActivity"=>"2012-05-18T22:08:19Z", "replies"=>[{"type"=>"REPLY", "parentID"=>49597, "annotationUri"=>"info:doi/10.1371/reply/1f391159-4688-452c-99a5-7c3f246c4f0c", "title"=>"RE: Media Coverage of This Article", "body"=>"The following articles represent some of the media coverage that has occurred for this paper:\n\nPublication: BioTechniques \nTitle: “BioTechniques - No Two Cancer Cells Are Alike”\nhttp://www.biotechniques.com/news/biotechniquesNews/biotechniques-330295.html\n\nPublication: GEN Genetic Engineering and Biotechnology News \nTitle: “GEN | News Highlights:Transcriptional Diversity Found in Circulating Tumor Cells from Individual Breast Cancer Patients”\nhttp://www.genengnews.com/gen-news-highlights/transcriptional-diversity-found-in-circulating-tumor-cells-from-individual-breast-cancer-patient/81246738\n\nPublication: Der Spiegel \nTitle: “Krebszellen in einem Tumor unterscheiden sich genetisch stark - SPIEGEL ONLINE”\nhttp://www.spiegel.de/wissenschaft/medizin/krebszellen-in-einem-tumor-unterscheiden-sich-genetisch-stark-a-831999.html\n\nIf you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article. ", "isRemoved"=>false, "created"=>"2012-05-18T22:08:19Z", "lastModified"=>"2012-05-18T22:08:19Z", "creator"=>{"userId"=>"80539"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"PLoS ONE Staff"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0033788", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2012-05-18T22:08:19Z", "replies"=>[]}]}
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- {"id"=>"237985280529952769", "text"=>"Single cell profiling of circulating tumor cells shows how diverse the population is that has left the primary site. http://t.co/9150f5xL", "created_at"=>"2012-08-21T18:51:27Z", "user"=>"jillagal", "user_name"=>"Jill Gallaher", "user_profile_image"=>"http://a0.twimg.com/profile_images/2438237354/jep6xfggmbpb2du8h715_normal.jpeg"}
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- {"month"=>"5", "year"=>"2017", "pdf_views"=>"46", "xml_views"=>"1", "html_views"=>"347"}
- {"month"=>"6", "year"=>"2017", "pdf_views"=>"27", "xml_views"=>"1", "html_views"=>"331"}
- {"month"=>"7", "year"=>"2017", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"263"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"53", "xml_views"=>"2", "html_views"=>"272"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"38", "xml_views"=>"1", "html_views"=>"282"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"42", "xml_views"=>"1", "html_views"=>"292"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"51", "xml_views"=>"0", "html_views"=>"339"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"40", "xml_views"=>"2", "html_views"=>"296"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"36", "xml_views"=>"2", "html_views"=>"203"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"44", "xml_views"=>"1", "html_views"=>"73"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"53", "xml_views"=>"0", "html_views"=>"109"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"71", "xml_views"=>"2", "html_views"=>"98"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"46", "xml_views"=>"1", "html_views"=>"61"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"36", "xml_views"=>"5", "html_views"=>"71"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"57", "xml_views"=>"6", "html_views"=>"76"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"34", "xml_views"=>"3", "html_views"=>"66"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"43", "xml_views"=>"0", "html_views"=>"47"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"74"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"164"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"63"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"87"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"33", "xml_views"=>"1", "html_views"=>"55"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"49", "xml_views"=>"0", "html_views"=>"90"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"62"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"38", "xml_views"=>"1", "html_views"=>"59"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"56", "xml_views"=>"0", "html_views"=>"65"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"70", "xml_views"=>"0", "html_views"=>"65"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"51", "xml_views"=>"0", "html_views"=>"49"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"36", "xml_views"=>"1", "html_views"=>"59"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"61"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"48"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"55"}
- {"month"=>"1", "year"=>"2020", "pdf_views"=>"37", "xml_views"=>"0", "html_views"=>"52"}
- {"month"=>"2", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"18"}
- {"month"=>"3", "year"=>"2020", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"40"}
- {"month"=>"4", "year"=>"2020", "pdf_views"=>"59", "xml_views"=>"0", "html_views"=>"32"}
- {"month"=>"5", "year"=>"2020", "pdf_views"=>"44", "xml_views"=>"1", "html_views"=>"22"}
- {"month"=>"6", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"21"}
- {"month"=>"7", "year"=>"2020", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"50"}
- {"month"=>"8", "year"=>"2020", "pdf_views"=>"72", "xml_views"=>"0", "html_views"=>"29"}
- {"month"=>"9", "year"=>"2020", "pdf_views"=>"31", "xml_views"=>"4", "html_views"=>"42"}
- {"month"=>"10", "year"=>"2020", "pdf_views"=>"47", "xml_views"=>"0", "html_views"=>"63"}
- {"month"=>"11", "year"=>"2020", "pdf_views"=>"47", "xml_views"=>"0", "html_views"=>"96"}
- {"month"=>"12", "year"=>"2020", "pdf_views"=>"47", "xml_views"=>"0", "html_views"=>"42"}
- {"month"=>"1", "year"=>"2021", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"27"}
PMC Usage Stats | Further Information
- {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"142", "unique-ip"=>"141", "pdf"=>"173", "year"=>"2012", "figure"=>"52", "scanned-summary"=>"0", "supp-data"=>"24"}
- {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"147", "year"=>"2012", "pdf"=>"136", "unique-ip"=>"140", "figure"=>"47", "scanned-summary"=>"0", "supp-data"=>"14"}
- {"unique-ip"=>"120", "full-text"=>"127", "pdf"=>"100", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"42", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
- {"unique-ip"=>"101", "full-text"=>"108", "pdf"=>"76", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"6", "cited-by"=>"1", "year"=>"2012", "month"=>"8"}
- {"unique-ip"=>"75", "full-text"=>"89", "pdf"=>"58", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"24", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
- {"unique-ip"=>"101", "full-text"=>"103", "pdf"=>"66", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"48", "supp-data"=>"11", "cited-by"=>"1", "year"=>"2012", "month"=>"10"}
- {"unique-ip"=>"43", "full-text"=>"38", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
- {"unique-ip"=>"67", "full-text"=>"74", "pdf"=>"35", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"9", "cited-by"=>"1", "year"=>"2013", "month"=>"1"}
- {"unique-ip"=>"51", "full-text"=>"52", "pdf"=>"31", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2013", "month"=>"3"}
- {"unique-ip"=>"73", "full-text"=>"78", "pdf"=>"32", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
- {"unique-ip"=>"59", "full-text"=>"62", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
- {"unique-ip"=>"72", "full-text"=>"74", "pdf"=>"55", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
- {"unique-ip"=>"48", "full-text"=>"54", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"7", "cited-by"=>"1", "year"=>"2013", "month"=>"5"}
- {"unique-ip"=>"37", "full-text"=>"30", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"5", "cited-by"=>"1", "year"=>"2013", "month"=>"6"}
- {"unique-ip"=>"41", "full-text"=>"43", "pdf"=>"22", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2013", "month"=>"7"}
- {"unique-ip"=>"34", "full-text"=>"54", "pdf"=>"20", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
- {"unique-ip"=>"45", "full-text"=>"53", "pdf"=>"30", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
- {"unique-ip"=>"44", "full-text"=>"52", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
- {"unique-ip"=>"39", "full-text"=>"43", "pdf"=>"37", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
- {"unique-ip"=>"40", "full-text"=>"48", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"26", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
- {"unique-ip"=>"42", "full-text"=>"37", "pdf"=>"26", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
- {"unique-ip"=>"25", "full-text"=>"22", "pdf"=>"13", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
- {"unique-ip"=>"33", "full-text"=>"37", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
- {"unique-ip"=>"25", "full-text"=>"22", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
- {"unique-ip"=>"42", "full-text"=>"43", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
- {"unique-ip"=>"31", "full-text"=>"31", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
- {"unique-ip"=>"66", "full-text"=>"84", "pdf"=>"29", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
- {"unique-ip"=>"49", "full-text"=>"64", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
- {"unique-ip"=>"43", "full-text"=>"47", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"21", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
- {"unique-ip"=>"48", "full-text"=>"47", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
- {"unique-ip"=>"45", "full-text"=>"48", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
- {"unique-ip"=>"40", "full-text"=>"50", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
- {"unique-ip"=>"37", "full-text"=>"35", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
- {"unique-ip"=>"51", "full-text"=>"45", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"7", "cited-by"=>"1", "year"=>"2015", "month"=>"9"}
- {"unique-ip"=>"47", "full-text"=>"50", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
- {"unique-ip"=>"30", "full-text"=>"32", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"7"}
- {"unique-ip"=>"53", "full-text"=>"57", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
- {"unique-ip"=>"64", "full-text"=>"50", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
- {"unique-ip"=>"41", "full-text"=>"35", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
- {"unique-ip"=>"38", "full-text"=>"39", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
- {"unique-ip"=>"40", "full-text"=>"41", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
- {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
- {"unique-ip"=>"37", "full-text"=>"47", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
- {"unique-ip"=>"36", "full-text"=>"46", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"5", "year"=>"2015", "month"=>"11"}
- {"unique-ip"=>"33", "full-text"=>"66", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2015", "month"=>"12"}
- {"unique-ip"=>"37", "full-text"=>"50", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
- {"unique-ip"=>"36", "full-text"=>"35", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
- {"unique-ip"=>"32", "full-text"=>"31", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
- {"unique-ip"=>"27", "full-text"=>"30", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
- {"unique-ip"=>"28", "full-text"=>"42", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
- {"unique-ip"=>"30", "full-text"=>"39", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"5", "cited-by"=>"1", "year"=>"2016", "month"=>"7"}
- {"unique-ip"=>"30", "full-text"=>"37", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
- {"unique-ip"=>"24", "full-text"=>"23", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
- {"unique-ip"=>"24", "full-text"=>"26", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
- {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
- {"unique-ip"=>"28", "full-text"=>"30", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
- {"unique-ip"=>"30", "full-text"=>"30", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"4", "year"=>"2017", "month"=>"1"}
- {"unique-ip"=>"27", "full-text"=>"29", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
- {"unique-ip"=>"24", "full-text"=>"26", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
- {"unique-ip"=>"27", "full-text"=>"29", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
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Relative Metric
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