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{"title"=>"Immunomodulatory effects of Streptococcus suis capsule type on human dendritic cell responses, phagocytosis and intracellular survival", "type"=>"journal", "authors"=>[{"first_name"=>"Marjolein", "last_name"=>"Meijerink", "scopus_author_id"=>"36168370000"}, {"first_name"=>"Maria Laura", "last_name"=>"Ferrando", "scopus_author_id"=>"37026059300"}, {"first_name"=>"Geraldine", "last_name"=>"Lammers", "scopus_author_id"=>"55203488400"}, {"first_name"=>"Nico", "last_name"=>"Taverne", "scopus_author_id"=>"6602132581"}, {"first_name"=>"Hilde E.", "last_name"=>"Smith", "scopus_author_id"=>"7406226559"}, {"first_name"=>"Jerry M.", "last_name"=>"Wells", "scopus_author_id"=>"7403356868"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"364720806", "sgr"=>"84860486193", "issn"=>"19326203", "pmid"=>"22558240", "scopus"=>"2-s2.0-84860486193", "doi"=>"10.1371/journal.pone.0035849", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"a07fc805-0056-3646-ba99-d756fc9a166c", "abstract"=>"Streptococcus suis is a major porcine pathogen of significant commercial importance worldwide and an emerging zoonotic pathogen of humans. Given the important sentinel role of mucosal dendritic cells and their importance in induction of T cell responses we investigated the effect of different S. suis serotype strains and an isogenic capsule mutant of serotype 2 on the maturation, activation and expression of IL-10, IL-12p70 and TNF-α in human monocyte-derived dendritic cells. Additionally, we compared phagocytosis levels and bacterial survival after internalization. The capsule of serotype 2, the most common serotype associated with infection in humans and pigs, was highly anti-phagocytic and modulated the IL-10/IL-12 and IL-10/TNF-α cytokine production in favor of a more anti-inflammatory profile compared to other serotypes. This may have consequences for the induction of effective immunity to S. suis serotype 2 in humans. A shielding effect of the capsule on innate Toll-like receptor signaling was also demonstrated. Furthermore, we showed that 24 h after phagocytosis, significant numbers of viable intracellular S. suis were still present intracellularly. This may contribute to the dissemination of S. suis in the body.", "link"=>"http://www.mendeley.com/research/immunomodulatory-effects-streptococcus-suis-capsule-type-human-dendritic-cell-responses-phagocytosis-3", "reader_count"=>23, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>4, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>4, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>11, "Medicine and Dentistry"=>5, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Argentina"=>1}, "group_count"=>0}

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• http://doi.org/10.1371/journal.pone.0123013
• http://doi.org/10.3389/fmicb.2018.02426
• http://doi.org/10.1038/srep38061
• http://doi.org/10.3390/pathogens6040046
• http://doi.org/10.3390/pathogens9010040
• http://doi.org/10.1371/journal.pone.0223864
• http://doi.org/10.1371/journal.pone.0114277
• http://doi.org/10.1371/journal.pone.0151623
• http://doi.org/10.1016/j.medmal.2017.10.001
• http://doi.org/10.1128/IAI.00787-19
• http://doi.org/10.1128/IAI.00113-13
• http://doi.org/10.1371/journal.pone.0087866
• http://doi.org/10.1093/infdis/jiu813
• http://doi.org/10.3892/mmr.2015.4211
• http://doi.org/10.1080/19490976.2016.1144008
• http://doi.org/10.1016/j.carres.2016.07.005
• http://doi.org/10.1186/s12866-016-0905-2
• http://doi.org/10.1371/journal.pone.0200453
• http://doi.org/10.1016/j.jff.2020.104289
• http://doi.org/10.13103/JFHS.2013.28.2.095
• http://doi.org/10.3389/fmicb.2017.01524
• http://doi.org/10.3389/fimmu.2018.01199
• http://doi.org/10.1080/21505594.2018.1428519
• http://doi.org/10.3390/pathogens5030047
• http://doi.org/10.1038/s41598-017-04403-3

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/646261"], "description"=>"<p>Phagocytosis by immature DCs with 6 different <i>S. suis</i> strains and an unencapsulated mutant at an MOI 10. This is a representative figure from 1 donor, out of 5 donors. *P<0.05.</p>", "links"=>[], "tags"=>["immunology", "Infectious diseases", "microbiology", "cell biology"], "article_id"=>316752, "categories"=>["Microbiology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Marjolein Meijerink", "Maria Laura Ferrando", "Geraldine Lammers", "Nico Taverne", "Hilde E. Smith", "Jerry M. Wells"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035849.g003", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phagocytosis_assay_/316752", "title"=>"Phagocytosis assay.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 05:51:55"}
• {"files"=>["https://ndownloader.figshare.com/files/646502"], "description"=>"a<p>The isogenic unencapsulated mutant strain 10 cpsΔEF parts of the cps2E and cps2F gene were replaced by an antibiotic resistance gene. HV high virulent V virulent AV avirulent. MRP muraminidase-released protein. EF extracellular factor. SLY suilysin. CPS capsular polysaccharide synthesis *, higher MW protein expressed; s, smaller MW protein expressed.</p>", "links"=>[], "tags"=>["strains"], "article_id"=>316995, "categories"=>["Microbiology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Marjolein Meijerink", "Maria Laura Ferrando", "Geraldine Lammers", "Nico Taverne", "Hilde E. Smith", "Jerry M. Wells"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035849.t001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_List_of_strains_used_in_this_study_/316995", "title"=>"List of strains used in this study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 05:53:11"}
• {"files"=>["https://ndownloader.figshare.com/files/646139"], "description"=>"<p>Cytokine production by monocyte derived dendritic cells with 6 different <i>S. suis</i> strains and SS2J28, with immature DCs as the negative control and LPS as the positive control. <b>A.</b> IL-10 <b>B.</b> IL-12p70 <b>C.</b> TNF-α. <b>D.</b> IL-10/IL-12 ratio. <b>E.</b> IL-10/TNF-α.</p>", "links"=>[], "tags"=>["secretion", "dendritic"], "article_id"=>316630, "categories"=>["Microbiology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Marjolein Meijerink", "Maria Laura Ferrando", "Geraldine Lammers", "Nico Taverne", "Hilde E. Smith", "Jerry M. Wells"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035849.g002", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cytokine_secretion_by_dendritic_cells_/316630", "title"=>"Cytokine secretion by dendritic cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 05:51:19"}
• {"files"=>["https://ndownloader.figshare.com/files/646387"], "description"=>"<p>HEK293 cells were incubated with 6 different <i>S. suis</i> strains and an unencapsulated mutant at a MOI10, PAM2CSK as a positive control and medium as a negative control. This figure is representative out of three hTLR2/6 assays. *P<0.05.</p>", "links"=>[], "tags"=>["immunology", "Infectious diseases", "microbiology", "cell biology"], "article_id"=>316874, "categories"=>["Microbiology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Marjolein Meijerink", "Maria Laura Ferrando", "Geraldine Lammers", "Nico Taverne", "Hilde E. Smith", "Jerry M. Wells"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035849.g005", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_hTLR2_6_assay_/316874", "title"=>"hTLR2/6 assay.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 05:52:32"}
• {"files"=>["https://ndownloader.figshare.com/files/646323"], "description"=>"<p><b>A.. </b><i>Kinetics of adhesion and phagocytosis</i> Immature DCs were inoculated with SS2 and SS2 J28 at a MOI of 10 bacteria/DC for subsequently 2, 3, 4, 5 and 24 hours of incubation. <b>B.. </b><i>Survival of S. suis inside DCs after 2 and 24 </i><i>hours</i> Immature DCs were inoculated with SS2 and SS2J28 at a MOI10 for 2 and 24 hours of incubation. The last hour the DCs were incubated with (24+) or without (24) antibiotics.</p>", "links"=>[], "tags"=>["dendritic"], "article_id"=>316812, "categories"=>["Microbiology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Marjolein Meijerink", "Maria Laura Ferrando", "Geraldine Lammers", "Nico Taverne", "Hilde E. Smith", "Jerry M. Wells"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035849.g004", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Survival_of_S_suis_inside_dendritic_cells_/316812", "title"=>"Survival of <i>S. suis</i> inside dendritic cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 05:52:13"}
• {"files"=>["https://ndownloader.figshare.com/files/646442"], "description"=>"<p><i>S. suis</i> 2 strain 10 shows a thick capsule, whereas no capsular material can be seen in isogenic mutant strain <i>S. suis</i> 2 10ΔcpsEF.</p>", "links"=>[], "tags"=>["encapsulation", "strains", "lrr", "staining", "electron"], "article_id"=>316926, "categories"=>["Microbiology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Marjolein Meijerink", "Maria Laura Ferrando", "Geraldine Lammers", "Nico Taverne", "Hilde E. Smith", "Jerry M. Wells"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035849.g006", "stats"=>{"downloads"=>2, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Detection_of_encapsulation_of_S_suis_strains_by_LRR_staining_and_transmission_electron_microscopy_/316926", "title"=>"Detection of encapsulation of <i>S. suis</i> strains by LRR staining and transmission electron microscopy.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 05:52:51"}
• {"files"=>["https://ndownloader.figshare.com/files/646041"], "description"=>"<p>The MFI of stained cell surface markers by monocyte derived dendritic cells with 6 different <i>S. suis</i> strains and SS2J28 mutant, with immature DCs as the negative control and LPS as the positive control. <b>A.</b> MFI of CD83 <b>B.</b> MFI of CD86. Bars showing unequal letters significantly differ in their surface marker expression (P<0.05). <b>C.</b> Histograms for expression of surface markers CD83 and CD86. Dotted lines represent the isotype controls and black lines the stimulated samples. In case of bacteria a black line represents a MOI 1 and a dashed line a MOI 10.</p>", "links"=>[], "tags"=>["fluorescence", "dendritic", "cells", "normalized"], "article_id"=>316527, "categories"=>["Microbiology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Marjolein Meijerink", "Maria Laura Ferrando", "Geraldine Lammers", "Nico Taverne", "Hilde E. Smith", "Jerry M. Wells"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035849.g001", "stats"=>{"downloads"=>4, "page_views"=>27, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_Fluorescence_Intensity_MFI_of_dendritic_cells_normalized_with_LPS_/316527", "title"=>"Mean Fluorescence Intensity (MFI) of dendritic cells normalized with LPS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 05:50:45"}

PMC Usage Stats | Further Information

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Relative Metric

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F1000Prime