Glycogen Synthase Kinase 3 (GSK3) Inhibitor, SB-216763, Promotes Pluripotency in Mouse Embryonic Stem Cells
- Publication Date
- June 26, 2012
- Journal
- PLOS ONE
- Authors
- Leslie A. Kirby, Jason T. Schott, Brenda L. Noble, Daniel C. Mendez, et al
- Volume
- 7
- Issue
- 6
- Pages
- e39329
- DOI
- https://dx.plos.org/10.1371/journal.pone.0039329
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0039329
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/22745733
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383737
- Europe PMC
- http://europepmc.org/abstract/MED/22745733
- Web of Science
- 000305808700021
- Scopus
- 84862746199
- Mendeley
- http://www.mendeley.com/research/glycogen-synthase-kinase-3-gsk3-inhibitor-sb216763-promotes-pluripotency-mouse-embryonic-stem-cells
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Mendeley | Further Information
{"title"=>"Glycogen Synthase Kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells", "type"=>"journal", "authors"=>[{"first_name"=>"Leslie A.", "last_name"=>"Kirby", "scopus_author_id"=>"55259640300"}, {"first_name"=>"Jason T.", "last_name"=>"Schott", "scopus_author_id"=>"57197885435"}, {"first_name"=>"Brenda L.", "last_name"=>"Noble", "scopus_author_id"=>"55260266900"}, {"first_name"=>"Daniel C.", "last_name"=>"Mendez", "scopus_author_id"=>"57196681358"}, {"first_name"=>"Paul S.", "last_name"=>"Caseley", "scopus_author_id"=>"55260412400"}, {"first_name"=>"Sarah C.", "last_name"=>"Peterson", "scopus_author_id"=>"55260252400"}, {"first_name"=>"Tyler J.", "last_name"=>"Routledge", "scopus_author_id"=>"55259900700"}, {"first_name"=>"Nilay V.", "last_name"=>"Patel", "scopus_author_id"=>"57198804099"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"22745733", "doi"=>"10.1371/journal.pone.0039329", "sgr"=>"84862746199", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "scopus"=>"2-s2.0-84862746199", "issn"=>"19326203", "pui"=>"365093325"}, "id"=>"fa7a4d95-674b-3293-8736-15474083f5c1", "abstract"=>"Canonical Wnt/β-catenin signaling has been suggested to promote self-renewal of pluripotent mouse and human embryonic stem cells. Here, we show that SB-216763, a glycogen synthase kinase-3 (GSK3) inhibitor, can maintain mouse embryonic stem cells (mESCs) in a pluripotent state in the absence of exogenous leukemia inhibitory factor (LIF) when cultured on mouse embryonic fibroblasts (MEFs). MESCs maintained with SB-216763 for one month were morphologically indistinguishable from LIF-treated mESCs and expressed pluripotent-specific genes Oct4, Sox2, and Nanog. Furthermore, Nanog immunostaining was more homogenous in SB-216763-treated colonies compared to LIF. Embryoid bodies (EBs) prepared from these mESCs expressed early-stage markers for all three germ layers, and could efficiently differentiate into cardiac-like cells and MAP2-immunoreactive neurons. To our knowledge, SB-216763 is the first GSK3 inhibitor that can promote self-renewal of mESC co-cultured with MEFs for more than two months.", "link"=>"http://www.mendeley.com/research/glycogen-synthase-kinase-3-gsk3-inhibitor-sb216763-promotes-pluripotency-mouse-embryonic-stem-cells", "reader_count"=>72, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Researcher"=>13, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>25, "Student > Postgraduate"=>3, "Student > Master"=>7, "Other"=>4, "Student > Bachelor"=>11, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Researcher"=>13, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>25, "Student > Postgraduate"=>3, "Student > Master"=>7, "Other"=>4, "Student > Bachelor"=>11, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>8, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>43, "Neuroscience"=>2, "Sports and Recreations"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>4, "Psychology"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>2}, "Chemistry"=>{"Chemistry"=>4}, "Social Sciences"=>{"Social Sciences"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>43}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>2, "Japan"=>1, "United Kingdom"=>3, "France"=>1, "Chile"=>1, "Australia"=>1, "Portugal"=>2, "Germany"=>1}, "group_count"=>6}CrossRef
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Scopus | Further Information
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